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Dosimetric Effects of Intrafractional Organ Motion in Field-in-Field Technique for Whole-Breast Irradiation

  • Hong, Chae-Seon;Ju, Sang Gyu;Choi, Doo Ho;Han, Youngyih;Huh, Seung Jae;Park, Won;Ahn, Yong Chan;Kim, Jin Sung;Lim, Do Hoon
    • Progress in Medical Physics
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    • v.30 no.3
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    • pp.65-73
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    • 2019
  • Purpose: We evaluated the motion-induced dosimetric effects on the field-in-field (FIF) technique for whole-breast irradiation (WBI) using actual patient organ motion data obtained from cine electronic portal imaging device (cine EPID) images during treatment. Materials and Methods: Ten breast cancer patients who received WBI after breast-conserving surgery were selected. The static FIF (SFIF) plan involved the application of two parallel opposing tangential and boost FIFs. To obtain the amplitude of the internal organ motion during treatment, cine EPID images were acquired five times for each patient. The outside contour of the breast (OCB) and chest wall (CW) contour were tracked using in-house motion analysis software. Intrafractional organ motion was analyzed. The dynamic FIF (DFIF) reflecting intrafractional organ motion incorporated into the SFIF plan was calculated and compared with the SFIF in terms of the dose homogeneity index (DHI90/10) for the target and V20 for the ipsilateral lung. Results: The average motion amplitudes along the X and Y directions were 1.84±1.09 mm and 0.69±0.50 mm for OCB and 1.88±1.07 mm and 1.66±1.49 mm for CW, respectively. The maximum motion amplitudes along the X and Y directions were 5.53 and 2.08 mm for OCB and 5.22 and 6.79 mm for CW, respectively. Significant differences in DHI90/10 values were observed between SFIF and DFIF (0.94 vs 0.95, P<0.05) in statistical analysis. The average V20 for the lung in the DFIF was slightly higher than that of the SFIF in statistical analysis (19.21 vs 19.00, P<0.05). Conclusion: Our findings indicate that the FIF technique can form a safe and effective treatment method for WBI. Regular monitoring using cine EPID images can be effective in reducing motion-induced dosimetric errors.

Design of 2-Ch DC-DC Converter with Wide-Input Voltage Range of 2.9V~5.6 V for Wearable AMOLED Display (2.9V~5.6V의 넓은 입력 전압 범위를 가지는 웨어러블 AMOLED용 2-채널 DC-DC 변환기 설계)

  • Lee, Hui-Jin;Kim, Hak-Yun;Choi, Ho-Yong
    • Journal of IKEEE
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    • v.24 no.3
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    • pp.859-866
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    • 2020
  • This paper proposes a 2-ch DC-DC converter with a wide-input voltage range from 2.9V~5.6V for wearable AMOLED displays. For positive voltage VPOS, a boost converter is designed using an over-charged voltage permissible circuit (OPC) which generates a normal output voltage even if over-input voltage is applied, and a SPWM-PWM dual mode with 3-segmented power transistors to improve efficiency at light load. For negative voltage VNEG, a 0.5x regulated inverting charge pump is designed to increase power efficiency. The proposed DC-DC converter was designed using a 0.18-㎛ BCDMOS process. Simulation results show that the proposed DC-DC converter generates VPOS voltages of 4.6 V and VNEG voltage of -0.6V~-2.3V for input voltage of 2.9V to 5.6V. In addition, it has power efficiency of 49%~92%, output ripple voltage has less than 20 mV for load current range of 1 mA~70 mA.

Determinants of International Standardization: An Empirical Analysis in the ICT field (ICT 국제표준화 결정요인에 관한 실증분석 연구)

  • Kim, Bum-Hoan;Park, Jongbong
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.37C no.11
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    • pp.1064-1076
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    • 2012
  • This study is an attempt to identify factors determining the success of international standardization and understand the relationship between the factors, such as government-driven standardization activities. Six factors were identified through factor analysis; namely, 'Direct government support', 'Indirect government support', 'Utilization of standardization bodies', 'Standardization strategy', 'Attainment of a dominant market power', and 'Adoption as an international standard.' The results showed that firstly, support from the government, whether direct or indirect, had no direct effect on the outcome of international standardization efforts, but produced an indirect influence on it through mediating factors such as the attainment of a dominant market power. Secondly, the attainment of a dominant market power proved to be the most important success factor of international standardization, suggesting that the government must direct its efforts to help boost the market power of target standards through measures like promoting a timely market entry and the development of high-quality standards, in a manner to induce market satisfaction, increasing lock-in effects and building a quasi-vertical integration system. Thirdly, direct support from the government holds the key to the success of international standardization with de jure standardization bodies, while the strategic use of standardization bodies appears the most important for the positive outcome of standardization concerning de facto standardization bodies.

Examining the Effect of Cognitive and Affective Images of a Farm Party Venue on Consumer Satisfaction and Revisit Intention (팜파티 농가에 대한 인지적 이미지와 정서적 이미지가 소비자 만족, 재방문 의도에 미치는 영향)

  • Kim, Na-Hyung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.12
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    • pp.548-556
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    • 2017
  • The purpose of this study is to examine the effects of cognitive and affective images of a farm party venue on consumer satisfaction and revisit intention with a research model and hypothesis test. First, the cognitive and affective images of a farm party venue had a significant effect on consumer satisfaction in the test and the cognitive image had greater impact on consumer satisfaction than the affective image had. Second, consumer satisfaction had a significant effect on the revisit intention in the test, which indicates that farm party venues are required to find a way to boost the satisfaction of tourists in order to encourage their intentions to revisit. In order to revitalize rural tourism through farm party and raise income in rural areas, it is most important that farm party venue produce images that are differentiated from other farmhouses. In order to activate the farm party for the 6th industry, it will be possible to establish images of the farmers and utilize them in promotional marketing for the promotion of rural tourism. The present study is limited in that it did not collect feedback from farm party operators in action. With this in mind, another study is planned, focusing on those farm party operators.

Impact of Lifestyles of Cultural Center Users in Discount Stores on the Store Usage Intention: Mediating Effect of Shopping Value (대형마트부설 문화센터 이용고객의 라이프스타일 유형이 대형마트 이용의도에 미치는 영향: 쇼핑가치의 매개효과)

  • Lee, Gi-Hwang;Kim, Sang-Cheol;Kim, Pan-Jin
    • Journal of Distribution Science
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    • v.13 no.10
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    • pp.83-91
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    • 2015
  • Purpose - The purpose of this study is to identify whether the operation of cultural centers in discount stores contributes to their profitability. Thus, this study is aimed at exploring how the lifestyles of customers who use the cultural centers influence their intention to use the discount stores. Specifically, the effect of shopping value on the correlation between the lifestyle types and usage intention of the customers were examined through a structured research model. To verify the effect, a survey on 139 customers of the Cultural Center of Nonghyup Hanaro Club's S branch was conducted and the valid questionnaires were used for analysis. Research design, data, and methodology - The findings are as follows. First, the lifestyles seeking self-realization had a positive effect on utilitarian value, and lifestyles seeking pop cultures had a positive effect on hedonic value. Second, the mediating effect of shopping value on the correlation between the lifestyle types and usage intention of the customers is as follows. Utilitarian value had a mediating effect only on the lifestyles seeking self-realization. In case of lifestyles seeking pop cultures, the use of Cultural Center had no effect on the intention to use the discount store. Third, an analysis of a revised research model revealed that the store usage intention of lifestyles seeking pop cultures can be enhanced by boosting the utilitarian value through hedonic value. Results - The findings suggest the following. Customers with lifestyles seeking self-realization, who value what is beneficial to them with little attention to the perceptions of others, are highly interested in the benefits they can gain from shopping. As for customers with lifestyles seeking pop cultures, they are highly likely to consume products popular in a particular culture such as new products and sports, based on financial stability they pursue. Thus, they prefer more subjective, personal experience, unlike consumers pursuing utilitarian value. Conclusions - As a result, the former pursues hedonic value gained in the process of shopping with fun and joy, rather than doing shopping with a particular purpose in mind. Therefore, Cultural Centers need to offer information that fits the lifestyles of the users so that they are more likely to use the discount stores. However, if the Cultural Centers offer unified, profit-driven products and information, just to increase their store sales, it can backfire, which occurred in the past. On the other hand, if they provide information that fits the lifestyles of the users, it can actually increase the sales. Also, the findings suggest that sophisticated marketing strategies that can boost the hedonic value of customers by linking the educational contents of Cultural Centers to actual shopping, which is beneficial to consumers, should be set and operated by discount stores. In particular, customers with lifestyles seeking self-realization can be encouraged to use the stores by making them recognize the utilitarian value. However, the use of Cultural Centers doesn't necessarily lead to higher sales among customers with lifestyles seeking pop cultures. As mentioned previously, unified marketing strategy is not as effective for Cultural Centers of large discount stores.

Application and Policy Direction of Blockchain in Logistics and Distribution Industry (물류 및 유통산업의 블록체인 활용과 정책 방향)

  • Kim, Ki-Heung;Shim, Jae-Hyun
    • The Journal of Industrial Distribution & Business
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    • v.9 no.6
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    • pp.77-85
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    • 2018
  • Purpose - The purpose of this study is to subdivide trade transaction-centered structure in a logistics/distribution industry system to apply blockchain, to establish and resolve with which types of technology, and to provide policy direction of government institution and technology to apply blockchain in this kind of industry. Research design, data, and methodology - This study was conducted with previous researches centered on cases applied in various industry sectors on the basis of blockchain technology. Results - General fields of blockchain application include digital contents distribution, IoT platform, e-Commerce, real-estate transaction, decentralized app. development(storage), certification service, smart contract, P2P network infrastructure, publication/storage of public documents, smart voting, money exchange, payment/settlement, banking security platform, actual asset storage, stock transaction and crowd funding. Blockchain is being applied in various fields home and abroad and its application cases can be explained in the banking industry, public sector, e-Commerce, medical industry, distribution and supply chain management, copyright protection. As examined in the blockchain application cases, it is expected to establish blockchain that can secure safety through distributed ledger in trade transaction because blockchain is established and applied in various sectors of industries home and abroad. Parties concerned of trade transaction can secure visibility even in interrupted specific section when they provide it as a base for distributed ledger application in trade and establish trade transaction model by applying blockchain. In case of interrupted specific section by using distributed ledger, blockchain model of trade transaction needs to be formed to make it possible for parties concerned involved in trade transaction to secure visibility and real-time tracking. Additionally, management should be possible from the time of contract until payment, freight transfer to buyers through land, air and maritime transportation. Conclusions - In order to boost blockchain-based logistics/distribution industry, the government, institutionally, needs to back up adding legal plan of shipping, logistics and distribution, reviewing standardization of electronic switching system and coming up with blockchain-based industrial road maps. In addition, the government, technologically, has to support R&D for integration with other high technology, standardization of distribution industry's blockchain technology and manpower training to expand technology development.

A Study on Oral Health Projects for the Disabled in public health center (보건소의 장애인 구강보건사업에 관한 연구)

  • Woo, Seung-Hee;Kim, Youn-Jung;Gkuk, Jung-Suk
    • Journal of Korean society of Dental Hygiene
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    • v.8 no.3
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    • pp.1-11
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    • 2008
  • Oral health projects that cater to the disabled should be more prevailing in order to ensure the maintenance and successful promotion of the oral health of disabled people. 70 public dental clinics that conducted oral health projects geared toward the disabled were examined to get a precise grip on their oral health projects. The findings of the study were as follows: 1. 31 out of 70 public dental clinics investigated(44.3%) were equipped with two or more dental hygienists who were professional human resources in charge of the oral health projects for the disabled. As for the age and disability type of the beneficiaries of the oral health projects, adolescents(74.3%) and people with mental retardation(87.1%) benefited most from the oral health projects. Concerning the most common implementation frequency of the projects, the projects were carried out once to three times a week(62.9%). 2. The most dominant oral disease treatment provided to disabled people was amalgam treatment and resin treatment(68.6%), which were the early dental caries treatment. The most common preventive treatment that was offered to improve their oral health was oral prophylaxis(82.9%). As for reform measures for the oral health projects, education of personnels in charge of the projects and their specialization(58.6%) were most emphasized. 3. Regarding factors related to the preventive oral health projects for the disabled, the implementation of oral prophylaxis and toothbrushing education was linked to the age of the beneficiaries. More oral prophylaxis was offered to teens, and more toothbrushing education was provided to preschoolers and adolescents. The age of the beneficiaries and the number of dental hygienists responsible for the projects had something to do with the application of fluorides. 4. Concerning the relationship of the preventive oral health projects for the disabled to the number of dental hygienists, one of the personnels in charge of the projects, the application of fluorides( 54.4%) and pit & fissure sealing(56.8%) were more prevalent when there were two or more dental hygienists. There was a statistically significant disparity in that regard(p<0.05). The above-mentioned findings illustrated that in order to boost the oral health of the disabled, dental hygienists who are responsible for the oral health projects for the disabled should put ceaseless efforts into fostering their professional knowledge and ability and offering quality service to disabled patients. Every public dental clinic should be equipped with plenty of professional personnels to enlarge the scope of treatment and ensure the efficiency of treatment and the preventive projects.

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Radiation Therapy In Management Of Primary Non-Hodgkin's Lymphoma Of Central Nervous System (원발성 중추신경계 림프종에 대한 방사선치료)

  • Hong, Seong-Eon
    • Radiation Oncology Journal
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    • v.12 no.1
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    • pp.33-42
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    • 1994
  • From 1982 to 1991, sixteen Patients with primary non-Hodgkin's lymphoma of the central nervous system(CNS) were seen at Kyung Hee University Hospital. The most common subtypes were large, noncleaved cell lymphoma and immunoblastic lymphoma of B cells. Lesions most commonly involved were the parietal lobes and/or deep nuclei. Positive cerebrospinal fluid cytology was rare at initial presentation. Sixteen patients were treated with surgical biopsy or resection followed by whole brain radiotherapy at a median dose of 40 Gy(range=30-50 Gy) with variable boost doses. Of 16 patients who underwent surgery and postoperative radiotherapy, fourteen patients died between 2 and 49 months following treatment, and two are alive with no evidence of disease at 8 and 22 months. The 1-and 2-year survival rates were 55.6$ \% $ and 34.7$ \% $, respectively with 12 months of median survival. Patterns of failure were analyzed in eleven patients of total 16 patients. Failure at the original site of involvement was uncommon after radiotherapy treatment. In contrast, failure in the brain at sites other than those originally invovled was common in spite of the use of whole brain irradiation. Failure occurred in the brain 11/16(68.7$ \% $), in spinal axis 4/16(25.0$ \% $). The age, sex, location of involvement within CNS, numbers of lesion, or radiation dose did not influence on survival. The authors conclude that Primary CNS lymphoma is a locally aggressive disease that is poorly controlled with conventional radiation therapy. The limitation of current therapy for this disease are discussed, and certain promising modality should be made in regarding the management of future patients with this disease.

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Metabolic Engineering of the Brassinosteroid Biosynthetic Pathways (Brassinosteroid의 대사공학)

  • Lee, Mi-Ock;Song, Ki-Hong;Lee, Hyun-Kyung;Jung, Ji-Yoon;Choe, Vit-Nary;Choe, Sung-Hwa
    • Journal of Plant Biotechnology
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    • v.29 no.2
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    • pp.139-144
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    • 2002
  • Sterols play two major roles in plants: a bulk component in biological membranes and precursors of plant steroid hormones. Physiological effects of plant steroids, brassinosteroids (BRs), include cell elongation, cell division, stress tolerance, and senescence acceleration. Arabidopsis mutants that carry genetic defects in BR biosynthesis or its signaling display characteristic phenotypes, such as short robust inflorescences, dark-green round leaves, and sterility. Currently there are more than 100 dwarf mutants representing 7 genetic loci in Arabidopsis. Mutants of 6 loci, dwf1/dim1/cbb1, cpd/dwf3, dwf4, dwf5, det2/dwf6, dwf7 are rescued by exogenous application of BRs, whereas bri1/dwf2 shares phenotypes with the above 6 loci but are resistant to BRs. These suggest that the 6 loci are defective in BR biosynthesis, and the one locus is in BR signaling. Biochemical analyses, such as intermediate feeding tests, examining the levels of endogenous BR, and molecular cloning of the genes revealed that dwf7, dwf5, and dwf1 are defective in the three consecutive steps of sterol biosynthesis, from episterol to campesterol via 5-dehydroepisterol. Similarly, det2/dwf6, dwf4, and cpd /dwf3 were shown to be blocked in D$^4$reduction, 22a-hydroxylation, and 23 a-hydroxylation, respectively. A signaling mutant bril/dwf2 carries mutations in a Leucine-rich repeat receptor kinase. Interestingly, the bri1 mutant was shown to accumulate significant amount of BRs, suggesting that signaling and biosynthesis are dynamically coupled in Arabidopsis. Thus it is likely that transgenic plants over-expressing the rate-limiting step enzyme DWF4 as well as blocking its use by BRIl could dramatically increase the biosynthetic yield of BRs. When applied industrially, BRs will boost new sector of plant biotechnology because of its potential use as a precursor of human steroid hormones, a novel lead compound for cholesterol-lowering effects, and a various application in plant protection.

A Study on Women's Wear Manufacturing Industries (II) - Automation of the Facilities and Ratio of Impaired goods - (숙녀복(淑女服) 봉제업계(縫製業界) 실태(實態) 연구(硏究) (II) - 생산설비(生産設備) 자동화(自動化)와 생산제품(生産製品) 불량수준(不良水準) -)

  • Uh, Mi-Kyung;Sohn, Hee-Soon
    • Journal of Fashion Business
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    • v.1 no.2
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    • pp.46-54
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    • 1997
  • The purpose of this study is to understand women's wear manufacturing industries. First, the study was to investigate the present production systems and how much the automatic facility are by comparing them. This study enhanced more efficient, stable, and suitable work line. This intern will direct the way in which automatic facilities will be created. Second, through this study on the general character of the inspectors, the ratio of impaired goods, and the reasons for unsatisfactory goods, I intended to find out a way to decrease the impaired goods and to produce competitive and high quality goods. The results of the survey can be summarized as follows; 1. The result of the research on the automatic industrial facilities shows that the majority of the factories (77.4%) are 40% below the automatic facility rate. The reasons for this according to order are that was a deficit in money, no reason for expensive machines, and lack of the technique and the number of workers required to handle the machines. 2. At this time, the most required equipments are shown according to its importance; automatic sewing machine, automatic cutting machine, automatic spreading machine, and finishing & pressing machine. So in the women's wear manufacturing industries, they think that they need more automatic cutting machine, automatic spreading machine in the cutting field rather than high price automatic machine in the sewing field such as pattern former, pocket welting, automatic sleeve connecting machine and automatic label connecting machine. 3. The result of the research in the goods quality shows that the average impaired rate is 12.7% at the first inspection. In addition the average rate for complete impaired rate is 1.52%. The line system shows that it has a impaired rate that is double the rate of the pair system. Because of this, the industries plan to combine the line system and pair system to create an improved and suitable production system which can boost the quality and productivity of the goods. 4. The fabric is the main point of the impaired goods. The factors of the impaired goods in manufacturing are the lack of mental abilities of the worker, impaired fabrics and a lack of cooperation in the working system. Furthermore, there is a lack of technique for new material. 5. To prohibit impaired goods in manufacturing, there need to be a way to educate the workers and to enhance the workers' mind on the productive goods. Also there need to increase in the investments of automatic production machines. Finally there need to be a standardized working line. Therefore, there need to be an improvement on the management of the production of goods, the development of technique and an increase in the education for the workers, with this there will be a decrease in impaired goods, and an increase in better quality of goods to enforce the domestic apparel industries.

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