• Journal of Korean Dental Science
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• 제4권2호
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• pp.67-72
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• 2011

Purpose: This study sought to evaluate the effects of bone graft wedging on the initial stability of implants in bone sites of unfavorable quality. Materials and Methods: Three male beagle dogs were used in this study. Osteotomies were performed with parallel drills (${\O}4.1{\times}10mm$), and fixtures (${\O}3.3{\times}8mm$) were placed. The control group was given implants without bone graft. Experiment group A was given implants with minimal initial stability using autobone grafts, whereas experiment group B was given xenografts. Groups were also divided by healing times at 4, 8, and 12 weeks. Results: All implants in the control group failed to osseointegrate. On the other hand, all implants in the experiment groups were clinically well-maintained during the entire experiment period. After 4, 8, and 12 weeks, bone-to-implant contact (BIC) ratio and implant stability quotient (ISQ) increased in the experiment groups. The differences between experiment groups A and B were not statistically significant, however. Conclusion: In unfavorable bone regions for dental implants, bone graft packing into the osteotomy prior to implant placement secured minimal initial stability and showed reasonable BIC ratios and ISQ values throughout the study period.

• Journal of Multimedia Information System
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• 제6권2호
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• pp.67-74
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• 2019

Bone density is one of the factors in the early failure of dental implants and doctors should make a preoperative assessment of jaw bone density using patient's CT data before dental implant surgery in order to find out whether the patient has osteoporosis and osteopenia. The main goal of this study was to propose a method that based on image processing techniques in order to provide accurate information about where to drill and place an abutment screw of implants in the jaw bone for doctors and reduce human activity for the estimation of the local cancellous bone density of mandible using CT data. The experiment was performed on a computed tomography data of the jaw bone of two different individuals. We assumed that the result of the estimation of jaw bone density depends on the angle of drilling and average HU (Hounsfield Unit) values were used to evaluate the quality of local cancellous bone density of mandible. As a result of this study, we have been developed a toolbox that can be used to estimate jaw bone density automatically and found a positive correlation between the angle of the drill and time complexity but a negative correlation between the diameter of the drill and time complexity.

• The Korean Journal of Pain
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• 제23권4호
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• pp.230-235
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• 2010

Background: Bone cancer pain has a disruptive effect on the cancer patient's quality of life. Although ginsenosides have been used as traditional medicine in Eastern Medicine, the effect on bone cancer pain has not been throughly studied. The aim of this study was to determine whether ginsenosides may alter the bone cancer pain at the spinal level. Methods: NCTC 2472 tumor cells ($2.5{\times}10^5$) were injected into the femur of adult male C3H/HeJ mice to evoke bone tumor and bone cancer pain. To develop bone tumor, radiologic pictures were obtained. To assess pain, the withdrawal thereshold was measured by applying a von Frey filament to the tumor cells inoculation site. The effect of intrathecal ginsenosides was investigated. Effect of ginsenosides (150, 500, $1,000{\mu}g$) was examined at 15, 30, 60, 90, 120 min after intrathecal delivery. Results: The intrafemoral injection of NCTC 2472 tumor cells induced a radiological bone tumor. The withdrawal threshold with tumor development was significantly decreased compared to the sham animals. Intrathecal ginsenosides effectively increased the withdrawal threshold in the bone cancer site. Conclusions: NCTC 2472 tumor cells injection into the mice femur caused bone tumor and bone cancer pain. Intrathecal ginsenosides attenuated the bone cancer-related pain behavior. Therefore, spinal ginsenosides may be an alternative analgesic for treating bone cancer pain.

• 구강회복응용과학지
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• 제26권1호
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• pp.47-57
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• 2010

임플란트-골 계면상에 미세동요 없이 회복기를 가지는 것은 골융합을 위해서 필수적이다. 이를 위해 임플란트의 초기 안정성은 성공적인 예후를 위해서 중요한 요건이다. 충분한 골질과 골량은 임플란트의 초기 안정성과 조기 실패 방지를 위해 중요한 요소이지만, 임플란트가 갖는 외형적 특성이 초기 안정성에 미치는 영향에 대한 연구는 부족하다. 이에 본 연구는 임플란트의 형태가 초기 안정성에 미치는 영향을 알아보고자 하였다. 골질에 따라 피질골과 해면골의 두께가 서로 다른 모형골에 straight body의 US II, GS II, SS II system과 tapered body의 GS III system (OSSTEM Implant Co., Seoul, Korea) 임플란트를 식립하고 식립 회전력과 공진 주파수 및 동요도를 측정하였다. 이번 실험에서 초기 안정성에 주요한 영향을 미치는 요소는 골질로 나타났다. 임플란트의 형태에 따라 이중 나사선을 가지는 GS II 임플란트가 초기 안정성은 높게 나타났으며 tapered 한 임플란트가 straight 임플란트에 비해서 높은 초기 안정성을 얻을 수 있음을 알 수 있었다. 또한 tapered 임플란트 식립 시 임플란트의 외형과 조화된 식립구를 형성하는 것이 피질골이 두꺼운 경우 피질골에 과도한 압축력을 감소시키고 반대의 경우 해면골로부터 좀 더 많은 골고정을 얻을 수 있음을 알 수 있었다.

• Archives of Reconstructive Microsurgery
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• 제9권2호
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• pp.134-138
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• 2000

Arthrodesis of the ankle joint is inevitable in the cases of severe arthrosis or defective bony structures around ankle joint. There have been many kinds of arthrodesis methods were introduced. In cases with failed athrodesis with previous arthrodesis surgery and neuropathic joints have difficulty to achieve fusion of joint with conventional methods. Authors underwent four cases of ankle fusion with vascularized fibular graft from 1997 in the cases of three failed fusions and one diabetic neuropatic joint. Two of four performed free vascularized fibular transplantation from contralateral side leg with microvascular anastomosis, two of four performed with pedicled fibular transposition to the ankle joint in same side leg. Three of four cases achieved arthrodesis average 9.2 months after surgery, one case was failed due to vascular thrombosis of the anastomosed site in diabetic neuropathic condition. The result of this technique revealed 75%(three of four) success rate and longer bone union time required. However, in these cases had no recommendable options with conventional bone graft and additional ankle joint fusions procedure because of poor bone quality and defect of distal tibia and talus portions. Free vascualrized fibular transfer to the failed athrodesis of ankle joint is one of the effective alternative methods in failed ankle fusion cases, especially the quality of the bone around previous fusion site is poor.

• 대한두개안면성형외과학회지
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• 제24권6호
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• pp.251-259
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• 2023

Background: Periosteum-mediated bone regeneration (PMBR) is a recognized method for mandibular reconstruction. Despite its unpredictable nature and the limited degree to which it is understood, it does not share the concerns of developmental changes to donor and recipient tissues that other treatment options do. The definitive role of the periosteum in bone regeneration in any mammal remains largely unexplored. The purpose of this study was to identify the genetic determinants of PMBR in mammals through a systematic review. Methods: Our search methodology was designed in accordance with the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. We conducted a quality assessment of each publication, and evaluated the differences in gene expression between days 7 and 15. Results: A total of four studies satisfied the inclusion criteria. The subjects and tissues examined in these studies were Wistar rat calvaria in two studies, mini-pigs in one study, and calves and mice in one study. Three out of the four studies achieved the necessary quality score of ≥ 3. Gene expression analysis showed increased activity of genes responsible for angiogenesis, cytokine activities, and immune-inflammatory responses on day 7. Additionally, genes related to skeletal development and signaling pathways were upregulated on day 15. Conclusions: The results suggest that skeletal morphogenesis is regulated by genes associated with skeletal development, and the gene expression patterns of PMBR may be characterized by specific pathways.

• 한국정밀공학회지
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• 제22권8호
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• pp.182-191
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• 2005

It is very important to obtain a high quality of bone image for an accurate ultrasonic measurement of bone mineral density. In this study, we suggested a technique to acquire an optimal image by adapting an acoustic lens and a properly selected ultrasonic probe. Also, we have applied an image processing algorithm with which automatically makes a decision of brightness and contrast of image by generating threshold level, a composition of ultrasonic data, an elimination of noise using modified median filter, and a real time interpolation. We could confirm much improved resolution of bone image with acoustic lens attached to the ultrasonic probe and with the image processing algorithm suggested in this study. Therefore, it became possible to precisely diagnose the osteoprosis using ultrasonic imaging technique.

• Imaging Science in Dentistry
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• 제40권1호
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• pp.1-7
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• 2010

Purpose : The purpose of this study was to examine the significance of increased bone density according to whether bone grafts were applied using demographic data with Cone Beam Computed Tomography (CBCT) and to compare the bone densities between before and after implant prosthesis using the Hounsfield index. Materials and Methods : Thirty-six randomly selected computed tomography (CT) scans were used for the analysis. The same sites were evaluated digitally using the Hounsfield scale with V-Implant $2.0^{TM}$, and the results were compared with maxillary posterior bone graft. Statistical data analysis was carried out to determine the correlation between the recorded Hounsfield unit (HU) of the bone graft and implant prosthesis using a Mann-Whitney U test and Wilcoxon Matched-pairs test. Results : The bone grafted maxillary posterior teeth showed an increase in the mean values from-157 HU to 387 HU, whereas non-grafted maxillary posterior teeth showed an increase from 62 HU to 342 HU. After implantation, the grafted and non-grafted groups showed significantly higher bone density than before implantation. However, the grafted group showed significantly more changes than the non-grafted group. Conclusion : Bone density measurements using CBCT might provide an objective assessment of the bone quality as well as the correlation between bone density (Hounsfield scale) and bone grafts in the maxillary molar area.

• 구강회복응용과학지
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• 제29권3호
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• pp.272-279
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• 2013

골치유 기간 중 임플란트-골 계면에서 일정 수준 이상의 미세동요가 발생하게 되면 임플란트의 골유착이 방해받게 되므로 임플란트 식립 후 초기 골반응에 관해 임플란트 안정성은 하나의 지표가 된다. 본 연구의 목적은 임플란트 식립 후 전향적인 연구를 통해 초기 임플란트 안정성 변화를 추적하여 골치유 양상을 추론하고자 하였다. 총 26명의 환자에게 식립된 30개의 임플란트를 대상으로 하악골에 1회법으로 식립 직후 1주 간격으로 12주간 공진주파수분석을 시행하여 초기 안정성의 변화를 구하였으며 식립 직후와 1개월 간격으로 변연골 흡수 정도를 방사선학적 방법으로 측정하였다. 식립 직후와 각 치유기간 동안의 ISQ값 비교에서 식립 4주에서 6주사이에 골질에 따른 차이를 보였으나(P<0.05), 6주 이후에는 골질군 간에는 임플란트 안정성 변화에 차이가 없었다(P>0.05). 방사선학적 검사에서는 변연골의 차이가 관찰기간내에 유의하게 변화하지 않았다(P>0.05). 임플란트 식립 후 초기 골치유과정은 골흡수과정에 연속적인 과정으로 4주 이후 바람직한 골치유과정이 진행됨을 공진주파수분석으로 관찰할 수 있었다.

• 분석과학
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• 제35권3호
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• pp.136-142
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• 2022

안락사 시킨 유기견의 사체를 고온 및 고압 처리하여 가루로 만들고 사료 원료(육골분)로 사용했다는 언론보도에 따라 안락사에 사용된 마취제 케타민과 덱스메데토미딘의 사료 내 잔류가능성이 제기되었다. 이에 신속한 잔류 조사를 위해 QuEChERS 전처리와 질량분석기를 이용한 동시분석법을 개발하였다. 개발된 동시분석법의 직선성은 0.999 이상을 보였다. 선택성은 무처리 시료와 케타민과 덱스메데토미딘이 정량한계수준으로 처리된 시료의 비교를 통해 평가하였고, MRM 크로마토그램을 확인한 결과 각각의 머무름 시간에서 매질의 간섭은 없었다. 검출한계는 0.6 ㎍/L, 정량한계는 2 ㎍/L로 설정하였으며, 분석법의 최종 정량한계는 10 ㎍/kg로 설정하였다. 육골분, 육분, 애완용 배합사료 중 케타민의 회수율 실험 결과, 80.48-98.63 %, 상대표준편차 5.00 % 이하의 결과를 보였으며, 덱스메데토미딘은 회수율 72.75-93.00 %, 상대표준편차 4.83 % 이하의 결과를 보였다. 개발된 분석법을 활용하여 케타민과 덱스메데토미딘의 잔류실태조사를 실시하였다. 해당 원료가 배포된 시기에 제조된 육골분 등의 사료 6 점을 수거하여 분석한 결과, 육골분 시료 한점에서 케타민이 10.8 ㎍/kg이 검출되었고, 덱스메데토미딘은 정량 한계 미만의 농도로 확인되었다. 이에 해당 원료를 사용한 제품은 전량 회수, 폐기되었다. 이후에도 육골분 사료의 안전성 확보를 위해 육골분 및 배합사료 등의 시료 32점을 추가로 수거하여 케타민과 덱스메데토미딘에 대한 잔류 조사를 실시 하였고, 분석결과 두 성분 모두 검출되지 않았다. 하지만 이번 조사를 통해 마취제 같은 의약품들이 고온 및 고압에도 분해되지 않고 잔류할 수 있다는 사실을 확인하였고, 이에 따라 육골분 사료에서 관리하고 있지 않은 다른 잠재적 유해물질들에 대한 조사의 필요성이 제기되었다.