• Composites Research
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• 제23권1호
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• pp.1-7
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• 2010

본 논문에서는 상용 유한요소해석 프로그램인 ABAQUS 6.71을 이용하여 수술 직후 골절부 거동을 예측할 수 있는 해석을 수행하였다. 스테인리스 고정판과 적층순서를 달리한 복합재료 고정판을 대상으로 대퇴골의 골절치료에 대한 효과를 비교 분석 하였다. 실제 상태를 모사하기 위해 고정판과 골절뼈 및 골절부간 접촉조건을 부여하였으며, 스크류 체결과정과 하중부가 과정을 두 단계로 나누어 해석을 수행하였다. 유한요소해석을 통하여 스테인리스 고정판과 복합재료 고정판이 체결된 경우에 대한 골절부 틈새의 변화 및 응력분포 등을 계산하고 그 차이를 비교하였다. 복합재료 고정판은 골절뼈와의 접촉에 의한 불필요한 응력 증가를 감소시키고 골절부위의 응력은 증가시켜 골절치료에 더 효과적인 것으로 나타났다.

• 대한본초학회지
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• 제24권3호
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• pp.69-77
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• 2009

Objectives : This study was designed to investigate the effects of horse bone powder extract on the growth of longitudinal bone in adolescent male rats. Methods： Longitudinal bone growth was measured by fluorescent microscopy. To examine the effects on the growth plate metabolism, the total height of growth plate, the induction of local insulin-like growth factor-1 (IGF-1), and bone morphogenetic protein-2 (BMP-2) were measured. Results： Horse bone powder extract enhanced longitudinal bone growth and total height of the growth plate. Also, it promoted the induction of local IGF-1 and BMP-2 of the growth plate. Conclusions： This study shows that the horse bone powder extract effects longitudinal bone growth in adolescent rats and might be used for both stunted adolescents and inherent growth failure patients.

• Journal of Trauma and Injury
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• 제31권2호
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• pp.107-111
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• 2018

Segmental bone defects of the tibia present a challenging problem for the orthopedic trauma surgeon. These injuries are often complicated by soft tissue defects and infection. Many techniques are reported, from bone graft to bone transport. To our knowledge, bone transport over the plate in the distraction site has not been described for the treatment of tibial bone defect. We report an instance including procedure and subsequent complications after bone transport over the plate, to restore a tibial bone defect.

• 한국재료학회지
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• 제20권6호
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• pp.312-318
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• 2010

Multilayer Poly methyl methacrylate (PMMA)/ Poly vinyl alcohol (PVA) bone plates were fabricated using electrospinning and in vitro investigations were carried out for pre-clinical biocompatibility studies. The initial cellular cytotoxicity of the methacrylate (PMMA)/ Poly vinyl alcohol (PVA) bone plates was measured by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay using fibroblast-like L-929 cells. Cellular adhesion and differentiation studies were carried out using osteoblast-like MG-63 cells. As simulated body fluid (SBF) contains the same ionic concentration of body fluid and any bioactive material tends to deposit bone-like apatite on the samples surfaces into the SBF, in vitro bioactivity of the multilayer bone plates were investigated using SBF. We also studied the internal organization and tensile strength of the multilayer PMMA/PVA bone plates using micro-computed topography (${\mu}$-CT) and universal testing instrument (UTI, Korea) respectively. The cellular cytotoxicity study with MTT confirmed that the cellular viability was 78 to 90% which indicates good cyto-compatibility. Scanning electron microscopic findings revealed a good attachment and adhesion phenomenon of MG-63 cells onto the surfaces of the samples. Cellular differentiation studies also showed that osteogenic differentiation was switched on in a timely manner and affirmed along with that of the control group. Bone-like apatite formation on the surfaces was confirmed within 14 days of SBF incubation. Initial organizations of the multilayer PMMA/PVA bone plates were characterized as dense and uniform. The tensile strength of the post-pressing electronspun mat was higher than that of the pre-electronspun mat. These results suggest that a multilayer PMMA/PVA bone plate system is biocompatible, bioactive and a very good alternative bone plate system.

• 한국방사선학회논문지
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• 제9권6호
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• pp.349-356
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• 2015

본 연구는 TW3법에서 골성숙 가중치가 가장 높은 7부위를 선정하여 성장판과 골 말단부 사이의 길이를 측정하여 연령과의 상관관계를 알아보고자 하였다. 실험은 2014년 3월에서 2015년 3월까지 성장판검사를 시행한 소아 72명(남 36명, 여 36명)을 대상으로 하였으며, 소아 손 전후영상에서 성장판과 골 말단부 사이의 길이를 측정하여 회귀분석을 하였다. 그 결과 각 연령마다 특정범위에 상응하는 평균과 표준편차 값이 나타났으며, 연령이 증가할수록 성장판과 골 말단부 사이 길이가 감소하였다. 또한 여아가 남아에 비해 평균값이 작게 나타났으며, 회귀분석 결과에서 성장판과 골 말단부 부위 측정 길이와 연령이 통계적으로 유의(p<0.001)한 것으로 나타났다. 따라서 소아 손 전후영상에서 TW3법의 응용을 통한 회귀방정식으로 골연령의 예측이 가능함을 알 수 있었다.

• 대한본초학회지
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• 제32권1호
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• pp.69-74
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• 2017

Objectives : This study aimed to investigate the effects of Angelicae sinensis Radix on longitudinal bone growth rate in rats. We have screened traditional medicinal herbs to develop the longitudinal bone growth stimulator by well-established rat model. A. sinensis was identified as one of the effective herbs in the screening process. Methods : Adolescent female rats were administered A. sinensis at doses of 30 mg/kg and 300 mg/kg for 10 consecutive days. To observe the rate of longitudinal bone growth, tetracycline was injected intraperitoneally on day 8 to stain a fluorescent band on the anew formed bone. To elucidate the mode of action, we observed insulin-like growth factor-1 (IGF-1) and bone morphogenetic protein-2 (BMP-2) expression after A. sinensis administration in growth plate. Results : In the 300 mg/kg A. sinensis group, the length between the proximal endpoint of the tetracycline label and the division line between growth plate and bone was significantly increased compared with vehicle-treated control group. Height of the proximal tibial growth plate was higher in the A. sinensis group compared with control group. A. sinensis also upregulated the expressions of IGF-1 and BMP-2 in the proliferative zone and hypertrophic zone of the proximal tibial growth plate. Conclusions : A. sinensis increases longitudinal bone growth rate in rats. According to immunohistochemistry, A. sinensis increases local IGF-1 and BMP-2 expressions in the growth plate which can be considered as direct stimulation of GH on the local growth plate.

• Archives of Plastic Surgery
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• 제45권5호
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• pp.458-465
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• 2018

Background Volar plate avulsion fracture of the proximal interphalangeal (PIP) joint is one of the most common hand injuries. In this study, we divided patients into two groups: patients with pure volar plate avulsion fracture, and patients with volar plate avulsion fracture concomitant with collateral ligament rupture. The purpose of this study was to compare long-term surgical outcomes between the two groups. As a secondary measure, the Mitek bone anchoring and polydioxanone (PDS) bone suturing techniques were compared. Methods A single-institutional retrospective review of the surgical treatment of volar plate avulsion fracture was performed. The cases were divided into those with pure volar plate avulsion fracture (group A, n=15) and those with volar plate avulsion fracture concomitant with collateral ligament rupture (group B, n=15). Both groups underwent volar plate reattachment using Mitek bone anchoring or PDS bone suturing followed by 2 weeks of immobilization in a dorsal protective splint. Results The average range of motion of the PIP joint and extension lag were significantly more favorable in group A (P<0.05). Differences in age; follow-up period; flexion function; visual analog scale scores; disabilities of the arm, shoulder, and hand scores; and the grip strength ratio between the two groups were non-significant. No significant differences were found in the surgical outcomes of Mitek bone anchoring and PDS bone suturing in group A. Conclusions Overall, the surgical outcomes of volar plate reattachment were successful irrespective of whether the collateral ligaments were torn. However, greater extension lag was observed in cases of collateral ligament injury.

• Journal of Veterinary Science
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• 제21권6호
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• pp.90.1-90.11
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• 2020

Background: Mandibular fractures are common in camels, leading to considerable economic losses. This study explored methods of improving mandibular fractures repair, adjuvant with interdental wire, or bone plate fixation. Autologous bone marrow (BM) injection enhances osteogenesis and rapid healing. Objectives: To investigate the effect of autologous BM aspirate as an adjuvant treatment for repairing mandibular fractures in camels with interdental wire, or bone plate fixation. Methods: Thirty dromedary camels aged 5-8 years and of both sexes were randomly divided into 4 treatment groups: group 1 (n = 10) treated with stainless steel wire fixation and BM injection at the fracture line, group 2 (n = 10) treated with plate fixation and BM injection at the fracture line, group 3 (n = 5) treated with stainless steel bone wire fixation and placebo saline injection at the fracture line, and group 4 (n = 5) treated with plate fixation and placebo injection at the fracture line. The mandibular fractures were followed weekly for 12 weeks postoperatively to assess improvement and healing based on clinical evaluation, radiographic union scale, and bone turnover markers (i.e., bone alkaline phosphatase, osteocalcin, pyridinoline, and deoxypyridinoline). Results: Compared to other groups, elevated bone turnover markers in group 1 were demonstrated (p < 0.05) on the seventh postoperative day. Likewise, compared to other groups, both clinical findings and radiographic union scale significantly improved (p < 0.05) in group 1 on the 56th postoperative day. Conclusions: BM aspirate has a promising beneficial osteogenic effect on mandibular fracture repair in camels, most notably when combined with interdental wire fixation.

• Composites Research
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• 제22권3호
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• pp.29-34
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• 2009

본 논문에서는 유한요소해석을 이용하여 경극 골절부의 변형률 분포를 계산하였다. 16주에 걸친 골절 회복기간 동안 최적의 가골 형성의 조건을 찾기 위해 스테인리스 강 고정판과 다양한 적층순서를 가지는 복합재료 고정판이 고려되었다. 이 연구를 통해 골절부 가골 형성을 촉진하는 $2{\sim}10%$ 변형률을 유발하는 최적 하중 조건을 계산하였다. 해석결과로부터 복합재료 고정판의 경우 최적의 변형률을 가지게 하는 하중조건은 스테인리스 강 고정판의 경우보다 낮았으며, 응력방패 현상을 감소시켜 골절치료에 유리함을 가지는 것을 알 수 있었다.

• 한국식품영양학회지
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• 제34권6호
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• pp.568-575
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• 2021

The purpose of this study was to investigate the effects of extract mixture of C. wilfordii and P. umbrosa (IPLUS-CWPU) on bone growth in 4-week old young male SD rats. To confirm the effect of IPLUS-CWPU, we measured the length of bone growth plate, the ratio of proliferative zone to the length of growth plate and the expression level of insulin-like growth factor, IGF-1. The IPLUS-CWPU treatment shows a significant increase of tibial and femoral growth plate and the ratio of proliferative zone in growth plate. Especially, the length increased by 13.9% and 25.3% in the tibia and femur, respectively, in the high-dose group compared to the normal group. Moreover, the expression of IGF-1 gene in liver was upregulated in IPLUS-CWPU treated groups. These results indicated that IPLUS-CWPU administration could increase the proliferative zone of bone growth plate in early developmental stage by upregulation of IGF-1 gene.