• 대한핵의학회지
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• 제27권1호
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• pp.118-122
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• 1993

전이성 분화갑상선암을 치료할 목적으로 사용된 $^{131}I$에 의한 염색체 손상여부를 검정하기 위하여 치료 전후의 자매염색분체교환(SCE)의 빈도 및 말초혈액의 백혈구수를 정상대조군과 환자군에서 조사하였다. 1) 정상인으로 설정한 대조군에 있어서의 자매염색분체교환 빈도수가 $3.8{\pm}0.4$인데 비하여 $^{131}I$ 투여전의 SCE 빈도가 $4.2{\pm}0.7$으로 차이를 보이지 않았다(p=0.17). 2) $^{131}I$ 투여후 2일째 SCE 빈도는 $7.9{\pm}0.8$으로 치료전에 비해 유의하게 증가하였으며 (p<0.001), 9일째에는 $6.4{\pm}0.6$으로 2일째에 비해서는 유의하게 감소하였으나(p=0.002), 치료전에 비해서는 아직도 유의하게 높았다 (P<0.001). 3) 같은 기간동안 백혈구의 수는 유의한 변화를 보이지 않았다. 결과적으로, $^{131}I$ 치료후 염색분체의 손상은 일어나며, 서서히 회복되나 1주일 이내에는 완전한 회복을 보이지 않음을 알 수 있었다.

• 대한의용생체공학회:의공학회지
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• 제25권5호
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• pp.361-367
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• 2004

척추체간 유합케이지의 성능평가에 있어서 압축강도와 상대적인 3차원적 안정성 그리고 골유도를 촉진시킬 수 있는 형상은 성공적인 골유합의 정도를 판가름 할 수 있는 중요한 척도이다. 새로 고안된 박스형 유합케이지 스파이크의 형상변화에 따른 척추체의 골단판에 미치는 응력분포 양상과 케이지의 안정성을 비교하기 위하여 압축하중 작용 초기에 스파이크 끝딘과 골단판이 접촉하는 경우와 스파이크가 골단판에 삽입되었을 경우를 구분하여 스파이크의 높이, 폭 및 각도를 변화시켜 가면서 유한요소 해석을 실시하여 고찰하였다. 유합케이지 2개가 척추체간에 삽입되어 있는 상태에서 수직하중 1700N이 가해질 때 척추체 골단판에 전달되는 응력분포를 조사하였으며, 전, 후방향으로 케이지 하나에 100N의 pull out하중을 부과하여 케이지의 스파이크 형상변화에 따른 미세이동 정도를 비교 평가하였다. 그 결과, 척추체 골단판의 응력 집중 정도에 가장 큰 영향을 미치는 요인은 케이지스파이크 끝단 폭의 크기이며, 케이지 스파이크의 높이 및 각도의 변화는 스파이크 끝단과 접촉하는 척추체 골단판에 미치는 응력 정도에 큰 영향을 미치지 않았다. 스파이크 경사면 각도조절 및 양방향혼합형의 대칭 배열을 통하여 전후방향 pull-out하중에 대한 변위량을 저감시킬 수 있었다. 본 연구의 결과를 통하여 척추체에서의 응력집중을 피할 수 있고 케이지의 초기 접촉시 골단판의 파괴를 방지하고 골유합에 유리한 케이지 스파이크 형상을 설계하였고, 케이지 치환술 후 운동시 전후방향으로 이동을 최소화하여 기계적 안정성을 높일 수 있는 새로운 척추체간 유합 케이지의 최적 형상을 제안하였다.

• Journal of Periodontal and Implant Science
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• 제41권4호
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• pp.176-184
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• 2011

Purpose: The final goal of regenerative periodontal therapy is to restore the structure and function of the periodontium destroyed or lost due to periodontitis. However, the role of periosteum in periodontal regeneration was relatively neglected while bone repair in the skeleton occurs as a result of a significant contribution from the periosteum. The aim of this study is to understand the histological characteristics of periosteum and compare the native periosteum with the repaired periosteum after elevating flap or after surgical intervention with flap elevation. Methods: Buccal and lingual mucoperiosteal flaps were reflected to surgically create critical-size, "box-type" (4 mm width, 5 mm depth), one-wall, intrabony defects at the distal aspect of the 2nd and the mesial aspect of the 4th mandibular premolars in the right and left jaw quadrants. Animals were sacrificed after 24 weeks. Results: The results from this study are as follows: 1) thickness of periosteum showed difference as follows (P<0.05): control group ($0.45{\pm}0.22$ mm)> flap-elevation group ($0.36{\pm}0.07$ mm)> defect formation group ($0.26{\pm}0.03$ mm), 2) thickness of gingival tissue showed difference as follows (P<0.05): defect formation group ($3.15{\pm}0.40$ mm)> flap-elevation group ($2.02{\pm}0.25$ mm) > control group ($1.88{\pm}0.27$ mm), 3) higher cellular activity was observed in defect formation group and flap-elevation groups than control group, 4) the number of blood vessles was higher in defect formation group than control group. Conclusions: In conclusion, prolonged operation with increased surgical trauma seems to decrease the thickness of repaired periosteum and increase the thickness of gingiva. More blood vessles and high cellular activity were observed in defect formation group.

• 대한치과교정학회지
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• 제20권3호
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• pp.447-462
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• 1990

The objective of this experiment is to observe structural differences in the othodontic movement of vital (control group) and devitalized (experimental group) teeth in the mongrel dogs. The 5 utilized dogs in this experiment were approximately 1 year of age and their average weight was about 12 Kg. Endodontic therapy was performed on the 2nd premolars in upper & lower jaws of each animal under the general anesthesia by intravascular injection of 25mg/kg of pentobarbital sodium. The canals of the teeth were obturated by using gutta percha in conjunction with root canal sealer (AH26 Densply). One of the roots in the 2nd premolars was hemisected to make an extraction space for the devitalized teeth to be moved. The edgewise technique was employed for the movement of the teeth. Orthodontic models and intraoral roentgenograms were taken before and after orthodontic tooth movement. The open coil springs (.010 x .040) were used at interbraket space in order to provide equal forces (75gm) between the teeth in each arch wire. After 13 weeks of active orthodontic tooth movement, dogs were sacrified and the experimental results w ere examined through the intraoral radiography, microscopic examination and scanning electromicroscopic examination at the root sulfate. From the results of the study, the following conclusions may be drawn: The root resolution and cemental deposition were observed within the pressure and tension site in both group. 2. The root resorbed lacunae were observed in the cementum and/or into the dentin in both group. 3. The prominent osteoblastic activities were observed on the alveolar margin in the tension site in both group. 4. A few of blood vessels were observed in the pressure site, but also lots of blood vessels were observed in the tension site especially in the periphery of the alveolar bone in both group. 5. In the pressure site, resorbed lacunae were formed with deep and narrow cavity in the control group; the shallow and wide cavity in the experimental group. 6. In the pressure site, the repaired cementum or cementoid tissue was lined on cementum in the experimental group, but not in the control group. 7. There was no significant difference between external root resolution of endodontically and vital teeth when both were subjected to orthodontic forces.

• 대한치과교정학회지
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• 제31권1호
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• pp.1-13
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• 2001

성장기 환자에서 치아의 배열이나 입술의 외형을 개선하거나 경미한 악골 부조화에 의한 부정교합을 절충(camouflage)하기 위하여 발치가 적용될 수 있는데, 하악 치열궁에 총생의 양이 미약하거나 전치부 분절을 과도하게 후방견인 시킬 필요가 없는 경우 하악 제 2소구치 발치를 계획할 수 있다. 그러나, 성장기 환자에서 이러한 제 2소구치 발치의 기준과 치료에 의한 상, 하악 치아의 이동양상에 대한 연구는 부족한 실정이다. 본 연구는 상, 하악 소구치 발치를 통한 포괄적 교정치료를 시행한 성장기 환자를 대상으로 상악 제 1소구치와 하악 제 1 소구치를 발치한 군(4/4발치군, 14명)과 상악 제 1 소구치, 하악 제 2 소구치를 발치한 군(4/5발치군, 15명)의 치료 전, 후의 측모두부규격방사선사진을 비교하여 하악 제 2소구치 발치의 적응증에 대한 진단기준을 평가하고, 안정골 구조물을 참고한 중첩법을 이용하여 치아이동에 어떠한 차이가 있는지를 평가하여 다음과 같은 결론을 얻었다. 1. 4/4발치군과 4/5발치군은 치료 전 계측치에서 교합평면에 대한 상악전치의 치축각도, 구치부 교합관계, IMPA 그리고 interincisal angle에서 차이를 나타내었다. 2. 하악 제 1 대구치의 전방 이동량은 4/5 발치군에서 더 전방이동 되는 경향을 나타내었다(p<0.05). 3. 치료 전, 후의 상악 치아의 이동양상은 4/4 발치군과 4/5 발치군 사이에 차이가 없었다(p<0.05).

• Imaging Science in Dentistry
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• 제33권2호
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• pp.79-83
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• 2003

Purpose : To assess the relationship between the direction of the indicating rod of the radiographic stent for ideal prosthetic design and the actual possible path of implant fixture placement when residual ridge resorption is considered. Materials and Methods: The study materials consisted of 326 implant sites (male 214 cases and female 112 cases) from a total of 106 patients (male 65 patients and female 41 patients) who desired implant prostheses. Computed tomography of patients were taken and reformatted using ToothPix/sup (R)/ software. Bony defects, bony sclerosis, the change of the direction of indicating rod, and root proximity of the adjacent teeth were examined on the CT-derived images. Results: The rate of the irregular crestal cortex was relatively high on premolar and molar area of maxilla. Mandibular molar area showed relatively high rate of focal sclerosis on the area of implant fixture insertion. The position of the indicating rods were relatively acceptable on the molar areas of both jaws. However, the position of the indicating rods should be shifted to buccal side with lingual rotation of the apical end on maxillary anterior teeth and premolar area. Conclusion: Clinically determined rod direction and position of the indicating rod for implant placement was not always acceptable for insertion according to the reformatted CT images. The pre-operative treatment plan for implant should be determined carefully, considering the state of the alveolar bone using the reformatted CT images.

• 대한소아치과학회지
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• 제25권3호
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• pp.549-554
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• 1998

저자는 매복된 상악 정중 과잉치를 주소로 내원한 환아를 3차원 전산화 단층촬영술을 이용해 매복된 과잉치의 위치를 파악하였으며 다음의 결론을 얻었다. 1. 인접한 영구치에 대한 위해한 영향을 주지 않기 위해 상악 정중 매복 과잉치의 정확한 위치 판별이 요구된다. 2. 3차원 전산화 단층촬영법은 매복 과잉치의 위치판별에 있어서 객관적인 중요한 정보를 제공한다.

• 한국병원경영학회지
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• 제14권1호
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• pp.123-144
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• 2009

Recently, a long strike by hospital labor union emerged as a serious social issue. During the Worldcup Games in June, 2002, labor strikes broke up at 'C', 'K' and other hospitals, and in 2007, 'Y' hospital suffered much from a strike. Such series of extreme labor disputes have awakened people of importance of a more stable labor-management relationship for the medical institutions responsible for people's health than any other business organization. The purpose of this study was to examine the labor-management disputes at 'Y' hospital in 2007 and 'C' and 'K' hospitals in 2002. The results of this study can be summarized as follows; First, requests of the labor union such as pay raise, reemployment of the irregular workers as regular employees and participation of the labor union in personnel affairs are the long-held or core issues suffered by the medical institutions. Such issues are not independent from each other but complicated with each other surrounding the pay raise. Accordingly, it is not easy to determine the genuine bone of issue for labor-management disputes. Second, the model type of disputes between labor and management at medical institutions may be strike. However, it is conceived that the type of disputes would be subject to change as the essential medical service area system began to be operated since 2008. Third, the common characteristic of the labor strike among the 3 sample hospitals was occupation of the hospital lobby for a sit-in strike to maximize the negative effects of strike. Article 42 (Prohibition of Violence) of Labor Union and Labor Relation Coordination Act prohibits occupation of production or other important business facilities. In addition, since Ministry of Labor interprets that the hospital lobby belongs to the important business facilities enumerated by Article 42 of the above act, occupation of the hospital lobby for a sit-in strike may be too controversial to be admitted as a fair act of labor dispute when its legitimacy should be judged. Fourth, the counter-measures taken by the hospitals against the strike were observance of the principle 'no labor no pay,' closure, legal action, accusation, claim for recovery of damage, provisional seizure, disciplinary punishment, etc., but the principle of 'no labor, no pay' was not applied in a fair manner by 'C' and 'K' hospitals. However, 'Y' hospital applied this principle thoroughly to the strike; the hospital conduced to correction of the wrong labor-management relationship by refusing inclusion in the labor collective agreement of a provision about payment of wage during the period of strike or labor union's request to that effect during a strike. In addition, 'Y' hospital took an effective measure to end the strike earlier by notifying the labor union of cancellation of the collective agreement and banning the unionists from entering the hospital.

• 대한치과보철학회지
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• 제41권3호
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• pp.271-287
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• 2003

Statement of problem: Resonance frequency analysis (RFA) has been increasingly served as a non-invasive and objective method for clinical monitoring of implant stability. Many clinical studies must be required for standardized baseline data using RFA. Purpose: This study was performed to evaluate RFA value changes in two stage surgery group and one stage surgery group in patients. Material and method: Forty-seven mandibles in consecutively implant installed patients were selected for this study and 141 fixtures were installed. Ninety-three fixtures were double threaded, machined surface design ($Br{\aa}anemark^{(R)}$ MK III, Nobel Biocare AB, Goteborg, Sweden) and 48 fixtures were root form, threaded, HA-coated surface one ($Replace^{TM}$, Steri-Oss/Nobel Biocare AB, USA). Among those, each 10 fixture was installed in one stage group patients. ISQ values were measured using $Osstell^{TM}$ (Integration Diagnostics Ltd. Sweden) during fixture installation, at healing abutment connection and in the loading period for two stage surgery group patients and during at each 4, 6, 8, 10, 12week and in the loading phase for one stage surgery group patients and evaluated the changes according to the time and fixture type. Results: In two stage surgery group, mean and SO of ISQ values of machined surface implants were $76.85{\pm}3.74,\;75.76{\pm}5.04,\;75.73{\pm}4.41$ and those of HA-coated surface implant were $75.05{\pm}6.23,\;77.58{\pm}5.23,\;78.32{\pm}4.29$ during fixtures installation, at healing abutment connection and in the loading period, respectively. In one-stage surgery group, the ISQ values of machined surface and HA-coated surface implants decreased until 4 or 6 week and maintained at plateau for 1-3 week and increased to the loading period. Conclusions: Machined and HA-coated surface implants showed minimal ISQ changes with time if they were installed at the sites showing at least intact cortical plate and good bone qualities. And HA-coated implants had a tendency to show somewhat increased ISQ values with time.

• Journal of Periodontal and Implant Science
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• 제31권2호
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• pp.277-285
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• 2001

Periodontal disease is characterized by inflammation and subsequent loss and/or damage to tooth-supporting tissues such as bone, cementum,and periodontal ligament. Periodontal ligament and cementum are the key tissues in the initial process of regeneration following periodontal disease. Therefore, studies on cementoblasts, which form cementum are emphasized. It is still unclear which cells cementoblast differentiate from. This study was conducted under the hypothesis that PDL fibroblast can differentiate into either cementoblast or osteoblast depending on the conditions of surrounding tissue. Clinically, with excessive traction force of orthodontic appliances or excessive occlusion hypercementosis is observed, and this has been confirmed histologically. Consequently, activation of cementoblast can be expected in rats when mechanical stimuli are given to PDL fibroblast. Therefore, the purpose of this article is to prove that PDL fibroblast differentiates into cementoblast in rats under mechanical stimuli using histologic and molecular methods. In this study, twenty rats were given hard diet. Ten of them were sacrificed after 1 week, and the others were sacrificed after two weeks. Slides were made from tooth specimen, and they were studied under the microscope. In addition, PDL fibroblast and cementum from the extracted teeth were analyzed with Northern blotting. In histologic examination, as time passed, PDL fibroblast migrated to the dentin side, differentiated into cementoblast, and formed new cementum. In Northern blotting, it was found that mRNA expression of cementoblast-specific proteins such as BSP, OC, OPN, and type I collagen were more prominent in rats sacrificed after 2 weeks of hard-diet than rats sacrificed after 1 week. From these findings we can conclude that PDL fibroblast can differentiate into cementoblast under mechanical stimuli. We think that 'Rat Models' used in this study will be beneficial to future studies regarding cementoblast.