• Toxicological Research
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• v.34 no.1
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• pp.55-63
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• 2018

As a part of general toxicity studies of Enterococcus Faecalis 2001 (EF 2001) prepared using heat-treatment bacillus mort body EF 2001 in mice, this study examined the toxicity of EF 2001 in single and repeated administrations following the previous report in order to apply this product to preventive medicine. The safety of oral ingestion of EF 2001 was examined in 6-week-old male and female ICR mice with 1,000 mg/kg, 3,000 mg/kg and 5,000 mg/kg body weight/day administrated by gavage of the maximum acceptable dose of EF 2001. The study was conducted using distilled water as a control following the methods for general toxicity studies described in the "Guidelines for Non-clinical Studies of Pharmaceutical Products 2002". As a control, 1) observation of general conditions, 2) measurement of body weight, 3) determination of food consumption, 4) determination of water consumption, 5) blood test and urinalysis and 6) pathological examination were performed for the administration of EF 2001. Mice received EF 2001 for 13 weeks and results were compared with those of the control group that received distilled water. The results of the above examinations revealed no significant differences between control and EF 2001 groups for both males and females. Thus, no notable toxicity was confirmed with single and repeated oral administrations of EF 2001. Oral administration in the above doses did not result in abnormal symptoms or death during the observation period. No abnormalities in blood cell count or organ weights were seen. Without any evidence of toxicity to cells and organs, EF 2001 is speculated to not adversely affect living organisms. The 50% lethal dose of EF 2001 with oral administration in mice is estimated to be greater than 5,000 mg/kg body weight/day for both male and female mice. Therefore, $LD_{50}$ value for animals was 5,000 mg/kg or more.

• Journal of the East Asian Society of Dietary Life
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• v.22 no.4
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• pp.480-488
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• 2012

Polyphenols may be primarily responsible for the health benefits associated with tea consumption. However, the benefits of the tea polyphenols to bone health have not been studied well. The purpose of this study was to investigate the effects of Oolong tea on bone mineral density and bone-related markers in ovariectomized rats. Sprague-Dawley female rats were randomly assigned to Sham-Control, Sham-Oolongtea, Ovx-Control, and Ovx-Oolongtea groups. Bone mineral density (BMD) and bone mineral content (BMC) were estimated by using PIXImus (GE Lunar Co, Wisconsin.) in the spine and femur. After 6 weeks of the experimental diets, body weight gain, food intake, and food efficiency ratio (FER) were significantly higher in Ovx groups than in Sham groups regardless of diet. The serum concentration of calcium, phosphorus, ALP, and calcitonin were not significantly different according to Oolong tea supplementation. There were no significant differences in urinary calcium and phosphorus excretion between all groups. The urinary DPD crosslinks value was significantly higher in the Ovx-Control group than in the Sham-Oolongtea group. Spine BMD, femur BMD, and spine BMD per body weight were significantly lower in the Ovx groups than in the Sham groups regardless of diet. In the OVX group, spine BMC per body weight, femur BMD per body weight and femur BMC per body weight were significantly higher in the Oolong tea groups than in Control groups. It was concluded that Oolong tea supplementation positively influenced bone health in ovariectomized rats.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.2 no.3
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• pp.13-24
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• 2004

The purpose of this study is to reveal the effect of electrical stimulation of body composition in obese person. Subjects were 30s to 40s aged healthy workers(2004. 3. 8~4. 17) in the S general Hospital in Suwon and they were brought to manage obesity. Subjects were divided into control group(Female<0.85, Male<0.90) and study group(Female>0.85, Male>0.90) by WHR(waist-hip ratio) that is measured by Automatic body composition analyzer(InBody 3.0). And we divided the study group with randomized methods into group A(n=8) and group B(n=8). Then we compared and analyzed the change of muscle mass, body fat, abdominal girth, WHR, BMI(body mass index) after application of electrical stimulation, three times a week, for 30 minutes in each session with 50 Hz of pulse frequency, $20\;{\mu}s$ or $250\;{\mu}s$ of pulse duration. There was statistically meaningful decrement of body fat(p<0.05) and abdominal girth(p<0.05) but not of body weight, muscle mass, WHR and BMI in the control group after application of electrical stimulation with 50 Hz, $20\;{\mu}s$. There were meaningful change of abdominal girth(p<0.05), WHR(p<0.05) and BMI(p<0.05), but not of body weight, muscle mass and body fat after application of electrical stimulation with 50 Hz, $20\;{\mu}s$ in group A. We applied electrical stimulation with 50 Hz, $250\;{\mu}s$ in group B, then there were meaningful change of body weight(p<0.05), body fat(p<0.01), abdominal girth(p<0.01), WHR(p<0.05) and BMI(p<0.01) but not of muscle mass only. Consequently, the pulse duration is the main parameter of electrical stimulation that affect the body composition of obese person in this study and if we combined the diet control to reduce blood components we could have better result. So it would be more effective to manage localized obesity(in abdomen, thigh, upper arm, etc.) if you apply electrical stimulation considering the pulse duration.

• Journal of Digital Convergence
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• v.15 no.3
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• pp.237-245
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• 2017

The purpose of this study was to examine relationships among body-esteem, obesity stress, self-esteem and weight control behavior in high school girls. The descriptive correlational study design was used. The data were collected by Self-reported questionnaires from 135 high school girls in the two high school located B and J city. There was except for none weight control behavior or actual BMI was identified with a low body weight. The collected data were analyzed using t-test, one way ANOVA, Pearson's correlation coefficient in SPSS statistics 20.0 program. As results of examining the correlation, body-esteem(r=-.18, p<.05), obesity stress(r=-.39, p<.001), self-esteem(r=-.32, p<.001) were related to their unhealthy weight control behavior in high school girls. Based on the results of this study, it is necessary to be considered body-esteem, obesity stress, self-esteem variables during development convergence programs to attract the healthy weight control behaviors in high school girls.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.5
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• pp.3353-3360
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• 2015

This study was conducted to identify the BMI of enlisted soldiers, to understand the difference between their BMI and that of other men in their age group, and to identify the influence factors of enlisted soldiers' BMI change. The survey has been conducted self-evaluation questionnaire from 23 Feb. 2009 to 31 Mar. 2009 from 4 different forces as methods. Independent-sample T-test, chi-square test and multiple linear regression analysis were used for statistical analysis from 301 collected data. As a result of surveying enlisted soldiers' BMI, their obesity rate 18.6% was lower than 22.1% of other men in their age group. In terms of health behavior, the underweight&normal weight group(2.39) showed higher diet score than the overweight group(2.13), showing that the underweight&normal weight group ate relatively slowly, less spicy and less sweet food compared to the overweight group. The overweight group(2.25) showed lower satisfaction with their body type than the underweight&normal weight group(2.98), while the overweight group(4.01) showed a significantly higher score than the underweight&normal weight group(3.37) for weight control activity. The influence factors of BMI change were diet habit, subjective perception of body type, and weight control activity. In order to improve of enlisted soldiers' BMI, it would be necessary to improve the food service and the snack bars for interventional control of food that influence obesity, rather than personal effort, in addition, education for right body-shape perception and encouraging on weight control activity.

• Environmental Analysis Health and Toxicology
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• v.6 no.1_2
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• pp.59-70
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• 1991

This study was performed to investigate the effect of olive oil diet on the immune response in ICR male mice. Experimental diets of 4 groups were fed ad libitum to the ICR male mice for 27 days. The results of this study were summarized as followings: 1. 10% Olive oil diet group as compared with the control diet group significantly decreased liver weight rate but significantly increased hemagglutination titer (HA), Arthus reaction, delayed type reaction (DTH), rosette forming cell (RFC), and phagocyte activity. 2. 20% Olive oil hypersensitivity diet group as compared with the control diet group significantly increased body weight gain, liver weight rate, and HA but significantly decreased Arthus reaction, DTH, RFC, phagocyte activity, and peripheral circulating white blood cell (WBC). 3. 30% Olive oil diet group as compared with the control diet group significantly increased liver weight rate but significantly decreased body weight gain, Arthus reaction, plaque forming cell (PFC), DTH, RFC, phagocyte activity, and WBC. The results showed that the increase of olive oil doses significantly decreased humoral and cellular immune responses, phagocyte activity, and WBC.

• Child Health Nursing Research
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• v.7 no.2
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• pp.213-224
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• 2001

This study was conducted to identify the effect on the weight control of the REBT group program as a nursing intervention. For this purpose, non-equivalent control group design with pretest and posttest and follow-up test as quasi-experiment was used. Subjects of the study were consisted of twenty-four obese girls (Experimental group: 10, control group: 14) who appeared to having above 20％ of the body mass index from ane high school in M city. The whole program was carried out from January to June, 2000. Used dependent variables for evaluating the effect of the REBT group program including were weight control belief(rational thinking, emotion about exercise, eating self-efficacy, eating behavior), body mass index and serum lipids(total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein). For evaluating the effect of the program, dependent variables was analyzed by experimental stages three times; the first week, the fourth week, and the eighth week since the experimental input began. Data were analyzed by the SAS PC＋ program with t-test, repeated measure ANOVA to determine the effect of program. The results of this study can be summarized as follows; 1. After the REBT group program, only eating self-efficacy among the weight control belief of experimental group was significantly increased than that of control group. 2. After the REBT group program, body mass index of experiment group was significantly decreased than that of control group. 3. After the REBT group program, triglyceride and low density lipoprotein among the serum lipids in the experiment group were significantly decreased than those of control group.

• Journal of the Korean Home Economics Association
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• v.20 no.1
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• pp.57-64
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• 1982

This study was designed to observe the effect of two levels of dietary protein intake on the development and growth of rats from fetus to adult. The pregnant rats were fed either 20% casein diet or 7% casein diet. After weaning or two weeks postweaning, some of the pups from malnourished mothers were rehabilitated by feeding 20% casein diet. The results were. 1. On the 14th day of gestation, no differences were found in weight and total body fat or protein between fetuses from dams fed 7% casein diet and those from those from 20% casein diet. 2. The birth weight of the pups from 7% casein diet group were significantly lower than those from 20% casein diet group. 3. After rehabilitation, the total body fat and protein of low protein group were not different from those of control group when they were compared at the same body weights regardless the age of rats or the duration on the low protein diet. 4. The nitrogen retention of low protein group, after rehabilitation, was higher than that of control group when they were compared at the same body weight.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.7
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• pp.3338-3348
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• 2013

The purpose of this research is to access the dietary habits and weight control attitudes in college women, and to correlate them to the subjective fatigue symptoms. The research subjects are 508 women enrolled for studies in undergraduate school from freshmen to senior year in Daejeon city. The survey was conducted with self-administered questionnaire from Apr. 1st to May 1st to May 31st, 2012. In the questionnaire encompasses general characteristics, daily life style factors, dietary habits, attitude toward body type and weight control, and subjective fatigue symptoms. As a results, the affecting factors on the subjective fatigue symptoms were selected various factors such as frequency of the one food, frequency of dining out, having dinner, frequency of instant food intake, frequency of cereal, ice-cream intake, frequency of bean, soybean product intake, frequency of milk, milk product intake, consider excessive intake of sugar, consider excessive intake of salt, self-perception on body type and desire to control weight. Therefore, we can find out that their subjective fatigue symptoms are correlated to the factors in dietary habits, attitude toward body type and weight controls. It is concluded dietary habits and attitude toward body type and weight control themselves cause one's subjective fatigue symptoms, not because of each variables. So, it need efforts of having regular diets, making balanced body and controling body weights by objective ranges.

• Toxicological Research
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• v.11 no.2
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• pp.253-259
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• 1995

To investigate an effect of ethanol pretreatment on the bromobenzene metabolism, the brornobenzene (400 mg/kg body wt. i. p.) was given 3 times at intervals of one day to the male rats orally pretreated with 5% ethanol throughout 2 months. In the ethanol pretreated rats, liver injuries were not demonstrated on the basis of the liver weight per body weight, serum levels of alanine aminotransferase (ALT) activity and histopathologic findings. By the bromobenzene treatment, ethanol pretreated rats showed the more decreased levels of serum ALT and liver weight/body weight(%), and decreased degree of liver damage on histopathological observation than the control group. The ethanol pretreated rats showed the more increased activities of hepatic aniline hydroxylase, glutathione Stransf erase (GST) and the more decreased contents of glutathione than the control. Concomitantly the ethanol pretreated rats showed the more decreased contents of hepatic glutathione and increased activities of GST by the bromobenzene treatment. Above results indicate that ethanol pretreatment enhance the metabolizing ability of bromobenzene in rats.