• Title/Summary/Keyword: blood physiology

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A Study on Subchronic Toxicity Test and Method of Increasing Output of Scolopendrid Pharmacopuncture (오공약침의 아만성독성 시험 및 생산량 증가방안에 관한 연구)

  • Kim, Sung-Chul
    • Journal of Pharmacopuncture
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    • v.11 no.4
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    • pp.25-37
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    • 2008
  • Purpose The purpose of this study was to investigate sub-chronic toxicity of scolopendrid pharmacopuncture in mouse and method of increasing output of scolopendrid pharmacopuncture. Methods In order to prove the clinical safety of scolopendrid pharmacopuncture during 90 days, We have observed the physical reaction(side effect) and clinical pathology test after scolopendrid pharmacopuncture treatment and investigated method of increasing Output of scolopendrid pharmacopuncture for 90%, 80%, 70% ethanol. Results In subchronic toxicity test, there was no significant sign in clinical sign, opthalmological values, body weights, hematological values and urinalysis values. And we could see that food consumptions and water consumptions increased significantly, albumin, triglycerides, GPT in blood chemical values and Liver, Testis(right) in organ weights changed significantly in some groups, compared with those in the S1 group. But these changes were observed within the scope of physiology. So there was no sign of toxication in subchronic toxicity test, and we can tell that NOAEL(No Observed Adverse Effect Level) is above 0.286mg/kg/day. And 70% ethanol solution of scolopendrid was yielded the most amount of substance. Conclusions This study demonstrates that scolopendrid pharmacopuncture is to treatment of safety for a long time and we can obtain much amount from 70% ethanol solution of scolopendrid.

Weighting of Stroke Pattern Identification Using an AHP (AHP 기법을 이용한 중풍 변증지표의 가중치 설정)

  • Kang, Byoung-Kab;Kim, So-Yeon;Lee, Jung-Sup;Kim, No-Soo;Ko, Mi-Mi;Kwon, Se-Hyug;Bang, Ok-Sun
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.25 no.1
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    • pp.149-153
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    • 2011
  • In this study, we structuralized the diagnostic indices used for pattern identification (PI) of stroke, and suggested an AHP method to obtain the weights of PI indices. AHP of the subjects under consistency ratio 0.1 showed that the critical indices for stroke PI consists of 9 for Qi-deficiency, 13 for Phlegm/dampness, 7 for blood stagnation, 12 for Yin-deficiency and 16 for Fire/heat. Furthermore, AHP analysis rendered the weights of indices of each PI that will be useful for oriental medical experts to perform objective PI.

Effects of BHOSB on Various Immunological Factors Related to Pathogenesis of Atopic Dermatitis in DNCB Treated NC/Nga Mice (비허온습만(脾虛蘊濕万)이 아토피 피부염 유발 NC/Nga 생쥐의 혈액내 면역 관련 인자에 미치는 영향)

  • Park, Sung-Hee;Jin, Mi-Rim;Koo, Young-Sun;Kim, Dong-Hee
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.21 no.4
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    • pp.849-855
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    • 2007
  • Atopic dermatitis is an allergic inflammatory skin disease caused by aberrant and overreactive immune responses including overactivation of $T_H2$ immune responses, high levels of IgE as well as proinflammatory cytokines and chemokines. We examined whether BHOSB, a traditional herbal medicine, has modulatory effects on various immunological factors related to pathogenesis of atopic dermatitis in ONCB treated NC/Nga mice. Oral administration of BHOSB at the concentration of 10.8 mg/mouse/day significantly inhibited the production of IgE compared with control, and the levels of IgG2a and IgG2b, but not IgG1, were also significantly reduced. Production of IL-6 and TNF-a was greatly decreased. The results from flowcytometry of peripheral blood mononuclear cells indicated that the percentages of C03+C069+ cells and C04+ were significantly decreased by BHOSB. Theses results suggested that BHOSB has suppressive effects on aberrant and overreactive immunological activities in ONCB-induced dermatitis mice of NC/Nga.

Anti-allergic Effects of Shinbijen (신비전(新鼻煎)의 항알레르기 효과)

  • Kim, Kyung-Yeol;Kim, Sang-Tae;Lee, Jong-Hwa
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.21 no.6
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    • pp.1525-1533
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    • 2007
  • The discovery of drugs on the treatment of rhinitis and allergic disease is a very important subject in human heath. The Shinbijen has been used for centruries as a traditional medicine in Korea and is known to have an anti-inflammatory effect. However, its specific mechanism of action is still unknown. In this report, we investigated the effect of hot water extract from Shinbijen on OVA-mediated allergic reaction and studied its possible mechanism of action using fluorescenc microscopy and RT-PCR analysis. Shinbijen inhibited OVA-induced rhinitis, total cells in BFA and lymphocyte related to inflammation in mice. Shinbijen decreased immuno response, which activated by IL-4, COX-2 and iNOS expression. in tissue. Shinbijen reduced inflammatory molecule release from mice lung tissue and CD4/CD8 cells activated by cardiac blood. Shinbijen decreased OVA-induced IL-4 and iNOS levels in pulmonary alveoli. Our findings provide evidence that Shinbijen inhibits OVA-induced allergic reactions, and also demonstrate the involvement of inflammation and allergic disease in these effects.

An Analysis of Experimental Research on Foot Reflexology from Year 2000 to 2020 (발반사요법의 실험연구 문헌분석: 2000-2020년)

  • Cha, Nam-Hyun
    • Journal of the Korea Convergence Society
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    • v.11 no.9
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    • pp.385-393
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    • 2020
  • The purpose of this study was performed to analyze the trend of foot reflexology and effectiveness. This study analyzed 118 articles published over 20 years on the effect of intervention therapy. Year of presentation, type of research, characteristics, results of intervention variables, and so on of preceding papers on foot reflexology were analyzed. Collected data were analyzed using SPSS/PC Ver. 26.0 statistical program. Results of this study confirmed that foot reflexology therapy was effective in psychological state, physical state, body systems, vital signs, lipids, and blood. Results of this study could be used as basic data for the development of interventional methods of foot reflexology for human health.

Loranthus ferrugineus: a Mistletoe from Traditional Uses to Laboratory Bench

  • Ameer, Omar Z.;Salman, Ibrahim M.;Quek, Ko Jin;Asmawi, Mohd. Z.
    • Journal of Pharmacopuncture
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    • v.18 no.1
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    • pp.7-18
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    • 2015
  • Objectives: Loranthus ferrugineus (L. ferrugineus) from Loranthaceae, a mistletoe, is a medicinal herb used for a variety of human ailments. Traditionally, decoctions of this parasitic shrub have been mainly used to treat high blood pressure (BP) and gastrointestinal complaints; usage which is supported by experimental based pharmacological investigations. Nonetheless, there is still limited data available evaluating this plant's traditions, and few studies have been scientifically translated toward evidence based phytomedicine. We therefore provide a concise review of the currently available L. ferrugineus literature and discuss potential directions for future areas of investigation. Methods: We surveyed available literature covering ethnopharmacological usage of L. ferrugineus and discussed relevant findings, including important future directions and shortcomings for the medicinal values of this parasitic shrub. Results: Evidence based pharmacological approaches significantly covered the medicinal application of L. ferrugineus for hypertension and gastrointestinal complaint management, with a particular focus on the active hydrophilic extract of this herb. Conclusion: Understanding the sites of action of this plant and its beneficial effects will provide justification for its use in old traditional treatments, and potentially lead to the development of therapies. Other medicinal applicative areas of this parasitic shrub, such as wound healing, gerontological effects, and antiviral and anticancer activities, are yet to be researched.

Literatural study on the Causal Pathogenesis and Pathology of Kyeolhyung (결흉(結胸)의 병인병리에 대한 문헌적 고찰)

  • Jeon, Sang-Yun;Kim, Sung-Jin;Hong, Seok;Chung, Su-Mi;Han, Hong-Jun;Chung, Jong-An
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.6
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    • pp.1442-1446
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    • 2006
  • This study was wrriten in order to to help understanding of Kyeolhyung(結洶). Kyeolhyung is a syndrome of epigastric pain and fullness due to accumulation of pathogen in the chest mostly caused by too early purgation of Taiyang(太陽) channel syndrome which leads to the exterior syndrome of heat from the exterior into the interior or combines with the original excessive fluid of the chest. The knotted chest can be divided into large, small, heat and substantice, cold and substantice, water and blood Kyeolhyung. Kyeolhyung is basically treated by purgation but practically it is treated by according to its own symptom and syndromes. And we were cured of the Kyeolhyung discriminating from Zanggyul(藏結) and Bijeung(비증).

Study on Application of the Herbal Medicines Mentioned in ${\ulcorner}$Sanghanron${\lrcorner}$, ${\ulcorner}$GeumGweyoryak${\lrcorner}$ with Regards to the abdominal Diagnoses Impressions of Epigastric Fullness and Rigidity (심하부 복진 소견과 연관된 상한론, 금궤요략 수재 약물, 처방의 응용에 관한 연구)

  • Choi, Myong-Hee;Kim, June-Ki
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.6
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    • pp.1375-1387
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    • 2006
  • Through abdominal diagnoses, deficiency and excess, and cold and heat of the eight principles for differentiating syndromes can be determined, pathogens such as fluid retention, dry stool, retention of undigested food, abdominal mass, blood stagnation, stagnation of Gi, deficiency of Kidney Yang, and, spermatorrhea can be identified, nature and stages of the symptoms can be understood and then pathogenesis analyzed. Abdominal diagnosis can be one of primary factors in deciding treatment, expecting prognosis and treatment effect, and choosing herbal prescriptions. Representative herbs for epigastric stuffiness/fullness are Radix Ginseng, Pericarpium Citri, etc; for fullness of epigastrium, Rhizoma Pinelliae, Pericarpium Citri, Rhizoma Rhei, etc.; for severely rigid epigastrium, Radix Glycyrrhizae, Radix Ginseng, etc.; for epigastric pain, Rhizoma Pinelliae, Pericarpium Citri, etc.; for epigastric fullness and rigidity, Rhizoma Coptidis, Radix Ginseng, etc.; for feeling of obstruction in the epigastirum, Radix Bupleuri, Radix Ginseng, etc.; for palpitation in the epigastrium, Radix Glycyrrhizae, Ramulus Cinnamomi, etc. It is essential to rightly diagnose through comprehensive analysis of the data gained by the four methods of diagnosis, and in doing this, further studies on how to utilize abdomen diagnosis for clinical practice.

Concept of Health from the View of Korean Medical Science (한의학의 관점에서 살펴본 건강의 개념)

  • Bang, Jung-Kyun
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.5
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    • pp.1111-1116
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    • 2006
  • Medical science is an area of study that focuses on maintaining health and treating disease. However, modern medicine focuses on treating disease and neglects methodology of maintaining health. Although the definition of heal this defined by the World Health Organization (WHO) and as the concept of harmonizing Yin and Yang in Korean medicine, there is no specific details regarding the definition. Thus, the following conclusion was obtained after the concept of health is viewed through Yin-Yang(陰陽), Vital Essence(精), Qi(氣), and Healthy Person(平人). Although Yin and Yang have opposite properties, they work very closely, maintaining the overall balance and harmony. Secondly, Vin and Yang would each function by the effects of one another, and the body could maintain normal physiological activities through this function. Thirdly, it maintains normal physiological state through the ascending Kidney-Water and descending Heart-Yang(水升火降). Fourthly, Vital Essence is divided into the congenital Essence(先天之精) and the acquired Essence(後天之精) in which the former is related with reproduction and the latter, nourishing. Fifthly, Qi is resistant to pathogens and related with the physique so that Qi and physique should be balanced. Sixthly, Healthy Person is the state where the exchange of Qi-Blood is active.

Report on the Korean Standard Differentiation of the Symptoms and Signs for the Stroke-1 (한의 중풍변증 표준안-I에 대한 보고)

  • Kim Joong-Kil;Seol In-Chan;Lee In;Jo Hyun-Kyung;Yu Byeong-Chan;Choi Sun-Mi
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.1
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    • pp.229-234
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    • 2006
  • To develop the Korean standard differentiation of the symptoms and signs for the stroke(KSDS), the committee on Stroke Diagnosis Standardization of traditional Korean medicine(TKM) was organized dy nineteen experts in college of Korean medicine. On July 9th 2005, the second consultation meeting was held in Daejeon, Korea. Fifteen experts of the committee attended the meeting and they discussed the KSDS and came to a consensus. The 15-member committee consensus was as follows: First, board members defined the stroke on the basis of TKM. Second, they divided the symptoms and signs of stroke into five categories- fire and heat, dampness and phlegm, blood stasis, qi deficiency, yin deficiency. Third, the symptom indicator of each differentiation type for the stroke was recommended. KSDS-1 will be applied to the clinical practice and revised.