• Korean Journal of Microbiology
• /
• v.55 no.3
• /
• pp.206-212
• /
• 2019

Propionibacterium acnes (P. acnes) lives in the hair follicles and pores, and it uses cell debris, sebum and metabolic byproducts of surrounding skin tissues as energy and nutrients. Increased production of sebum due to sebaceous hyperplasia or blockage of the follicle can cause growth and proliferation of P. acnes. The rapid growth of P. acnes in follicles produces cell damage, metabolic byproducts and bacterial chips, which can cause inflammation. In this study, we examined the possibility of Senecio iscoensis Hieron. (S. iscoensis) extract to regulate P. acnes-induced inflammatory signaling pathways. We observed that S. iscoensis extract effectively inhibited P. acnes-induced pro-inflammatory cytokine expressions such as IL-$1{\beta}$, TNF-${\alpha}$, and iNOS in mouse macrophage cell line Raw 264.7. The inhibitory effect of S. iscoensis in pro-inflammatory cytokine levels was accompanied by the inhibition of the transcription factors NF-${\kappa}B$ and NF-AT. However, S. iscoensis did not alter the P. acnes-induced MAPK signaling pathways. This study first suggests the potential of using S. iscoensis extract as an alternative agent for the treatment of acne.

• Journal of Coastal Disaster Prevention
• /
• v.5 no.4
• /
• pp.173-182
• /
• 2018

As the research about increasing the efficiency of dredging soil transport, the technology, which reduce the friction between pipe wall and fluid in the pipe and disturbed generating pipe blockage, has been developed. So for the purpose of applying this technology to real construction site, main test has been tried at the real scale test in field. As a test result, this paper will show 30% flow efficiency increasing by permitted electro magnetic force to the pipe. And test result was evaluated as a ultra sonic velocity profiler. To propose the design technique and the execution manual of the high efficiency dredging material transport technic, this research have confirmed flow status changing depending on a soil material kind under electro-magnetic field and analyze the effect of electro-magnetic field which affects to each dredged soil material transportation. For achieving this research, EMF(Electro-Magnetic Field) generator is installed on the dredger(20,000HP) and through monitored flow status, dredging soil flow rate and sampled material specification is confirmed. Also dredger operating condition is measured and dredger power for soil transportation, hydraulic gradient and flow rate are compared, as transportation efficiency is calculated by this parameter, it is possible to check transportation efficiency improvement depending on each dredged soil material under electro-magnetic field. To verify the technique of dredged soil transfer using electromagnetic field, which is the core technique of the high efficiency dredged soil transfer, and the technique of expert system for pipeline transfer and the flow state. This could lead to a verification of transfer efficiency according to the characteristics of the dredged soil (sand, clay, silt) and the transfer distance (5km, 10km, 15km), which is planned to be used for a technology development of pump power reduction and long-distance transfer applying the high efficiency dredged soil transfer technology.

• (The)Study of the Eastern Classic
• /
• no.73
• /
• pp.281-302
• /
• 2018

The role of mind is very important in Xunzi's thought. The way is permanent rule of politics that is under the control of mind which is recognizing organ for both thinking and acknowledging things in his thought. Nevertheless the mind in Xunzi's thought has desire as an organ of body to be controlled. On the other hand, the mind has conflicting two fold aspects in the course of its recognition of things like storage and vacancy, movement and calmness, and two kinds of recognizing opinion against one object. And there are various evils in thinking system of mind. In a sense, the mind of human is to be cleaned and cultivated. Xunzi proposed managing energy and cultivating mind as a thinking system. Mengzi proposed to enliven vast-flowing energy and to cultivate mind through shortening desire, while Xunzi did managing energy and caring about mind for controlling other body systems and publicly recognizing things. In Xunzi's idea the mind in the recognition of things is similar to the water in bowl as a mirror for looking at any things, and thus it is imperative for us to sink grounds in mind for becoming good water mirror. In this need the grounds of human mind would be to be sunk and also the cultivation of it would be to be demanded. Ultimately there should need the recognition of mind that is cleaned and cultivated for brightly discovering the great principle and recovering the unchangeable way with a view to preparing the condition for national peace. This thesis, in this context, to approach the meaning of mind, its two fold aspects, and the necessity of it.

• The Korea Journal of Herbology
• /
• v.28 no.4
• /
• pp.63-69
• /
• 2013

Objectives : The purpose of present study was to investigate the vasorelaxant activities and mechanisms of action of the ethanol extract of P. yedoensis leaf (PYL) on isolated rat aortic rings. Methods : Dried P. yedoensis leaves were extracted 3 times with 100% ethanol for 3 h in a reflux apparatus. Isolated rat aortic rings were suspended in organ chambers containing 10 ml Krebs-Henseleit (K-H) solution. The rings were maintained at $37^{\circ}C$ and aerated with a mixture of 95% $O_2$ and 5% $CO_2$. Changes in their tension were recorded via isometric transducers connected to a data acquisition system. Results : PYL relaxed the contraction of aortic rings induced by phenylephrine (PE, 1 ${\mu}M$) or KCl (60 mM) in a concentration dependent manner. However, the vasorelaxant effects of PYL on endothelium-denuded aortic rings were lower than endothelium-intact aortic rings. And the vasorelaxant effects of PYL on endothelium-intact aortic rings were reduced by pre-treatment with $N{\omega}$-Nitro-L-arginine methyl ester (10 ${\mu}M$), methylene blue (10 ${\mu}M$), 1-H-[1,2,4]-oxadiazolo-[4,3-${\alpha}$]-quinoxalin-1-one (10 ${\mu}M$), tetraethylammonium (5 mM). In addition, PYL inhibited the contraction induced by extracellular $Ca^{2+}$ in endothelium-denuded aortic rings pre-contracted by PE or KCl in $Ca^{2+}$-free K-H solution. Conclusions : These results suggest that PYL exerts its vasorelaxant effects via the activation of Nitric Oxide (NO) formation by means of L-arginine and NO-cGMP pathways and via the blockage of receptor operated calcium channels, voltage dependent calcium channels and calcium-activated potassium channels.

• Journal of the Korean GEO-environmental Society
• /
• v.23 no.9
• /
• pp.5-16
• /
• 2022

In recent years due to the development of urban and underground space, the number of ground disasters is increasing, and it is also leading to social problems. To solve the problem, a grouting method is generally used. However, the grouting method has material (grout) limitations in permeability, gelation properties and tensile resistance. Therefore, research on grout materials mixed with fibers is actively carried out to improve the problems. However, in the actual ground injection process, many difficulties have been faced causing the blockage of the inlet port and the injection tube. In this study, 'CNT-mixed grout material' was developed using CNT powder that can reinforce the tensile strength of soils. The uniaxial compressive and tensile strength tests were performed to obtain the optimal content and mechanical properties of the CNT Powder-mixed grout. It was found that the optimal CNT powder content is 0.5% that gives the average maximum strength. A one-dimensional injection test and the bulb formation test were carried out, and it was identified that the injection rate and bulb form could be controlled by pressure and mixing ratio. Field application of the CNT-Mixed grout is simulated using numerical analysis of slopes, foundations, and tunnels reinforced in several types. The positive effect of reducing plastic ranges and settlements was confirmed.

• Journal of Practical Agriculture & Fisheries Research
• /
• v.7 no.1
• /
• pp.35-46
• /
• 2005

This research was conducted to improve and establish Bokto direct seeding technology use of silicate in rice. Bokto direct seeding technology has recently released to alternative new method for transplanting method of the rice plant. In recent rice production has serious problem due to higher cost and labor shortage in Korea. In particular rice has been faced on open market to internationally due to WTO, FTA agreement etc. Thus rice growers in Korea have been more concentrated on cost reduction using by direct seeding technology such as dry seeding and water seeding while those methods have severe constraints like poor seedling, more weed occurrence, lodging and poor grain quality. In recent a new technology for improvement of these problem has released to farmer's field and proven to alternative rice growing technology of transplanting. In this technology there was additional application of silicate which has known as soil improvement and this research was obtained in the following results. At the application of silicate, sand, and soil there was high in seedling establishment by 90~100% in pot experiment but there was 55.0% seedling stand of the untreated control. Under dry condition seedling stand was 0% at the untreated control while 65~100% high in application of silicate, sand, and soil. Meanwhile, under rainy condition untreated control there was 85% of seedling stand but soil application was 20% of seedling establishment due to blocking of oxygen and physical soil blockage.

• Journal of Chest Surgery
• /
• v.34 no.11
• /
• pp.809-822
• /
• 2001

Background: Ischemic preconditioning(IP) is known to be effective in the protection of myocardial necrosis, arrhythmia, and the restoration of the myocardial function in the ischemia-reperfusion state of the heart. However the exact mechanism is not clearly understood. The purpose of this study was to elucidate the trigger mechanism 7f IP on the restoration of the myocardial function after ischemia-reperfusion. Material and Method: By connecting a Langendorff perfusion apparatus with an isolated heart of a rat, the normal temperature of the heart was maintained. The experiment was conducted in seven groups, which were divided according to the preconditioning stimuli and blockage methods Group I(n=10) was a group without IP, Group II(n=10) a group of three-minute IP, Group III(n=10) a group of PEIP, Group IV(n=10) a group of clonidine IP, Group V(n=10) a group of If after reserpine, Group Vl(n=10) a group of PE & prazosin IP, and Group Vll(n=10) a group of clonidine & yohimbine IP. Hemodynamic parameters of DP, LVEDP, $\pm$dP/dT and the changes of perfusion in the coronary artery were evaluated. Result: Developed pressure and +dP/dT changed per unit time. After 20 minutes of reperfusion, those of Group II and III were 63.1$\pm$3.7%, 64.8$\pm$4.6% and 64.5$\pm$4.6%, 63.8$\pm$4.4%, which improved more significantly than those of Group I(P<0.05), However, there were no significant differences between the Groups V and Vl, and Group I. Conclusion: The Brief ischemic preconditioning and pharmacological preconditioning using $\alpha$-receptor sympatho-mimetics have protecting effects on the restoration of myocardial function after reperfusion. And the protecting effect of preconditioning seems to be related to sympathetic neurotransmitters and to the selective action of the $\alpha$$_1$-adrenergic receptor.

• Journal of the Korean Institute of Traditional Landscape Architecture
• /
• v.31 no.1
• /
• pp.98-107
• /
• 2013

Big and old trees in the scenic spots with the attributes of remote villas are vulnerable to man-made damages and very sensitive to the external environment such as soil conditions, so the corresponding management plans are required. Thus this study has been conducted to survey the big and old trees in the scenic remote villas and suggest the ideal management plans. The results can be summarized as follows. First, regarding the tree heath above the ground, transformation of tree, death of branches, and death of barks are closely related to tree vigor. Particularly, the areas receiving many visitors require prompt countermeasures against the dried and dead tress above the ground and the areas in which dried and dead tress occurred and also the safety measures for the visitors and facilities. Second, regarding the soil environment, visitor traffic is closely related to the tree vigor. In 15 remote villa gardens, 64% of trees are exposed to heavy traffic and the tree vigor has declined due to an increase of visitor. Thus, there is a need to give positive consideration the installation of the complementary facilities and the plantation of herbal plants in the congested areas to form the ground surface that can tolerate the heavy visitor traffic. Third, remote gardens are in general located adjacent to ponds and mountain streams and thus the trees in the waterfront areas require the prompt countermeasures against the decline of growth due to the excess-moisture in the soil. Further the blockage of the sewage system due to the heavy rains dampens the surrounding soil, which results in lethal damages to the trees. Thus, there is a need of the maintenance of the waterfront areas and sewage system before and after the rainy season. In addition, there is a need to establish medium-long term management polices through the recognition of the importance of the main trees of remote villa gardens in scenic spots and prepare the tree management manual depending on the attributes of the corresponding areas. I strongly suggest making manuals for the systematic management as well as the extensive PR activities and education for the preservation of tress on a long-term basis; and furthermore securing the budget and manpower for the research and development of a systematic management system.

• The Korean Journal of Physiology
• /
• v.22 no.2
• /
• pp.189-206
• /
• 1988

The effects of ouabain on the contractile and electrical activities were investigated in the isolated preparations of guinea-pig taenia coli, and compared with those of vanadate. Spontaneous contractions were recorded with force transducer, and electrical activites were measured by use of suction electrode, or single sucrose-gap technique. The contractions were induced by the electrical stimulation for 5 seconds every 1 minute with alternating current (60 Hz, 3.0 V/cm) through the platinum electrodes located in parallel with the long axis of the preparation. All experiments were performed in tris-buffered Tyrode solution which was aerated with $100%{\;}O_2$ and kept at $35^{\circ}C$. The results obtained were as follows: 1) Responses of spontaneous contractions to ouabain were concentration-dependent; $10^{-7}M$ ouabain caused a rise of basal tone. Above the concentration of $10^{-6}M$ ouabain, an initial increase followed by a decrease in tension was observed. 2) A continuous spike discharge was induced by the administration of $10^{-7}M$ ouabain. Above $10^{-6}M$ ouabain, a transient initial increase followed by a decrease in spike frequency and amplitude was produced, and finally membrane potential was sustained at a certain level without a spike discharge. 3) The characteristic response to $10^{-7}M$ ouabain was not blocked by the pretreatment with $10^{-7}M$ atropine. 4) The electrically induced contractions were completely suppressed at the concentration of $2{\times}10^{-7}M$ ouabain. These contractions were blocked more rapidly in paralled with the increase in ouabain concentration. 5) Effects of vanadate on the spontaneous activities were quite different from those of ouabain; $10^{-6}M$ vanadate increased the amplitude of contractions and $10^{-5}M$ vanadate increased slightly both amplitude and frequency of spontaneous contractions. $10^{-4}M$ vanadate showed irregular phasic contractions superimposed on the increased basal tone. 6) $10^{-5}M$ vanadate depolarized the membrane potential and shortened the interval between the bursts of spike discharge, whereas $10^{-4}M$ vanadate induced continuous spike discharge with membrane depolarization. 7) Vanadate caused a characteristic inhibitory response to the contractions induced by electrical stimulation; An initial rapid inhibition of tension development and then gradual recovery to a certain level. From the above results, the following conclusions could be made: 1) The rise of basal tone at $10^{-7}M$ ouabain is due to continuous spike discharge without a silent period. The continuous spike discharge is likely to be associated with a slight membrane depolarization caused by the blockage of Na pump. 2) The biphasic response induced by above $10^{-6}M$ ouabain seems to occur by the different mechanisms. The initial increase in tension is associated with depolarization along with an increase in spike frquency, whereas the subsequent relaxation occurs through a non-electrical mechanism. 3) The characteristic response to $10^{-7}M$ ouabain is resulted not from the action on intrinsic nerve terminal, but from its direct action on the membrane of smooth muscle cells. 4) The phasic contractions superimposed on the increased basal tone at the concentration of $10^{-4}M$ vanadate is resulted from the continuous spike discharge with membrane depolarization, of which mechanism remains unknown. 5) The inhibitory action of ouabain on the electrically induced contractions suggests that the increasein intracellular Na in some way inhibits the electrically induced $Ca^{2+}$ influx. The mechanism of vanadate action on the induced contractions remains unknown.

• Korean Journal of Ecology and Environment
• /
• v.39 no.2 s.116
• /
• pp.271-283
• /
• 2006

A systematic water quality survey was conducted in August, 2005 for a drinking water supply reservoir (the Jeolgol reseuoir located in an island), which is at an early stage of impoundment, to investigate the causes of water color deterioration of the reservoir and the clogging of filter beds of a water treatment plant. The reservoir shape was simple and its average depth was 5.5 m, increasing from upreservoir toward the downreservoir end near the dam. Dissolved oxygen (DO) and chloropllyll-a (chi-a) showed a large variation while water temperature had a smaller range. Transparency ranged from 0.6 to 0.9 m (average 0.7 m). The average value of turbidity was 9.3 NTU, ranging from 8.0 ${\sim}$ 12.1 NTU. The transparency and the turbidity appear to be affected by a combination of biological and non-biological factors. The poor transparency was explained by an increase of inorganic colloids and algal bloom in the reservoir. The blockage of the filter bed was attributed to the oversupply of phytoplanktons from the reservoir. The range and the average concentration of chi-a within the reservoir were 31.6 ${\sim}$ 258.9 ${\mu}g\;L^{-1}$, 123.6 ${\mu}g\;L^{-1}$ for the upper layer, and 17.0 ${\sim}$ 37.4 ${\mu}g\;L^{-1}$, 26.5 ${\mu}g\;L^{-1}$ for the bottom layer, respectively. A predominant species contributing the algal bloom was Dinophyceae, Peridinium bipes f. occultatum. The distribution of Peridinium spp. was correlated with chi-a concentrations. The standing crop of phytoplankton was highest in the upreservoir with $8.5\;{\times}\;103\;cells\;mL^{-1}$ and it decreased toward the downresevoir. Synedra of Bacillariophyceae and Microcystis aeruginosa of Cyanophyceae appeared to contribute to the algal bloom, although they are not dominated. It is mostly likely that sloped farmlands located in the watershed of the reservoir caused water quality problems because they may contain a significant amount of the nutrients originated from fertilizers. In addition, the aerators installed in the reservoir and a shortage of the inflowing water may be related to the poor water quality. A long-term monitoring and an integrated management plan for the water quality of the watersheds and the reservoir may be required to improve the water quality of the reservoir.