• Neonatal Medicine
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• v.18 no.2
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• pp.395-398
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• 2011

Sick sinus syndrome (SSS) is a disorder characterized by sinus node dysfunction. Although the condition is most common in the elderly, it can occur in children including neonates and its recognition and treatment are important. The diagnosis of SSS is based on the presence of sinus bradycardia, sinus arrest or exit block, combinations of sinoatrial and atrioventricular nodal conduction disturbances, and atrial tachyarrhythmias documented in the Holter recordings. In most children with SSS, previous history of congenital heart malformation or cardiac surgery is noted. SSS is also seen in the children including neonates without heart disease or other contributing factors, however SSS is most often idiopathic. The treatment of SSS depends on the basic rhythm problem, but generally involves the placement of a cardiac pacemaker. We report a case of SSS in extremely low birth weight infant without congenital heart disease and suggest that the treatment system is necessary for preterm infants with SSS.

• Explosives and Blasting
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• v.28 no.2
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• pp.1-16
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• 2010

This study focuses on the phenomenon that the blast damaged zone developed on rock slope surfaces can be affected by joint characteristics rather than by explosive power when the pre-splitting is applied to excavate a jointed rock slope. The characteristics of rock joints on a slope were investigated and categorized them into 4 cases. Also an image processing system has been used for comparing the distribution pattern of rock blocks. From this investigation, it was found that the rock blocks bigger than 2,000 mm occupied 42% in the case of single joint set and it showed the well efficiency of pre-splitting blast. In cases of 2~3 parallel joint sets and 2~3 intersecting joint sets are developed on rock surfaces, the rock blocks in the range of 1,000~2,000 mm occupied 43.6% and 35.8%, respectively, and it showed that the efficiency of pre-splitting was decreased. When more than 3 joint sets are randomly developed, however, the rock blocks in the range of 250~500 mm occupied 35% and there was no block bigger than 1,000 mm. This denotes that the blasting with pre-splitting was not effective. The numerical analysis using PFC2D showed that the blast damaged zone in a rock mass could be directly influenced by the pre-splitting. It is, therefore, required to investigate the discontinuity pattern on rock surfaces in advance, when the pre-splitting method is applied to excavate jointed rock slopes and to apply a flexible blating design with a consideration of the joint characteristics.

• Biomolecules & Therapeutics
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• v.3 no.1
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• pp.21-27
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• 1995

The only compounds with antagonistic activity via AT$_1$receptor, one of two subtypes of angiotensin II (AII) receptor, have been demonstrated to block the vasoconstriction effects of AII and thereby provide therapeutic potential. This initiated the search for compounds with high specific affinity to AT$_1$receptor and their effective screening methods. The radioligand binding assay for the AII receptor is regarded as the primary method for the evaluation of AT$_1$receptor antagonists for their activity. In this paper, we characterized the liver AT$_1$receptor and describe the efficient method of the radioligand binding assay using rat liver as a source of AT$_1$receptor. Equilibrium binding studies with rat adrenal cortex, adrenal medulla, liver and bovine adrenal showed that the specific bindings of [$^3$H] AII were saturable in all tissues and the Scatchard plots of those data were linear, suggesting a single population of binding sites. Hill slopes were very near to the unity in all tissues. Kinetic studies of [$^3$H) AII binding in rat liver homogenates yielded two association rate constants, 4.10$\times$10$^{7}$ M$^{-1}$ min$^{-1}$ and 4.02$\times$10$^{9}$ M$^{-1}$ min$^{-1}$ , with a single dissociation rate constant, 7.07$\times$10$^{-3}$ min-$^{-1}$ , possibly due to the partial dissociation phenomenon. The rank order of inhibition potencies of [$^3$H] AII binding in rat liver was AII>Sarile>Losartan>PD 123177. Rat liver homogenates revealed to have very high density of homogeneous population of the AT$_1$receptor subtype, as the specifically bound [$^3$H] AII was not inhibited by PD 123177, the nonpeptide antagonist of AT$_2$. The results of this study demonstrated that the liver homogenates from rats could be the best receptor preparation for the AT$_1$receptor binding assay and provide an efficient system for the screening of newly synthesized candidate compounds of AT$_1$receptor antagonist.

• Journal of the Korean Society of Tobacco Science
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• v.26 no.2 s.52
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• pp.152-158
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• 2004

Among short-term in vitro genotoxicity assays, micronucleus assays are rapid, inexpensive, and less labor-intensive system. We have undertaken a comparative study of sensitivity of cigarette smoke condensate(CSC) by general micronucleus(MN) assay and cytokinesis-block micronucleus(CBMN) assay. In this study, V79 Chinese hamster cells were employed to evaluate and compare the genotoxicity of CSC of Kentucky Reference Cigarette 2R4F by 2 kinds of in vitro MN assay methods. To determine the optimum concentration of cytochalasin B(CYB) to obtain the maximal number of binucleated cells for CBMN assay, triplicate cultures of growing cells were treated with CYB for 15 h. CYB treatments caused a concentration-dependent increase in cytotoxicity($1\~4{\mu}g/mL$) and proportion($0.25\~1\;{\mu}g/mL$) of binucleated cells. These data suggested that 1 ug/mL of CYB is as an optimum dose for CBMN assay in binucleated V79 cells. Short treatment(4 h) of CSC induced a micronucleated cells with a concentration-dependent response in the presence or absence of CYB, but CSC-induced MNs were weakened when S9 was present. Long treatments(19 h) of CSC also induced a significant increase MN formation with a concentration-dependent response. At a concentration of 75 ${mu}g/mL$, the MN cell frequencies of general MN assay and CBMN assay were $6.5\%\;and\;11.7\%$, respectively. Linear regression analysis revealed a good correlation in CBMN assay between a concentration of CSC and MN cell frequency. All these data indicated that CBMN assay is more sensitive to the induction CSC-induced MN than general MN assay.

• Polymer(Korea)
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• v.34 no.3
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• pp.274-281
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• 2010

In this study, PEG-PLA(or PLGA) amphiphilic di-block copolymers were synthesized by ring opening polymerization of D,L-lactide(or glycolide) and applied to polymeric micelle system for solubilization of a rosiglitazone as diabetes drug. The drug could be efficiently loaded into the polymer micelle by solid dispersion technique, and the drug-loaded micelles were characterized and evaluated as a drug delivery carrier by fluorescence spectrometer, DSC, and DLS measurements. The colloidal stability of drug loaded micelles in aqueous media could be enhanced by addition of 2-hydroxy-N-picolylnitinamide as a hydrotropic agent. The polymer micelles also showed biocompatible and nontoxic properties in vitro cell viability using MTT assay, and the drug loaded micelles were observed to be more effective than free drug for decreasing glucose in blood of rats.

• Journal of Korea Multimedia Society
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• v.8 no.7
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• pp.924-942
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• 2005

Recently, large-scale directories have been developed for LINUX cluster file systems to store and retrieve huge amount of data. One of them, GFS directory, has attracted much attention because it is based on extendible hashing, one of dynamic hashing techniques, to support fast access to files. One distinctive feature of the GFS directory is the flat structure where all the leaf nodes are located at the same level of the tree. Hut one disadvantage of the mode structure is that the height of the mode tree has to be increased to make the tree flat after a byte is inserted to a full tree which cannot accommodate it. Thus, one byte addition makes the height of the whole mode tree grow, and each data block of the new tree needs one more link access than the old one. Another dynamic hashing technique which can be used for directories is linear hashing and a couple of researches have shown that it can get better performance at file access times than extendible hashing. [n this research, we have designed and implemented an extendible hashing directory and a linear hashing directory for large-scale LINUX cluster file systems and have compared performance between them. We have used the semi-flat structure which is known to have better access performance than the flat structure. According to the results of the performance evaluation, the linear hashing directory has shown slightly better performance at file inserts and accesses in most cases, whereas the extendible hashing directory is somewhat better at space utilization.

• Journal of The Korean Association For Science Education
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• v.30 no.8
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• pp.1097-1109
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• 2010

The purpose of this study is to analyze the ERF components patterns of observers who have different cognitive styles using magneto-encephalography (MEG). The task was developed based on the CSA (Cognitive Style Analysis) program. Eight right-handed, healthy male college students participated in voluntarily. To investigate college students' ERF components during the task, an MEG system with block design was used to measure magnetic signals in their brains. For examining the observation characteristic by cognitive style, MEG ERF components were analyzed. As a result, four ERF components (M1, M2, M3, M4) were observed. Through the results of this study, the reason for different observation characteristics by cognitive styles was verified in the neurophysiological methods. This study will have implications to establish theories on scientific observation and cognitive styles.

• Journal of Sericultural and Entomological Science
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• v.34 no.2
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• pp.6-12
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• 1992

To study the effects of irrigation on the mulberry, 3 experiments were conducted. In experiment 1, four treatments, conventional (no irregation), drip irrigation, fertigation and fertigation with 20% extra fertilizer were examined. Irrigation hose was hurried at 20cm depth under the surface (Experiment 1). Water potential was controled at 0.1, 0.2, 0.5 and 1.0 bar to understand the optimum irrigation potential under rain-block system with plastic film hose(experiment 2). Five leading mulberry varieties, Cheongilppong, Youngcheonppong, Suseongppong, Kaeryangppong and Shinilppong were examined for irrigation response(experiment 3). Fertigation and fertigation with extra fefilizer increased yield by 22%, repectively compared with conventional. Irrigation increased by 8%, but with no significance statistically compared with the conventional. Irrigation, especially fertigation increased water content, P$_2$O$_{5}$, $K_2$O and CaO in leaves, suggested improving leaf quality in fall. Fertigation increased available P$_2$O$_{5}$ content in the sub-soil. More root distribution showed at the sub-soil in fertigation. Weed did not occured in fertigation due to sub-soil fertilization, whereas the conventional received surface fertilization showed 931kg/10 a weed in fresh weight. No effect showed at the 20% extra fertilizer than the conventional amount Maximun yield showed at the 0.5 bar water potential. Irrigation increased yield by 22-25% with Cheongilppong and Yongcheonppong, and by 9-13% with Suseongppong, Shinilppong and Kaeryangppong.

• The KIPS Transactions:PartC
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• v.12C no.5 s.101
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• pp.765-772
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• 2005

In this paper, we propose E-mail sending-server authorization method using a distance estimation algorithm between W addresses to check whether the E-mail sending server is registered in the domain of mail sending server or belongs to the domain for filtering spam mail. This method utilizes the distance between the IP address of sending server and IP addresses registered in the DNS to figure out that the E-mail sending server exists in the domain to filter spam mail. The experimental result of applying the proposed algorithm to sample E-mails gathered in a large size laboratory says that 88 percents of legitimate E-mails and only 10 percents of spam mails are sent by servers in the same domains of senders. The algorithm may be effectively used to block spam mails sent by servers outside of the domains of mail senders. It may be also hired as a temporary E-mail protecting system until the standard E-mail authorization protocol is fully deployed.

• KIPS Transactions on Computer and Communication Systems
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• v.2 no.9
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• pp.381-392
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• 2013

During the last decade, the multitude of advances attained in terminal computers, along with the introduction of mobile hand-held devices, and the deployment of high speed networks have led to a recent surge of interest in Quality of Service (QoS) for video applications. The main difficulty is that mobile devices experience disparate channel conditions, which results in different rates and patterns of packet loss. One way of making more efficient use of network resources in video services over wireless channels with heterogeneous characteristics to heterogeneous types of mobile device is to use a scalable video coding (SVC). An SVC divides a video stream into a base layer and a single or multiple enhancement layers. We have to ensure that the base layer of the video stream is successfully received and decoded by the subscribers, because it provides the basis for the subsequent decoding of the enhancement layer(s). At the same time, a system should be designed so that the enhancement layer(s) can be successfully decoded by as many users as possible, so that the average QoS is as high as possible. To accommodate these characteristics, we propose an efficient transmission scheme which incorporates SVC-aware dual-channel repetition to improve the perceived quality of services. We repeat the base-layer data over two channels, with different characteristics, to exploit transmission diversity. On the other hand, those channels are utilized to increase the data rate of enhancement layer data. This arrangement reduces service disruption under poor channel conditions by protecting the data that is more important to video decoding. Simulations show that our scheme safeguards the important packets and improves perceived video quality at a mobile device.