• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.16-16
• /
• 2022

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2022.10a
• /
• pp.236-236
• /
• 2022

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2022.10a
• /
• pp.238-238
• /
• 2022

• Proceedings of the Korean Society of Life Science Conference
• /
• 2006.09a
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• pp.44.2-44.2
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• 2006

• Molecules and Cells
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• v.45 no.8
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• pp.550-563
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• 2022

Hepatocellular carcinoma (HCC) is an aggressive and incurable cancer. Although understanding of the molecular pathogenesis of HCC has greatly advanced, therapeutic options for the disease remain limited. In this study, we demonstrated that SETD5 expression is positively associated with poor prognosis of HCC and that SETD5 depletion decreased HCC cell proliferation and invasion while inducing cell death. Transcriptome analysis revealed that SETD5 loss downregulated the interferon-mediated inflammatory response in HCC cells. In addition, SETD5 depletion downregulated the expression of a critical glycolysis gene, PKM (pyruvate kinase M1/2), and decreased glycolysis activity in HCC cells. Finally, SETD5 knockdown inhibited tumor growth in xenograft mouse models. These results collectively suggest that SETD5 is involved in the tumorigenic features of HCC cells and that targeting SETD5 may suppress HCC progression.

• Proceedings of the Zoological Society Korea Conference
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• 2006.08a
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• pp.20-20
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• 2006

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.74-74
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• 2005

• Proceedings of the Korean Society of Life Science Conference
• /
• 2005.04a
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• pp.189-189
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• 2005

• Proceedings of the PSK Conference
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• 2002.04a
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• pp.195.2-195.2
• /
• 2002

• Bulletin of the Korean Chemical Society
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• v.27 no.10
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• pp.1537-1541
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• 2006

The $^1H$ and $^{13}C$ chemical shifts of eleven flavone derivatives were completely determined by basic 1D and 2D NMR experiments. Nineteen flavone derivatives including the above eleven derivatives were examined for anti-oxidative effects using the 1,1-diphenyl-2-picryl-hydrazyl assay and Caenorhabditis elegans. In order to understand the relationships between the structures of flavone derivatives and their anti-oxidative activities, a Comparative Molecular Field Analysis was performed.