• Animal cells and systems
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• v.7 no.1
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• pp.63-68
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• 2003

Until recently, interest in human complement receptor type I (CR1) has focused on immune complex processing, which contributed to our understanding of regulatory mechanism of complement activation. However, the promoter structure and transcriptional regulation of human CR1 gene has not been clear. To study the unique regulation of human CR1 gene expression, we assessed promoter activity of the $5^1$-flanking region of human CR1 gene using transient transfection and gel mobility shift assays. In this study we demonstrated that NF-Y binds to the inverted CCAAT element and that the functional interaction with protein(s) which bind to the GC-rich motif may be necessary for optimal transcription of human CR1 gene. We also show that sequence elements which located at-95/58 and +45/+50 are important for optimal transcription of CR1 gene.

• Proceedings of the PSK Conference
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• 2004.10a
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• pp.147.1-147.1
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• 2004

• Proceedings of the Microbiological Society of Korea Conference
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• 2009.05a
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• pp.55-56
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• 2009

• Proceedings of the Korean Society of Life Science Conference
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• 2006.09a
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• pp.74.2-74.2
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• 2006

• Proceedings of the Plant Resources Society of Korea Conference
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• 2001.11b
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• pp.98-98
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• 2001

• Proceedings of the Plant Resources Society of Korea Conference
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• 2001.11b
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• pp.102-102
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• 2001

• Proceedings of the Plant Resources Society of Korea Conference
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• 2001.11b
• /
• pp.103-103
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• 2001

• Proceedings of the Korean Society of Crop Science Conference
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• 2001.05a
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• pp.246-247
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• 2001

• Journal of Microbiology and Biotechnology
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• v.26 no.6
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• pp.1162-1162
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• 2016

• Mycobiology
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• v.40 no.2
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• pp.145-146
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• 2012

The root of Hibiscus syriacus (Malvaceae) has been used for treatment of fungal diseases such as tinea pedis (athlete's foot). In this study, we investigated the antifungal constituent of the root of Hibiscus syriacus Ggoma, which was produced by a mutation breeding using gamma ray irradiation, and compared the antifungal activity of H. syriacus Ggoma and its parent type. According to the results, the methanolic extract of H. syriacus Ggoma exhibited four times higher antifungal activity than its parent type against Trichophyton mentagrophytes. Following purification through various column chromatographies, the antifungal substance was identified as nonanoic acid on the basis of spectroscopic analysis.