• Proceedings of the Polymer Society of Korea Conference
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• 2006.10a
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• pp.244-244
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• 2006

We developed novel polymer materials composed of thermoresponsive pNIPAAm main chain and photo-resnposive side chains of spirobenzopyran, and analyzed the photoresponsive characteristrics of the aqueous solutions of these copolymers. Further, we prepared various photoresponsive hydrogels composed of the copolymer, and investigated the effect of light irradiation on their properties. As a result, the copolymer exhibited quite unique response to light irradiation and the change in temperature and pH. Especially the drastic photo-induced dehydration was observed in low pH conditions, and photo-induced micro-relief formation was demonstrated using the hydrogel layer composed of the polymer.

• BMB Reports
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• v.52 no.6
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• pp.379-384
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• 2019

Epithelial-mesenchymal transition (EMT) is widely-considered to be a modulating factor of anoikis and cancer metastasis. We found that, in MDA-MB-231 cells, TP53I11 (tumor protein P53 inducible protein 11) suppressed EMT and migration in vitro, and inhibited metastasis in vivo. Our findings showed that hypoxic treatment upregulated the expression of $HIF1{\alpha}$, but reduced TP53I11 protein levels and TP53I11 overexpression reduced $HIF1{\alpha}$ expression under normal culture and hypoxicconditions, and in xenografts of MDA-MB-231 cells. Considering $HIF1{\alpha}$ is a master regulator of the hypoxic response and that hypoxia is a crucial trigger of cancer metastasis, our study suggests that TP53I11 may suppress EMT and metastasis by reducing $HIF1{\alpha}$ protein levels in breast cancer cells.

• Korean Journal of Computational Design and Engineering
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• v.20 no.3
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• pp.246-253
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• 2015

In this paper, we propose calibration methods that can be applied to the markerless surgical robotic system for Intracerebral Hematoma (ICH) Surgery. This surgical robotic system does not require additional process of patient imaging but only uses CT images that are initially taken for a diagnosis purpose. Furthermore, the system applies markerless registration method other than using stereotactic frames. Thus, in overall, our system has many advantages when compared to other conventional ICH surgeries in that they are non-invasive, much less exposed to radiation exposure, and most importantly reduces a total operation time. In the paper, we specifically focus on the application of calibration methods and their verification which is one of the most critical factors that determine the accuracy of the system. We implemented three applications of calibration methods between the coordinates of robot's end-effector and the coordinates of 3D facial surface scanner, based on the hand-eye calibration method. Phantom tests were conducted to validate the feasibility and accuracy of our proposed calibration methods and the surgical robotic system.

• Korean Journal of Computational Design and Engineering
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• v.21 no.2
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• pp.196-203
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• 2016

In this paper, we propose a virtual surgical planning system specialized to mandible reconstruction surgery. Mandible reconstruction surgery is one of the most difficult surgeries, even for experienced surgeons. Compared to the traditional surgical procedures, virtual surgical planning can reduce the operation time in operating room while expecting better surgical outcome with optimized planning. However, with existing software systems, it requires much time and manual operations in virtual surgical planning. To reduce preparation time and improve accuracy of virtual surgical planning, we have developed optimized functions for virtual surgical simulation of mandible reconstruction with user-friendly interface. We found that the proposed system shortened the preparation time by half compared to the existing system from the experiments. The proposed system supports surgeons to make accurate plan faster and easier. The virtually planned results are used to make surgical cutting guide by 3D printing, and this will enhance surgical performance in operating room.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1954-1957
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• 2005

A quantitative evaluation of postural balance training using a virtual reality bicycle system was performed. In the experiment, the effectiveness of virtual reality bicycle system on postural balance training was analyzed with four male subjects in their twenties. The parameters measured during cycling were cycling time, average velocity, number of times subject deviated from path, and weight shift. Those parameters were evaluated for the quantification of the extent of control. We also measured the parameters on postural control capability after 5th trial and 10th trial in a balance testing system with a force plate to find out the effectiveness of the training. In the balance test with force plate, it was found out that the weight shift was almost zero and the deviation from the target trace reduced significantly after the training with the virtual cycle. The result showed that the virtual bicycle system was an effective system as a rehabilitation training device.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2006.10a
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• pp.457-458
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• 2006

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2006.10a
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• pp.441-442
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• 2006

• Structural Engineering and Mechanics
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• v.14 no.2
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• pp.135-150
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• 2002

Numerical analysis of ultimate behaviour of thin bionics shells is treated in present paper. Interactive conditions in resonance and stability ultimate response are considered. Numerical treatment of nonlinear problems appearing is made using the updated Lagrangian formulation of motion. Each step of the iteration approaches the solution of linear problem and the feasibility of parallel processing FETM-technique with adaptive mesh refinement and substructuring for the analysis of ultimate action of thin bionics shells is established. Some numerical results are submitted in order to demonstrate the efficiency of the procedures suggested.

• Korean Journal of Computational Design and Engineering
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• v.17 no.5
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• pp.303-311
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• 2012

Laparoscopic surgery is a surgical procedure which uses long laparoscopic instruments through tiny holes in abdomen while watching images from a laparoscopic camera through umbilicus. Laparoscopic surgeries have many advantages rather than open surgeries, however it is hard to learn the surgical skills for laparoscopic surgery. Recently, some virtual simulation systems for laparoscopic surgery are developed to train novice surgeons or resident surgeons. In this study, we introduce the techniques that we developed for laparoscopic surgical training simulator for cholecystectomy (gallbladder removal), which is one of the most frequently performed by laparoscopic surgery. The techniques for cholecystectomy simulation include modeling of human organs (liver, gallbladder, bile ducts, etc.), real-time deformable body calculation, realistic 3D visualization of surgical scene, high-fidelity haptic rendering and haptic device technology, and so on. We propose each simulation technique for the laparoscopic cholecystectomy procedures such as identifying cystic duct and cystic artery to clamp and cut, dissecting connective tissues between the gallbladder and liver. In this paper, we describe the techniques and discuss about the results of the proposed cholecystectomy simulation for laparoscopic surgical training.

• Journal of the Korean Chemical Society
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• v.67 no.1
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• pp.68-71
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• 2023