• 대한예방한의학회지
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• 제7권1호
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• pp.47-53
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• 2003

쥐와 생쥐의 혈관내 봉한관을 채취하는 새로운 방법을 개발하였다. 복대정맥과 동맥에서 양끝을 겸자로 묶고 혈액을 뽑아냄으로써 부서진 봉한관 조각들을 찾아 광학 현미경으로 관찰하는 방법이다. 장점은 피브린이 없이 순수 봉한관을 얻는 것이고, 단점은 그 길이가 너무 짧은 점이다.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.118-120
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• 1997

Intel's 80C196KD has been applied at the moving-actuator type total artificial heart ( MA-TAH ) from about early 1990th at our laboratory and it fulfilled its role successively. But the increased need of higher performance brought the other-type of the CPU, and the new challenge of ASIC to the application to the MA-TAH accelerated its need. So the new concept of the utilization of the DSP based CPU to the motor control was surveyed and analyzed deeply or about ew months and the results were introduced and summarized in this paper.

• 한국보건간호학회지
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• 제23권2호
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• pp.262-272
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• 2009

Objectives: This study sought to provide basic data for the establishment of a desirable sense of ethics in medical service by analyzing the consciousness of biomedical ethics of nursing students. Methods: Subjects were nursing students selected from four-year and three-year nursing colleges (n=355 and 360, respectively) in D city and G buk-Do region. The Data was analyzed using t-test, one-way ANOVA, and multiple regression. Results: The average point of the consciousness of biomedical ethics was 2.99. As result of analyzing general and specific aspects of the consciousness of biomedical ethics, statistically significant differences were found in age, religion, participation in religious activity, kinds of student group activity in subjects, ethical values, experience of hearing for biomedical ethics, quantity and quality of biomedical ethics in the current curriculum, the experience of conflict for biomedical ethical problem in subjects. The predicting variables that influence the consciousness of biomedical ethics, ethical values, quantity and quality of biomedical ethics in the current curriculum, religion, age, and experience of hearing for biomedical ethics. Conclusions: An arbitration program that could promote either changeable or controllable ethical values must be considered with attention to the significant variables that can promote the consciousness of biomedical ethics of nursing students.

• 센서학회지
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• 제19권3호
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• pp.169-175
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• 2010

Urinalysis is an important clinical test to diagnose urinary diseases, and dipstick method with visual inspection is widely applied in practice. Automated optical devices recently developed have disadvantages of long measurement time, big size and heavy weight, accuracy degradation with time, etc. The present study proposed a new computer scanning technique, in which the test strip and the standard chart were simultaneously scanned to remove any environmental artifacts, followed by automated differentiation with the minimum distance algorithm, leading to significant enhancement of accuracy. Experiments demonstrated an accuracy of 100 % in that all test results were identical with the human visual inspection. The present technique only uses a personal computer with scanner and shortens the test time to a great degree. The results are also stored and accumulated for later use which can be transmitted to remote locations through a network, thus could be easily integrated to any ubiquitous health care systems.

• 감성과학
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• 제14권4호
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• pp.571-580
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• 2011

본 연구에서는 50대 택시 운전자를 대상으로 동작 신호인 Jerk-Cost function(JC)와 차간거리의 분산계수(Anterior-Posterior Coefficient of Variation, APCV), 차선이격거리의 분산계수(Medial-Lateral Coefficient of Variation, MLCV)와 같은 차량 통제 데이터를 이용하여 운전 중 문자 메시지 전송 또는 네비게이션 검색과 같은 동시 과제 수행이 운전 수행 능력에 어떠한 영향을 미치는지를 알아보고자 하였다. 남성 14명과 여성 14명을 대상으로 실험을 진행하였다. 피험자는 일정 속도(80km/hr or 100km/hr)로 주행하는 선행 차량과 일정 거리 30m를 유지하며 주행하도록 하였다. 처음 1분간은 운전만을 수행하게 하였으며, 다음 1분 동안은 운전만을 수행하거나 운전과 함께 동시 과제를 수행하도록 하였다. MLCV와 APCV는 80km/hr와 100km/hr 주행 시 Driving only에 비해 Driving + Sending Text Message(STM)와 Driving + Searching Navigation(SN)에서 유의하게 증가하였다. JC 또한 주행 시 Driving only에 비해 Driving + STM과 Driving + SN에서 증가하였다. 본 연구를 통해 운전 경력이 길고 운전 전문가라고 할 수 있는 50대 택시 운전자도 운전만을 수행하는 경우에 비해 운전과 함께 문자 메시지 전송 또는 네비게이션 검색 과제를 수행하게 될 경우 동작 패턴이 거칠어지고 차량 통제가 어려워진다는 사실을 도출할 수 있었다.

• 감성과학
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• 제13권4호
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• pp.703-710
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• 2010

본 연구에서는 선행 연구에서 개발된 촉각 자극 시스템의 시스템적인 문제, 자극 제어에 관한 문제, 기타 부가적인 문제들을 보완할 수 있는 촉각 자극기를 개발하였다. 개발된 장치는 제어부(control unit), 구동부(drive unit), 진동부(vibrator)의 세부분으로 구성된다. 제어부는 E-Prime 소프트웨어로부터 명령을 전송받고 진동 자극 신호를 발생한다. 구동부는 촉각 자극기가 효과적으로 진동 자극을 발생할 수 있도록 충분한 전류를 공급한다. 진동부는 작은 동전(coin) 형 진동기(vibrator)와 벨크로(velcro)로 구성되며 피험자의 손에 쉽게 고정 할 수 있도록 제작하였다. 개발된 장치는 소형, 경량, 저전력 구동, 간단한 구조, 최대 35개의 자극 채널, 시각 및 청각과의 다양한 자극 조합을 지연시간 없이 제시할 수 있도록 설계 되어 시스템적인 문제들을 보완하였다. 자극의 크기와 시간을 10단계로 조절할 수 있도록 하고, 넓은 동작주파수 범위를 확보하여 자극 제어에 관한 문제들을 보완하였다. 저전압 구동으로 인체에 대한 안정성을 확보하고, 손가락 이외에 신체의 어느 부분이든 자극 제시가 가능하도록 제작하였다. 특히 본 시스템은 인지과학 연구에서 범용으로 사용되는 소프트웨어인 E-Prime을 기반으로 개발되었기 때문에 활용성이 매우 높을 것으로 판단된다.

• 한국의학물리학회지:의학물리
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• 제28권1호
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• pp.1-10
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• 2017

The difference between three-dimensional (3D) and four-dimensional (4D) dose could be affected by factors such as tumor size and motion. To quantitatively analyze the effects of these factors, a phantom that can independently control each factor is required. The purpose of this study is to develop a deformable lung phantom with the above attributes and evaluate the characteristics. A phantom was designed to simulate diaphragm motion with amplitude in the range 1~7 cm and period up to ${\geq}2s$ of regular breathing. To simulate different tumors sizes, custom molds were created using a 3D printer and filled with liquid silicone. The accuracy of the phantom diaphragm motion was assessed by comparing measured motion with predicted motion. Because the phantom diaphragm motion is not identical to the tumor motion, the correlation between the diaphragm and tumor motions was calculated by a curve fitting method to emulate user-intended tumor motion. Tumors of different sizes were located at same position, and tumor set-up positions were evaluated. The accuracy of phantom diaphragm motion was better than 1 mm. The diaphragm-tumor correlation showed that the tumor motion in the superior-inferior direction increased with increasing diaphragm motion. The tumor motion was larger in the $10cm^3$ tumor than in the $90cm^3$ tumor. The range of difference between the tumor set-up positions was 0 to 0.45 cm. This phantom showed independently adjusting factors such as tumor size and motion to facilitate quantitative analysis of the dosimetric impact of respiratory motion according to these factors.

• 센서학회지
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• 제21권3호
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• pp.223-228
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• 2012

In this study, a fiber-optic pH sensor based on a pH sol-gel film is fabricated. The sol-gel film is made by co-polymerizing tetramethoxysilane, trimethoxymethylsilane, ethanol and distilled water. As a pH indicator, a neutral red is immobilized in a thin porous film formed by the sol-gel process. The pH change in a sensing probe gives rise to a change in the color of the pH sol-gel film, and the absorbance of reflected light through the pH sol-gel film is also changed. By using a spectrometer, therefore, the spectra of reflected lights in the sensing probe with different pH values are measured. Also, the relationships between the pH values and the absorbance are analyzed on the basis of the color variations of the pH sol-gel films. In repeated experiments, the fiber-optic pH sensor shows that it has reversibility, a high reproducibility and a wide absorbance change in a pH range from pH 5 to 9. Also, we confirmed that the fabricated pH sol-gel film exhibits a fast response time, little or no pH indicator leaching and a dynamic range of 2.04 dB from pH 5 to 9. Based on the results of this study, a fiber-optic pH sensor can be developed for the pH monitoring in the harsh environments.

• Journal of Microbiology and Biotechnology
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• 제23권4호
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• pp.518-526
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• 2013

Gut-derived lipopolysaccharides (LPS) are critical to the development and progression of chronic low-grade inflammation and metabolic diseases. In this study, the effects of probiotics Lactobacillus and Bifidobacterium on gut-derived lipopolysaccharide and inflammatory cytokine concentrations were evaluated using a human colonic microbiota model. Lactobacillus reuteri, L. rhamnosus, L. plantarum, Bifidobacterium animalis, B. bifidum, B. longum, and B. longum subsp. infantis were identified from the literature for their anti-inflammatory potential. Each bacterial culture was administered daily to a human colonic microbiota model during 14 days. Colonic lipopolysaccharides, and Gram-positive and negative bacteria were quantified. RAW 264.7 macrophage cells were stimulated with supernatant from the human colonic microbiota model. Concentrations of TNF-${\alpha}$, IL-$1{\beta}$, and IL-4 cytokines were measured. Lipopolysaccharide concentrations were significantly reduced with the administration of B. bifidum ($-46.45{\pm}5.65%$), L. rhamnosus ($-30.40{\pm}5.08%$), B. longum ($-42.50{\pm}1.28%$), and B. longum subsp. infantis ($-68.85{\pm}5.32%$) (p < 0.05). Cell counts of Gram-negative and positive bacteria were distinctly affected by the probiotic administered. There was a probiotic strain-specific effect on immunomodulatory responses of RAW 264.7 macrophage cells. B. longum subsp. infantis demonstrated higher capacities to reduce TNF-${\alpha}$ concentrations ($-69.41{\pm}2.78%$; p < 0.05) and to increase IL-4 concentrations ($+16.50{\pm}0.59%$; p < 0.05). Colonic lipopolysaccharides were significantly correlated with TNF-${\alpha}$ and IL-$1{\beta}$ concentrations (p < 0.05). These findings suggest that specific probiotic bacteria, such as B. longum subsp. infantis, might decrease colonic lipopolysaccharide concentrations, which might reduce the proinflammatory tone. This study has noteworthy applications in the field of biotherapeutics for the prevention and/or treatment of inflammatory and metabolic diseases.

• 대한인간공학회지
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• 제29권6호
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• pp.853-860
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• 2010

This study investigated differences in blood oxygen saturation($SpO_2$) and heart rate(HR) according to flow rate, gender, and phase in males and females in their 60s when the supply of 93% highly concentrated oxygen administration was changed (1L/min, 3L/min, and 5L/min). It recruited totally 20 elderly subjects including 10 males($68.0{\pm}2.6$ years) and 10 females ($65.5{\pm}3.1$ years). The experiment consisted of three phages of Rest 1(5 min), Hyperoxia(10 min), and Rest 2(10 min), and $SpO_2$[%] and HR[bpm] were measured during all phages. $SpO_2$ was higher in Hyperoxia phase supplied with highly concentrated oxygen than in Rest phases. Higher flow rate was associated with more increase in $SpO_2$. HR was reduced in Hyperoxia phase compared to Rest phases. More supply of highly concentrated oxygen was associated with more decrease of HR. However, there were no differences in both $SpO_2$ and HR according to gender.