• Title/Summary/Keyword: biomedical

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Histological Analysis of Hepatic Steatosis, Inflammation, and Fibrosis in Ascorbic Acid-Treated Ovariectomized Mice

  • Lee, Mijeong;Jeon, Suyeon;Lee, Jungu;Lee, Dongju;Yoon, Michung
    • Biomedical Science Letters
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    • v.28 no.2
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    • pp.101-108
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    • 2022

  • High-fat diet (HFD)-fed ovariectomized (OVX) female mice were used as an animal model of obese postmenopausal women. We investigated the effects of ascorbic acid on the histological changes induced in the liver. Plasma alanine aminotransferase levels and liver weights were higher in mice fed an HFD for 18 weeks than in mice fed a low-fat diet, effects that were inhibited by ascorbic acid. Similarly, mice fed an ascorbic acid-supplemented HFD had less hepatic lipid accumulation than did mice fed an HFD alone. Moreover, administration of ascorbic acid reduced inflammatory cells, including mast cells and CD68-positive cells, and inflammatory foci in the liver and inhibited hepatocyte ballooning. Hepatic collagen levels were lower in ascorbic acid-treated versus non-treated mice. These results suggest that ascorbic acid inhibits hepatic steatosis, inflammation, and fibrosis in obese OVX mice. Thus, ascorbic acid intake may be useful for postmenopausal women with nonalcoholic fatty liver disease.

  • https://doi.org/10.15616/BSL.2022.28.2.101 인용 PDF KSCI

Utilizing Optical Phantoms for Biomedical-optics Technology: Recent Advances and Challenges

  • Ik Hwan Kwon;Hoon-Sup Kim;Do Yeon Kim;Hyun-Ji Lee;Sang-Won Lee
    • Current Optics and Photonics
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    • v.8 no.4
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    • pp.327-344
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    • 2024

  • Optical phantoms are essential in optical imaging and measurement instruments for performance evaluation, calibration, and quality control. They enable precise measurement of image resolution, accuracy, sensitivity, and contrast, which are crucial for both research and clinical diagnostics. This paper reviews the recent advancements and challenges in phantoms for optical coherence tomography, photoacoustic imaging, digital holographic microscopy, optical diffraction tomography, and oximetry tools. We explore the fundamental principles of each technology, the key factors in phantom development, and the evaluation criteria. Additionally, we discuss the application of phantoms used for enhancing optical-image quality. This investigation includes the development of realistic biological and clinical tissue-mimicking phantoms, emphasizing their role in improving the accuracy and reliability of optical imaging and measurement instruments in biomedical and clinical research.

  • https://doi.org/10.3807/COPP.2024.8.4.327 인용 PDF