• Biomolecules & Therapeutics
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• v.18 no.3
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• pp.271-279
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• 2010

Streptococcus pneumoniae is the major pathogen that frequently causes serious infections in children, the elderly and immunocompromised patients. S. pneumoniae is known to produce reactive oxygen species (ROS) and S. pneumoniae-produced ROS is considered to play a role in pneumococci pathogenesis. SIGN-R1 is the principal receptor of capsular polysaccharides (CPSs) of S. pneumoniae. However, there is a considerable lack of knowledge about the protective role of SIGN-R1 against S. pneumoniae-produced ROS in SIGN-$R1^+$ macrophages. While investigating the protective role of SIGN-R1 against ROS, we found that SIGN-R1 intimately bound to peroxiredoxin-1 (Prx-1), one of small antioxidant proteins in vitro and in vivo. This interaction was increased with ROS generation which was produced by stimulating SIGN-R1 with dextran, a polysaccharide ligand of SIGN-R1. Also, SIGN-R1 crosslinking with 22D1 anti-SIGN-R1 antibody increased Prx-1 in vitro or in vivo. These results suggested that SIGN-R1 stimulation with CPSs of S. pneumoniae increase the expression level of Prx-1 through ROS and its subsequent interaction to SIGN-R1, providing an important antioxidant role for the host protection against S. pneumoniae.

• Biomolecules & Therapeutics
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• v.28 no.6
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• pp.527-536
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• 2020

Liver fibrosis constitutes a significant health problem worldwide due to its rapidly increasing prevalence and the absence of specific and effective treatments. Growing evidence suggests that apoptosis-signal regulating kinase 1 (ASK1) is activated in oxidative stress, which causes hepatic inflammation and apoptosis, leading to liver fibrogenesis through a mitogen-activated protein kinase (MAPK) downstream signals. In this study, we investigated whether selonsertib, a selective inhibitor of ASK1, shows therapeutic efficacy for liver fibrosis, and elucidated its mechanism of action in vivo and in vitro. As a result, selonsertib strongly suppressed the growth and proliferation of hepatic stellate cells (HSCs) and induced apoptosis by increasing Annexin V and TUNEL-positive cells. We also observed that selonsertib inhibited the ASK1/MAPK pathway, including p38 and c-Jun N-terminal kinase (JNK) in HSCs. Interestingly, dimethylnitrosamine (DMN)-induced liver fibrosis was significantly alleviated by selonsertib treatment in rats. Furthermore, selonsertib reduced collagen deposition and the expression of extracellular components such as α-smooth muscle actin (α-SMA), fibronectin, and collagen type I in vitro and in vivo. Taken together, selonsertib suppressed fibrotic response such as HSC proliferation and extracellular matrix components by blocking the ASK1/MAPK pathway. Therefore, we suggest that selonsertib may be an effective therapeutic drug for ameliorating liver fibrosis.

• Korean Journal of Optics and Photonics
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• v.21 no.1
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• pp.16-20
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• 2010

In this study, we have fabricated a fiber-optic dosimeter using an organic scintillator and a plastic optical fiber. The dosimeter measure skin dose and percentage depth dose in a build-up region for an incident high energy photon beam. The scintillating light generated in the organic sensor probe embedded in a solid water phantom is guided by 30 m plastic optical fiber to a light-measuring device such as a PMT or an electrometer. In addition, using a fiber-optic dosimeter or a GAFCHROMIC EBT film, skin dose and percentage depth dose in the build-up region are measured and compared.

• Journal of Sensor Science and Technology
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• v.18 no.2
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• pp.173-178
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• 2009

In this study, we have fabricated a fiber-optic dosimeter using an organic scintillator and a plastic optical fiber for measuring percentage depth dose with high energy X-ray beam. The scintillating light generated in organic sensor probe embedded in a solid water are guided by 20 m plastic optical fiber to the light-measuring device such as a photodiode- amplifier system. Using a fiber-optic dosimeter and an ion chamber, percentage depth dose curves are measured with 6 and 15 MV energies of X-ray beam whose field sizes are $2\;cm\;{\times}\;2\;cm$ and $10\;cm\;{\times}\;10\;cm$.

• Korean Journal of Applied Biomechanics
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• v.26 no.3
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• pp.303-308
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• 2016

Objective: This study evaluated the vertical and horizontal forces in the frontal plane acting on a pedal due to the vertical alignment of the lower limbs. Method: Seven male subjects (age: $25.3{\pm} 0.8years$, height: $175.4{\pm}4.7cm$, weight: $74.7{\pm}14.2kg$, foot size: $262.9{\pm}7.6mm$) participated in two 2-minute cycle pedaling tests, with the same load and cadence (60 revolutions per minute) across all subjects. The subject's saddle height was determined by the height when the knee was at $25^{\circ}$ flexion when the pedal crank was at the 6 o'clock position (knee angle method). The horizontal force acting on the pedal, vertical force acting on the pedal in the frontal plane, ratio of the two forces, and knee range of motion in the frontal plane were calculated for four pedaling phases (phase 1: $330{\sim}30^{\circ}$, phase 2: $30{\sim}150^{\circ}$, phase 3: $150{\sim}210^{\circ}$, phase 4: $210{\sim}330^{\circ}$) and the complete pedaling cycle. Results: The range of motion of the knee in the frontal plane was decreased, and the ratio of vertical force to horizontal force and overall pedal force in the complete cycle were increased after vertical alignment. Conclusion: The ratio of vertical force to horizontal force in the frontal plane may be used as an injury prevention index of the lower limb.

• Journal of Sensor Science and Technology
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• v.24 no.3
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• pp.202-207
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• 2015

As a feasibility study on development of a gamma imaging probe, we developed a scintillating film-based gamma imaging detector that can obtain scintillation images with information of gamma-ray distribution. The scintillating film-based gamma imaging detector was composed of a sensing probe, an image intensifier, and a beam profiler. To detect and transmit scintillation image, the sensing probe was fabricated by coupling a scintillating film, a fiber-optic image conduit, and a fiber-optic taper, consecutively. First, the optical images of USAF 1951 resolution target were obtained and then, modulation transfer function values were calculated to test the image quality of the sensing probe. Second, we measured the scintillation images according to the activity of the 137Cs and the distance between the surface of 137Cs and the distal-end of sensing probe. Finally, the intensities of scintillating light as functions of the activity and the distance were evaluated from the region of interest in the scintillation image. From the results of this study, it is expected that a fiber-optic gamma imaging detector can be developed to detect gamma-rays emitted from radiopharmaceuticals during radioimmunoguided surgery.

• Korean Journal of Optics and Photonics
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• v.20 no.4
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• pp.201-206
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• 2009

In this study, we have fabricated a fiber-optic radiation sensor for detection of tritium using inorganic scintillators and optical fibers. We have tested various kinds of inorganic scintillators such as $Gd_2O_2S$ : Tb, $Y_3Al_5O_{12}$ : Ce, and CsI : Tl to select the most effective sensor tip. In addition, we have measured the scintillating lights using a photomultiplier tube as a function of distance between sensor tips to the source with the different activities of hydride tritium. The final results are compared with those which are obtained using a surface activity monitor.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.43 no.4
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• pp.365-371
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• 2017

This study was carried out to investigate the effect of lacquer tree (Rhus verniciflua) extract on ganodermanondiol (GN), tyrosinase and melanin biosynthesis inhibitor, biosynthesis in Ganoderma lucidum mycelia. In HPLC analysis, GN contents were significantly increased in G. lucidum mycelial extracts supplemented with of 1, 5, 10, and 15% lacquer tree extracts (LTE). In addition, G. lucidum mycelial extracts supplemented with LTEs which had no cytotoxicity activity against B16F10 cells, significantly inhibited melanogenesis in B16F10 cells. GN biosynthesis was facilitated by LTE. Taken together, we propose that G. lucidum mycelial extracts supplemented with LTE can be used as an effective ingredient of skin care products in the future.

• Journal of Sensor Science and Technology
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• v.18 no.5
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• pp.402-407
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• 2009

In this study, plastic optical fiber sensors which can measure thermal neutron dose in a mixed neutron-gamma field are developed and characterized. Using $^{252}Cf$ and $^{60}Co$ sources, the scintillators suitable for thermal neutron detection, are tested and the scintillating lights generated from a plastic optical fiber sensor in the Kyoto University Critical Assembly (kuca) core are measured. Also, the distributions of thermal neutron and gamma-ray are measured in a mixed field as a function of the distance from the center of the reactor core at KUCA and the distribution of thermal neutron is obtained using a subtraction method. Sensitivity of the fiber-optic radiation sensor system is about 0.49 V/mW according to power of the KUCA core and its relative error is about 1.2 %.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2003.11a
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• pp.392-395
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• 2003

For the purpose of digital x-ray imaging, many materials such as $PbI_2$, $HgI_2$, TlBr, CdTe and CdZnTe have been under development for servaral years as direct converter layer. $Hgl_2$ film detector have recently been shown as one of the most promising semiconductor materials to be used as direct converters in x-ray digital radiography. This paper, the $HgI_2$ films are deposited on conductive-coated glass by screen printing, in which $HgI_2$ powder is embedded in a binder and solvent, and the slurry is used to coat the conductive-coated glass. We investigated electrical characteristic of the fabricated $HgI_2$ films. The x-ray response to radiological x-ray generator of 70Kvp using the current integration mode will be reported for screen printing films. These results indicate that $HgI_2$ detectors have high potential as new digital x-ray imaging devices for radiography.