• Analytical Science and Technology
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• v.19 no.1
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• pp.107-114
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• 2006

Early diagnosis and medical intervention are critical for the treatment of patients with metabolic disorders. A rapid analytical method was developed for simultaneous quantification of organic acids and amino acids in urine without labor-intensive pre-extraction procedure showing high sensitivity and specificity. A new method consisted of simple two-step trimethylsilyl (TMS)-trifluoroacetyl (TFA) derivatization using GC/MS-selective ion monitoring (SIM). Filter paper urine specimens were dried under nitrogen after being fortified with internal standard (tropate) in a mixture of distilled water and methanol. Methyl orange was added to the residue as indicator reagent. Silyl derivative of carboxylic functional group was followed by trifluoroacetyl derivative for amino functional group. N-methyl-N-(trimethylsilyl-trifluoroacetamide) and N-methyl-bistrifluoroacetamide were consecutively added and heated for 15-20 min at $65^{\circ}C-70^{\circ}C$, for TMS-TFA derivative, respectively. This reactant was analyzed by GC/MS-SIM. Linear dynamic range showed 0.001-50 mg with the detection limit of (S/N=3) 10-200 ng, and the quantification limit of 80-900 ng in urine. Correlation coefficient of regression line was 0.994-0.998. When the method was applied to the patients 'urine, it clearly differentiated the normal from the patient with metabolic disorder. The study showed that the developed method could be the method of choices in rapid and sensitive screening for organic aciduria and amino acidopathy.

• The Journal of the Convergence on Culture Technology
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• v.9 no.2
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• pp.525-531
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• 2023

In Korea, which is entering a super-aged society, the number of elderly patients who have difficulty walking independently is expected to increase rapidly, and it is necessary to develop wheelchair products with various functions to improve the quality of life of people with walking disabilities. Recently, wheelchair power assist devices that provide propulsion power by being attached to a manual wheelchair has been developed and is entering the domestic and global markets. In this study, we compared and analyzed the process of obtaining medical device certification for wheelchair power assist devices in Korea, the United States, and Europe. In Korea, a Class 2 medical device certification process was developed in 2021, and in the US FDA, it corresponds to Class 2 like the existing electric wheelchair and must pass the 510k certification process. In the case of Europe, it is uniquely regulated as Class I, and the CE mark can be attached through a relatively easy self-declaration of conformity. The Korean medical device industry, which is struggling with MDR certification, a new European medical device regulation, should pay attention to the relatively easy entry into the global market for wheelchair power assist products.

• Therapeutic Science for Rehabilitation
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• v.11 no.1
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• pp.35-47
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• 2022

Objective : In this study, we conducted a questionnaire survey of occupational therapists to examine their perceptions on and willingness to provide telerehabilitation dementia prevention education. Methods : From March 13 to 19, 2021, a questionnaire survey targeting occupational therapists in Busan, Ulsan, and Gyeongnam was conducted. 100 questionnaires were distributed but only 70 were collected. The collected data were subjected to frequency analysis and descriptive statistics using the statistical program SPSS version 23.0. Results : The average scores by region were as follows. The average compatibility score was highest at 3.92 score, intention to providing education, doctors 3.89 score, community-centric rehabilitation awareness 3.81 score, cost saving 3.78 score, perceiver usefulness 3.75 score, accessibility 3.62 score, the quality of telerehabilitation service was in order of 3.49 score. Conclusion : All items asking whether occupational therapists participate in community-centered rehabilitation and non-face-to-face dementia prevention education programs showed high scores, indicating the willingness to participate actively. In the future, in addition to follow-up research on the implementation of telerehabilitation dementia prevention education, measures for improving accessibility within the local and national government should be discussed.

• Resources Recycling
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• v.32 no.3
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• pp.3-8
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• 2023

This study discussed production, demand, and future prospects of rubidium, which is an alkali group metal that is highly reactive to various media and requires carefulness in handling, but no significant environmental hazard of rubidium has been reported yet. Rubidium is used in various fields such as optoelectronic equipment, biomedical, and chemical industries. Because of difficulty in production as well as limited demand, the transaction price of rubidium is relatively high, but its detail information such as market status and potential growth is uncertain. However, if the mass production of versatile ultra-high-performance equipment such as quantum computers and the necessity of rubidium use in the equipment are confirmed, there is a possibility that the rubidium market will expand in the future. Rubidium is often found together with lithium, beryllium, and cesium, and may be present in granite containing minerals such as lepidolite and pollucite, as well as in seawater and industrial waste. Several technologies such as acid leaching, roasting, solvent extraction, and adsorption are used to recover rubidium. The maximum recovery efficiency of the rubidium from the sources and the processing above is generally high, but, in many practices, rubidium is not the main recovery target, and therefore the actual recovery effects should depend on presence of other valuable components or impurities, together with recovery costs, energy consumption, environmental issues, etc. In conclusion, although the current production and consumption of rubidium are limited, with consideration of the possible market fluctuations according to the emergence of large-scale demand sources, etc., further investigations by related institutions should be necessary.

• Journal of Korea Entertainment Industry Association
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• v.13 no.8
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• pp.515-524
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• 2019

The purpose of this study was to investigate the influences of adolescents on self-rated health and happiness, physical activity, and mental health according to time of smartphone use. The researcher used raw data from the Korea youth risk-behavior web-based survey(2017). A total of 64,991 adolescents were enrolled and 54,603 were analyzed in logistic regression analysis. The researcher set gender, self-rated health and happiness, physical activity, and mental health as independent variables and performed logistic regression analysis with smartphone overuse time as dependent variables. As a result, the female had a smartphone overuse of 1.49 to 1.67 times higher than male. Subjectively healthy people were 1.2 to 1.35 times more likely to use smartphones than those who did not(p<.001). People with higher physical activity were higher by 1.17 to 1.18 times than people without physical activity(p<.001). Subjective happiness did not predict smartphone usage(p>.05). People with subjective stress were higher 1.13 to 1.22 times than people without stress, and person with sadness and despair and suicide plan, 1.37 to 1.54 times, 1.17 to 1.24 times than those who did not(p<.001). Depression tended to become more serious as smartphone use increased. These investigation suggest that the self-rated health, physical activity, and mental health excluding self-rated happiness are related to overuse of smartphone.

• The Journal of the Convergence on Culture Technology
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• v.9 no.5
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• pp.133-140
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• 2023

The origin of texts we refer to as literary or artistic may be imagination, but many are based on experiences. In fact, experiences can be the source of artistic imagination since imagination often builds upon experiences. Therefore, the act of verbalizing human experiences using them as raw material can become a great form of art. Transforming past experiences into stories and infusing them with vitality inevitably requires a creative process of reconstruction, which is essentially a literary process. As such, 'Personal Narrative' holds significance as a literary process that weaves facts into stories and shapes them into forms. Individual experiences are stored as personal memories, and these 'personal memories' continuously generate stories. Collections of individual stories are stored as multiple memories, which gradually form 'collective memories' with distinct social and cultural inclinations through the passage of time and invisible yet potent societal and cultural censorship. The problem lies in the fact that individuals may tend to align their own memories with the inclinations of collective memory rather than simply recalling what they personally experienced. In the context of actual history, personal memories and collective memories communicate with each other, producing non-fictional content close to reality and sometimes manifesting as fiction content enriched with imagination. 'Personal Narrative' holds a significant genre as one genre of non-fiction content within our culture.

• Journal of dental hygiene science
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• v.23 no.4
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• pp.320-329
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• 2023

Background: Oral frailty has garnered considerable interest following its identification as a risk factor for physical frailty. The Korean oral frailty diagnosis criteria have emphasized the need for extensive research on oral frailty diagnostic items and interventions. Our study performed an in-depth analysis of the tongue-palate pressure patterns in healthy community-dwelling older adults. Methods: Of the 217 older adults aged ≥60 years who visited a senior center in Wonju, 205 participants who completed tongue pressure measurement were included in the final analysis. Pressure changes over time were recorded by instructing the participants to press their tongue against the hard palate with for 7 seconds per cycle. The participants were divided into the normal and abnormal tongue pressure (NTP and ATP, respectively) groups based on whether they achieved the target tongue pressure at least once; tongue pressure patterns were compared between the groups. Furthermore, the average time taken to achieve the standard tongue pressure value was calculated for the participants in the NTP group and used to evaluate the decrease in tongue pressure in the ATP group. Results: Among the 205 participants, 40.5% had ATP. The tongue pressure graph revealed a gentle and consistent incline that was maintained even after achieving standard tongue pressure in the NTP group. The graph was more extreme in the ATP group, and the changes in the pressure type varied across individuals; the tongue pressure was only 48.4%, 40.7%, 31.9%, and 22.6% of the NTP in the participants in their 60s, 70s, 80s, and ≥90s, respectively (p<0.05). Conclusion: Tongue pressure weakness was observed in 40.5% of the healthy community-dwelling older adults. Furthermore, ATP graphs were observed in the patients with tongue pressure weakness. Thus, activities improving the oral function in community-dwelling older adults and systematic oral rehabilitation programs should be devised to promote normal swallowing.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.16 no.5
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• pp.338-346
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• 2023

During isometric elbow flexion, forearm length should be an important factor to determine not only joint torque but also maximum endurance time (MET), when the forearm is perpendicular to the direction of the force. The purpose of this paper is to examine the effect of forearm length as an additional factor on empirical models of MET such as an exponential model and a power model during isometric elbow flexion. Thirty volunteers participated in our experiment to measure factor variables such as circumferences and lengths of their upper and lower arms. Their METs were measured according to the percent of maximum voluntary contraction intensity (%MVC). For the multiple linear regression model of ln(MET) using these measurements, significant variables could be observed in %MVC and forearm lengths (P<0.05). The empirical models were assessed by these models using forearm length as the additional factor. Mean absolute deviations (MAD) between the measured METs amd the two empirical models were about 19.4 [s], but MAD using models applied forearm lengths were reduced to about 16.2 [s]. The correlation coefficients and intraclass correlation coefficients were about 0.87, but those applied forearm lengths were increased to about 0.91. These results demonstrated that forearm length was a significant additional factor to the empirical model.

• Journal of the Korean Society of Radiology
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• v.17 no.5
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• pp.679-684
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• 2023

Venous puncture is widely used to obtain blood samples for pathological examination. Because the invasive venipuncture method using a needle is repeatedly performed, the pain suffered by the patient increases, so our research team pre-developed a miniaturized near-infrared (NIR) imaging system in advance. To improve the image quality of the acquired NIR images, this study aims to model the non-local means (NLM) algorithm, which is well known to be efficient in noise reduction, and analyze its applicability in the system. The developed NIR imaging system is based on the principle that infrared rays pass through dichroic and long-pass filters and are detected by a CMOS sensor module. The proposed NLM algorithm is modeled based on the principle of replacing the pixel from which noise is to be removed with a value that reflects the distances between surrounding pixels. After acquiring an NIR image with a central wavelength of 850 nm, the NLM algorithm was applied to segment the final vein area through histogram equalization. As a result, the coefficient of variation of the NIR image of the vein using the NLM algorithm was 0.247 on average, which was an excellent result compared to conventional filtering methods. In addition, the dice similarity coefficient value of the NLM algorithm was improved by 62.91 and 9.40%, respectively, compared to the median filter and total variation methods. In conclusion, we demonstrated that the NLM algorithm can acquire accurate segmentation of veins acquired with a NIR imaging system.

• Journal of Life Science
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• v.33 no.11
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• pp.876-886
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• 2023

In some cases of head and neck cancers (HNC), surgical interventions may result in the loss of organs and/or changes to their functions, thereby significantly affecting the patient's quality of life. As a result, the surgical treatment of HNC patients is often limited to specific cases, and alternative treatment modalities, such as chemotherapy, are considered. However, serious adverse effects caused by chemotherapy, such as severe nausea and vomiting, necessitate the need for the development of adjunctive methods to minimize patient suffering. Chuanxiong, Ligusticum chuanxiong (L. chuanxiong), is a natural herb used in Eastern medicine to treat cerebrovascular disorders and headaches. This study aimed to predict the effect and potential of L. chuanxiong as an auxiliary anticancer drug through network-based pharmacology and molecular docking analysis. The study results showed that 40 out of 41 genes of L. chuanxiong shared common targets of HNC and their proteins could be used to target HNC cells to prevent cancer progression. The results of the functional enrichment analysis confirmed that L. chuanxiong is associated with the neuroactive-ligand metabolism and neurotransmitter pathways, indicating its potential medicinal value as an adjuvant in HNC treatment. Lastly, our findings demonstrated that the active ingredient of L. chuanxiong, (Z)-Ligustilide, has the ATP binding site of heat shock protein 90, a protein known to promote the activation of cancer cells. These results suggest that L. chuanxiong is a promising candidate for developing auxiliary anticancer drugs, and further research could potentially lead to the discovery of newer and safer anti-cancer agents.