• Progress in Medical Physics
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• v.18 no.1
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• pp.42-47
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• 2007

Purpose: To evaluate the tracing of optic nerve tract using manganese enhanced magnetic resonance Imaging. Materials and Methods: After injecting $30{\mu}l$ of $MnCl_2(1mol)$ (1 mol) Into the retina of female New Zealand white rabbit, the contrast enhancements at major anatomical structures of optic nerve tract were evaluated by high resolution T1-weighted Images 12 hours, 24 hours, and 48 hours after $MnCl_2(1mol)$ Injection using 3D FSPGR (Fast Speiled Gradient Recalled echo) pulse sequence at 1.5T clinical MR scanner with high performance gradient system. Also, for quantitative evaluation, the signal-to-noise ratios of circular ROI on anatomical locations were measured. Results: The major structures on the optic nerve tract were enhanced after injecting $MnCl_2(1mol)$. The structures, which showed enhancement, were right optic nerve, optic chiasm, left optic tract, left lateral geniculate nucleus, left superior colliculus. The structures on the contralateral optic pathway to the right retina were enhanced whereas the structures on the ipsilateral pathway did not show enhancement. Conclusion: The Mn transport through axonal pathway of optic nerve sys)em was non- invasively observed after injecting injecting $MnCl_2$ at the retina, which is the end terminal of optic nerve system. This Mn transport seems to occur by voltage gated calcium $(Ca^{2+})$ channel and In case of direct Injection Into the retina, the fast transpori pathway of voltage gated calcium channel seems to be responsible for Mn transport.

• Progress in Medical Physics
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• v.19 no.1
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• pp.42-48
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• 2008

Bio-implantable devices such as heart pacers, gastric pacers and drug-delivery systems require power for carrying out their intended functions. These devices are usually powered through a battery implanted with the system or are wired to an external power source. This paper describes an inductive power transmission link, which was developed for an implantable stimulator for direct stimulation of denervated muscles. The carrier frequency is around 1MHz, the transmitter coil has a diameter of 46mm, and the implant coil is 46mm. Data transmission to the implant with amplitude shift keying (ASK) and back to the transmitter with passive telemetry can be added without major design changes. We chose the range of coil spacing (2 to 30mm) to care for lateral misalignment, as it occurs in practical use. If the transmitter coil has a well defined and reliable position in respect to the implant, a smaller working range might be sufficient. Under these conditions the link can be operated in fixed frequency mode, and reaches even higher efficiencies of up to 37%. The link transmits a current of 50 mA over a distance range of 2-15 mm with an efficiency of more than 20% in tracking frequency. The efficiency of the link was optimized with different approaches. A class E transmitter was used to minimize losses of the power stage. The geometry and material of the transmitter coil was optimized for maximum coupling. Phase lock techniques were used to achieve frequency tracking, keeping the transmitter optimally tuned at different coupling conditions caused by coil distance variations.

• Journal of fish pathology
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• v.24 no.2
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• pp.53-64
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• 2011

In quantitative studies of clinical signs, rock bream of adults and juveniles infected with Megalocytivirus IVS-1 isolated from rock bream (Oplegnathus fasciatus) in Korea showed average $4.49{\pm}1.13$ and $4.85{\pm}1.06$ of spleen index respectively. In challenge experiments, Megalocytivirus IVS-1 induced 100% cumulative mortality in both adult and juvenile rock bream. However we found 60% cumulative mortality in juvenile red sea bream (Pagrus major) even after 30 days of injection, which contradicted with the results of other laboratories. Interestingly, IVS-1 infected red sea bream of the same juvenile size with rock bream showed lower spleen index compared to that of rock bream. In real-time PCR, there was continuous increasing of the numbers of viral copies ($2.03{\times}10^7$ copies/mg) in the spleen of juvenile rock bream infected, which were different from those in adult rock bream showing plateau level after reaching to the peak level. Moreover, enlarged cell numbers in the infected spleen were also increased continuously in the juvenile but not in adult of rock bream, even decreased after reaching to peak level. Consequently, significant differences in clinical signs: cumulative mortality. spleen index and viral copy number were found between rock bream and red sea bream, but not between adult and juvenile rock bream. Certainly quantitative expression of clinical sign as in this study may be a way to compare the progression of megalocitiviral disease more accurately in different species or physiological conditions.

• The Journal of Korean Academy of Sensory Integration
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• v.14 no.1
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• pp.41-49
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• 2016

Objective : The purpose of this study was to investigate how undressing skill training based on Neuro-developmental treatment (NDT) approach effected on the midline orientation and protective reaction of children with cerebral palsy (CP). Methods : Two participants of this study were 3 years 5 months old boy and 4 years 5 months old girl, living in B city. They were medically diagnosed as cerebral palsy. Research design used in this study is AB design for a single subject research. There was no intervention on the baseline A phases, and functional activity based NDT was used undressing skill training during the B phases. Midline orientation was tested by Stepping subtest in MAP. Protective reaction was measured by Protective reaction subtest in QUEST. Results : In comparison with the baseline (A), midline orientation was improved above 2 standard deviations at intervention phase (B). and protective reaction was improved above averages in both hands. Conclusion : The study showed undressing skill training based on NDT approach that were effective for midline orientation of children with CP. Undressing skill training was one of the major functional activities. Thus, large studies are required to ensure the training effects.

• The Journal of Korean Academy of Sensory Integration
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• v.14 no.2
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• pp.33-45
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• 2016

Objective : The purpose of this article is to study the effectiveness of a group occupational therapy for children via systematic review, and to provide clinical evidences. Methods : The systematic review initially included articles in Pubmed, Ovid, RISS, KISS, and DBpia, published until 2014. Total 14 articles have been chosen, using different keyword of each domestic/foreign studies. Selected articles were divided depending on the level of evidence, and eventually been organized into group PICO (Patient, Intervention, Comparison, Outcome). Results : The results indicated that there are more diagnosed children than normal in participants and especially children with sensory integration disorder (28.6%) appeared to be the most common. In intervention, group sensory integrative intervention had the largest frequency, and instruments measuring social skills were used most for analyzing the intervention results. The effectiveness of interventions showing statistically significant results were 40.7% of Total. Conclusion : Group occupational therapy for children should be provided to various diagnosis with widely better quality of interventions providing the enough support for the evidence level.

• Tuberculosis and Respiratory Diseases
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• v.57 no.2
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• pp.125-131
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• 2004

Tuberculosis (TB) remains an enormous global health problem, and a new vaccine against TB more potent than the current inadequate BCG vaccine is urgently needed. We constructed three recombinant Mycobacterium bovis BCG (rBCG) strains over-expressing antigen (Ag) 85A, Ag85B, or both of M. tuberculosis using their own promoter and secretory sequence, or hsp60 promoter. SDS-PAGE analysis of rBCG proteins showed overexpression of Ag85A and Ag85B proteins in higher level than of those in their parental strain of BCG. In addition, rBCG(rBCG/B.FA) over-expressing Ag85A and Ag85B induced strong IFN-${\gamma}$ production in splenocytes. However, there was no significant difference in protective efficacy between rBCG and their parental BCG strain. In this study, therefore, rBCG over-expressing Ag85A, Ag85B, or both failed to show enhanced protection against M. tuberculosis infection in a mouse model.

• The Journal of Korean society of community based occupational therapy
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• v.1 no.1
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• pp.29-39
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• 2011

Object : The relationships between the TSQ(Time structure questionnaire) and Well-being were examined. Methods : TSQ and questionnaire about Well-being were executed for 223 university students from April 26th to May 7th, 2010. The questionnaire adapted the item of the TSQ and Korean WHOQOL-BREF, SWLS(Satisfaction with Life Scale), LSES(Life Satisfaction Expectancy Scale), SHS(Subjective Happiness Scale). The questionnaires were distributed directly to the participants. Relativity between the TSQ and questionnaire about Well-being were analyzed using Pearson's correlation analysis. Results : As a result of the relationship between the TSQ and questionnaire about Well-being, overall there was a positive correlation. TSQ(sense of purpose, structured routine, persistence, past orientation) and questionnaire about Well-being showed a statistically significant correlation(p<.05). Conclusion : A structured time use and well-being by investigating the relationship, we were able to see the importance of time management. Currently, clinical occupational therapy focused on performance components, in future, intervention of personal time management to help make ones live well-being.

• KSBB Journal
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• v.30 no.2
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• pp.58-62
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• 2015

A 3-weeks feeding trial with 288 laying hens were conducted to determine the efficacy of lecithin-free egg yolk at different levels of dietary Ca on performance and Ca absorption. Laying hens were divided into 6 groups according to calcium level and testing agent; 0% calcium feed (A), 0.2% calcium feed (B), 0.4% calcium feed (C, normal feed), 0.6% calcium feed (D), 0.4% calcium feed + 0.2% egg byproduct (C+0.2), 0.4% calcium feed + 0.4% egg byproduct (C+0.4). The final body weight gain of C+0.2 and C+0.4 groups were higher by 1.5% and 7.4% respectively than group C. Tibia ash contents did not show significantly difference, but calcium contents increase (p<0.05) in C+0.2 and C+0.4 groups. Parallel undecalcified tibia joint sections were stained for calcium absorption by the von Kossa's stain. This result show that lecithin free egg byproduct supplementation to normal calcium feed improved growth performance and calcium utilization in laying hens.

• Korean Chemical Engineering Research
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• v.46 no.3
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• pp.626-632
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• 2008

The purpose of this study was to enhance gas exchange by producing hemosome, a hemoglobin microencapsulated with phospholipid of egg, and perfluorocarbone(PFC) emulsion solution. In the experiment, stable emulsion solution with 437 nm of mean particle size could be produced by Flusol-DA sonication, and shortening of emulsion time could be attained with higher stability as well. $0.8{\mu}m$ sized hemosome could be produced by microencapsulation of hemoglobin with phospholipid extracted from egg yolk. The pattern of oxygen saturation curve of hemosome was S shape, which is similar to that found in normal blood, and $P_{50}$ was measured to be 24 mmHg. The oxygen saturation in the mixed solution of hemosome and blood in 1:4(V/V%) ratio was similar to that of normal blood, and the same result was found in the mixed solution of PFC emulsion and blood in 1:4(V/V%) ratio.

• Korean Chemical Engineering Research
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• v.50 no.6
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• pp.1056-1063
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• 2012

Recent rapidly growth in nanotechnolgies is promised novel benefits through the exploitation of their unique industrial and biomedical applications. With increasing utilization of nanomaterials in consumer products, the potential release of nanomaterials into the environment and their impacts on the ecosystem and human health have been the issues of concern. Nanomaterials that was exposed unintentionally in environment might be accumulated in various environmental media, and finally it will be influenced to human and ecosystems. Therefore, it is important to understand the fate and behavior of nanoparticles for understanding effects on environmental media (air, water, and soil phase). Therefore, in this work, we investigated the several cases for environmental exposure of nanomaterials and suggested the direction of further research. In workplace, exposure to air media is dominant, but finally waste and wastewater was moved to the water and soil phase. In addition, we found the existing sewage treatment plant was not suitable to remove completely nanomaterials in wastewater flow. To deeper study, environmental monitoring tool must be developed additionally and we suggested the several analyzing method for aged and pristine physicochemical properties of nanomaterials exposed into environmental media. This review for nanomaterials' exposure to environmental media will be helpful to investigate the environmental fate of nanomaterials and define the suitable treatment method for nano-waste.