• Journal of Microbiology and Biotechnology
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• v.15 no.5
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• pp.971-976
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• 2005

In a 30-1 bioreactor culture, whole differentiation occurred from 48 h, and then proceeded rapidly. As swollen hyphal fragments and arthrospores increased, cephalosporin C (CPC) production increased exponentially to $1.85\;g/1^{-1}$ at 72 h. To explain the morphological changes of Cephalosporium acremonium M25 more quantitatively, specific differentiation rates and fractal analysis were employed. Specific differentiation rates of morphological factors varied greatly during the period of culture time from 48 h to 72 h, when CPC production increased significantly. Changes of fractal dimensions showed a pattern similar to that of the specific rate of arthrospores. Furthermore, it was inversely related to the specific rate of tips. Overall, it was suggested that the fractal dimension had potential for a new morphological parameter of fungal morphology, showing complex differentiation patterns.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.51 no.11
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• pp.616-621
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• 2002

With biological effects by ELF (Extremely Low Frequency) magnetic field generated from power system, the transient magnetic field from electric appliances is a major issue presently. Because the transient magnetic field induces higher current than the power frequency field inside living bodies, transient magnetic field exposure has been much focused. In this paper, it is shown that transient magnetic field from electric home appliances can be characterized as magnetic dipole moment. In this method, the dipole moment vector is assumed by allowing an uncertainty of 6dB in the estimated field. A parameter M that represents biological interaction was applied also. The proposed method was applied to 7 types of appliances (hair drier, heater, VDT, etc.) and their equivalent magnetic dipole moment and harmonic components were estimated. As the results, the useful data for quantifying magnetic field distribution around electric appliances were obtained.

• Journal of Biomedical Engineering Research
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• v.16 no.1
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• pp.67-76
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• 1995

Explosive evaporative removal process of biological tissue by absorption of a CW laser has been simulated by using gelatin and a multimode Nd: YAG laser. Because the point of maximun temperature of laser-irradiated gelatin exists below the surface due to surface cooling, evaporation at the boiling temperature is made explosively from below the surface. The important parameters of this process are the conduction loss to laser power absorption (defined as the conduction-to-laser power parameter, Nk), the convection heat transfer at the surface to conduction loss (defined as Bi), dimensionless extinction coefficient (defined as BrJ, and dimensionless irradiation time (defined as Fo). Dependence of Fo on Nk and Bi has been observed by experiment, and the results have been compared with the numerical results obtained by solving a 2-dimensional conduction equation. Fo and explosion depth (from the surface to the point of maximun temperature) are increased when Nk and Bi are increased. To find out the minimum laser power for explosive evaporative removal process, steady state analysis has been also made. The limit of Nk to induce evaporative removal, which is proportional to the inverse of the laser power, has been obtained.

• Korean Chemical Engineering Research
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• v.47 no.2
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• pp.163-168
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• 2009

Negative differential resistance(NDR) behaviors of Keggin-type and Wells-Dawson-type heteropolyacids with cation, heteroatom, and polyatom substitutions were investigated by scanning tunneling microscopy. A reliable correlation between NDR peak voltage and reduction potential of heteropolyacid catalysts was established. It was found that more reducible heteropolyacid catalyst showed NDR behavior at less negative voltage, regardless of the structural difference. Thus, NDR peak voltage of heteropolyacid catalyst could be utilized as a single correlating parameter for the reduction potential of heteropolyacid catalyst.

• Journal of the Ergonomics Society of Korea
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• v.30 no.1
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• pp.237-250
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• 2011

The train transportation has a lot of advantages-energy efficiency is high, it is eco-friendly, safety is better than normal roads and it is possible for people to arrive on time. In these days, the valuation of ride comfort, which is only limited to road transportation, is newly recognized in order to having competitiveness from other transportation. Especially, in the development of the Korean high-speed railroad business, the ride comfort enhancement of train is very important problem to be solved. Currently, there are international standards of ride comfort such as UIC13, ISO2631. In Korea case, although it has own standard like KS R9216, it mainly depends on the physical parameter such as vibration and noise. So recently, in the valuation of ride comfort, the movements of living parameter technique introduction are increasing on the base of Japan and many developed countries of Europe techniques. Presently, the method of train ride comfort is mainly based of vibration, that is, mechanical parameter adding selection of variable acceleration and noise. This paper would like to show biological parameter; heart rate and blood pressure variation. This method is more direct, based on human body response, than mechanical parameter method. In this experiment, the variability of heart rate and blood pressure of passengers according to tilting angle change of Train, the Korean tilting train, we are supposed to know that the extent of tilting on the simulation has influence on variability of heart rate and blood pressure, which are living parameter of heart's blood.

• Journal of Biomedical Engineering Research
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• v.38 no.5
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• pp.219-226
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• 2017

Penalized-likelihood (PL) reconstruction methods for transmission tomography are known to provide improved image quality for reduced dose level by efficiently smoothing out noise while preserving edges. Unfortunately, however, most of the edge-preserving penalty functions used in conventional PL methods contain at least one free parameter which controls the shape of a non-quadratic penalty function to adjust the sensitivity of edge preservation. In this work, to avoid difficulties in finding a proper value of the free parameter involved in a non-quadratic penalty function, we propose a new adaptive method of space-variant smoothing with a simple quadratic penalty function. In this method, the smoothing parameter is adaptively selected for each pixel location at each iteration by using the image roughness measured by a pixel-wise standard deviation image calculated from the previous iteration. The experimental results demonstrate that our new method not only preserves edges, but also suppresses noise well in monotonic regions without requiring additional processes to select free parameters that may otherwise be included in a non-quadratic penalty function.

• Journal of Biomedical Engineering Research
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• v.24 no.4
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• pp.329-337
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• 2003

Blood in congenital or acquired AY fistula(arteriovenous fistula) flows from arteries directly to veins. detouring peripheral micro-circulation. This makes a great effect on the hemodynamics of human cardiovascular system. In this study, a computational method using lumped parameter mode) was proposed to simulate the cardiovascular hemodynamics of patients with acute AV fistula The cardiovascular system model with a fistula compartment in left lower limb was built using 17 standard lumped compartments. Using fourth order Runge-Kutta method. we solved numerically the unsteady linear set of the ordinary differential equations resulting from application of Kirchhoff's law to the lumped parameter hemodynamic model. The baroreceptor reflex system was implemented to explain the auto-regulation effect of the cardiovascular system with acute AV fistula.

• Journal of Biomedical Engineering Research
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• v.25 no.2
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• pp.129-135
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• 2004

In the home health management system, we often face the situation to handle biological signals that are frequently measured from normal subjects. In such a case, it is necessary to decide whether the signal at a certain moment is normal or abnormal. Since ECC is one of the most frequently measured biological signals, we describe algorithms that detect QRS-complex and decide whether it is normal or abnormal. The developed QRS detection algorithm is a simplified version of the conventional algorithm providing enough performance for the proposed application. The developed classification algorithm that detects abnormal from mostly normal beats is based on QRS width, R-R interval and QRS shape parameter using Karhunen-Loeve transformation. The simplified QRS detector correctly detected about 99% of all beats in the MTT/BIH ECG database. The classification algorithm correctly classified about 96% of beats as normal or abnormal. The QRS detection and classification algorithm described in this paper could be used in home health management system.

• Korea-Australia Rheology Journal
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• v.20 no.2
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• pp.89-94
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• 2008

To satisfy good mechanical and optical properties of polymer-coated film products, it will be indispensable to elucidate the molecular orientation of polymer chains within coating liquids in coating flows. Using hybridized numerical method between computational fluid dynamics (CFD) and Brownian dynamics (BD) simulations can provide the useful information for the better quality control of coated films. Flexible polymer chains, e.g., ${\lambda}$-DNA molecules here, change their conformation according to the flow strength and the flow type. The molecular conformation within the coated film on the web or substrate is quite different, because the polymer chains experience the complicated flow strength and flow types in flow field. Especially in the slot coating flow, these chains are more extended by the extension-like flow field generated in the free surface curvature just beyond the downstream die region. Also, the polymer chain extension beneath the free surface can be affected by the die geometry, e.g., the coating gap, changing flow field.

• Korea-Australia Rheology Journal
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• v.14 no.1
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• pp.11-16
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• 2002

Cephalosporium acremonium is a filamentous microorganism producing cephalosporin C. The morphological differentiation of C. acremonium in submerged culture is closely related with the rheological properties of culture broth and production of cephalosporin C. In this study, the rheological and morphological properties of culture broth of C. acremonium were investigated. In the seed broths of shake-flask and fermenter culture, the Herschel-Berkley equation was in excellent agreement with experimental results in the whole range of shear rate. In the seed broths of shake-flask culture, morphological differentiation into arthrospores affected to changes of apparent viscosity. But results in the fermenter culture, morphological factors such as mean hyphal thickness and the number of tips gave more effect on changes of apparent vitacosity than differentiation into arthrospores. Overall, it suggested that the morphological parameters measured by image analysis can be used as a good parameter to indicate the rheological properties of culture broth of C. acremonium M25.