• Journal of Korean Biological Nursing Science
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• 제3권2호
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• pp.69-90
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• 2001

The purpose of this study was to determine the effect of dance sports on physiological variables, depression and quality of life in the elderly. The study was performed on a non-equivalent control group pretest-posttest design for 47 elderly, who were conveniently assigned to experimental group and control group. The experimental group were selected from D-welfare facility and the control group were selected from G-elderly church club in G-city. The data were collected from April 2, 2001 to June 30, 2001, and analyzed by frequency, $x^2$-test, t-test and paired t-test using SAS/PC program. The results of this study were summarized as follows; 1. The first hypothesis, "the experimental group would have improved physiological variables than the control group.". 1-1. The hypothesis, "the experimental group would have lower blood pressure than the control group" was rejected. 1-2. The hypothesis, "the experimental group would have lower heart rate than the control group" was supported(t=-2.031, p=0.048). 1-3. The hypothesis, "the experimental group would have higher peripheral vessel $O_2$ Saturation than the control group" was rejected. 2. The second hypothesis, "the experimental group would have lower depression score than the control group" was supported(t=2.832, p=0.006). 3. The third hypothesis, "the experimental group would have higher quality of life score than the control group" was supported(t=2.604, p=0.012). After 12 weeks of dance sports program, it was shown that the program was effective to improve the physiological varibles, reduce depression and improve quality of life.

• Journal of Korean Biological Nursing Science
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• 제4권2호
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• pp.139-150
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• 2002

본 연구는 노인에게 노화의 속도를 지연시킬 수 있는 운동을 격려하는 방법으로 장소의 제한 없이 앉은 자리에서 쉽고 안전하게 할 수 있도록 스트레칭을 구성, 실시하여 노인의 건강을 증진시킴으로써 노인의 삶의 질, 우울, 총콜레스테롤에 미치는 효과를 규명하고자 시도하였다. 본 연구는 노인에게 스트레칭운동을 실시한 후 노인의 삶의 질, 우울, 총콜레스테롤에 미치는 효과를 파악하기 위한 원시실험연구로 사전사후 설계이다. 자료수집기간은 2002년 4월 3일부터 6월 19일까지 12주간이었다. 대상자는 G시에 거주하는 노인 22명을 대상으로 하였다. 수집된 자료는 SPSS/PC 프로그램을 이용하여 일반적 특성은 실수와 백분율로, 대상자의 스트레칭운동 실시 전 후의 차이 검정은 paired t-test로 분석하였다. 본 연구를 통하여 얻어진 연구결과는 다음과 같다. 1) 대상자의 삶의 질 점수는 스트레칭운동 실시 전 평균 144.9점이었고, 스트레칭운동 실시 후 평균 140.0점으로 유의한 차이를 보이지 않았다((t=-1.734, p=0.097). 2) 대상자의 우울 점수는 스트레칭운동 실시 전 평균 84.4점이었으나, 스트레칭운동 실시 후 평균 83.9점으로 유의한 차이를 보이지 않았다(t=-0.200, p=0.843). 3) 대상자의 총콜레스테롤 수치는 스트레칭운동 실시 전 평균 $234.3mg/d{\ell}$이었으나, 스트레칭운동 실시 후 평균 $227.2mg/d{\ell}$로 유의한 차이를 보이지 않았다(t=-1.050, p=0.083).

• Journal of Korean Biological Nursing Science
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• 제4권1호
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• pp.51-69
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• 2002

The purpose of this study was to identify the effect of cerebral ischemia on affected(Lt) and unaffected(Rt) side of soleus, plantaris and gastrocnemius muscle mass and determine the effect of exercise on affected and unaffected side on soleus, plantaris and gastrocnemius muscle mass during acute stage of stroke. Sixteen male Sprague-Dawley rate with 200-270g body weight were randomly divided into three groups: control, stroke, and exercise after stroke(St+Ex) group. The control group received sham operation and the stroke group and St+Ex group received transient right MCA(middle cerebral artery) occlusion operation. The St+Ex groups ran on a treadmill for 20min/day at 10m/min and $10^{\circ}$ grade for 6days. During the experimental period body weight and diet intake was measured every morning. On the 7th day after operation, muscles were dissected from both affected and unaffected side of hindlimb. Cerebral infarction of stroke and St+Ex groups were identified by staining with TCC for 30 minutes. The data were analyzed by Kruskal-Wallis test and Mann-Whitney U test using the SPSSWIN 9.0 program. Significance was accepted at the level of p<0.05. The results were summarized follows : 1) There were no significant difference of the body weight on the first day of experiment among 3 groups. Whereas on the 7th day, the body weight of both stroke group and St+Ex group were significantly smaller than that of control group. Body weight of St+Ex group on the 7th day tended to be larger than that of stroke group. 2) Total diet intake of both stroke group and St+Ex group were also significantly smaller than that of control group. While total amount of diet intake in St+Ex group tended to be larger than that of stroke group. 3) The weight of gastrocnemius muscle of affected side in stroke group significantly decreased compared to that of control group and the weight of soleus and plantaris muscle of affected side in stroke group tended to decrease compared to that of control group. 4) The weight of plantaris muscle of unaffected side in stroke group significantly decreased compared to that of control group and the weight of soleus and gastrocnemius muscle of unaffected side in stroke group tended to decrease compared to those of control group. 5) The weight of gastrocnemius muscle of affected side in stroke group significantly decreased compared to that of unaffected side and there was no significant difference of the weight of soleus and plantaris muscle in stroke group between affected side and unaffected side. 6) The weight of soleus, plantaris and gastrocnemius muscle of both affected side and unaffected side in St+Ex group had a tendency of increase compared to those of stroke group. The relative weight of soleus and gastrocnemius muscle of affected side and soleus muscle of unaffected side in St+Ex group had a tendency to increase compared to those of stroke group. Based on these results, exercise during acute stage of stroke might attenuate muscle atrophy of both affected and unaffected side of hindlimb muscles.

• Journal of Korean Biological Nursing Science
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• 제6권2호
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• pp.43-55
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• 2004

Purpose : This study was conducted to identify the peritonitis occurence of CAPD, by which a basis for efficient patient management could be provided. Method: Data were collected by questionnaires and hospital record from 55 people who underwent or were going through CAPD from January 1998 to April 2004 in a university subsidiary hospital kidney department. Result: 1) There were many elderly people of 61 years or above taking up 50.9%, 75% had low levels of education with middle school graduation or less, and the cases where separate individual rooms enabling the exchange of CAPD were not possessed was shown to be 61.8%. 2) With the management feature of CAPD, those who bathed once or less per 7 days made up 60.0%, and 60% washed their hands well before exchanging solutions which meant that 40% did not wash well or just washed moderately, and in terms of CAPD education, the proportion of those receiving education both before and after dialysis was 29.1%. also, with nutrition conditions, cases where the level of serum albumin was lower than 3.0 made up 38.2%, and those who were conducting self CAPD management was 65.5%, and cases where the management was done by the spouse or family members was revealed to be 34.5%. 3) There were Peritonitis occurrences in 40% of cases, and the number of Peritonitis occurrences within the period was 36, with an occurrence rate of $0.65{\pm}0.99$. Also, 66.7% of the causing bacteria were no growth, Gram positive bacteria made up 27.8%, and Gram negative bacteria consisted of 5.5%. 4) No significant difference was found peritionitis occurrence according to general and management characteristics. Lower peritionitis occurrence were shown with those who had spouses or family members conducting CAPD management as opposed to self-managing patients(p=0.037). Conclusion: Elderly patients there needs to be the participation of family or other support resources rather than subjecting them to self-management of solution exchange and entry/exit. Also, The high occurrence rate from Gram positive bacteria is shown so the importance of CAPD management education including bathing and hand washing needs to be emphasized.

• Journal of Korean Biological Nursing Science
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• 제3권2호
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• pp.35-50
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• 2001

This study was conducted for the evaluation of the effects of singing program combined with physical exercise on the physiologic changes, perception function and degree of depression. The subjects were the members of elderly women's glee club in D care center for the elderly, who have been singing for more than 6 months. 30 members were allocated to study group and 30 to control group. The singing program designed for both physical therapy and music therapy was consisted of initial physical exercise, singing art songs and classical song and the finishing physical exercise. This program was performed twice a week and about forth minutes was consumed for one session. We checked the heart rate, peripheral arterial oxygen saturation, perception function and degree of depression before and after the program. We used a pulse oxymeter to check the heart rate to oxygen saturation and a questionnaire for the evaluation of perception function and degree of depression. We need SPSS program for data analysis. The results of the investigated personnel complying with general characteristics were analyzed by frequency, two groups by t-test, data before and after the program by paired t-test, respectively. The results were as follows. 1) Heart rate after the program was significantly lower than that before program in test group(p<0.05). 2) Peripheral oxygen saturation after the program was significantly higher than that before the program(p<0.05). 3) Ability to match the right sign with a certain predetermined number was improved after the program. The frequency of wrong matching the sign with number before program was 30. But the frequency was decreased to 8 after the program. 4) Ability to calculate was improved after the program. The frequency of wrong calculation before the program was $1.10{\pm}1.94$. But the frequency after the program was decreased to $0.97{\pm}1.84$. 5) The degree of depression after the program($2.07{\pm}0.49$) was significantly lower than that before program(p<0.001). These results show that singing program combined with physical exercise improves the oxygen delivery to peripheral circulation, stability of heart function, the perception function(calculating and matching ability) and decreases the degree of depression. In conclusion, singing program combined with physical exercise can be used for the effective measure to improve the health of elderly and prevent dementia.

• Journal of Korean Biological Nursing Science
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• 제4권2호
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• pp.19-40
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• 2002

The purpose of this study was to determine the effect of DHEA on Type I(soleus) and II muscles(plantaris, gastrocnemius) in a focal brain ischemia model rat. Thirty-seven male Sprague-Dawley rats with $200{\sim}250g$ body weights were randomly divided into four groups : CINS(cerebral ischemia + normal saline), CIDH(cerebral ischemia + DHEA), SHNS(sham + normal saline), SHDH (sham + DHEA). Both the CINS and CIDH groups were undergone a transient right middle cerebral artery occlusion operation. In the SHNS and SHDH groups, a sham operation was done. DHEA was administered daily at a dose of 0.34mmol/kg, and normal saline was administered daily at the same dose by intraperitoneal injection for 7days after operation. Cerebral infarction in the CINS and CIDH groups was identified by staining with 2% triphenyltetrazolium chloride solution for 60 minutes. The data were analyzed by Kruskal-Wallis test and Mann-Whitney U test using the SPSSWIN 9.0 program. The results were summarized as follows: 1) The muscle weights of soleus(Type I), plantaris and gastrocnemius(Type II) in CINS group were significantly less than those of the SHNS group(p<.01). The muscle fiber cross-sectional area of the CINS group was significantly less than that of the SHNS group in Type I muscle fiber of the soleus and Type II muscle fiber of the plantaris and gastrocnemius(p<.05). The myofibrillar protein content of the CINS group was significantly less than that of the SHNS group in the left gastrocnemius and right soleus(p<.05). 2) The muscle weights of the soleus, plantaris and gastrocnemius except the unaffected side of the plantaris in the CIDH significantly increased compared to those of the CINS group(p<.05). The muscle fiber cross-sectional area of the CIDH group significantly increased compared to that of the CINS group in Type II muscle fiber of the plantaris and gastrocnemius(p<.05). The myofibrillar protein content of the CIDH group significantly increased compared to that of the CINS group in the left soleus(p<.05). 3) On the post-op 8 day, the body weight of the CINS group was significantly less than that of the CIDH, SHNS and SHDH groups(p<.01). Total diet intake of the CINS and CIDH groups was significantly less than that of the SHNS and SHDH groups(p<.01). Based on these results, it was identified that muscle atrophy could be induced during the 7 days after cerebral infarction, and DHEA administration during the early stage of cerebral infarction might attenuate muscle atrophy.

• Journal of Korean Biological Nursing Science
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• 제1권1호
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• pp.71-85
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• 1999

The purpose of this study was to determine the effect of periodic low-intensity exercise during hindlimb suspension on the mass, relative weight, myofibrillar protein content in soleus, plantaris and gastrocnemius muscles. To examine the effectiveness of periodic low-intensity exercise on mass, and myofibrillar protein content of hindlimb muscles, adult female Wistar rats were suspended(HS) and half of these rats walked on a treadmill for 45min/day(15 min every 4h) at 5m/min and a $15^{\circ}$ grade(HS-EX). Soleus wet weight was 33.51% significantly smaller(p<0.005) and relative soleus weight of hindlimb suspended rats was 31.96% smaller(p<0.005) compared with those of control rats following seven days of hindlimb suspension. Plantaris wet weight was 7.5% smaller(p<0.01) and relative plantaris weight was 11.83% smaller(p<0.05) compared with those of control rats following seven days of hindlimb suspension. Gastrocnemius wet weight was 11.31% significantly smaller(p<0.005) and relative gastrocnemius weight was 17.13% significantly smaller(p<0.005) compared with those of control rats following seven days of hindlimb suspension. Soleus wet weight while increased by relative soleus weight increased by 25.13%, 27.59% each through periodic low intensity exercise during hindlimb suspension(p<0.05, p<0.05). Plantaris wet weight and relative plantaris weight increased by 1.04%, 10.98%(p<0.05) each, and gastrocnemius wet weight and relative gastrocnemius weight increased by 1.98%, 12.02%(p<0.05) each through periodic low intensity exercise during hindlimb suspension. Wet weight of soleus, plantaris and gastrocnemius in HS-EX rats did not recover to control level. Myofibrillar protein content of soleus, plantaris and gastrocnemius was 48.24%, 40.85% and 37.33% significantly smaller(p<0.005) respectively compared with those of control rats following seven days of hindlimb suspension. Myofibrillar protein content of soleus, plantaris and gastrocnemius increased by 40.68%, 25.07% and 17.93%(p<0.005) each through periodic low intensity exercise during hindlimb suspension. Myofibrillar protein content of soleus, plantaris, and gastrocnemius in HS-EX rats did not recover to control level. The results suggest that periodic low intensity exercise can attenuate hindlimb muscle atrophy induced by hindlimb suspension.

• 한국산학기술학회논문지
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• 제16권10호
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• pp.7098-7108
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• 2015

본 연구는 간호대학생들의 기초간호과학 해부학교육에 팀기반 학습이 학습태도, 학습동기와 자기주도적 학습력에 미치는 효과를 측정하기 위해 시행된 방법론적 트라이앵귤레이션 연구이다. 해부학 교과목을 수강한 145명을 6~7명의 팀을 나누어 팀기반 학습을 12주간 시행하여 교과목 수강전후 설문조사와 팀기반 학습에 대한 적용에 대한 반구조적인 면담술을 하였다. 양적연구는 SPSS WIN 18.0 을 이용하여 빈도, paired t-test, Pearson Correlation Coefficient으로, 질적연구는 내용분석을 시행하였다. 연구결과 간호대학생들의 학습동기(t=-2.97, p<.003)와 자기주도적 학습력(t=-2.40, p<.018)이 유의하게 증가하였다. 또한, 학습태도, 학습동기와 자기주도적 학습력 간에 유의한 상관관계가 있었다. 따라서 팀기반 학습을 해부학 수업에 효과적인 교육법이며 추후 타 교과목에서의 팀기반 학습 적용에 대한 지속적인 연구가 필요하다.

• 한국산학기술학회논문지
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• 제14권8호
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• pp.3804-3814
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• 2013

본 연구는 여자 청소년의 생물학적 위험성향, 사회문화적 위험요인, 자기통제, 사회적지지 및 자살생각의 관계에 대한 구조모형의 부합도를 검증하고자 시도되었다. 자료수집은 2012년 12월 3일부터 2013년 3월 28일까지 D광역시의 여자 중고등학생 343명을 대상으로 하였다. 자료는 SPSS 및 AMOS 프로그램을 이용하여 분석하였다. 연구결과, 여자 청소년의 자살생각에 대해 생물학적 위험성향, 사회문화적 위험요인, 자기통제 및 사회적지지는 직접효과, 생물학적 위험성향과 사회문화적 위험요인은 간접효과가 있었다. 여자 청소년의 생물학적 위험성향과 사회문화적 위험요인은 자기통제와 사회적지지에 직접효과가 있었다. 이러한 결과에서 여자 청소년의 자살생각을 예방하기 위해 생물학적 위험성향과 사회적 위험요인을 감소시키고 자기통제와 사회적지지를 증진시키는 중재 프로그램 개발이 필요하다.

• The Korean Journal of Physiology and Pharmacology
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• 제15권2호
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• pp.67-81
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• 2011

Epilepsy is a chronic disease occurring in approximately 1.0% of the world's population. About 30% of the epileptic patients treated with availably antiepileptic drugs (AEDs) continue to have seizures and are considered therapy-resistant or refractory patients. The ultimate goal for the use of AEDs is complete cessation of seizures without side effects. Because of a narrow therapeutic index of AEDs, a complete understanding of its clinical pharmacokinetics is essential for understanding of the pharmacodynamics of these drugs. These drug concentrations in biological fluids serve as surrogate markers and can be used to guide or target drug dosing. Because early studies demonstrated clinical and/or electroencephalographic correlations with serum concentrations of several AEDs, It has been almost 50 years since clinicians started using plasma concentrations of AEDs to optimize pharmacotherapy in patients with epilepsy. Therefore, validated analytical method for concentrations of AEDs in biological fluids is a necessity in order to explore pharmacokinetics, bioequivalence and TDM in various clinical situations. There are hundreds of published articles on the analysis of specific AEDs by a wide variety of analytical methods in biological samples have appears over the past decade. This review intends to provide an updated, concise overview on the modern method development for monitoring AEDs for pharmacokinetic studies, bioequivalence and therapeutic drug monitoring.