• Journal of Korean Biological Nursing Science
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• v.4 no.2
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• pp.51-58
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• 2002

The purpose of this study was to identify clinical characteristics of type 2 diabetic patients with hypertension. The subjects were 209 type 2 diabetic patients who visited at the endocrine center at Kangnam St. Mary's Hospital of Catholic University in Seoul from beginning of March through the end of April in 2001. The patient's clinical laboratory data were assessed at medical record review. The data were analyzed using for t-test, $x^2$ test. The results were as follows: 1) There were no significant differences in age, body mass index, sex, family history of diabetes and oral hypoglycemic agents between hypertensive group and normotensive group, However, percentage of patients receiving insulin treatment was higher significantly in the hypertensive group. 2) Creatinine and microalbuminuria levels were higher significantly in the hypertensive group. However, fasting blood glucose levels were lower significantly in the hypertensive group. There were no significant differences in $HbA_1c$, 2-hour postprandial blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol, lipoprotein(a) and blood urea nitrogen between two groups. Our present study supports that Creatinine and microalbuminuria levels were higher significantly in the hypertensive group.

• Journal of Korean Biological Nursing Science
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• v.4 no.2
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• pp.127-137
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• 2002

The purpose of this study was to compare the hand disinfection effect of waterless alcohol gel hand washing agent with that of soap and water, 4% chlorhexidine gluconate, and 10% povidone-iodine. Hands of fourty subjects were artificially contaminated with Acinetobacter baumannii $5m{\ell}$ and randomly distributed to each hand washing methods. Samples were collected from gloved hand by glove juice sampling procedure. Mean log reduction after hand washing were compared with baseline values. Number of microorganisms were converted to log and tested by ANOVA in SPSSWIN 10.0. Mean log reduction of soap and water, alcohol gel, 4% chlorhexidine gluconate, 10% povidone-iodine were $2.76{\pm}0.62$, $2.97{\pm}0.56$, $4.66{\pm}1.70$, $4.60{\pm}0.91$, respectively. The bactericidal effect of alcohol gel was similar to that of soap and water, but the effect was much less than chlorhexidine gluconate and povidone-iodine(p<0.001). In terms of microorganism reduction, the efficacy of waterless alcohol gel was almost the same as soap and water hand washing. Further evaluation of the bactericidal effect of waterless alcohol gel is needed because waterless alcohol gel is simple, convenient, and non-irritating hand washing agent and also very effective in busy hospital environment.

• Journal of Korean Biological Nursing Science
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• v.2 no.1
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• pp.20-33
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• 2000

The author was used for the ICR mouse and induced diabetes with the streptozotocin(50mg/kg)and alloxan(40mg/kg). After the testing and the identifying the diabetes, the histological changes of the glomerulus, blood test for the values of blood sugar, and urine test for the values of urine protein were investigated. The results are as follows : 1. The values of high blood sugar appeared from the 2 group were about $378mg/d{\ell}{\sim}709mg/d{\ell}$, in the treated groups with the streptozotocin and alloxan. The glycosuria were obviously continued from the 2 weeks to the 12 weeks of the streptozotocin and the alloxan treated groups and the proteinuria was ${\pm}{\sim}+$ in the 4 weeks and 8 weeks of streptozotocin treated group and were + in all the 12 weeks. The ketonuria were generally negative. 2. In the view of the light microscope, there was no significant histological changes until the 8 weeks. However, in the 12 weeks group treated with the streptozotocin, the mesangial matrix of glomerulus increased Bowman's capsules adhered to each other and changed them to the crescence shapes because of increasing the exothelial cells.

• Journal of Korean Biological Nursing Science
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• v.7 no.1
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• pp.57-68
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• 2005

Purpose : The purpose of this study was to develop a tool to assess the need for hospice care in families of patients with cancer. Method : Research design was a methodological study. The tool was developed in 3 stages : first, preliminary items were developed based on a questionnaire about the needs for hospice care that was given to 8 families of patients with cancer; second, a panel of specialists reduced the number of preliminary items using 2 validity tests on the contents. Finally, reliability and validity were tested by a sample of 98 families who have a patient with cancer from April 2003 to July 2004. Result: Cronbach's alpha coefficient for internal consistency was .94 for the final total 22 items. Using the factor analysis, 4 factors with eigenvalue of more than 1.0 were extracted and these factors explained 65% of the total variance. The four factors were labeled as 'control of terminal physical problems', 'emotional care', 'spiritual care for preparing for death', and 'family support'. The final items of the tool developed on the need of hospice care consisted of 22 items. Conclusion : The instrument, for accessing the need for hospice care in families of patients with cancer, developed in this study was identified as a tool with a high degree of reliability and validity. In this sense, this tool can be effectively utilized for implementing and improving hospice care for patients with terminal cancer.

• Journal of Korean Biological Nursing Science
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• v.7 no.1
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• pp.47-56
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• 2005

nm23-H1 gene expression has been inversely correlated with tumor metastatic potential in certain tumors including melanomas, breast carcinomas, and hepatocellular carcinomas. However, its role with respect to the invasive behavior of central nervous system tumors has scarcely been addressed Because cell motility and invasion plays an essential role in metastatic dissemination, we have studied whether motile human glioma cell(U87MG) transfected with nm23-H1 complementary DNA have any alterations in their ability to migrate and invade. There was no significant changes in the shape and size of the cells following nm23-H1 transfection. The role of nm23-H1 in glioma migration and invasion have been evaluated by in vitro simple scratch technique and brain slice invasion model Basal migration ability of nm23-H1 transfectants cell(U87MG-pEGFP-nm23) were lesser than U87MG. Accordingly, U87MG-pEGFP-nm23 didn't migrate away apparently from the tumors implanted site comparing U87MG in brain slice invasion model. These results suggest that nm23-H1 may play an important role in suppressing the human glioma migration and invasion.

• Journal of Korean Biological Nursing Science
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• v.8 no.1
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• pp.23-37
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• 2006

Purpose: This study was performed to identify climacteric symptoms corresponding to the use of complementary and alternative therapy(CAT) in middle aged women. Method: The subjects of the study were 603women(40-64years) and were chosen by convenient sampling from 1 April to 31 July 2004. The collected data was analyzed using descriptive statics, chi-square, t-test analysis by SPSS/WIN program. Results: 1. It was shown that 63.8% of subjects have utilized one or more types of CAT. 2. It was shown that the most frequently used types are health supplement(40.5%), gold acupuncture(31.2%), acupress(24.7%), hand acupuncture(21.8%) 3. There was significant difference in the using experience CAT by religion(p=.029), job(p=.018), hormone replacement(p=.016), exercise(p=.007), health state(p=.013). 4. There was significant difference in climacteric symptoms(p=.000) corresponding to the using experience of CAT. 5. There was significant difference in climacteric symptoms(p=.028) corresponding to the using experience hand therapy of CAT. Conclusion: We found that middle aged women used CAT more than others populations. Future research examining the determinants of CAT use, incorporating attitudinal and health conditions, as well as clinical efficacy, effectiveness, and health outcome studies of specific CAT therapies are warranted.

• Journal of Korean Biological Nursing Science
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• v.9 no.1
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• pp.59-69
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• 2007

목적: 본 연구의 목적은 뇌사자로부터 공여받은 신장을 이식한 대상자들이 프레드니손을 생체이식 대상자들보다 더 많이 투여받는 임상상황에서 프레드리손이 근력과 일상생활활동에 영향을 주는지 규명하기 위함이다. 방법: 연구 대상은 뇌사자로터 신장을 응급으로 수여받은 32명이었으며 모두 혈액투석을 하고 있었다. 이식 수술 전날, 환자의 일반적인 정보, 근력, 일상생활활동에 대해 조사하였으며 이식수술 후 12주째 되는 날 외래에서 근력과 일상생활활동을 다시 조사하였다. 프레드니손 용량은 임상기록지를 통해 수집하였다. 연구결과: 신장이식술 후 12주의 근력은 고관절 신전근력을 제외하고는 유의하게 감소되지 않았다. 그러나 신장이식 후 12주의 일상생활활동은 수술 직전보다 유의하게 감소된 것으로 나타났다. 근력은 혈액투석을 시행한 기간에 의한 영향을 더 받았으며 일상생황활동의 저하는 3개월간 활동을 제한하는 퇴원교육의 영향이 큰 것으로 볼 수 있다. 결론: 본 연구에서 대상자의 근력과 일상생활활동은 프레드니손 투약의 영향을 받지 않았으며 오히려 혈액투석을 시행했던 기간에 따라 영향을 받은 것으로 나타났다. 따라서 혈액투석 환자들의 근력 증진을 위한 간호중재 개발이 필요하다.

• Journal of Korean Biological Nursing Science
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• v.10 no.1
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• pp.41-52
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• 2008

Purpose: This study was to evaluate and compare the effectiveness of a progressive functional training program on ADL performance in stroke patients at home after selecting subjects through Resident Assessment Instrument for Home Care (RAI-HC). Method: Ninety stroke patients had a structured training which was 50 min in duration, six times per week for a period of 6 weeks. The subjects were divided into three groups as measured using the RAI-HC progressive functional training program group; the resident rehabilitation exercise group and the control group. Result: The study observed that the functional training program for stroke patients increased the level of activities of daily living (ADL), performance of functional fitness and balance. It also reduced blood lipid and the score of client assessment protocols (CAPs). The functional training program is expected to improve the quality of life in the stroke patients at home. Conclusion: The authors, with the results of this study concluded that, the functional training program is necessary for the stroke patients to improve their quality of life. Hence, the program should be employed immediately.

• Journal of Korean Biological Nursing Science
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• v.3 no.1
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• pp.63-74
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• 2001

The purpose of this study was to determine the effect of DHEA with dexamethasone on body weight and wet weight and relative weight of atrophied hindlimb muscles induced by dexamethasone treatment. $200{\sim}225g$ Wistar rats were divided into control(C), dexamethasone(D), dexamethasone and DHEA(DDH) groups. Dexamethasone was injected daily at a dose of 5mg/kg. DHEA was administered daily at a dose of 5mg/kg by oral ingestion during 7days. The data were analyzed by Kruskal-Wallis test and Mann-Whitney U test using the SPSSWIN 9.0 program. Body weight and muscle weight of plantaris and gastrocnemius of dexamethasone group decreased significantly compared with that of control group. Muscle weight of plantaris of DDH group increased significantly compared with dexamethasone group. Body weight of DDH group decreased significantly compared to control group, but relative weight of plantaris and gastrocnemius of DDH group increased significantly compared to control group. Based on these results, it can be suggested that DHEA administration during dexamethasone treatment can be suggested that DHEA administration during dexamethasone treatment can increase weight of atrophied plantaris muscle induced by dexamethasone treatment.

• Journal of Korean Biological Nursing Science
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• v.8 no.2
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• pp.13-27
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• 2006

Purpose: The purpose of this study was to review the elderly people's sexual life, their perception of sex and identify difference between perception of sex of elderly and adults. Methods: A structured questionnaire survey was conducted for 188 elderly people and 181 adults. Collected data was analyzed with frequency, percentage, $x^2$-test, t-test, ANOVA. Results: 54.0% of the elderly were keeping their sexual life. 44.6% of those keeping their sexual life had a sexual affair once or twice a month. 56.4% of them had a sexual affair with their spouses. The elderly subjects scored 2.04 on average out of the full point of 4.0 about their perception of sexual life. Specifically, male subjects scored higher(2.41) than female subjects(1.67). There was significant difference between the elderly people's perception of sexual life and adults' the perception of sexual life about the elderly. The perception of sexual life differed significantly depending on the existence and non-existence of the spouse, sex, education, health state, present sexual life, sexual frequency, sexual satisfaction, the solution of its desire, the feeling about the sex. Conclusion: It was demonstrated through this study that the elderly people were maintaining their sexual desire and life continuously, and therefore, it is conceived that the elderly people's sex should be assessed and handled from a general perspective.