• Journal of Wetlands Research
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• v.23 no.3
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• pp.224-233
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• 2021

This study analyzed global Knowledge Sharing Platforms and collected stakeholder's suggestions to develop the "Korea-ASEAN Wetland Knowledge Sharing Platform (KSP)." As a result of the analysis, ① financial support and ② knowledge outcomes are essential to maintain the KSP and conduct the platform sustainably. Stakeholder suggest three significant projects (① comparative analysis of the inventory of wetlands in the Korea-ASEAN region, ② knowledge gap analysis in wetland research trends, and ③ establishing a web infrastructure for wetlands information sharing). The "Korea-ASEAN Wetland KSP" defined to be consistent with the international conventions (e.g., Ramsar Convention, Convention on Biological Diversity) goals by comprehensively considering the literature analysis and stakeholder suggestions. Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) selected as the fundamental model of the KSP. As with IPBES, knowledge management and assessment, capacity building, policy support, communication and participation adopted as the platform's core objectives. The KSP will be able to share knowledge related to the same type of wetland ecosystem within the Korea-ASEAN region and provide necessary information for establishing science-based policies.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.67 no.1
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• pp.61-66
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• 2022

Sesamin and sesamolin are major lignan components with a wide range of potential biological activities of sesame seeds. Near infrared reflectance spectroscopy (NIRS) is a rapid and non-destructive analysis method widely used for the quantitative determination of major components in many agricultural products. This study was conducted to develop a screening method to determine the lignan contents for sesame breeding. Sesamin and sesamolin contents of 482 sesame samples ranged from 0.03-14.40 mg/g and 0.10-3.79 mg/g with an average of 4.93 mg/g and 1.74 mg/g, respectively. Each sample was scanned using NIRS and calculated for the calibration and validation equations. The optimal performance calibration model was obtained from the original spectra using partial least squares (PLS). The coefficient of determination in calibration (R²) and standard error of calibration (SEC) were 0.963 and 0.861 for sesamin and 0.875 and 0.292 for sesamolin, respectively. Cross-validation results of the NIRS equation showed an R² of 0.889 in the prediction for sesamin and 0.781 for sesamolin and a standard error of cross-validation (SECV) of 1.163 for sesamin and 0.417 for sesamolin. The results showed that the NIRS equation for sesamin and sesamolin could be effective in selecting high lignan sesame lines in early generations of sesame breeding.

• Journal of Microbiology and Biotechnology
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• v.32 no.4
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• pp.531-540
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• 2022

Due to the high incidence of malignant melanoma, the establishment of in vitro models that recapitulate the tumor microenvironment is of great biological and clinical importance for tumor treatment and drug research. In this study, 3D printing technology was used to prepare GelMA/PEGDA composite scaffolds that mimic the microenvironment of human malignant melanoma cell (A375) growth and construct in vitro melanoma micro-models. The GelMA/PEGDA hybrid scaffold was tested by the mechanical property, cell live/dead assay, cell proliferation assay, cytoskeleton staining and drug loading assay. The growth of tumor cells in two- and three-dimensional culture systems and the anti-cancer effect of luteolin were evaluated using the live/dead staining method and the Cell Counting Kit-8 (CCK-8) method. The results showed a high aggregation of tumor cells on the 3D scaffold, which was suitable for long-term culture. Cytoskeleton staining and immunofluorescent protein staining were used to evaluate the degree of differentiation of tumor cells under 2D and 3D culture systems. The results indicated that 3D bioprinted scaffolds were more suitable for tumor cell expansion and differentiation, and the tumor cells were more aggressive. In addition, luteolin was time- and dose-dependent on tumor cells, and tumor cells in the 3D culture system were more resistant to the drug.

• Journal of Biomedical Engineering Research
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• v.43 no.3
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• pp.136-146
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• 2022

In this study, it is intended to provide basic data that can help develop a cardiovascular simulator for performance evaluation of pulse wave detectors by identifying the development status of domestic and overseas cardiovascular simulators. A total of 119 papers were selected by excluding duplicate literature, gray literature, and literature not related to a cardiovascular simulator. Based on the selected literature, the research trend of cardiovascular simulators was analyzed. As a result of analyzing the purpose of the study, most of the simulators were developed to evaluate the hemodynamic properties of artificial hearts and valves. In addition, it was used for simulation evaluation or hemodynamic studies such as pulse wave studies. As a result of analyzing configurations of the simulators, a heart most often consisted of only one left ventricle. For blood vessels, the Windkessel model was most often constructed using chambers and valves. In most studies, blood was reproduced by mixing glycerin and water to reproduce both density and viscosity. In addition, as a result of analysis from the perspective of medical device performance evaluation, simulators for evaluating artificial heart and artificial valves have been studied a lot, whereas simulators for blood pressure, pulse wave, and blood flow devices have been relatively insignificant. Based on the review results, we suggested considerations when developing a simulator for performance evaluations of a pulse wave detector.

• Journal of Biomedical Engineering Research
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• v.43 no.5
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• pp.308-318
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• 2022

The purpose of this study is to evaluate the biomechanical properties of fractured adjacent soft tissue during closed reduction after forearm fracture using the finite element method. To accomplish this, a finite element (FE) model of the forearm including soft tissue was constructed, and the material properties reported in previous studies were implemented. Based on this, nine finite element models with different fracture types and fracture positions, which are the main parameters, were subjected to finite element analysis under the same load and boundary conditions. The load condition simulated the traction of increasing the fracture site spacing from 0.4 mm to 1.6 mm at intervals of 0.4 mm at the distal end of the radioulnar bone. Through the finite element analysis, the fracture type, fracture location, and displacement were compared and analyzed for the fracture site spacing of the fractured portion and the maximum equivalent stress of the soft tissues adjacent to the fracture(interosseous membrane, muscle, fat, and skin). The results of this study are as follows. The effect of the major parameters on the fracture site spacing of the fractured part is negligible. Also, from the displacement of 1.2 mm, the maximum equivalent stress of the interosseous membrane and muscle adjacent to the fractured bone exceeds the ultimate tensile strength of the material. In addition, it was confirmed that the maximum equivalent stresses of soft tissues(fat, skin) were different in size but similar in trend. As a result, this study was able to numerically confirm the damage to the adjacent soft tissue due to the fracture site spacing during closed reduction of forearm fracture.

• Journal of Korea Water Resources Association
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• v.54 no.spc1
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• pp.1053-1060
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• 2021

Current water quality monitoring systems in Korea carried based on in-situ grab sample analysis. It is difficult to improve the current water quality monitoring system, i.e. shorter sampling period or increasing sampling points, because the current systems are both cost- and labor-intensive. One possible way to improve the current water quality monitoring system is to adopt a modeling approach. In this study, a modeling technique was introduced to support the current water quality monitoring system, and an artificial neural network model, the computational tool which mimics the biological processes of human brain, was applied to predict water quality of the river. The approach tried to predict concentrations of Total coliform at the outlet of the river and this showed, somewhat, poor estimations since concentrations of Total coliform were rapidly fluctuated. The approach, however, could forecast whether concentrations of Total coliform would exceed the water quality standard or not. As results, modeling approaches is expected to assist the current water quality monitoring system if the approach is applied to judge whether water quality factors could exceed the water quality standards or not and this would help proper water resource managements.

• The Korea Journal of Herbology
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• v.28 no.4
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• pp.83-92
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• 2013

Objectives : Lespedeza Cuneata has been used to treat leukorrhea, asthma, stomach pain, diarrhea, acute mastitis, in Korean traditional medicine. According to recent studies, Lespedeza Cuneata has antioxidation, hypoglycemia, cell protective, insulin secretion, whitening, corpora cavernosa smooth muscle relaxation and antimicrobial activities, but it has been rarely conducted to evaluate the immuno-biological activity. The present study was examined to evaluate the anti-inflammatory effects of the Lespedeza Cuneata MeOH extract (LCE) in vivo and in vitro. Methods : In vitro, inflammatory mediators, such as cytokines, nitric oxide and prostaglandin $E_2$ were detected after the addition of LPS with or without LCE in Raw 264.7 macrophage cell line. In vivo, anti-edema effect of LCE was determined in the carrageenan-induced paw edema model in rats. Results : In vitro assay, LCE decreased release of nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) via suppression of iNOS and COX-2 expression. LCE inhibited the phosphorylation of $I{\kappa}B$ indicating the suppression of NF-${\kappa}B$ pathway. In vivo assay, LCE significantly inhibited the formation of paw edema induced by carrageenan injection in rats. LCE effectively inhibited increases of hind paw skin thickness and inflammatory cell infilterations. Conclusion : These findings demonstrate that LCE has inhibitory effect on inflammatory mediators in LPS-activated Raw 264.7 cells and on paw edema in carrageenan-stimulated rats, showing the possibility of anti-inflammatory use of Lespedeza Cuneata.

• Korean journal of applied entomology
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• v.61 no.2
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• pp.369-376
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• 2022

Five different methanol extracts of plants were evaluated as a mosquito repellent against Aedes albopictus in nude mice model. The volatile components of plants were analyzed with GC-MS. The effective dose was the highest in Nepeta cataria with 72.9, 83.7, 86.4, and 97.3% efficiencies at 10, 50, 100, and 200 ㎍/mL, respectively. Nepeta cataria, Actinidia polygama, and Artemisia annua extracts were the most effective in duration time test. And there was no difference compared to negative control in the low mosquito repellent efficiency from 30 minutes. As a result of analyzing the volatile components of each plant, a total of 28 components in Mentha suaveolens, 19 components in Actinidia polygama, 27 components in Artemisia annua, 26 components in Nepeta cataria, and 19 components in Taraxacum platycarpum were detected. Especially, nepetalactone known as an effective ingredient of a mosquito repellent was identified (27.95 mg/Kg) in one of volatile components of Nepeta cataria. Overall, our results provide the possibility to develop mosquito repellents material using natural plants which contain various volatile components.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.35 no.4
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• pp.215-226
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• 2022

Significant efforts have been devoted to developing high-performance composite materials by emulating the structure of biological creatures with superior mechanical characteristics. Nacre has been one of the most sought-after natural structures due to its exceptional fracture toughness compared with the constituent materials. However, the effect of manipulating the nacre-like geometry on the impact performance has not been fully investigated thus far. In this study, composites of randomly manipulated nacreous geometry are numerically developed and the impact performance is analyzed. We develop an algorithm by which the planar area of platelets in the nacre-like design is randomly resized. Thereafter, the numerical models of nonuniform nacre-patterned multi-layer structures are developed and the drop-weight impact simulation is performed. The impact behaviors of the model are evaluated by using the ratio of absorbed energy, the von Mises stress distribution, and the impact force-time curve. Therefore, the effect of the geometric irregularity on the nacre-patterned design is elucidated. This insight can be efficiently utilized in establishing the optimum design of the nacre-patterned structure.

• Korean journal of applied entomology
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• v.61 no.1
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• pp.129-142
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• 2022

Nutrition dictates nearly all biological processes and determines Darwinian fitness in all living organisms, including insects. Research on insect nutrition has a long history in the field of insect physiology and the importance of understanding insect nutrition has become increasingly apparent with the growing need for producing insects as food and feed. Nevertheless, it is only in recent years that we have witnessed a major breakthrough in our knowledge of insect nutrition. The multivariate, interactive, and dynamic nature of nutrition has long hampered our complete understanding of insect nutrition. However, the challenge posed by such nutritional complexity has been overcome with the advent of the Nutritional Geometry, which is an integrative and multidimensional framework that enabled us to model complex interactions between multiple nutrients. In this review, we introduce the basic concepts and principles of the Nutritional Geometry and describe how this innovative framework has revolutionized the field of insect nutrition and has placed nutrition in the centre of the interface between physiology, ecology, and evolution. We close this review by discussing potentially fertile research areas that can benefit tremendously from the application of this powerful nutritional paradigm in the future.