• Korean Journal of Occupational Health Nursing
• /
• v.20 no.1
• /
• pp.35-45
• /
• 2011

Purpose: The purpose of this study was to propose and to test a predictive model that could explain the workers' quality of life. Methods: Data were collected using self-report questionnaires from 901 workers in Daejeon, Korea. The questionnaires included nine measured variables (safety culture, self-efficacy, activity of occupational health provider, knowledge in occupational health, age, health promotion behavior, workplace environment, health level, and quality of life), as revised PRECEDE model has suggested. The collected data were analyzed using SPSS/WIN 15 and AMOS 6.01 version. Results: Based on the constructed model, behavior, environment, and health were found to have significant direct effect on quality of life. Indirect factors were perceived biological, predisposing, reinforcing, and enabling. The proposed model was concise and extensive in predicting quality of life of the participants. The final modified model yielded GFI=.85, AGFI=.89, NFI=.79, and RMSEA=.11 and exhibited good fit indices. Conclusion: Findings of this study may contribute to development of effective nursing interventions for promoting quality of life in workers.

• Journal of Korean Society on Water Environment
• /
• v.35 no.6
• /
• pp.539-549
• /
• 2019

In 2016, Benthic Macroinvertebrates Streambed Index (BMSI) was proposed as an index to evaluate streams as benthic macroinvertebrate depending on the substrate type of streambed. However, orignal BMSI were selected without consideration of water quality. Analyzes without water quality do not constitute biological indices based solely on the substrate type of streambed. Therefore, in this study, the indicator value was improvement in consideration of water quality, and the distribution characteristics of benthic macroinvertebrates according to the substrate type of streambed were analyzed under relatively equal water quality conditions. We surveyed 20,155 sampling units in Korea from 2008 to 2018, and we re-estimated each lithophility of 191 taxa. As a result of estimating the streambed of each newly lithophilic value classification group considering the water quality, it was different from the original lithophilic value. Representative integer lithophilic values were newly calculated from 126 taxa among the 191 index taxa used in the analysis. The correlation between new constructed BMSI and community structure was compared and analyzed. It showed extreamely significance (p<0.001) in the dominance index, diversity index, abundance index, and evenness index of the community structure. Diversity index, abundance index, and evenness index showed positive correlation, and dominance index showed negative correlation. The correlation coefficient (r) was the highest in the richness index of about 0.664.

• Korean Journal of Agricultural Science
• /
• v.45 no.1
• /
• pp.58-65
• /
• 2018

Meat quality includes technological quality attributes, consumer acceptance, and credence characteristics. In terms of credence characteristics, animal welfare is one of the most interesting topics to both consumers and the livestock industry. Consumers prefer meat produced from livestock that has been raised in low stress and ecofriendly environments. The livestock industry cares about animal welfare to meet the requirements of consumers. Animal welfare is closely associated with the stress and physiological response of livestock to stress. Moreover, stress just before slaughter (i.e., pre-slaughter stress) has negative effects on not only animal welfare but also ultimately on meat quality. It is well-documented that pre-slaughter stress can influence ante- and post-mortem biological changes of the muscles, especially their metabolic properties and metabolites. The metabolic properties and metabolites contents also can modulate the postmortem changes of the muscles. Conversion of muscles to meat during postmortem is a very important process because it determines ultimately the meat quality. Thus, understanding pre-slaughter stress and physiological responses to stress in farm animals is important for animal welfare and meat quality. The purpose of this paper was to examine the concept of stress, physiological responses to stress, measurement of stress, and the relationships between stress indices and meat quality traits.

• Proceedings of the Korean Society for Bioinformatics Conference
• /
• 2005.09a
• /
• pp.249-255
• /
• 2005

Angiotensin-converting enzyme (ACE) is primarily responsible for human hypertension. Current ACE drugs show serious cough and angiodema health problems due to the un-specific activity of the drug to ACE protein. The availability of ACE crystal structure (1UZF) provided the plausible biological orientation of inhibitors to ACE active site (C-domain). Three-dimensional quantitative structure-activity relationship (3D-QSAR) models have been constructed using the comparative molecula. field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) for a series of 28 ACE inhibitors. Alignment for CoMFA obtained by docking ligands to 1UZF protein using FlexX program showed better statistical model as compared to superposition of corresponding atoms. The statistical parameters indicate reasonable models for both CoMFA (q$^2$ = 0.530, r$^2$ = 0.998) and CoMSIA (q$^2$= 0.518, r$^2$ = 0.990). The 3D-QSAR analyses provide valuable information for the design of ACE inhibitors with potent activity towards C-domain of ACE. The group substitutions involving the phenyl ring and carbon chain at the propionyl and sulfonyl moieties of captopril are essential for specific activity to ACE.

• Journal of Satellite, Information and Communications
• /
• v.6 no.1
• /
• pp.6-11
• /
• 2011

In this paper presents a new approach to evaluate reliability indices of electric distribution systems using genetic Algorithm (GA). The use of reliability evaluation is an important aspect of distribution system planning and operation to adjust the reliability level of each area. In this paper, the reliability model is based on the optimal load transferring problem to minimize load generated load point outage in each sub-section. This approach is one of the most difficult procedures and become combination problems. A new approach using GA was developed for this problem. GA is a general purpose optimization technique based on principles inspired from the biological evolution using metaphors of mechanisms such as natural selection, genetic recombination and survival of the fittest. Test results for the model system with 24 nodes 29 branches are reported in the paper.

• Korean Journal of Environmental Biology
• /
• v.19 no.4
• /
• pp.278-281
• /
• 2001

Ecological measurement and biological environment of the Moak Provicial Park surveyed based on the habitat; deciduous broad leaved forest (Quercus mongolica variabilis-Pinus densiflora, Capinus tschonoskii, Quercus Mongolica, Quercus acutissima-Pinus densiflora, and Quercus variabilis), coniferous forest (Pinus densiflora), plantation forest (Pinus rigida), and the other place (pond, lake, rice field, stream, and river). Totally, 1 orders, 4 families, 8 species of amphibians were found at Mt. Moak provincial park. Biodiversity indices of studied region were as follow; richness was 1.270, diversity was 1.775, and evenness was 0.853 in amphibians. 42.1% of amphibians were found in deciduous broad leaved forest, 11.3% in coniferous forest, 1.6% in plantation forest, and 45.0% in the other region.

• Journal of Biomedical Engineering Research
• /
• v.28 no.1
• /
• pp.1-7
• /
• 2007

To determine the effect of posture change on autonomic activity and to investigate valid parameters to reflex the autonomic activity from time-series pupil size data, a posture-related experiment was performed with 15 subjects, which involved measuring their electrocardiograms and pupil sizes. The experimental procedure consisted of three-sequence postures-supine, sitting and upright-for 5 minutes each, with rest sessions between postures. The subjects were notified of the entire experimental procedure. The parameters of the subjects' heart rate variability showed significant differences between the postures (heart rate: 63-70-80 beat, normalized low frequency power: 28-50-75, normalized high frequency power: 72-49-25 and ratio: 0.5-1.2-4.4 in supine-sitting-upright position respectively) as did the parameters of their mean pupil sizes (41300-53900-53700 pixels respectively) and the major frequencies (the third trend: 0.23-0.2-0.18 Hz respectively) of their pupil size variability according to changes in their autonomic activities induced by posture change. The experiment thus proved that posture change affects autonomic activity and that such activity can be estimated by the parameters of pupil size as similar as heart rate variability.

• The Korean Journal of Physiology and Pharmacology
• /
• v.15 no.6
• /
• pp.423-429
• /
• 2011

B13 analogues are being considered as therapeutic agents for cancer cells, since B13 is a ceramide analogue and inhibits ceramidase to promote apoptosis in cancer cells. B13 sulfonamides are assumed to have biological activity similar to B13, since they are made by bioisosterically substituting the carboxyl moiety of B13 with sulfone group. Twenty B13 sulfonamides were evaluated for their in vitro cytotoxicities against human colon cancer HT-29 and lung cancer A549 cell lines using MTT assays. Replacement of the amide group with a sulfonamide group increased cytotoxicity in both cancer cell lines. The sulfonamides with long alkyl chains exhibited activities two to three times more potent than that of B13 and compound (15) had the most potent activity with $IC_{50}$ values of 27 and $28.7{\mu}M$ for HT-29 and A549, respectively. The comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were used to carry out QSAR molecular modeling of these compounds. The predictive CoMSIA models for HT-29 and A549 gave cross-validated q2 values of 0.703 and 0.830, respectively. From graphical analysis of these models, we suppose that the stereochemistry of 1,3-propandiol is not important for activity and that introduction of a sulfonamide group and long alkyl chains into B13 can increase cytotoxicity.

• YAKHAK HOEJI
• /
• v.54 no.4
• /
• pp.288-294
• /
• 2010

Three dimensional quantitative-structure relationships (3D-QSARs) models between structures of phenoxy, phenylthio or benzyloxy substituted quinolone analogues and their antitrypanosomal activity against Chagas disease (Trypanosoma cruzi) were derived and discussed quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods. The optimized CoMFA 1 model ($q^2$=0.528 and $r^2$=0.964) showed the best statistical results. According to the optimized CoMFA 1 model, the antitrypanosomal activities were dependent on the steric (60.0%) and electrostatic (36.2%) factors of quinolone derivatives. From the contour maps, it is predicted that the activity will be increased when sterically favored groups were located in $R_4$ and $R_5$ position and sterically disfavored groups were located in $R_2$ position. Also, the positively charged groups on $R_2$ would be able to increase the antitrypanosomal activities.

• Rapid Communication in Photoscience
• /
• v.2 no.2
• /
• pp.46-51
• /
• 2013

This study reports a fiber-optic sensor detecting biomolecule by simultaneously monitoring localized surface plasmon resonance (LSPR) from gold nanoparticles (Au NPs) of ca. $50{\pm}5$ nm attached on one end of optical fiber and surface enhanced Raman scattering (SERS) of the reporter molecules adsorbed on the gold surfaces as an additional sensing tool. The sensor was fabricated by immobilizing Au NPs on one end of an optical fiber by chemical reaction. LSPR and SERS signals of the sensor were measured using various refractive indices solutions. Finally, the sensor was applied to observe real-time LSPR sensor-gram and SERS spectra of the reporter molecule of 4-aminothiphenol during the antibody-antigen reaction of interferon-gamma (IFN-${\gamma}$) as a proof-concept experiment of biological applications.