• 한국자원식물학회지
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• 제24권1호
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• pp.40-47
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• 2011

본 연구에서는 척리 즉 물이끼를 이용한 고부가가치 기능성 소재를 개발하기 위하여 물이끼의 Ethanol 추출물을 이용한 항암활성과 식물화학적 성분연구를 수행 하였다. 3종의 암세포주(A549, HeLa, SK-OV-3)에 대하여 세포독성연구를 수행해 본 결과 폐암세포주인 A549에서 유의성 있는 결과를 보였다. 이 결과는 난치성 질환인 암을 치료하려는 목적 의약품 보다는 Chemopreventive agent로서의 예방 의학적 기능성 소재로 충분한 가치가 있음이 사료 되어지기에 식물화학적 성분연구를 실시하여 7종의 화합물(Comp.1 : Coumarin, Comp.2 : Caffeic acid, Comp.3 : Quercetin, Comp.4 : Astragalin, Comp.5 : Luteolin, Comp.6 : Chlorogenic acid, Comp.7 : Rutin) 를 분리하여 구조동정 하였다.

• 한국식품영양과학회지
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• 제34권8호
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• pp.1169-1174
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• 2005

본 연구는 다이옥신(2,3,7,8-tetrachlorodibenzo-P-dioxin, TCDD)에 노출된 랫드에 있어 녹용의 고환 독성에 대한 방어 효과를 조사하기 위하여 수행되었다. 실험은 30마리의 수컷 랫드를 10마리씩 3개군으로 나누어 정상대조군(CO)에는 vehicle을 TCDD-단독투여군(TA)과 녹용 에탄올 추출물(EAV) 투여군(TE)에는 50 $\mu$g/kg body weight의 다이옥신을 일회 복강내 주사하였다. TE는 다이옥신 노출 1주 전부터 녹용 에탄올 추출물을 20 mg/kg body weight씩 5주 동안 매일 복강 주사하였다 TA에서는 다이옥신에 의한 체중감소(CO 대비 61.1$\%$)가 현저하였으며 TE 역시 체중은 감소(CO 대비 77.0$\%$)하였으나 YA와 비교해 볼 때 그 정도는 유의하게 경감되 는 것을 알 수 있었다. 다이옥신(TCDD)에 의하여 야기되는 고환 중량, 정세관의 직경 및 Johnsen's score의 감소와 고환조직의 병변은 녹용 에탄올 추출물 투여에 의하여 유의하게 경감되었다. 이상의 결과로 보아 녹용은 랫드에 있어 다이옥신에 의하여 야기되는 고환 독성을 경감시킬 수 있다고 판단한다.

• Journal of Ginseng Research
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• 제38권3호
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• pp.173-179
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• 2014

Background: Ginsenosides are the major components responsible for the biochemical and pharmacological actions of ginseng, and have been shown to have various biological activities. In this study, we investigated the antiviral activities of seven ginsenosides [protopanaxatriol (PT) type: Re, Rf, and Rg2; protopanaxadiol (PD) type: Rb1, Rb2, Rc, and Rd)] against coxsackievirus B3 (CVB3), enterovirus 71 (EV71), and human rhinovirus 3 (HRV3). Methods: Assays of antiviral activity and cytotoxicity were evaluated by the sulforhodamine B method using the cytopathic effect (CPE) reduction assay. Results: The antiviral assays demonstrated that, of the seven ginsenosides, the PT-type ginsenosides (Re, Rf, and Rg2) possess significant antiviral activities against CVB3 and HRV3 at a concentration of $100{\mu}g/mL$. Among the PT-type ginsenosides, only ginsenoside Rg2 showed significant anti-EV71 activity with no cytotoxicity to cells at $100{\mu}g/mL$. The PD-type ginsenosides (Rb1, Rb2, Rc, and Rd), by contrast, did not show any significant antiviral activity against CVB3, EV71, and HRV3, and exhibited cytotoxic effects to virus-infected cells. Notably, the antiviral efficacies of PT-type ginsenosides were comparable to those of ribavirin, a commonly used antiviral drug. Conclusion: Collectively, our findings suggest that the ginsenosides Re, Rf, and Rg2 have the potential to be effective in the treatment of CVB3, EV71, and HRV3 infection.

• 동서간호학연구지
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• 제2권1호
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• pp.83-95
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• 1997

Cooking food is very important in Chinese medicine when we regard the food to be the principal origin of the nutrition of human body and the condition required to maitain the activities of the life of human body. Chinese medicine has accumulated the diverse and rich experience of cooking food through long clinical experience as well as made an important contribution to the healthy and long life through the unique theory of cooking food. Chineses medicine has deep view on the relations between food cooking and healthy and long life as well as presented the principle of cooking food created unique ways of food cooking such as food treatment. As the above, from the ancient times, Chinese medicine established Chinese medical science of nutrition under the consciousness of the theory that food and medicine have the same origin and practiced the methods of promoting the health through rightly selecting the foods. Therefore it has been thought that human beings can enjoy healthy life by rich supply of the nutrition. Comfortable ways of sleeping requie the emotion and peace with temperation in pleasure and anger, and also we should be temporate in eating, acting, sleeping posture and be flee from the wind, and we should not put on a quilt when sleep, and we should sleep alone and be careful about sexual life. The concrete measures for sexual intercourse are that: 1) we should marry at the right age not to be married at early age. 2) we should obey nature and not live unmarried life. 3) we should be temperate in having sexual intercoure and in excessive sexual desire. Regarding the residence and clothes: the residence environment should be calm and beautiful and the room for the residence should be well designed to be clean and sanitary and we should wear suitable clothes. All living creatures are living according to the rhythm of the living body and the change of the great nature. The Reason why the living things show the periodical rhythm is not that it is the truth of the great nature, but that the living life itself shall be ceased to be existed in case of running counter to such rhythm. There are 2 specially important things: one is about food in biological view and the other is the residence in social side. By starting from the theory that food and medicine have the same origin and root, we should rightly select the foods to promote the health at the maximum, and it is very important for human to be well obeying the environment and temperate in the life of residence and mind (Choi, Sam Byun, Shon, Sook Young, 1997). As the above, the cook in Chinese medicine suggests us the suitable ways of achieving the goal of nursing. Therefore the continuous study of this field is necessary based on this my study though it is unsatisfactory at this time but it would be the basic materals in establishing the nursing science of Chinese medicine.

• 한국환경보건학회지
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• 제26권4호
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• pp.29-37
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• 2000

Fenton’s oxidation process is one of the most commonly applied processes to the wastewater which cannot be treated by conventional biological treatment processes. However, it is necessary to minimize the cost of Fenton’s oxidation treatment by modifying the treatment processes or other means of chemical treatment. So, as a method for the chemical oxidation of biorefractory or nonbiodegradable organic pollutants, the Photo-Fenton-Reaction which utilizes iron(11)salt. $H_2O$$_2$ and UV-light simultaneously has been proprosed. Therfore, the purpose of this study is to test a removal efficiency of dye-wastewater and treatment cost with Fenton’s and Photo-Fenton’s oxidation process. The Fe(11)/$H_2O$$_2$ reagent is referred to as the fenton’s reagent. which produces hydroxy radicals by the interaction of Fe(11) with $H_2O$$_2$. In this exoeriment, the main results are as followed; 1. The Fenton oxidation was most efficient in the pH range of 3-5. The optimal condition for initial reaction pH was 3.5 for the high CO $D_{Cr}$ & TOC-removal efficiency. 2. The removal efficiency of TOC and CO $D_{Cr}$ increased up to the molar ration between ferrate and hydrogen peroxide 0.2:1, but above that ratio removal efficiency hardly increased. 3. The highest removal efficiency of TOC and CO $D_{Cr}$ were showed when the mole ration of ferrate to hydrogen peroxide was 0.2:3.4. 4. Without pretreatment process, photo-fenton oxidation which was not absorbed UV light was not different to fenton oxidation. 5. And Fenton oxidtion with pretreatment process was similar to Fenton oxidation in the absence of coagulation, the proper dosage of F $e^{2+}$: $H_2O$$_2$ was 0.2:1 for the optimal removal efficiency of TOC or CO $D_{Cr}$ .6. Also, TOC & CO $D_{Cr}$ removal efficiency in the photo-fenton oxidation with pretreatment was increased when UV light intensity enhanced.7. Optimum light intensity in the range from 0 to 1200 W/$m^2$ showed that UV-intensity with 1200W/$m^2$ was the optimum condition, when F $e_{2+}$:$H_2O$$_2$ ratio for the highest decomposition was 0.2:2.5.EX>$_2$ ratio for the highest decomposition was 0.2:2.5.

• 한국환경보건학회지
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• 제26권4호
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• pp.49-57
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• 2000

This study was carried out to find the optimal condition to treat refractory organic matter which can’t treat clearly with biological treatment and to find the optimal division dosage and division dose timing in the modification of Fenton oxidation which is used resolve the problem that hydrogen peroxide is too expensive. The results are following; 1. The highest TOC removal efficiency was 41% and color removal efficiency was 64% when the dilution magnitude of leachate is fold. This suggests that dilution is efficiency when high concentration of leachate is treated. 2. The removal efficiency of TOC and color increased up to the molar ratio between ferrate and hydrogen peroxide was 1:1. However above that ratio, removal efficiency hardly increased. The highest removal efficiency of TOC and color were 38% and 71% when the mole ratio of ferrate to hydrogen peroxide was 1.5:1. 3. When the mole ratio between ferrate and hydrogen peroxide was fixed, the removal efficiency of TOC and color increased as the dosage of hydrogen peroxide increased. 4. pH of samples were adjusted at pH 3, 5, 7, 9, 11. After oxidation reaction, pH of samples were dropped to 2.59, 2.54, 5.34, 6.36 and 9.68. The highest color removal efficiency was 75.7% when initial pH was at pH 7. 5. The removal of TOC and color was ended within 10. min. and the removal efficiency increased logarithmically within 10min. However after 10 min., the removal efficiency of hardly increased. 6. The color removal efficiency was higher with modification of fentone oxidation than that with fentone oxidation by 5%. Optimal division dosage ratio was 1:1 and optimal dose timing ratio was 2:1. However the TOC removal efficiency was not higher with modification of Fenton oxidation than that with Fenton oxidation.7. The CO $D_{Mn}$ /BO $D_{5}$ Ratio decreased with the time went by. It meant bioresolution increased as time went by. However, after 15 min., the CO $D_{Mn}$ /BO $D_{5}$ Ratio did not decrease any more. 8. In the case of $H_2O$$_2$ Divisiom Dose experiment, the increase of bioresolution was highest at the $H_2O$$_2$ Division dosage Ratio of 3:7.3:7.

• 대한의용생체공학회:의공학회지
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• 제29권1호
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• pp.66-72
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• 2008

The major risk associated with the use of automated power injectors is the well known complication of contrast material extravasation at the injection site. Automated injection of computed tomography (CT) contrast media can produce the compartment syndrome. The purpose of this study was to assess the ability of this device during clinically important episodes of extravasation. The extravasation detection accessory (EDA) system was composed of a strain gage, an amplifier and a computer based system. A strain gage pliable adhesive patch was applied to the skin aver the intravenous catheter and the catheter was connected to the power injector with a cable to monitor the resolution data. If the programmed monitoring, which was developed with MS Visual C++, at the extravasation occurred, then the injection was interrupted the auto injector. CT was used to demonstrate the clinically important extravasation. This study was a prospective, observational study in which the EDA system was used to monitor the automated mechanical injection of contrast material in 7 dogs. There were two true-positive cases (range of extravasation volumes: $18{\sim}22ml$), twenty three true-negative cases, three false-positive cases and no false-negative cases. The EDA system had a sensitivity of 100% and a specificity of 88% for the detection of clinically important extravasation. The EDA system had good sensitivity for the detection of clinically important extravasation and the EDA system has the clinical potential for the early detection of extravasation of the contrast medium that is administered with power injectors. The EDA system is easy to use safe and accurate for the monitoring extravasation of the intravenous injections, and this system may prove especially useful in CT applications.

• 생약학회지
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• 제36권3호통권142호
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• pp.164-170
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• 2005

개쑥부쟁이의 생리활성 기능을 탐색하고 기능성 신물질을 개발하기 위하여 개쑥부쟁이의 부위별 즉, 꽃, 줄기, 뿌리로 나누어 화학성분, UV 흡광도 측정 및 항산화 활성을 조사하였다. 일반성분 분석은 부위별에 따라 다소 차이는 있으나 탄수화물 $73{\sim}81%$, 수분 $11{\sim}15%$, 조회분 $4{\sim}7%$, 조단백 $2{\sim}6%$, 조지방 $1{\sim}4%$ 순으로 나타났다. 주요 무기성분은 Ca, K, Na, P로 나타났으며, 꽃에서 K이 가장 많았으며, 줄기와 뿌리에서는 Na이 가장 많은 것으로 나타났다. 주요 지방산은 linoleic acid, palmitic acid, oleic acid, linolenic acid 으로 나타났으며, 포화 지방산$(27{\sim}40%)$에 비해 불포화 지방산$(59{\sim}72%)$이 높게 나타났다. 구성당은 총 4종이 분리동정되었는데, glucose가 줄기>꽃>뿌리 순으로 보여주었고, xylose, galactose, arabinose순으로 나타났다. 페놀성 화합물의 함량은 280 nm에서 흡광도를 측정 결과 뿌리와 줄기의 chloroform 추출물에서 가장 높았고, 꽃과 뿌리의 ethanol 추출물과 뿌리의 75% ethanol 추출물에서 높게 나타났다. 또한 카로티노이드계 화합물은 꽃의 ethanol 추출물에서, 줄기의 chloroform 추출물에서 높게 나타났다. 항산화 효과는 뿌리의 75% ethanol 추출물에서 가장 높았고, 뿌리의 ethanol 추출물과 꽃의 ethanol 추출물이 높은 항산화 효과를 나타내었다.

• 대한임상검사과학회지
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• 제51권4호
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• pp.484-494
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• 2019

심혈관 질환의 위험 요인은 선천적으로 노화, 당 대사의 문제, 가족력과 성별이 있으며 생리학적 요인으로 고혈압, 혈청 콜레스테롤이 있다. 그 외 환경적 요인으로 흡연, 섭식, 스트레스 등이 있다. 본 연구는 최근 2013~2017년 국민건강영양조사 내용을 바탕으로 50세이상 남녀를 대상으로 한 건강설문조사와 검진조사를 이용하여 심혈관 질환의 위험 요인 및 유병률을 낮출 수 있는 방법을 연구하고자 하였다. 생리학적 요소와 영양성분 권장섭취 여부와의 상관성을 보기 위해 리보플라빈과 나이아신의 권장량을 확인하여 권장섭취군과 비권장섭취군으로 나눈 후 생리학적 요소변수와 분석하였다. 리보플라빈은 고혈압, 고혈당, 낮은 HDL-콜레스테롤에서, 나이아신은 고혈압, 고혈당, 허리둘레, 낮은 HDL-콜레스테롤에서, 둘을 복합적으로 보았을 때는 고혈압, 고혈당, 허리 둘레, 낮은 HDL-콜레스테롤에서 상관성이 있는 것으로 나타났다 (P<0.05). 결론적으로 리보플라빈, 나이아신의 권장섭취는 고혈당, 허리 둘레, HDL-콜레스테롤 등의 생리학적 요소에 영향을 줄 수 있으며, 이를 통해 심혈관 질환의 유병률을 낮출 수 있다. 이는 심혈관 질환의 위험율을 낮출 수 있는 가치 있는 연구로서 의의가 있다고 사료된다.

• 여성건강간호학회지
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• 제9권1호
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• pp.39-49
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• 2003

This study is an attempt to provide fundamental information on how to manage menstruation discomforts by surveying the subjective viewpoint s on menstruation from female college students. Utilizing 40 Q-samples in Seoul between May 1 and June 30, 2001, data has been collected from 30 randomized P-samples. Data analysis involves the PC QUANL Program, Q-factor analysis, and Principal Component Analysis. The result of the data analysis gives four types of categorizat ion as follows : The first is the "inconvenience-recognizing" type that includes 10 subjects out of 30. During menstruation, this type of subject usually complained of physical discomfort such as pain in the lower back and abdomen. Even though they considered menstruation to be troublesome, they did nothing about the in convenience. The second is the "positively-accepting" type that includes 7 subjects out of 30. This type of subject takes menstruation as natural and even a privilege for a woman. They think they are blessed to conceive a new life through their biological cycle. Therefore unlike other types, they rarely complained of any physical and psychological discomfort caused by menstruation. The third is the "destined course" type that includes 6 subjects out of 30. This type of subject endures the discomfort caused by menstruation with out any medication or medical treatment. They appeared to take menstruation a s fate without having any specially negative or positive attitude. The fourth is the "negatively-accepting" type that includes 7 out 30. This type of subject takes menstruation as negative, even if it is unavoidable for a woman. Menstruation, very negatively taken, felt uncomfortable and caused them to have pain in the lower back and abdomen and an oversensitive nervous system. The four types of attitude towards menstruation show their own characteristic features in dealing with menstruation. Understanding these features in detail will enhance nursing implementation which is related to menstruation. This study is intended to provide fundamental information with which nurses can deal with menstruation problems by investigating subjective viewpoints about menstruation. This study is a stepping stone on which further study on this subject can build to develop an effective and efficient way to deal with menstruation discomforts.