• Journal of Korean Society on Water Environment
• /
• v.36 no.6
• /
• pp.621-635
• /
• 2020

Water quality models are scientific tools that simulate and interpret the relationship between physical, chemical and biological reactions to external pollutant loads in water systems. They are actively used as a key technology in environmental water management. With recent advances in computational power, water quality modeling technology has evolved into a coupled three-dimensional modeling of hydrodynamics, water quality, and ecological inputs. However, there is uncertainty in the simulated results due to the increasing model complexity, knowledge gaps in simulating complex aquatic ecosystem, and the distrust of stakeholders due to nontransparent modeling processes. These issues have become difficult obstacles for the practical use of water quality models in the water management decision process. The objectives of this paper were to review the theoretical background, needs, and development status of water quality modeling technology. Additionally, we present the potential future directions of water quality modeling technology as a scientific tool for national environmental water management. The main development directions can be summarized as follows: quantification of parameter sensitivities and model uncertainty, acquisition and use of high frequency and high resolution data based on IoT sensor technology, conjunctive use of mechanistic models and data-driven models, and securing transparency in the water quality modeling process. These advances in the field of water quality modeling warrant joint research with modeling experts, statisticians, and ecologists, combined with active communication between policy makers and stakeholders.

• The Journal of the Korea Contents Association
• /
• v.20 no.12
• /
• pp.95-102
• /
• 2020

The purpose of this study is to seek a new understanding of human beings by examining, through the various types of futuristic humans in SF narratives, the changes of human condition and identity, raised by the discussion on the posthuman today. The rapid development of science and technology blurs the line between humans and machines, predicting the birth of the 'new human posterior to the human'. The advancement of technology enables the production of 'human beyond the biological human' through the combination of humans and machines, and humans are becoming more mechanized. On the other hand, machines are gradually developing to the stage of resembling not just the exterior body structure, but the thinking abilities and emotions of human beings. However, by colliding with the traditional view of human beings, artificial changes to the human condition as a result of cutting-edge technology demand a new perspective on the meaning of a new being and changes in human conditions. Therefore, the study examines how human conditions and perceptions have changed in accordance with the evolution of science and technology, and then explores the direction of co-evolution between humans and machines through the various types of futuristic humans that appear in the SF narratives, as well as the potential of futuristic humans as the new subject.

• The Journal of the Korea Contents Association
• /
• v.21 no.3
• /
• pp.114-120
• /
• 2021

Furniture is an essential element in the area of human residence, and the necessity of system furniture suitable for the pursuit of unity in design, which clearly distinguishes the various and flexible arrangements and characteristics of space, is gradually expanding. The elderly population in Korea currently exceeds 15%, and is expected to be close to 40% by 2050. An increasing number of elderly generations are showing different behavioral patterns, such as sharing information, health care, and seeking independence from children. In order to maintain an independent daily life, a stable living environment has become essential, but as a result of a study that safety accidents caused by households increase due to a decrease in cognitive ability and physical ability, the need for a suitable household has increased. Therefore, the biological changes and characteristics of the elderly were investigated, and the concept definition, scope and limitations of system households were studied. In addition, by grasping the changes in the home appliance market and trends in the home appliance market, the design direction of system furniture required by the elderly was presented.

• Journal of Korean Neurosurgical Society
• /
• v.65 no.5
• /
• pp.697-709
• /
• 2022

Objective : The present study aimed to identify the function of ischemic stroke (IS) patients' peripheral blood and its role in IS, explore the pathogenesis, and provide direction for clinical research progress by comprehensive bioinformatics analysis. Methods : Two datasets, including GSE58294 and GSE22255, were downloaded from Gene Expression Omnibus database. GEO2R was utilized to obtain differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs were performed using the database annotation, visualization and integrated discovery database. The protein-protein interaction (PPI) network of DEGs was constructed by search tool of searching interactive gene and visualized by Cytoscape software, and then the Hub gene was identified by degree analysis. The microRNA (miRNA) and miRNA target genes closely related to the onset of stroke were obtained through the miRNA gene regulatory network. Results : In total, 36 DEGs, containing 27 up-regulated and nine down-regulated DEGs, were identified. GO functional analysis showed that these DEGs were involved in regulation of apoptotic process, cytoplasm, protein binding and other biological processes. KEGG enrichment analysis showed that these DEGs mediated signaling pathways, including human T-cell lymphotropic virus (HTLV)-I infection and microRNAs in cancer. The results of PPI network and cytohubba showed that there was a relationship between DEGs, and five hub genes related to stroke were obtained : SOCS3, KRAS, PTGS2, EGR1, and DUSP1. Combined with the visualization of DEG-miRNAs, hsa-mir-16-5p, hsa-mir-181a-5p and hsa-mir-124-3p were predicted to be the key miRNAs in stroke, and three miRNAs were related to hub gene. Conclusion : Thirty-six DEGs, five Hub genes, and three miRNA were obtained from bioinformatics analysis of IS microarray data, which might provide potential targets for diagnosis and treatment of IS.

• BMB Reports
• /
• v.55 no.6
• /
• pp.267-274
• /
• 2022

Molecular imaging is used to improve the disease diagnosis, prognosis, monitoring of treatment in living subjects. Numerous molecular targets have been developed for various cellular and molecular processes in genetic, metabolic, proteomic, and cellular biologic level. Molecular imaging modalities such as Optical Imaging, Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Computed Tomography (CT) can be used to visualize anatomic, genetic, biochemical, and physiologic changes in vivo. For in vivo cell imaging, certain cells such as cancer cells, immune cells, stem cells could be labeled by direct and indirect labeling methods to monitor cell migration, cell activity, and cell effects in cell-based therapy. In case of cancer, it could be used to investigate biological processes such as cancer metastasis and to analyze the drug treatment process. In addition, transplanted stem cells and immune cells in cell-based therapy could be visualized and tracked to confirm the fate, activity, and function of cells. In conventional molecular imaging, cells can be monitored in vivo in bulk non-invasively with optical imaging, MRI, PET, and SPECT imaging. However, single cell imaging in vivo has been a great challenge due to an extremely high sensitive detection of single cell. Recently, there has been great attention for in vivo single cell imaging due to the development of single cell study. In vivo single imaging could analyze the survival or death, movement direction, and characteristics of a single cell in live subjects. In this article, we reviewed basic principle of in vivo molecular imaging and introduced recent studies for in vivo single cell imaging based on the concept of in vivo molecular imaging.

• Journal of Biomedical Engineering Research
• /
• v.44 no.2
• /
• pp.125-138
• /
• 2023

The development of AI systems for radiation therapy is important to improve the accuracy, effectiveness, and safety of cancer treatment. The current system has the disadvantage of monitoring patients using CCTV, which can cause errors and mistakes in the treatment process, which can lead to misalignment of radiation. Developed the PMRP system, an AI automation system that uses depth cameras to measure patient's fine movements, segment patient's body into parts, align Z values of depth cameras with Z values, and transmit measured feedback to positioning devices in real time, monitoring errors and treatments. The need for such a system began because the CCTV visual monitoring system could not detect fine movements, Z-direction movements, and body part movements, hindering improvement of radiation therapy performance and increasing the risk of side effects in normal tissues. This study could provide the development of a field of radiotherapy that lags in many parts of the world, along with the economic and social importance of developing an independent platform for radiotherapy devices. This study verified its effectiveness and efficiency with data through phantom experiments, and future studies aim to help improve treatment performance by improving the posture correction mechanism and correcting left and right up and down movements in real time.

• The Korean Journal of Pain
• /
• v.36 no.1
• /
• pp.60-71
• /
• 2023

Background: The purpose of this research was to assess the role of heparanase (HPSE)/syndecan1 (SDC1)/nerve growth factor (NGF) on cancer pain from melanoma. Methods: The influence of HPSE on the biological function of melanoma cells and cancer pain in a mouse model was evaluated. Immunohistochemical staining was used to analyze HPSE and SDC1. HPSE, NGF, and SDC1 were detected using western blot. Inflammatory factors were detected using ELISA assay. Results: HPSE promoted melanoma cell viability, proliferation, migration, invasion, and tumor growth, as well as cancer pain, while SST0001 treatment reversed the promoting effect of HPSE. HPSE up-regulated NGF, and NGF feedback promoted HPSE. High expression of NGF reversed the inhibitory effect of HPSE down-regulation on melanoma cell phenotype deterioration, including cell viability, proliferation, migration, and invasion. SST0001 down-regulated SDC1 expression. SDC1 reversed the inhibitory effect of SST0001 on cancer pain. Conclusions: The results showed that HPSE promoted melanoma development and cancer pain by interacting with NGF/SDC1. It provides new insights to better understand the role of HPSE in melanoma and also provides a new direction for cancer pain treatment.

• Design Convergence Study
• /
• v.14 no.5
• /
• pp.87-102
• /
• 2015

Today, our digital media environments are shifting from a new biological paradigm that can be characterized by "personalization", "interaction", and "kinesis." According to this paradigm shift, the change of media skin is needed, which plays an important role on our urban environments. Thus, this research aims to propose a new media skin that supports user participation based on a new digital media paradigm. For this study, we begin by extracting the essential factors from the characteristics with personalization, interaction, and kinesis through exploring the theories related to the new digital media paradigm. Based on the extracted factors, we investigated the limitation of emerging media skins and proposed a new media skin in order to overcome it. The module-based media skin proposed in this study enables users to quickly and easily design and arrange their own form that they want and display diverse contents through intelligent interaction between modules. This research contributes to providing the framework for guiding designers when they design their media skins.

• Korean Chemical Engineering Research
• /
• v.61 no.3
• /
• pp.446-455
• /
• 2023

A mathematical model for predicting the liquid circulation velocity in an airlift reactor was developed based on the mechanical energy balance of the fluid circulation loop. The model considered the energy loss due to a 90° turn, the energy loss due to friction, and the energy loss due to the change in cross-sectional area at each part of the reactor. The model that separately considered the loss coefficients related to friction, direction change, and cross-sectional area change was able to predict the liquid circulation velocity better than the previous model using lumped parameters. The liquid circulation velocity was measured by the tracer pulse method. Most of our experimental results obtained in external-loop airlift reactors, which had the top and bottom connecting pipes, as well as other investigators' results obtained in various types of airlift reactors, were well predicted by the developed model with an error within 20%. Useful empirical equations for the loss coefficient related to the 90° turn of the circulating fluid were obtained in external and internal-loop airlift reactors and used to predict the liquid circulation velocity.

• Composites Research
• /
• v.36 no.2
• /
• pp.69-79
• /
• 2023

Oil-water separation is a critical process for several industrial applications, including oil production, wastewater treatment, food processing, and environmental area such as marine oil spills. The separation efficiency of oil-water mixtures can be influenced by various factors such as mixture composition, oil and water conditions, and the separation technology used. Over the years, various technologies have been developed to separate water and oil by physical, chemical and biological methods. This paper presents an overview of the various methods and technologies available for oil-water separation, including gravity separation, centrifugal separation, and separation using adsorbents, filters. The strengths and limitations of each method are discussed, along with recent research trends and future prospects. Furthermore, this paper aims to provide direction for future research and industrial application of sustainable and environmentally friendly oil-water separation technologies. In conclusion, we provide a comprehensive overview of recent oil-water separation technologies that will be beneficial to researchers and industrialists in the field of oil-water separation.