• 한국언론정보학보
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• 제61권
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• pp.5-27
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• 2013

유명인의 자살이 잇달아 발생하고 그 원인으로 우울증이 지목되면서 언론보도 전반에서 우울증에 대한 보도량이 늘고 있다. 그러나 선행연구의 부족으로 이러한 보도들이 질적인 측면에서 우울증을 건강행동이 필요한 질병으로 심층적으로 다루고 있는지는 불분명하다. 본 연구는 이를 알아보기 위해 2007년부터 약 5년간 온라인 전문 뉴스 미디어의 우울증 보도를 살펴보았다. 정신질환에 대한 선행연구들이 신문과 텔레비전 같은 전통적인 미디어에 초점을 맞춘데 반해, 본 연구는 최근 이용 빈도와 사회적 영향력 측면에서 중요한 온라인 보도를 분석했다. 연구 결과, 우울증 보도에 가장 많이 등장하는 정보원은 연예인, 스포츠스타, 정/재계 인사를 비롯한 유명인 환자였고, 일반인 환자와 비교해 4배 정도 많이 나타났다. 심지어 환자가 아닌 유명인도 일반인 환자보다 2배 이상 많이 등장했고, 의사를 비롯한 전문가도 유명인 환자의 절반 수준 밖에 등장하지 않았다. 또한 분석대상 기사의 약 3분의 1이 우울증의 원인에 대해 전혀 언급하지 않았고, 불우한 환경이나 소심한 성격 등 사회 심리 환경적 원인을 언급한 기사가 전체의 절반이 넘었으며 소수의 기사만이 뇌신경 손상, 호르몬 변화와 같은 신경생물학적 원인을 언급했다. 우울증의 치료방식 역시 분석 대상 기사의 절반 이상에서 전혀 언급되지 않았고, 의사 상담과 약물치료 같은 적극적 치료방식을 제시한 기사가 식이요법, 운동 및 주변 사람들과의 대화와 같은 소극적 치료방식을 제시한 기사에 비해 2배 이상 많았다. 전반적으로 우울증의 원인과 치료방식에 관해 언급하는 정도는 유명인 환자 중심의 기사에서 보다 일반인 환자 중심의 기사에서 높게 나타났다. 원인과 치료방식이 제시되는 정도 간 관계를 분석한 결과, 기사 내에서 우울증의 원인으로 신경생물학적 원인이 많이 제시될수록 적극적 치료방식과 소극적 치료방식 모두 제시되는 정도가 높게 나타났다. 한편 우울증 보도에 가장 많이 나타난 뉴스 프레임은 개인이 겪은 일화를 소개하는 인간적 흥미 프레임이었고, 사건, 사고, 분쟁을 다룬 갈등 프레임과 홍보 및 프로모션을 목적으로 한 상업적 프레임이 그 뒤를 따랐다. 또한 우울증 관련 보도에 한때 우울증을 겪었던 사람들이 회복한 후 이룬 긍정적인 업적이나 성취와 같은 내용이 나타나는 경우는 매우 적었다.

• 한국토양비료학회지
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• 제47권6호
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• pp.533-539
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• 2014

Mine wastes such as acid mine drainage (AMD) can cause the detrimental effects on surrounding environment, thereby eventually threatening human health. Main objective of this study was to evaluate the neutralizing effect of fly ash (FA) as a stabilizing material AMD. Field plot was constructed in a coal waste depot which has caused aluminium-whitening adjacent to the stream. Different mixing ratios of FA were applied on a top of the soil, and then the physicochemical properties of runoff and soil were monitored. Constructed plots were as following: control (mine waste only (W)), mine waste + 20% ($w\;w^{-1}$)of FA (WC20M), mine waste + 40% ($w\;w^{-1}$)of FA (WC40M), and WC40M dressed with a fresh soil at the top (WC40MD). Result showed that initial pH of runoff in control was 5.09 while that in WC40M (7.81) was significantly increased. For a plot treated with WC40M, the concentration of Al in runoff was decreased to $0.22mg\;L^{-1}$ compared to the W as the control ($4.85mg\;L^{-1}$). Moreover, the concentration of Fe was also decreased to less than half at the WC40M compared to the control. Application of FA can be useful for neutralizing AMD and possibly minimizing adverse effect of AMD in mining area.

• KSBB Journal
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• 제28권5호
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• pp.303-309
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• 2013

The extract from Lysimachia foenum-graecum (LFE) has been known to possess various instructive characters including anti-oxidant, anti-obesity, fungicidal activities. However, the accurate mechanism of those effects of LFE is not well known. In that respect, we evaluated the apoptotic effect and anti-cancer efficacy of extracts of LFE in MCF-7 breast cancer cells. In this study, we hypothesized that LFE may exert cancer cell apoptosis through regulating p53 and mitochondria-mediated apoptotic proteins. And this substance can generate ROS to cause free radical-induced apoptosis. Accordingly, the generation of ROS by LFE triggers the activation of p53 which are accompanied by pro-apoptotic protein activation and suppression of pro-survival proteins. We determined with MTT assay, flow cytometry for detection of intracellular ROS and Annexin V-PI staining, Western blotting. Consequently, our researches demonstrated that the treatment of LFE to breast cancer cells resulted in an activation of p53, Puma, Bax, cleaved-PARP and an inhibition of Bcl-2 expressions.

• 한국물환경학회지
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• 제24권4호
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• pp.458-464
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• 2008

Bulking phenomena and scum formation are common problem in suspended growth system like the activated sludge plants for wastewater treatment. Apart from wastewater composition, operating conditions, such as mechanical stress by insufficient oxygen supply, are often decisive for the occurrence of a bulking or scumming problem. There were the comparative aeration tanks in terms of sludge bulking caused by the difference of mechanical aeration facilities in the wastewater treatment plant of N paper mill company. In this study the cause of bulking was investigated through not only the biological isolation and identification but also a series of operational data consideration. On the basis of the investigation results for bulking cause, the operational criteria on dissolved oxygen concentration was derived to decrease the bulking problem.

• 약학회지
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• 제52권3호
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• pp.212-218
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• 2008

Manganese is a naturally occurring element which is widespread in the environment. Also, manganese is an essential trace element and plays a key role in important biological reactions catalyzed by enzymes. However, exposure to high levels of manganese can cause toxicity in neurone and inhalation system, also damage in various tissues. We investigated the toxicity induced by manganese compound ($MnCl_2$) in cultured rat cardiomyocytes. Treatment of manganese to cultured cardiomyocyte led to cell death, reactive oxygen species (ROS) increase, and cytosolic caspase-3 activation. The ROS increase was related with the decreased level of glutathione. Expressions of ROS related genes such as heme oxygenase-1, thioredoxin reductase, and NADH quinone oxidase were significantly induced in manganese treated cells. These results suggest that manganese induce oxidative stress and apoptosis in cardiomyocytes, and may be the one of risk factors to cause heart dysfunction in vivo.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2005년도 국제학술대회
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• pp.326-329
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• 2005

A worker who grinded the inner parts of camshafts for automobile engines using water-soluble metalworking fluid (MWF) for 14 years was diagnosed with sinusitis. We postulated that the outbreak of sinusitis could be associated with exposure to microbes contaminated in water-soluble MWF during the grinding operation. To suggest responsible agents for this outbreak, quantitative exposure assessment for chemical and biological agents and prevalence of work-related respiratory symptoms by questionnaire were studied. The exposure ranges of MWF mist (0.59 $mg/m^3$to 2.12 $mg/m^3$) measured during grinding exceeded 0.5 $mg/m^3$ of the recommended exposure limit (REL). Grinder's exposures to bacteria, fungi and endotoxins were also generally higher than not only the proposed standards, but also those reported by several studies to identify the cause of respiratory effects. Statistical test indicated that the prevalence rate of reported symptoms related to nasal cavities showed no significant differences among the operations. Evaluation on grinding operation characteristics and quantitative exposure assessment indicated that repeated exposure to MWF mist including microbes contaminated from the use of water-soluble MWF may cause respiratory diseases like sinusitis or at least increase susceptibility to the development of sinusitis

• Journal of Microbiology and Biotechnology
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• 제11권2호
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• pp.287-293
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• 2001

A fast and easy PCR-SSCP method was developed and assessed for the early detection of rifampin-resistant Mycobacterium leprae in skin biopsy samples from Korean leprosy patients. The 190 bp of the rpoB gene, in which mutation is known to cause resistance to rifampin, was amplified by PCR and then analyzed by SSCP and DNA sequencing, All PCR products showing mobility shift on PCR-SSCP contained mutations, demonstrating that this method can be used for an early diagnositic method to detect a putative rifampin-resistant M. leprae strain. DNA sequence analysis revealed that 19 of 34 patient samples contained M. leprae strains with missense mutations in the rpoB gene: five were the same mutations previously reported to cause rifampin resistance and eight were the new type of mutatios that likely cause rifampin resistance. These newly identified dmutations, whose all five cytosine bases of four amino acids were substitued with thymine, were found at different sites from those reported in Mycobacterium tuberculosis or M. leprae. Therefore, they may provide additional clues to understand the molecular biological basis on the rifampin resistance of M. leprae.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회B
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• pp.3122-3127
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• 2007

Water resource can be examined using biological sensors. Algae has been one of the biological sensors used to evaluate and monitor the water pollution. The monitoring system, however, could determine whether the examined water was safe or not. It needs additional expensive chemical test to figure out the cause of the water pollution. In this study, an endeavor is given to identify the toxicant in the water using the shape of the chlorophyll fluorescence induction curve(FIC) from algae using monitoring system. Fundamental curves are obtained from the experiments with specified amount of toxicant. Baysian method is utilized to determine the unknown toxicant in the water by comparing it with the fundamental curves. The results shows that the proposed method works fairly well.

• Environmental Analysis Health and Toxicology
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• 제2권1_2호
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• pp.43-53
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• 1987

Among the environmental toxic metals, cadmium and lead compounds are very hazard for human health because these may affect the biological function of human body and furthermore enhance the cause of various disease. In recent years, as the view of environmental toxicology, the combination of toxic metals suffering human health is especially significant cadmium chloride (10 mg/kg P. 0., 1 mg/kg I.P.) and lead acetate (20 mg/kg P.O., 2 mg/kg I.P.) were administered to rats for 4 weeks on alternate days and then examined the effect of these on body weight, tissue weight and also biochemical function in blood and tissue were investigated and comparision of the two experimental groups such as single and combined administration. According to the results of this experiment, accumulation of heavy metals increased and biological metabolic function grew worse but, in tissue, toxic effect decreased by combined administration and intraperitoneal administration was more toxic than per OS.

• Journal of Applied Biological Chemistry
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• 제44권4호
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• pp.177-179
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• 2001

Traditional wet chemical methods for testing of soil properties require extensive time and labor, and cause the discharge of pollutants, making them undesirable for routine soil analyses. This research was conducted to improve the accuracy of soil properties in soil fertility assessments. A total of 140 finely ground soil samples were used to obtain accurate calibrations and validation for estimating soil moisture, OM, and T-N. Finely ground soil samples satisfied the improved accuracy for routine NIR measuring of the field soils. The results indicated that NIR spectroscopy could be used as a routine method for quantitatively determining OM, moisture, and T-N of field soil, although this technique requires many combinations of sample pretreatments and data manipulations to obtain optimal predictions.