• The KIPS Transactions:PartD
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• v.9D no.6
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• pp.1091-1096
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• 2002

This paper presents the development of a protein interaction database. The developed system is characterized as follows. First, the proposed system not only maintains interaction data collected by an experiment, but also the genomic information of the protein data. Secondly, the system can extract details on interacting proteins through the developed wrappers. Thirdly, the system is based on wrapper-based system in order to extract the biologically meaningful data from various web sources and integrate them into a relational database. The system inherits a layered-modular architecture by introducing a wrapper-mediator approach in order to solve the syntactic and semantic heterogeneity among multiple data sources. Currently the system has wrapped the relevant data for about 40% of about 11,500 proteins on average from various accessible sources. A wrapper-mediator approach makes a protein interaction data comprehensive and useful with support of data interoperability and integration. The developing database will be useful for mining further knowledge and analysis of human life in proteomics studies.