• 한국산업보건학회지
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• 제25권1호
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• pp.20-26
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• 2015

Objectives: To evaluate the biodurability of Korean Chrysotile(KC), the changes in fibers numbers and changes in the element composition of fibers from the lung of Sprague-Dawley rats instilled KC(average size $4.74{\mu}m$, $59,043{\times}10^6$ fibers/mg) was estimated. Methods: Rats were administered 1 mg KC(low group) or 2 mg KC(high group) by a single intratracheal instillation. At each time point(5 days, 5 weeks, 10 weeks), the numbers of KC fibers and the changes of element composition(atomic %) of KC fibers from the lung of the rats were analyzed with transmission electron microscope equipped with energy dispersive X-ray spectrometer. Results: Over time, the number of fibers within the lungs of animals were reduced. The average length of the low and high group is significantly reduced from 5 days after administration. Over time, the fiber ratio of at least $5{\mu}m$ remaining in the lung tissue of the low concentration group was up but the high group was reduced. From day 5 after administration, the composition ratio(Mg) was significantly decreased in all groups. Conclusions: Size and composition of Korean Chrysotile in the lung tissue of rats was changed from 5 days.