• Journal of Sensor Science and Technology
• /
• v.30 no.3
• /
• pp.131-138
• /
• 2021

The optimization of the specifications of vertical silicon on insulator (SOI) slot optical waveguides suitable for integrated-optical biochemical sensors was performed through computational analysis of the confinement factor of the guided mode distributed in the slot in addition to analytical examination of the TE mode. The optimized specifications were confirmed based on sensitivity in terms of the change in the refractive index of the biochemical analyte. When the slot width, rail width, and height were set to 120 nm, 200 nm, and 320 nm, respectively, the confinement factor was evaluated to be about 56% and the sensitivity was at least 0.9 [RIU/nm].

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.21 no.1
• /
• pp.308-317
• /
• 2007

This study was investigated to know the correlation of complete blood count(CBC), biochemical examination and DSOM fluents(Diagnosis System of Oriental Medicine, (C)2005-01-122-004154). There are 5 fluents in DSOM such as DSOM score(病機點數), mean of the index for pathogenic factor(病機指標 平均), 5-division of DSOM score(病機點數 五點尺度), 5-division of the index for pathogenic factor(病機點數 五點尺度), weighted pathogenic factor(病機加重値).We have carried out clinical trials who volunteered for Sasang constitutional medicine and Oriental OB & GY, Oriental Medical hospital of Dong-Eui University, from May 2005 to June 2006. Volunteers were 245 persons. Because 7 persons didn't checkup DSOM, so we analyzed the results statistically for 238 persons. In the relation of CBC and DSOM, the scores(病機點數, zp) and mean of the index for Pathogenic factor(病機指標 平均, zps) showed correlation more frequently, and correlation with results of RBC, hemoglobin, hematocrit was more significant. Correlation with fluents of pathogenic factor(病機) were more significant and high in deficiency of blood(血虛), insufficiency of Yang(陽虛), coldness(寒), damp(濕), dryness(燥), kidney(腎), phlegm(痰), heat syndrom(熱), lung(肺), and was very low in spleen(脾). There was no correlation with deficiency of Yin(陰虛). If volunteers have DSOM fluents, results of RBC and RBC index was decreased(- derection), and results of RDW, ESR was increased(+ direction). But increase and decrease direction in heat syndrom(熱), lung(肺) was contrary to the others. Correlation with fluents of Pathogenic factor(病機) of WBC, platlet, PDW, MPV was not many. In the relation of biochemical examination and DSOM fluents, correlation with results of albumin, uric acid, triglyceride was more significant. If volunteers have fluents of pathogenic factor(病機), result of examination was usually decreased. Especially result of examination was decreased(- derection) highly in deficiency of blood(血虛), stagnation of (氣滯) coldness(寒), dryness(燥), and was increased(+ direction) highly in heat syndrom(熱), lung(肺). But there was a tendency to show high correlation with specific pathogenic factor (病機) and specific examination in biochemical examination.

• Journal of Sensor Science and Technology
• /
• v.30 no.6
• /
• pp.395-407
• /
• 2021

The effect of the specifications of a silicon-on-insulator vertical slot optical waveguide on the sensitivity of homogeneous and surface sensing configurations for TE and TM polarization, respectively, was systematically analyzed using numerical software. The specifications were optimized based on the confinement factor and transmission power of the TE-guided mode distributed in the slot. The waveguide sensitivities of homogeneous and surface sensing were calculated according to the specifications of the optimized slot optical waveguide.

• Korean Journal of Veterinary Service
• /
• v.16 no.2
• /
• pp.150-156
• /
• 1993

The present study was conducted to investigate the biochemical characteristics and anti-biotic resistance of pathogenic Escherichia coli (E. coli) isolated from piglets with diarrhea in Kyongbuk Western Area during the period from February to November 1992. 55 E. coli strains were isolated from 97 piglets with diarrhea and the biochemical and cultural reaction were compared with the classification criteria of Edwards and Ewing. The majority of E. coli were susceptible to amikacln, enrofloxacin and gentamicin. 51 (92.7%) out of 55 drug resistance stains carried R factor (R+) which were transferable to the recipients by conjugation.

• Journal of Sensor Science and Technology
• /
• v.31 no.2
• /
• pp.107-114
• /
• 2022

The effects of ring radius and coupling spacing on the free spectral range (FSR), full width at half maximum (FWHM), quality factor, and sensitivity of single-channel and add-drop channel slot ring resonators were systematically investigated using FIMMPROP and PICWAVE numerical software. The single-channel ring resonator exhibited better characteristics, namely, a wider FSR and narrower FWHM compared with the add-drop structure; thus, it was evaluated to be more suitable for biochemical sensors. The FSR, FWHM, quality factor, and sensitivity for a single channel ring resonator with a radius of 59.4 ㎛ and coupling gap of 0.5 ㎛ were 2.4 nm, 0.087 nm, 17677, and 550 [nm/RIU], respectively.

• Journal of Sensor Science and Technology
• /
• v.31 no.5
• /
• pp.353-359
• /
• 2022

This study investigated via computational analysis the application utility of series-cascaded ring resonators based on silicon-on-insulator (SOI) slot optical waveguides in integrated optical biochemical sensors. The radii of the two rings in the series-cascaded ring resonators were 59.4 ㎛ and 77.6 ㎛ respectively, and the coupling distance was 0.5 ㎛. The series-cascaded ring resonators were computationally analyzed using FIMMProp and PICWave numerical software. The free spectral range (FSR), full width at half maximum (FWHM), sensitivity, and quality-factor (Q-factor) of the series-cascaded ring resonators were 12.2 nm, 0.134 nm, 4100 nm/RIU, and 11580, respectively, and the measurement range was calculated to be slightly smaller than 3×10^-3 RIU. Although the measurement range was smaller than that of the single ring resonator, upon considering other characteristic parameters, the series-cascaded ring resonators are found to be more effective as integrated sensors than single ring resonators.

• Biomedical Science Letters
• /
• v.16 no.4
• /
• pp.247-258
• /
• 2010

The objective of this research was to evaluate the relationships of preoperative (Pre-OP) levels of hematological and biochemical indices to perioperative variables in patients that underwent coronary artery bypass graft surgery (CABG). Pre-OP levels of hematological factors [total white blood cells (T-WBC), erythrocytes, hemoglobin, hematocrit, glycohemoglobin A1c (HbA1c), or platelet] were negatively or positively related with biochemical indices [alanine aminotransferase (ALT), bilirubin, glucose, fructosamine, triglyceride, and high density lipoprotein cholesterol (HDL)]. Pre-OP levels of hematological factors and biochemical indices were negatively or positively correlated with echocardiographic variables. Pre-OP level of HbA1c had a relationship with C-reactive protein. Pre-OP levels of aspartate aminotransferase (AST), ALT, HDL, glucose, fructosamine, or blood urea nitrogen (BUN) were positively or negatively associated with Pre-OP levels of cardiac markers (brain natriuretic peptide, troponin-I, creatine kinase isoenzyme 2, or CRP). Pre-OP levels of hematological factors (excepting T-WBC) related with operation time (OPT), postoperative mechanical ventilation time (POMVT), intensive care unit-period (ICU-period) or hospitalization. Pre-OP levels of AST, ALT, bilirubin, triglyceride, HDL, low dwensity lipoprotein, fructosamine, or BUN were positively or negatively correlated with OPT, graft numbers, POMVT, ICU-period or hospitalization. Retrospective this study reveals that Pre-OP levels of hematological and biochemical markers are associated with echocardiographic variables, several cardiac markers and postoperative outcomes, suggesting that Pre-OP levels of hematological and biochemical markers may be useful predictors for the diagnosis and prognosis of coronary artery disease.

• Journal of Microbiology and Biotechnology
• /
• v.13 no.3
• /
• pp.344-347
• /
• 2003

Unnatural amino acid S-(2-nitrobenzyl)cysteine was incorporated into human erythropoietin by using a programmed suppression of nonsense codon in a cell-free protein synthesis system. Several controlling factors affecting the operational efficiency of the suppression were investigated and optimized. The amount of suppressor tRNA and the concentration of $Mg^2+$ were crucial not only for the efficiency but also for the control of the exact suppression. In addition, some general optimization factor are reported in order to improve the efficiency in an unnatural amino acid mutagenesis.

• Journal of the East Asian Society of Dietary Life
• /
• v.22 no.2
• /
• pp.219-223
• /
• 2012

The purpose of this study was to investigate the body composition, biochemical parameters, and consumption of convenience foods according to leptin receptor polymorphism in university students. A survey was conducted on a total of 418 students - 271 males and 147 females. Based on a self-reporting method, questionnaires were administered for over 20 minutes, and leptin receptor and blood samples were analyzed. The genotype frequencies of leptin receptor polymorphism were Gln/Arg heterozygote (64.8%) and Gln/Gln homozygote (35.2%). Leptin polymormphism showed no significant association with biochemical parameters(ALT, cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, and hemoglobin) and body composition. GG homozygote was associated with a higher risk of visceral fat obesity compared to those with GA heterozygote (odd ratio 1.758, 95% confidence intervals 0.812~3.803). Leptin polymorphism appeared to be a genetic risk factor for visceral fat obesity. This study suggests that leptin polymorphism has a causative role to body fat distribution in Korean.

• Biotechnology and Bioprocess Engineering:BBE
• /
• v.10 no.2
• /
• pp.128-135
• /
• 2005

Mixed-mode hydrophobic/ionic matrices exhibit a salt-tolerant property for adsorbing target protein from high-ionic strength feedstock, which allows the application of undiluted feedstock via an expanded bed process. In the present work, a new type of mixed-mode adsorbent designed for expanded bed adsorption, Fastline $PRO^{\circledR}$, was challenged for the capture of nattokinase from the high ionic fermentation broth of Bacillus subtilis. Two important factors, pH and ion concentration, were investigated with regard to the performance of nattokinase ad-sorption. Under initial fermentation broth conditions (pH 6.6 and conductivity of 10 mS/cm) the adsorption capacity of nattokinase with Fastline PRO was high, with a maximum capacity of 5,350 U/mL adsorbent. The elution behaviors were investigated using packed bed adsorption experiments, which demonstrated that the effective desorption of nattokinase could be achieved by effecting a pH of 9.5. The biomass pulse response experiments were carried out in order to evaluate the biomass/adsorbent interactions between Bacillus subtilis cells and Fastline PRO, and to demonstrate a stable expanded bed in the feedstock containing Bacillus subtilis cells. Finally, an EBA process, utilizing mixed-mode Fastline PRO adsorbent, was optimized to capture nattokinase directly from the fermentation broth. The purification factor reached 12.3, thereby demonstrating the advantages of the mixed-mode EBA in enzyme separation.