• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.401-401
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• 2005

• Proceedings of the Korean Society of Applied Pharmacology
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• 2003.11a
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• pp.27-28
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• 2003

Obesity is one of the most serious problems in human life which may cause various diseases, i.e., cancer, hypertension and diabetes. The biochemical and clinical researches on this issue have been widely studied worldwide, and the mechanism and improvement of obesity have been gradually clarified. In this workshop, three distinguished speakers from clinical, biochemical and pharmaceutical development fields have been invited. Professor Yasushi Saito is a high prestigious worldwide in terms of the study of obesity.

• Bulletin of the Korean Chemical Society
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• v.25 no.8
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• pp.1123-1124
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• 2004

• Proceedings of the Korean Society of Life Science Conference
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• 2007.10a
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• pp.26.1-26.1
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• 2007

See Full Text

• Proceedings of the Zoological Society Korea Conference
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• 1999.10b
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• pp.230.2-230
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• 1999

No Abstract, See Full Text

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.176.1-176.1
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• 2003

Bradykinin is an autocoid related to acute and chronic pain and inflammation. The non-peptide bradykinin antagonists are of interest as novel anti-inflammatory therapeutics. To understand the structural basis for the bradykinin antagonistic activity and to guide the design of more potent compounds we analysed the three dimensional pharmacophore model. Seven active compounds very recently reported such as FR 167344, FR 173657, LF 160687, and bradyzide were used as our pharmacophore model analysis. (omitted)

• Biotechnology and Bioprocess Engineering:BBE
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• v.7 no.3
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• pp.138-149
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• 2002

Plant cell culture provides a viable alternative over whole plant cultivation for the production of secondary metabolites. In order to successfully cultivate the plant cells at large scale, several engineering parameters such as, cell aggregation, mixing, aeration, and shear sensitivity are taken into account for selection of a suitable bioreactor. The media ingredients, their concentrations and the environmental factors are optimized for maximal synthesis of a desired metabolite. Increased productivity in a bioreactor can be achieved by selection of a proper cultivation strategy (batch, fed-batch, two-stage etc.), feeding of metabolic precursors and extraction of intracellular metabolites. Proper understanding and rigorous analysis of these parameters would pave the way towards the successful commercialization of plant cell bioprocesses.

• 한국생물공학회:학술대회논문집
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• 2005.04a
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• pp.227-227
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• 2005

• 한국생물공학회:학술대회논문집
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• 2005.04a
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• pp.223-223
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• 2005

• Natural Product Sciences
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• v.16 no.4
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• pp.228-232
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• 2010

Bioactivity-guided fractionation using on-line HPLC biochemical detection system on $CHCl_3$-soluble fraction of Lycoris radiata led to the isolation of deoxylycorenine (1), O-demethylhomolycorine (2), galanthamine (3), lycoramine (4), mixture of $6{\alpha}$-and $6{\beta}$-haemanthidine (5), and lycorine (6), identified by spectroscopic data and physicochemical property. Among the isolated compounds, 1, 3 and 6 showed acetylcholinesterase inhibitiory activities with $IC_{50}$ values of 18.0, 12.0 and $16.6\;{\mu}M$, respectively, in in vitro colorimetric microplate assay.