• Smart Structures and Systems
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• 제8권1호
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• pp.53-67
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• 2011

Human state in human-machine systems highly affects the overall system performance, and should be detected and monitored. Physiological cues are essential indicators of human state and useful for the purpose of monitoring. The study presented in this paper was focused on developing a bio-inspired sensing system, i.e., Nano-Skin, to non-intrusively measure physiological cues on human-machine contact surfaces to detect human state. The paper is presented in three parts. The first part is to analyze the relationship between human state and physiological cues, and to introduce the conceptual design of Nano-Skin. Generally, heart rate, skin conductance, skin temperature, operating force, blood alcohol concentration, sweat rate, and electromyography are closely related with human state. They can be measured through human-machine contact surfaces using Nano-Skin. The second part is to discuss the technologies for skin temperature measurement. The third part is to introduce the design and manufacture of the Nano-Skin for skin temperature measurement. Experiments were performed to verify the performance of the Nano-Skin in temperature measurement. Overall, the study concludes that Nano-Skin is a promising product for measuring physiological cues on human-machine contact surfaces to detect human state.

• 한국정보통신학회논문지
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• 제16권11호
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• pp.2557-2562
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• 2012

세포에서 질서를 유지하기 위해서는 유전정보에 대한 지속적인 감시와 회복체계를 필요로 한다. DNA는 염기쌍의 결합으로 이루어지는데, 틀린 염기쌍이 정상적인 염기쌍보다 훨씬 낮은 빈도로 형성되지만, 이것이 수정되지 않고 DNA내에 축적될 경우 세포가 죽기도 한다. 본 연구에서는 DNA 복제 시 발생하는 실수, 손상된 부분을 회복하는 DNA 복구 기능을 모사하여 공학적인 개념을 도입한다. 기존에 발표 되었던 부분을 보완하여 여러 군데에서 발생한 오류 위치를 찾아내고 복구시키는 효율적인 알고리즘을 제시한다.

• 정보처리학회논문지D
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• 제17D권3호
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• pp.175-184
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• 2010

최근 DNA 칩의 등장으로 유전자 관련 실험과 연구가 매우 용이해졌으며 이를 활용한 다양한 실험 결과로 대량의 데이터가 제공되고 있다. DNA칩에 의해 제공된 데이터는 2차원 행렬로 표현되며 하나의 축은 유전자를 나타내고 다른 하나의 축은 샘플정보를 나타낸다. 이러한 데이터에 대하여 빠른 시간 안에 좋은 품질의 군집화를 수행함으로써 이후의 분석 단계인 분류화 작업의 정확도와 효율성을 높일 수 있다. 본 논문에서는 생태계 모방 알고리즘의 하나인 Particle Swarm Optimization 알고리즘을 사용하여 방대한 양의 DNA칩 데이터에 대한 효율적인 군집화 기법을 제안하였으며 실험을 통해서 PSO 기반의 군집화 알고리즘이 기존의 군집화 알고리즘들보다 수행속도 및 품질 면에서 우수한 성능을 가짐을 보였다.

• 한국태양에너지학회:학술대회논문집
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• 한국태양에너지학회 2012년도 춘계학술발표대회 논문집
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• pp.410-413
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• 2012

A traditional fabrication method is very difficult to make small robots using embedded sensors, actuators and connectors. Fortunately, Shape Deposition Manufacturing can provide an alternative method, and it has many benefits. Firstly, the weight of robot can be lighter, as it can be consisted of composite materials. Secondly, SDM can make simple robot structures because this approach does not need to use connectors and fasteners. Lastly, SDM gives stiffness and flexibility at the specific parts. Therefore, in this paper, we present a design of 3 segment legs organized by SDM, what the SDM approach is, and compare SDM method with 3 segment prototype legs which uses a traditional approach and made by DGIST.

• 센서학회지
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• 제17권1호
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• pp.15-22
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• 2008

When designing image sensors including a CMOS vision chip for edge detection, resolution is a significant factor to evaluate the performance. It is hard to improve the resolution of a bio-inspired CMOS vision using a resistive network because the vision chip contains many circuits such as a resistive network and several signal processing circuits as well as photocircuits of general image sensors such as CMOS image sensor (CIS). Low resolution restricts the use of the application systems. In this paper, we improve the resolution through layout and circuit optimization. Furthermore, we have designed a printed circuit board using FPGA which controls the vision chip. The vision chip for edge detection has been designed and fabricated by using $0.35{\mu}m$ double-poly four-metal CMOS technology, and its output characteristics have been investigated.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2000년도 춘계학술대회
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• pp.6-7
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• 2000

Recently, free radicals such as active oxygen species, nitric oxide, etc are believed to be one of the key substances in physiological and pathological, toxicological phenomena, and oxidative damages, and all organism have defencing system against such as free radicals. Formation and extinction of free radicals may be regulated through bio-redox system, in which various enzymes and compounds should be involved in very complicated manner. Thus, direct and non-invasive measurement of in vivo free radical reactions with living animals must be essential to understand the role of free radicals in pathophysiological phenomena. Electron spin resonance spectroscopy (ESR) is very selective and sensitive technique to detect free radicals, but a conventional ESR spectrometer has large detect in application to living animals, since high frequent microwave is absorbed with water, resulting in generation of high fever in living body. In order to estimate in vivo free radical reactions in living whole animals, we develop in vivo ESR-CT technique using nitroxide radicals as spin probes. Nitroxide radicals and their reduced forms, hydroxylamines, are known to interact with various redox systems. We found that! ! the signal decay due to reduction of nitroxyl radicals is influenced by aging, inspired oxygen concentration, ischemia-referfusion injury, radiation, etc. In the present paper, I will introduce in vivo ESR technique and my laboratory recent results concerning non-invasive evaluation of free radical reactions in living mice.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
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• pp.229.1-229.1
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• 2014

Tactile sensors have widely been researched in the areas of electronics, robotic system and medical tools for extending to the form of bio inspired devices that generate feeling of touch mimicking those of humans. Recent efforts in adapting the tactile sensor have included the use of novel materials with both scalability and high sensitivity [1]. Graphene, a 2-D allotrope of carbon, is a prospective candidate for sensor technology, having strong mechanical properties [2] and flexibility, including recovery from mechanical stress. In addition, its truly 2-D nature allows the formation of continuous films that are intrinsically useful for realizing sensing functions. However, very few investigations have been carrier out to investigate sensing characteristics as a device form with the graphene subjected to strain/stress and pressure effects. In this study, we present a sensor of vertical forces based on single-layer graphene, with a working range that corresponds to the pressure of a gentle touch that can be perceived by humans. In spite of the low gauge factor that arises from the intrinsic electromechanical character of single-layer graphene, we achieve a resistance variation of about 30% in response to an applied vertical pressure of 5 kPa by introducing a pressure-amplifying structure in the sensor. In addition, we demonstrate a method to enhance the sensitivity of the sensor by applying resistive single-layer graphene.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2012년도 추계학술대회
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• pp.293-297
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• 2012

세포에서 질서를 유지하기 위해서는 유전정보에 대한 지속적인 감시와 회복체계를 필요로 한다. DNA는 염기쌍의 결합으로 이루어지는데, 틀린 염기쌍이 정상적인 염기쌍보다 훨씬 낮은 빈도로 형성되지만, 이것이 수정되지 않고 DNA내에 축적될 경우 세포가 죽기도 한다. 본 연구에서는 DNA 복제 시 발생하는 실수, 손상된 부분을 회복하는 DNA 복구 기능을 모사하여 공학적인 개념을 도입한다. 기존에 발표 되었던 부분을 보완하여 여러 군데에서 발생한 오류 위치를 찾아내고 복구시키는 효율적인 알고리즘을 제시한다.

• 대한기계학회논문집A
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• 제32권10호
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• pp.844-849
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• 2008

We present a novel cell deformability monitoring chip based on the digitally measured cell lysis rate which is dependent on the areal strain of the cell membrane. This method offers simple cell deformability monitoring by automated high-throughput testing system. We suggest the filter design considering the areal strain imposed on the cell membrane passing through the filter array having gradually increased orifice length. In the experiment using erythrocytes, we characterized the cell deformability in terms of average fracture areal strain which was $0.24{\pm}0.014\;and\;0.21{\pm}0.002$ for normal and chemically treated erythrocytes, respectively. We also verified that the areal strain of 0.15 effectively discriminates the deformability difference of normal and chemically treated erythrocytes, which can be applied to the clinical situation. We compared the lysis rates and their difference for the samples from different donors and found that the present chips can be commonly used without any calibration process. The experimental results demonstrate the simple structure and high performance of the present cell deformability monitoring chips, applicable to simple and cost-effective cell aging process monitoring.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권5호
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• pp.1286-1302
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• 2012

In this paper, the resource allocation problem with proportional fairness rate in cognitive OFDM-based wireless network is studied. It aims to maximize the total system throughput subject to constraints that include total transmit power for secondary users, maximum tolerable interferences of primary users, bit error rate, and proportional fairness rate among secondary users. It is a nonlinear optimization problem, for which obtaining the optimal solution is known to be NP-hard. An efficient bio-inspired suboptimal algorithm called immune clonal optimization is proposed to solve the resource allocation problem in two steps. That is, subcarriers are firstly allocated to secondary users assuming equal power assignment and then the power allocation is performed with an improved immune clonal algorithm. Suitable immune operators such as matrix encoding and adaptive mutation are designed for resource allocation problem. Simulation results show that the proposed algorithm achieves near-optimal throughput and more satisfying proportional fairness rate among secondary users with lower computational complexity.