• Genomics & Informatics
• /
• 제12권2호
• /
• pp.76-78
• /
• 2014

Owing to the generation of vast amounts of sequencing data by using cost-effective, high-throughput sequencing technologies with improved computational approaches, many putative proteins have been discovered after assembly and structural annotation. Putative proteins are typically annotated using a functional annotation system that uses extant databases, but the expansive size of these databases often causes a bottleneck for rapid functional annotation. We developed SFannotation, a simple and fast functional annotation system that rapidly annotates putative proteins against four extant databases, Swiss-Prot, TIGRFAMs, Pfam, and the non-redundant sequence database, by using a best-hit approach with BLASTP and HMMSEARCH.

• 한국정보처리학회:학술대회논문집
• /
• 한국정보처리학회 2015년도 추계학술발표대회
• /
• pp.1141-1143
• /
• 2015

데이터베이스 보안은 외부자나 내부자가 데이터베이스 및 데이터베이스 내에 저장된 데이터를 비인가 된 변경, 파괴, 노출 및 비 일관성을 발생시키는 사건이나 위협들로부터 보호하는 것이다. 이러한 DB의 보안위협들은 사용자의 실수, 오용, 내부자의 권한 남용, 비정상적인 접근행위 등 DB에 대해 알려진 보안 취약점들로부터 발생한다. 본 연구에서는 데이터베이스 보안의 고려사항과 연구동향에 대해 살펴보고 현재 데이터베이스 분야에서 보안이 적용된 시스템에 대해 분석하고 취급되는 정보보호의 중요성에 대해 고찰한다.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2008년도 제39회 하계학술대회
• /
• pp.1733-1734
• /
• 2008

We develope a riding robot system named as "RideBot" for health-care and entertainments. An algorithm for estimating riding position and volition is proposed by using bio-signals. We analyze the riding position and volition in real-horse riding environments and build up the database. With this database and sensor informations, standard positions are made. For the volition estimation, we use the acceleration and deceleration sensor information and bridle information for direction change. We propose a hybrid control algorithm in which discrete-state and continuous-state controls are combined. The efficiency of the proposed algorithm is evaluated thru various experiments.

• Genomics & Informatics
• /
• 제4권4호
• /
• pp.173-181
• /
• 2006

Pattern finding is one of the important tasks in a protein or DNA sequence analysis. Alignment is the widely used technique for finding patterns in sequence analysis. BLAST (Basic Local Alignment Search Tool) is one of the most popularly used tools in bio-informatics to explore available DNA or protein sequence databases. BLAST may generate a huge output for a large sequence data that contains various sequence patterns. However, BLAST does not provide a tool to summarize and analyze the patterns or matched alignments in the BLAST output file. BLAST lacks of general and robust parsing tools to extract the essential information out from its output. This paper presents a pattern summary system which is a powerful and comprehensive tool for discovering pattern structures in huge amount of sequence data in the BLAST. The pattern summary system can identify clusters of patterns, extract the cluster pattern sequences from the subject database of BLAST, and display the clusters graphically to show the distribution of clusters in the subject database.

• Interdisciplinary Bio Central
• /
• 제5권1호
• /
• pp.2.1-2.3
• /
• 2013

Birth and development of information biology are introduced with its definition and scientific basis. The discipline lives on the two types of nutrition, one is a huge amount of biological data on genomes, gene expressions, proteomes, protein 3D structures, protein networks, and so forth. The other is the method of using them on a computer. The scientific basis of the two is evolution. To collect genome and gene expression data form laboratories in the world, annotate and dissimilate back to researchers worldwide, they built the EMBL database in Europe in 1982, GenBank in USA in 1984 and DNA Data Bank of Japan in 1987. On the other hand, the methods of using and analyzing those data have accordingly been developed. The two aspects advance the discipline further and further.

• Bulletin of the Korean Chemical Society
• /
• 제29권8호
• /
• pp.1479-1484
• /
• 2008

Protein tyrosine phosphatase (PTP) 1B is the superfamily of PTPs and a negative regulator of multiple receptor tyrosine kinases (RTKs). Inhibition of protein tyrosine phosphatase 1B (PTP1B) has been proposed as a strategy for the treatment of type 2 diabetes and obesity. Recently, it has been reported that amentoflavone, a biflavonoid extracted from Selaginella tamariscina, inhibited PTP1B. In the present study, docking model between amentoflavone and PTP1B was determined using automated docking study. Based on this docking model and the interactions between the known inhibitors and PTP1B, we determined multiple pharmacophore maps which consisted of five features, two hydrogen bonding acceptors, two hydrogen bonding donors, and one lipophilic. Using receptor-oriented pharmacophore-based in silico screening, we searched the biflavonoid database including 40 naturally occurring biflavonoids. From these results, it can be proposed that two biflavonoids, sumaflavone and tetrahydroamentoflavone can be potent allosteric inhibitors, and the linkage at 5',8''-position of two flavones and a hydroxyl group at 4'-position are the critical factors for their allosteric inhibition. This study will be helpful to understand the mechanism of allosteric inhibition of PTP1B by biflavonoids and give insights to develop potent inhibitors of PTP1B.

• Interdisciplinary Bio Central
• /
• 제3권1호
• /
• pp.4.1-4.7
• /
• 2011

Forty-seven wild accessions of Lotus japonicus Regal (Japanese trefoil) indigenous to Japan were investigated for nine morphological characters. Average temperature and annual precipitation were negatively correlated with stem color and seed weight. On the other hand, latitude was positively correlated with these traits. Consequently, accessions from sites at higher latitudes with low temperatures and precipitation tend to have dark red stems and heavy seeds. Cluster analysis based on nine morphological characters classified 47 wild accessions into six major groups. Cluster I included four accessions of tall and erect plants. These plants are phenotypically similar to commercial variety 'Empire'. Cluster II consisted of three accessions of creep plants with pale red stems. Cluster III contained 24 accessions that had average values for all morphological characters evaluated. Cluster IV included two accessions of erect plants with rounded leaflets and dark red stems. Cluster V included four accessions of small, creep plants with pale red stems. Cluster VI included seven accessions of small and erect plants, a phenotype that also applies to ?Gifu B-129?, which is used as experimental strain worldwide. These data were deposited into LegumeBase, an online database (http://www.legumebase.brc.miyazaki-u.ac.jp/) supported by the National BioResource Project (NBRP) in Japan.

• 한국정보전자통신기술학회논문지
• /
• 제5권1호
• /
• pp.45-51
• /
• 2012

본 논문은 사용자의 생체 정보(맥박, 이완기 혈압, 수축기 혈압, 혈당)를 무선 센서들을 통하여 획득한 후 스트레스 지수에 따른 감성을 인식하여 대응되는 컬러와 음원을 분류하는 시스템으로서, 맥박 센서, 혈압 센서, 혈당 센서 등의 입력치를 받아 데이터베이스에 저장한 후 다중 SVM(Support Vector Machine) 알고리즘을 이용하여 스트레스 지수에 따른 감성을 분류한다. 2,000개의 데이터 집합을 사용하여 다중 SVM 알고리즘을 학습한 결과 약 87.7%의 정확도를 가졌다.

• 한국의류학회지
• /
• 제37권3호
• /
• pp.348-356
• /
• 2013

Denim washing is processed with different washing techniques such as stone washing, chemical washing, sand washing, and bio washing. Cellulase bio washing can meet environmental regulations that enhance and rectify problems associated with traditional decolorization techniques; however, stone washing needs to be added to the processing because it produces a low decolorization effect. There is also the problem of additional strength reduction. To prevent these problems, a new enzyme for bio washing is required. This study examines the optimum laccase treatment conditions on denim and evaluated the characteristics of laccase-treated denims to establish a database of eco-friendly new decolorization process on denim using a new laccase enzyme. The results show that the optimum conditions of laccase on denim are a pH of 4.0, $30^{\circ}C$, 7% (o.w.f.), and 6 hours in 10 mM of buffer concentration. UV absorbance and HPLC identified isatin coexist with anthranilic acid in solution after laccase treatment on denim. Results of the surface color, the surface morphology and the tensile strength indicate that laccase treatment shows an excellent decolorization effect without fiber damage. The wet cleaning fastness and the perspiration fastness also improved.

• Journal of Microbiology and Biotechnology
• /
• 제16권2호
• /
• pp.178-183
• /
• 2006

Microbes are one of the most important bioresources in bioindustry and provide high economic values. Although there are currently about 6,000 bacterial species with validly published names, microbiologists generally assume that the number may account for less than 1% of the bacterial species present on Earth. To discover the remaining species, studies of metagenomes, metabolomes, and proteomes related to microbes have recently been carried out in various fields. We have constructed an information system that integrates various data on microbial resources and manages bioinformation to support efficient research of microorganisms. We have designated this system 'Bio-Meta Information System (Bio-MIS).' Bio-MIS consists of an integrated microbial resource database, a microbial resource input system, an integrated microbial resource search engine, a microbial resource online distribution system, a portal service, and management via the Internet. In the future, this system is expected to be connected with various public databases. We plan to implement useful bioinformatics software for analyzing microbial genome resources. The Web site is accessible at http://biomis.probionic.com.