• Journal of The Korean Society of Clinical Toxicology
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• v.14 no.1
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• pp.16-25
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• 2016

Purpose: Patients suffering from acute poisoning by different substances often visit the emergency department (ED) and receive various prognoses according to the toxic material and patients' condition. Hyperlactatemia, which is an increased blood lactate level that generally indicates tissue hypoperfusion, is commonly utilized as a prognostic marker in critically ill patients such as those with sepsis. This study was conducted to investigate the relationships between blood lactate and clinical prognosis in acute poisoned patients. Methods: This retrospective study was conducted from January 2013 to June 2014 at a single and regional-tertiary ED. We enrolled study patients who were examined for blood test with lactate among acute intoxicated patients. The toxic materials, patient demographics, laboratory data, and mortalities were also reviewed. Additionally, we analyzed variables including blood lactate to verify the correlation with patient mortality. Results: A total of 531 patients were enrolled, including 24 (4.5%) non-survivors. Patient age, Glasgow coma scale (GCS), serum creatinine (Cr), aspartate transaminase (AST), and serum lactate differed significantly between survivors and non-survivors in the binary logistic regression analysis. Among these variables, GCS, AST, and lactate differed significantly. The median serum lactate levels were 2.0 mmol/L among survivors and 6.9 mmol/L among non-survivors. The AUC with the ROC curve and odds ratio of the initial serum lactate were 0.881 and 3.06 (0.89-8.64), respectively. Conclusion: Serum lactate was correlated with fatalities of acute poisoning patients in the ED; therefore, it may be used as a clinical predictor to anticipate their prognoses.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8893-8900
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• 2014

Dysregulated expression of microRNAs (miRNAs) has been shown to be closely associated with tumor development, progression, and carcinogenesis. However, their clinical implications for gastric cancer remain elusive. To investigate the hypothesis that genome-wide alternations of miRNAs differentiate gastric cancer tissues from those matched adjacent non-tumor tissues (ANTTs), miRNA arrays were employed to examine miRNA expression profiles for the 5-pair discovery stage, and the quantitative real-time polymerase chain reaction (qRTPCR) was applied to validate candidate miRNAs for 48-pair validation stage. Furthermore, the relationship between altered miRNA and clinicopathological features and prognosis of gastric cancer was explored. Among a total of 1,146 miRNAs analyzed, 16 miRNAs were found to be significantly different expressed in tissues from gastric cancer compared to ANTTs (p<0.05). qRT-PCR further confirmed the variation in expression of miR-193b and miR-196a in the validation stage. Down-expression of miR-193b was significantly correlated with Lauren type, differentiation, UICC stage, invasion, and metastasis of gastric cancer (p<0.05), while over-expression of miR-196a was significantly associated with poor differentiation (p=0.022). Moreover, binary logistic regression analysis demonstrated that the UICC stage was a significant risk factor for down-expression of miR-193b (adjusted OR=8.69; 95%CI=1.06-56.91; p=0.043). Additionally, Kaplan-Meier survival curves indicated that patients with a high fold-change of down-regulated miR-193b had a significantly shorter survival time (n=19; median survival=29 months) compared to patients with a low fold-change of down-regulated miR-193b (n=29; median survival=54 months) (p=0.001). Overall survival time of patients with a low fold-change of up-regulated miR-196a (n=27; median survival=52 months) was significantly longer than that of patients with a high fold-change of up-regulated miR-196a (n=21; median survival=46 months) (p=0.003). Hence, miR-193b and miR-196a may be applied as novel and promising prognostic markers in gastric cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8969-8974
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• 2014

Background: The aim of this study was to determine the predictors of health promoting lifestyle behaviour among medical students attending seven of the medical schools in Turkey. Materials and Methods: This crosssectional descriptive study was performed during the second semester of the first and last (sixth) years of study from March to May 2011. A questionnaire with two sections was specifically designed. The first section contained questions on demographic characteristics; the second consisted of the Health Promoting Lifestyle Profile II (HPLP) Scale. From a total of 2,309 medical students, 2,118 (response rate 91.7%) completed the questionnaire. Data were analyzed using descriptive statistics, t, Anova, Tukey test and binary logistic regression analysis. The research was approved by the Ethics Committee of Erciyes University. Results: The mean age was $20.7{\pm}2.9$ years and it was found that 55.1% were men, 62.3% were in the first year. The overall prevalence of smoking was 19.1%, and for drinking alcohol was 19.4%. HPLP point averages of the first year students were $129.2{\pm}17.7$, and for last year $125.5{\pm}19.0$. The overall mean score for the HPLP II was $2.5{\pm}0.4$. They scored highest on the spiritual growth subscale ($2.9{\pm}0.5$), interpersonal relations ($2.8{\pm}0.5$), health responsibility subscale ($2.3{\pm}0.5$), nutrition subscale ($2.3{\pm}0.5$), stress management subscale ($2.3{\pm}0.4$), and the lowest subscale physical activity ($2.0{\pm}0.5$). It is established that student's grade, educational level of parents, economic status of family, marital status, smoking and general health perception of the students resulted in a significant difference in HPLP Scale total score average and the mean score of majority of subscales. There was no statistically significant difference between the total HPLP when evaluated for gender, chronic disease, alcohol drinking status and BMI. Conclusions: Based on these results, particularly in the curriculum of medical students in order to increase positive health behaviours including physical activity, health promotion issues, and giving more space to aim at behaviour change in these matters is recommended.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.619-624
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• 2013

Background: Colorectal cancer (CRC) exists in a more common sporadic form and less common hereditary forms, associated with the Lynch syndrome, familial adenomatous polyposis (FAP) and other rare syndromes. Sporadic CRC is believed to arise as a result of close interaction between environmental factors, including dietary and lifestyle habits, and genetic predisposition factors. In contrast, hereditary forms such as those related to the Lynch syndrome result from inheritance of germline mutations of mismatch repair (MMR) genes. However, in certain cases, the influence of low penetrance alleles in familial colorectal cancer susceptibility is also undeniable. Aim: To investigate the genotype frequencies of MLH1 promoter polymorphism -93G>A and to determine whether it could play any role in modulating familial and sporadic CRC susceptibility risk. Methods: A case-control study comprising of 104 histopathologically confirmed CRC patients as cases (52 sporadic CRC and 52 Lynch syndrome patients) and 104 normal healthy individuals as controls was undertaken. DNA was extracted from peripheral blood and the polymorphism was genotyped employing PCR-RFLP methods. The genotypes were categorized into homozygous wild type, heterozygous and homozygous variants. The risk association between these polymorphisms and CRC susceptibility risk was calculated using binary logistic regression analysis and deriving odds ratios (ORs). Results: When risk association was investigated for all CRC patients as a single group, the heterozygous (G/A) genotype showed a significantly higher risk for CRC susceptibility with an OR of 2.273, (95%CI: 1.133-4.558 and p-value=0.021). When analyzed specifically for the 2 types of CRC, the heterozygous (G/A) genotype showed significantly higher risk for sporadic CRC susceptibility with and OR of 3.714, (95%CI: 1.416-9.740 and p-value=0.008). Despite high OR value was observed for Lynch syndrome (OR: 1.600, 95%CI: 0.715-3.581), the risk was not statistically significant (P=0.253). Conclusion: Our results suggest an influence of MLH1 promoter polymorphism -93G>A in modulating susceptibility risk in Malaysian CRC patients, especially those with sporadic disease.

• Journal of Korea Technology Innovation Society
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• v.17 no.3
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• pp.604-628
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• 2014

We analyse the impact of R&D cooperation on Industrial R&D programs of Government (Ministry of Trade, Industry & Energy, MOTIE), specially performance differentiating between type of R&D partners, type of R&D project leader organizations. And considering five performance measures: paper, patent, technology transfer, commercialization, new employment. Using data on a large sample of post-performance survey of MOTIE in Korea (2013), we examine the impact of R&D cooperation in 2008-2012. The method of analysis is binary logistic regression models operated by SPSS. The results of this study are follows; the performance is statistically significantly different between type of R&D partners, type of R&D project leader organizations on R&D cooperation. Specially, when a private enterprise cooperate with non-profit institutions, performance has a greater success of paper, patent, new employment. On the other hand, when a private enterprise cooperate with a private enterprise cooperate, performance decrease success of paper, technology transfer. Lastly, when non-profit institutions cooperate with a private enterprise, performance has a greater success of patent, technology transfer.

• Journal of Sasang Constitutional Medicine
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• v.20 no.1
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• pp.56-66
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• 2008

1. Objectives and Methods This study was performed to investigate the relationship between Sasang constitution and decision making style. Subjects were 69 men and 45 women. Decision making style score, physical measurements and results were measured and analyzed according to Sasang constitution. 2. Results Soeumin group had significantly high score in rational score compared with those of Soyangin. Soyangin group had significantly high score in intuitive score compared with those of Soeumin. Soeumin group had significantly high score in dependent score compared with those of Taeeumin. According to binary logistic regression analysis for decision making style score, Sasang constitution were significant risk factors and ORs of Taeeumin were significantly higer than those of Soyangin in rational score, ORs of Soyangin were significantly higer than those of Soeumin in intuitive score, and ORs of Soeumin were significantly higer than those of Taeeumin in dependent Score. 3. Conclusions Soyangin had significantly high score in intuitive score. Soeumin had significantly high score in dependent score. We found many evidences that Soyangin is intuitive style and Soeumin dependent style in the text of ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$ and other research. But as far as Taeeumin was concerned, the result of Taeeurnin’s was not coincident with other research. More cases and research were needed to confirm the personality and phychological type of Taeeumin. This study result will be an important method that classify Sasang Costitution and consultation of student career decision making and studying attitude.

• Journal of dental hygiene science
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• v.15 no.3
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• pp.318-324
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• 2015

The purpose of this study is to provide the basic date which is increase the number of revisits for scaling after analyzing factors that influence trend of dental revisits for 7 years. Research data was about 1,471 patients who visited S dental clinic in Seoul at 2007 for scaling. Data from January 2007 to December 2013 was collected. The subjects were divided into 3 groups by their trend in number of dental revisits for scaling: once, 2 times, 3~7 times. The data were analyzed using the chi-squire, independent-samples t-test and one-way ANOVA, binary logistic regression analysis. As a result, the trend of dental revisit for scaling is significantly decreased from first time to second time, and after 3rd time dental revisits were steadily continued. Factors affecting dental revisits for scaling are distance, family hospital, systemic disease, presence or absence of periodontal therapy. According to the results of the study, providing dental service in accordance with the patients' characteristics and increasing the dental revisits for scaling could give a positive influence to improvement of oral health.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.7863-7869
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• 2015

Purpose: To Examine the status of health behavior and identify the influencing factors of health behavior among pregnant women. Method: The participants were 1011 pregnant women who visited outpatient hospital of in Yanbian, China. Participants were interviewed using Chinese version of Edinburgh Postnatal Depression Scale(EPDS), Perceived Social Supports(PSSS), general self-efficacy, and characteristics. Descriptive statistics, t-test, ANOVA, pearson correlation coefficient, binary logistic regression were used for data analysis with SPSS 19.0. Results: The mean score of health behavior was $28.93{\pm}6.59$ scores(0~45 scores). Antepartum depression(OR=0.94[0.90-0.98]), perceived social supports(OR=1.07[1.05-1.09]), self-efficacy(OR=1.36[1.04-1.79]) were predictor of health behavior among pregnant women, on the contrary to this the characteristics of pregnant women were not statistically significant. Conclusion: The implement of the health behavior among pregnant women was not ideal. It's necessary to develop a health behavior intervention focus on antepartum depression, social support, and self-efficacy for pregnant women.

• Journal of Korean Society of Transportation
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• v.30 no.2
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• pp.43-52
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• 2012

A lane departure warning system (LDWS) is an effective technology-based countermeasure for preventing traffic crashes as it provides warning information to drivers. Understanding the characteristics of perception and satisfaction levels on LDWS is fundamental for deriving better performance and functionality enhancements of the system. The purpose of this study is to evaluate the user satisfaction of LDWS. A survey to collect user perception and user preference data was conducted. Both cross-tabulation analysis and binary logistic regression technique were adopted to identify the factors affecting user satisfaction for LDWS. The results revealed that the accuracy and timeliness of warning information was significant for evaluating the effectiveness of LDWS. In particular, the warning accuracy at a curve segment on the road was the most dominant factor affecting user satisfaction. The outcome of this study would be valuable in evaluating and designing LDWS functionalities.

• Korean Journal of Family Social Work
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• no.55
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• pp.129-156
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• 2017

The study was conducted to identify factors that affect the first childbearing decisions among married working women in South Korea and thereby to gain insight into effective ways to improve relatively low fertility and unfavorable workplace conditions for women of childbearing age. This study used the merged data(1st-5th waves) from Korean Longitudinal Survey of Women and Families (KLoWF), which were measured by the Korean Women's Development Institute. With 1,020 married business women, cross tab and binary logistic regression were conducted to determine which factors were significantly associated with the first childbearing decisions.