• Journal of Life Science
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• v.27 no.11
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• pp.1340-1348
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• 2017

Sanguinarine is a benzophenanthridine alkaloid derived from the roots of Sanguinaria canadensis L., which is used for the purpose of treating various diseases. Although studies of anticancer activities have been performed using various cancer cell lines, the phenomenon of inducing apoptosis in cancer cells by using sanguinarine requires more research. Therefore, this study investigated the anti-cancer activities and related mechanisms of sanguinarine used with Hep3B human hepatocellular carcinoma cells in terms of the regulation of apoptosis. Sanguinarine inhibited the proliferation of Hep3B cells in a concentration-dependent manner, which was associated with the induction of apoptosis. Sanguinarine also increased the activity of caspase-3, which is a typical effector caspase, and the activities of caspase-8 and caspase-9, which are key when initiating extrinsic and intrinsic apoptosis pathways, respectively. In addition, sanguinarine increased the expression of death receptor-related genes and pro-apoptotic BAX, which belongs to the Bcl-2 family, while suppressing the expression of anti-apoptotic Bcl-2. Sanguinarine promoted the truncation of Bid and enhanced the release of cytochrome c from the mitochondria to the cytoplasm due to a loss of mitochondrial membrane potential. Furthermore, the reduction of a survival rate that was induced by sanguinarine and the induction of apoptosis disappeared with the inhibition of artificial caspase activity. Therefore, the results of the study indicated that sanguinarine-induced apoptosis in Hep3B cells involves both extrinsic and intrinsic pathways; such apoptosis is a caspase-dependent phenomenon.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.1703-1712
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• 2010

The safety of tilting train running on curved track is, in general, evaluated with a derailment coefficient calculated by the ratio of wheel load and lateral force, Particularly on curve, the wheel load and lateral force on rail may cause trackbed to be deformed, depending on their intensity, and moreover, often result in critical accident such as derailment. This study hence was intended to identify the cause of wheel load and lateral force so as to suggest the allowable wheel load reduction rate, lateral force limit and derailment coefficient, thereby quantitatively evaluating the operational safety of tilting train. This study therefore was aimed to analyze the wheel load and lateral force occurred during tilting train's operation on circular curve in such a way of comparing with traditional trains, by axle and speed, in a bid to eventually evaluate the operational safety of tilting train.

• Journal of Construction Engineering and Project Management
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• v.2 no.4
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• pp.25-31
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• 2012

The growing rate of delays is adversely affecting the timely delivery of construction projects. This study therefore assesses construction stakeholders' perception of the causes of delays and its effects on project delivery in a bid to proffer solution in minimizing the occurrences of delays. Questionnaire was used to elicit responses from construction stakeholders; a total of thirty three causes of delays, seventeen resultant effects of delays and fifteen methods of minimizing construction delays were identified for the study based on literature reviews. The results suggest that client's cash flow related problems are the main causes of delays while time and cost overruns are the major identifiable effects of delays in construction projects. However, adequate project planning and budgeting were suggested as possible ways of minimizing the occurrences of delays.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2021.11a
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• pp.250-251
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• 2021

A subcontract work order is the basis of the construction process and consists of the root and trunk of the construction industry. The construction process through a subcontract work order is an important element of project success, and it is the basic unit of creating profit in the construction industry. Therefore, correct analysis and forecasting of subcontract work orders allow correct estimation of construction cost and profit which is the foundation of corporate decision making. This study has started to provide predictions of subcontractor's bidding-ratio for decision-making. Since the actual project data has been used in this study, the contribution level of the model is highly expected in actual field. The statistical confidential level of adjusted decision coefficient is concluded low because of limited sample numbers. However, its accuracy and confidence level can be increased through increasing sample numbers, considering more variables, and studying of reducing error.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.2
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• pp.195-200
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• 2021

In recent years, Vietnam's economic growth rate has been attributed to the growth of many well-managed industries within Southeast Asia. Among them is the civil construction industry. Construction projects typically take a long time to complete and require a huge budget. Many socio-economic variables and factors affect total construction project costs due to market fluctuations. In recent years, crucial socioeconomic development indicators of construction reached a fairly high growth rate. Also, most infrastructure and construction projects have a high degree of complexity and uncertainty. This makes it challenging to predict the accurate project price. These challenges raise the need to recognize significant factors that influence the construction price index of civil buildings in Vietnam, both micro and macro. Therefore, this paper presents critical factors that affect the construction price index using the fuzzy extent analysis process in an uncertain environment. This proposed quantitative model is expected to reflect the uncertainty in the process of evaluating and ranking the influencing factors of the construction price index in Vietnam. The research results would also allow project stakeholders to be more informed of the factors affecting the construction price index in the context of Vietnam's civil construction industry. They also enable construction contractors to estimate project costs and bid rates better, enhancing their project and risk management performance.

• The Journal of Fisheries Business Administration
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• v.40 no.1
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• pp.27-49
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• 2009

Recently, the Korea's economy concerns the second money crisis because of the rapid increase of the exchange rate. The Korea's economy which is very dependent on the foreign trade is more sensitive to the change of exchange rates. There are many literatures which analyze the effects of variations of the exchange rates on the secondary and tertiary industries such as the manufacturing industry and IT(Information Technology). But there have been no studies which try to figure out the effects of variations of exchange rate on the primary industries, especially, fisheries' industry. Therefore this paper tries to analyze the effect of price competition structure and the change of exchange rate on foreign fisheries exporting prices in Korea's fisheries import market. This study utilizes OLS(Ordinary Least Squares Analysis) for the analysis in the market of frozen yellow corvina, hairtail, angler fish which are major fisheries importable in Korea. The results show that the exporting country which has the highest market share is more sensitive to the change of the exchange rates itself than that of the other exporting countries' price when it starts to set up its exporting price. And the exporting countries which have low market share are more sensitive to the change of price which country has the highest market share than that of price whose countries have low market share and those of their exchange rate. Also we can find out that the countries which have similar market share try to set up price-setting strategy in the opposite direction. In other words, one country tries to bid up its price, other countries response to rival country by lowering their prices. In the consideration of the fact that most exporting countries aren't affected by Korea's fisheries' prices, the exporting countries in Korea's fisheries import market are more sensitive to the prices of other exporting countries than that of Korea's. This result indicates that the price leader-follower model could be applicable to the Korea's fisheries import market.

• Journal of the Korea Society of Computer and Information
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• v.28 no.12
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• pp.239-248
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• 2023

The purpose of this study is to analyze the factors for service contracts that affect the successful bid price rate, focusing on the case of the country market. In the study, ordering organizations and bidders differentiated themselves from existing studies by analyzing service contracts that affect the successful bid price rate in a wide range of country markets. Comparative analysis of the awarding price ratio for services, this work provides a comparable result to the existing results in the previous literature. The analytical model used five independent variables such as budget, contract method, the days of the public notice, the awarding method, and the lowest awarding ratio. In the survey and analysis, big data was collected using text mining for service bids for Nara Market over the past 18 years and data was analyzed in a multi-dimensional way. The results of the analysis are as follows, (1) if budget does not determine the awarding price ratio. This is not the case in small amounts. (2) The contract method affects the awarding price ratio. (3) The days of the public notice increase, the awarding price ratio decrease. (4) the awarding method affects the awarding price ratio. (5) The lowest awarding ratio determines the awarding price ratio. Based on the results of empirical analysis, policy implications were sought.

• Radiation Oncology Journal
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• v.9 no.2
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• pp.215-219
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• 1991

To evaluate the effect of MVP chemotherapy and hyperfractionated radiotherapy in Stage III unresectable non small cell lung cancer (NSCLC), authors have conducted a prospective randomized study since January 1991, Stage IIIa or IIIb unresectable NSCLC patients were treated with hyperfractionated radiotherapy (120 cGy/fx BID) up to 6500 cGy following 3 cycles of induction MVP (Mitomycin C 6 mg/$m^2$, Vinblastine 6 mg/$m^2$, Cisplatin 60 mg/$m^2$) and randomized for either observation or 3 cycles of maintenance MVP chemotherapy. Until August 1991, 18 patients were registered to this study. 4 cases were stage IIIa and 14 were stage IIIb. Among 18 cases 2 were lost after 2 cycles of chemotherapy, and 46 were analyzed for this preliminary report. The response rate of induction chemotherapy was $62.5\%$ : partial response, $50\%$ and minimal response, $12.5\%$. Residual tumor of the one partial responder was completely disappeared after radiotherapy. Among 6 cases who were progressed during induction chemotherapy, 4 of them were also progressed after radiotherapy. All patients were tolerated BID radiotherapy without definite increase of acute complications, compared with conventional radiotherapy group. But at the time of this report, one patient expired in two month after the completion of the radiotherapy because of treatment related complication. Although the longer follow up is needed, authors are encouraged with higher response rate and acceptable toxicity of this treatment. Authors believe that this study is worthwhile to continue.

• Journal of Science of Art and Design
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• v.11
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• pp.37-49
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• 2007

TV animation has come a long way to this date since popular animation programs were aired on TV, such as 'Run Little Tiger', 'Run Honey', 'Hurry-Scurry Yeongsimi', beginning with 'Wandering Magpie' on KBS in 1978. However, problematic production process has resulted in the degradation of quality. Consequently, the dwindling viewing rate forced animation advertisers to leave, and the animation production shrank. Under those unfavorable circumstances, the government started to heed messages transmitted from animation producers and went ahead with the 'animation broadcasting quota' in a bid to help revitalize Korean animation industry. This study aimed to identify problems and set the direction for the animation industry by analyzing its fundamental and structural problems.

• Journal of the Korea Society of Computer and Information
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• v.16 no.9
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• pp.35-43
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• 2011

To develop a software, there is a relationship between development organization's productivity, effort, development schedule, and software size. It is software equation that motive these relations. Basically, relationship between size-effort and size-schedule is applied. If this relationship is not proper, there would be no effect of the cost-schedule tradeoff equation that is derived from software equation, and the manpower profile analysis, etc. To solve these unwanted problems, we presented a modified software equation and a cost-schedule tradeoff model based on the modified software equation. To improve software development success rate, applying proposed model will help in contract negotiation or bid.