• BMB Reports
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• v.49 no.10
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• pp.554-559
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• 2016

Mycobacterium abscessus, a member of the group of non-tuberculous mycobacteria, has been identified as an emerging pulmonary pathogen in humans. However, little is known about the protective immune response of antigen-presenting cells, such as dendritic cells (DCs), which guard against M. abscessus infection. The M. abscessus gene MAB1843 encodes ᴅ-alanyl-ᴅ-alanine dipeptidase, which catalyzes the hydrolysis of ᴅ-alanyl-ᴅ-alanine dipeptide. We investigated whether MAB1843 is able to interact with DCs to enhance the effectiveness of the host's immune response. MAB1843 was found to induce DC maturation via toll-like receptor 4 and its downstream signaling pathways, such as the mitogen-activated protein kinase and nuclear factor kappa B pathways. In addition, MAB1843-treated DCs stimulated the proliferation of T cells and promoted Th1 polarization. Our results indicate that MAB1843 could potentially regulate the immune response to M. abscessus, making it important in the development of an effective vaccine against this mycobacterium.

• Journal of the Earthquake Engineering Society of Korea
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• v.12 no.1
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• pp.11-20
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• 2008

In probabilistic seismic analysis of nonlinear structural system, dynamic analysis is performed to obtain the distribution of the response estimate using input ground motion time histories which correspond to a given seismic hazard level. This study investigates the differences in the distribution of the responses and the failure probability according to input ground motion models. Two types of input ground motion models are considered: real earthquake records scaled to specified intensity level and artificial input ground motion fitted to design response spectrum. Simulation results fir a nonlinear SDOF system demonstrate that the spectrum matched input ground motion produces larger failure probability than those of scaled input ground motion due to biased responses. Such tendency is more remarkable in the site of soft soil conditions. Analysis results show that such difference of failure probability is due to the conservative estimation of design response spectrum in the range of long period of ground motion.

• Journal of Technology Innovation
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• v.14 no.1
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• pp.147-175
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• 2006

One of the biggest problems of Korean economy is polarization of firms for export and domestic demand and that of conglomerates and SME's achievement. One of the culprits lies weakness of intermediate industry such as machine tool. Since intermediate industry is important path where export performance affects domestic demand and whose actor usually is SMEs with high spill over effect in labor market. Especially, intermediate industry Is vulnerable because of industrial policy biased In backward linkage effect. However if a country fails to develop intermediate industry above some critical point, that country would fall in low-tech equilibrium without growth. In case of benign circle where final goods industry growth leads growth of intermediate industry and again it leads that of final goods industry, it can reach high-tech equilibrium. By contrast, in opposite case where in industrialization latecomer fails to link industries likewise above some critical point that country would fall in low-tech equilibrium without growth. Moreover, for several reasons, machine tool firms of Korea have difficulty in catching up technology above critical point. Firstly. Conglomerate demander neglects their product. Secondly, even after success of development overcoming difficulties they fail to get market share for response of dumping of foreign competitors. And the last one is patent litigation of foreign competitors that incapacitate the technology development. For these, Korean machine tool firms fell in 'middle-income country trap' itself, since they stuck in some extent when they technologically catch up. Consequently, for latecomer country in machine tool industry to leapfrog meaningfully policy support is necessary, Weak intermediate industry does not Induce domestic firms and remained fragile. Therefore, localization, policy should reflect condition of technological catch up more than before, in order to be effective and fruitful. There should be turning point over relationship between conglomerates, major demander of machine tool and SME's, for only with active purchasing of conglomerate Korean machine industry can grow.

• Nuclear Engineering and Technology
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• v.41 no.5
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• pp.723-728
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• 2009

The response property of the CZT detector ($5{\times}5{\times}5\;mm^3$), widely used in photon spectroscopy, was evaluated by considering the charge collection efficiency, which depends on the interaction position of incident radiation, A quantitative analysis of the energy spectra obtained from the CZT detector was also performed to investigate the tail effect at the low energy side of the full energy peak. The collection efficiency of electrons and holes to the two electrodes (i.e., cathode and anode) was calculated from the Hecht equation, and radiation transport analysis was performed by two Monte Carlo codes, Geant4 and MCNPX. The radiation source was assumed to be 59.5 keV gamma rays emitted from a $^{241}Am$ source into the cathode surface of this detector, and the detector was assumed to be biased to 500 V between the two electrodes. Through the comparison of the results between the Geant4 calculation considering the charge collection efficiency and the ideal case from MCNPX, an pronounced difference of 4 keV was found in the full energy peak position. The tail effect at the low energy side of the full energy peak was confirmed to be caused by the collection efficiency of electrons and holes. In more detail, it was shown that the tail height caused by the charge collection efficiency went up to 1000 times the pulse height in the same energy bin at the calculation without considering the charge collection efficiency. It is, therefore, apparent that research considering the charge collection efficiency is necessary in order to properly analyze the characteristics of CZT detectors.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.22 no.6
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• pp.860-873
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• 1998

In a low speed open-type wind tunnel, a group of parallel wakes downstream of two dimensional grid model consisting of several circular cylinders were experimentally investigated to study the response of the wake flows to the acoustic excitation, in hoping to promote the understanding of the underlying mechanism behind the gross flow change due to artificial excitation. In the unexcited wake flows, the development of the individual wakes behind cylinders was almost uniform for the ratio of the spacing to the cylinder diameter of s/d.geq.1.5. For smaller s/d, however, the jet streams issued through the gaps between the cylinders became biased in one side and the cylinders had wakes of different sizes. At s/d=1.25, the gap flow directions change in time, leading to unstable wake patterns. Further reduction in s/d made this unstable flip-flopping of the jets stable. The most effective excitation frequency was found to be in the Strouhal number range of St=0.5-0.6. This frequency was related to the vortex shedding. At s/d=1.75, the excitation frequency was 2 or 4 times the vortex shedding frequency. When the flow was excited at this frequency, the vortex sheddings were energized, and pairings between neighboring vortices were generated. Also, the merging process between individual wakes was accelerated. The unstable and unbalanced wake patterns at s/d=2.15 were made stable and balanced. The unstable and unbalanced wake patterns at s/d=2.15 were made stable and balanced. For smaller spacing of s/d .leq,1.0, the acoustic excitation became less effective in controlling the flow.

• Korean Journal of Cognitive Science
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• v.2 no.2
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• pp.279-307
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• 1990

The present research inverstigates the nature of contextual effects on pronoun reference resolution during text comprehesion.Through three experiments,this research examines how various contextuall informations influence on reference resolution and interact with syntactic variables.In experiment 1,the local context was controlled by biasing the pronoun-sentence context towards a certain preceding referent.The lexical decision time and the forced choice time for the correct referent were measured.The results showed that the local contexts have clear effect on reference resolution.The effects of syntactic ambiguity were also observed though the local context was biased towards a certain referent noun.In experiment 2,the global context effect was examined by introducing the text-thematic context in a preceding sentence while keeping the following pronoun-sentence context neutral.The results showed that the global thematic context bias towards a subject or object in a preceding sentence entails a faster response time than the thematically neutral context.In experiment 3,another aspects of context effects were inverstigated by manipulating the consistency of the preceding thematic context with the following pronoun-sentence context.The results showed that the lexical decision responses and forced referent choice responses were faster when the prethematic context and the post-anaphoric context match than when they mismatch.In sum,the overall results of three experiments of this research indicates that context has a clear effect on pronoun reference resolution during text comprehension.

• Journal of the Korean Institute of Navigation
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• v.20 no.1
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• pp.59-79
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• 1996

Waterfront redevelopment is an element in the process of inner-city regeneration now widespread in many ports of the world. Academic interest in the processes involved has yielded a literature biased towards specific locations rather than towards the analysis of processes and issues. The redevelopment of urban waterfronts does not, of course, occur exclusively in port cities but is found as a continuous process in most places where settlement and water are juxtaposed, whether or not commercial port activity is or was present. Port cities, however, as a result of the concentration and juxtaposition of urban and maritime influences, generally present the major issues involved in waterfront redevelopment most clearly. In this context, the general aim is to explore Korean dimensions of waterfront redevelopment in a range of port cities in a context of inner-urban renewal; and a specific objective is to examine the views of decision-makers in Korean port cities on the processes involved by a questionnaire method. The focus is on comparative strategies, and in particular upon the factors affecting the balance between social goals and commercial interests. To test the response of four categories of decision-makers in Korean port cities on a number of issues perceived as underpinning the processes involved in waterfront redevelopment, four catergories of respondents-port authority representatives(PO), urban planners(UP), port specialists(PS) and city-government official(GO)-were asked to fill in a questionnaire form. In three out of ten cases, the overall result broadly confirmed the a priori expectation; in six cases the confirmation was partial; and in one other the view of respondent was generally contrary to those anticipated. In many, but by no means all, cases there was substantial agreement between the four categories of respondents, but the range of scores was generally much wider than expected.

• IMMUNE NETWORK
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• v.13 no.1
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• pp.34-41
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• 2013

Interleukin-18 (IL-18) has been known to induce interferon-${\gamma}$ (IFN-${\gamma}$) production and promote Th1 immunity. Although mammalian IL-18 has been characterized in great detail, the properties and application of chicken IL-18 remain largely uninvestigated as of yet. In this study, we evaluated the immunomodulatory properties of Salmonella enterica serovar Typhimurium expressing chicken interleukin-18 (chIL-18) on immune responses induced by avian influenza (AI) and Newcastle disease (ND) vaccines. After oral administration of S. enterica serovar Typhimurium expressing chIL-18, chickens were vaccinated intramuscularly with the recommended dose of either inactivated AI H9N2 vaccine or ND (B1 strain) vaccine. Chickens receiving a primary vaccination were boosted using the same protocol 7 days later. Humoral and cell-mediated immune responses were evaluated in terms of HI antibody titers and proliferation and mRNA expression of IFN-${\gamma}$ and IL-4 of peripheral blood mononuclear cells (PBMC) in response to specific antigen stimulation. According to our results, oral administration of S. enterica serovar Typhimurium expressing chIL-18 induced enhanced humoral and Th1-biased cell-mediated immunity against AI and ND vaccines, compared to that of chickens received S. enterica serovar Typhimurium harboring empty vector. Therefore, we conclude that our proposed vaccination regimen using inactivated AI and ND viruses along with oral administration of S. enterica serovar Typhimurium expressing chIL-18 may provide a novel approach in protecting chicken from currently circulating AI and ND virus strains.

• Journal of Korea Water Resources Association
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• v.31 no.3
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• pp.347-360
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• 1998

Numerical simulations for fluid flow and solute transport in a fracture rock masses are performed by using a transient flow model, which is based on the three-dimensional stochastic and discrete fracture network model (DFN model) and is coupled hydraulic model with mechanical model. In the numerical simulations of the solute transport, we used to the particle following algorithm which is similar to an advective biased random walk. The purpose of this study is to predict the response of the tracer test between two deep bore holes (GPK1 and GPK2) implanted at Soultz sous Foret in France, in the context of the geothermal researches.l The data sets used are obtained from in situcirculating experiments during 1995. As the result of the transport simulation, the mean transit time for the non reactive particles is about 5 days between two bore holes.

• Korea journal of population studies
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• v.11 no.1
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• pp.1-13
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• 1988

This study examines the sampling bias that may have resulted from the large number of missing observations. Despite well-designed and reliable sampling procedures, the observed sample values in DSFH(Demographic Survey on Changes in Family and Household Structure, Japan) included many missing observations. The head administerd survey method of DSFH resulted in a large number of missing observations regarding characteristics of elderly non-head parents and their children. In addition, the response probability of a particular item in DSFH significantly differs by characteristics of elderly parents and their children. Furthermore, missing observations of many items occurred simultaneously. This complex pattern of missing observations critically limits the ability to produce an unbiased analysis. First, the large number of missing observations is likely to cause a misleading estimate of the standard error. Even worse, the possible dependency of missing observations on their latent values is likely to produce biased estimates of covariates. Two models are employed to solve the possible inference biases. First, EM algorithm is used to infer the missing values based on the knowledge of the association between the observed values and other covariates. Second, a selection model was employed given the suspicion that the probability of missing observations of proximity depends on its unobserved outcome.