• Nutrition Research and Practice
• /
• 제10권3호
• /
• pp.274-281
• /
• 2016

BACKGROUND/OBJECTIVES: The accumulation of amyloid-${\beta}$ ($A{\beta}$) in the brain is a hallmark of Alzheimer's disease (AD) and plays a key role in cognitive dysfunction. Perilla frutescens var. japonica extract (PFE) and its major compound, rosmarinic acid (RA), have shown antioxidant and anti-inflammatory activities. We investigated whether administration of PFE and RA contributes to cognitive improvement in an $A{\beta}_{25-35}$-injected mouse model. MATERIALS/METHODS: Male ICR mice were intracerebroventricularly injected with aggregated $A{\beta}_{25-35}$ to induce AD. $A{\beta}_{25-35}$-injected mice were fed PFE (50 mg/kg/day) or RA (0.25 mg/kg/day) for 14 days and examined for learning and memory ability through the T-maze, object recognition, and Morris water maze test. RESULTS: Our present study demonstrated that PFE and RA administration significantly enhanced cognition function and object discrimination, which were impaired by $A{\beta}_{25-35}$, in the T-maze and object recognition tests, respectively. In addition, oral administration of PFE and RA decreased the time to reach the platform and increased the number of crossings over the removed platform when compared with the $A{\beta}_{25-35}$-induced control group in the Morris water maze test. Furthermore, PFE and RA significantly decreased the levels of nitric oxide (NO) and malondialdehyde (MDA) in the brain, kidney, and liver. In particular, PFE markedly attenuated oxidative stress by inhibiting production of NO and MDA in the $A{\beta}_{25-35}$-injected mouse brain. CONCLUSIONS: These results suggest that PFE and its active compound RA have beneficial effects on cognitive improvement and may help prevent AD induced by $A{\beta}$.

• 디지털융복합연구
• /
• 제13권3호
• /
• pp.231-239
• /
• 2015

본 연구의 목적은 요양시설에서 거주하는 정신장애인의 삶의 만족에 영향을 미치는 요인을 파악하고자 함이다. 자료수집은 2014년 7월 1일 부터 28일까지였고, 연구대상은 시설에 거주하는 정신장애인 215명이었으며 연구 도구는 우울, 자아존중감, 사회적 지지, 병식, 삶의 만족이었다. 자료분석은 SPSS/WIN 18.0 프로그램을 이용하여 기술통계, t-test, ANOVA, Pearson's correlation 상관분석, 위계적 다중회귀분석을 실시하였다. 연구결과로 삶의 만족에 영향을 미치는 요인은 사회적 지지 (${\beta}=.518$, p=.000), 외출 (${\beta}=.155$, p=.001), 자아존중감 (${\beta}=.155$, p=.013), 우울 (${\beta}=-.147$, p=.015), 성별 (${\beta}=-.125$, p=.011) 순이었다. 결론적으로, 사회적 지지와 자아존중감을 높이고 우울수준을 낮출 수 있는 프로그램을 개발하는 것이 필요할 것이다.

• 디지털융복합연구
• /
• 제17권11호
• /
• pp.357-367
• /
• 2019

본 연구의 목적은 직장인의 인터넷 건강정보에 대한 태도, e-헬스 리터러시가 건강정보 추구행동과 건강관련 행위의도에 미치는 영향을 파악하기 위함이다. 서울, 경기도, 충청도 거주하고 있는 직장인 152명에게 구조화된 설문지를 이용하여 조사하였다. 자료는 t-test, ANOVA, 다중회귀분석으로 분석하였다. 연구결과, 건강정보 추구행동 영향요인으로는 e-헬스 리터러시(${\beta}=.33$, p<.011)와 인터넷 건강정보에 대한 지각된 유용성(${\beta}=.28$, p=.002)이, 건강관련 행위의도 영향요인으로는 인터넷 건강정보에 대한 지각된 유용성(${\beta}=.33$, p=.001)과 정보활용도(${\beta}=.24$, p=.003), e-헬스리터러시(${\beta}=.18$, p=.002)가 확인되었다. 이상의 결과를 토대로 직장인의 e-헬스 리터러시를 고려하여 정보활용도를 높이는 인터넷 건강정보의 전달시스템 구축과 교육프로그램 개발이 필요하다.

• 한국보건간호학회지
• /
• 제27권3호
• /
• pp.539-550
• /
• 2013

Purpose: The objectives of this study were to investigate the level of meaning in life(MIL) among university students as well as identify the effects of death perception, including good death and concerns about dying, and self-esteem on MIL. Methods: A questionnaire survey was developed and carried out using a convenient sampling method (N=301). Data were analyzed by applying descriptive statistics, t-test, ANOVA, Duncan test, Pearson's correlation coefficient, and stepwise multiple regression. Results: The average score for MIL was 4.70 on a 7-point scale. The factor of purpose of life received highest score among all factors in MIL. MIL was positively correlated with age, good death, and self-esteem. However, concerns about dying were negatively correlated with MIL. MIL showed a strong association with self-esteem(r=.72). Specifically, self-esteem(${\beta}$=.608), satisfaction of school life(${\beta}$=.190), relationship with parents(${\beta}$=.180), good death(${\beta}$=.080), school grades(${\beta}$=.078), and age(${\beta}$=.074) all significantly influenced MIL. These variables accounted for 61.0% of the total variance. Conclusion: The results show that self-esteem is an important factor for MIL among university students. Therefore, self-esteem should be carefully considered to increase their MIL. These research findings can be utilized to support programs such as counseling and education of university students.

• 지역사회간호학회지
• /
• 제24권4호
• /
• pp.461-470
• /
• 2013

Purpose: This study examined factors influencing subjective quality of life in baby boom generation men. Methods: This was a descriptive survey study. Data were collected from 279 baby boom generation men from September to October 2012. The instruments used included a subjective quality of lifescale, a self-esteem scale, a spiritual well-being scale, a communication with spouse scale, a social support scale, and a job satisfaction scale. Data were analyzed using descriptive statistics, t-test, one-way ANOVA and Scheff$\acute{e}$ test, Pearson's correlation coefficients, and Hierarchical multiple regression. Results: All variables were positively correlated with subjective quality of life. As a result, factors influencing subjective life of quality were self-esteem (${\beta}$=.21, p<.000), social support (${\beta}$=.20, p<.002), job satisfaction (${\beta}$=.19, p<.001), communication with spouse (${\beta}$=.15, p<.004), spiritual well-being( ${\beta}$=.16, p<.004), and family income (${\beta}$=.15. p<.023). These factors accounted for 61% of the total variances. Conclusion: The findings indicate a need to develop nursing intervention programs for community health nurses in consideration of these variables to improve the subjective quality of life for baby boom generation men.

• 한국치위생학회지
• /
• 제15권6호
• /
• pp.1009-1017
• /
• 2015

Objectives: The study aimed to investigate the effect of communication competence on the organizational effectiveness in dental hygienists. Methods: A self-reported questionnaire was completed by 248 dental hygienists in Seoul, Incheon, and Gyeonggido from November 1 to 30, 2014. The questionnaire consisted of general characteristics of the subjects(4 items), job characteristics(10 items), communication competence(49 items), organizational commitment(15 items), job satisfaction(16 items), and turnover intention(5 items). The instrument for communication competence and organizational commitment was done by Likert 5 points scale. Data were analyzed by t test, one way ANOVA, stepwise multiple regression test, and post-hoc Scheffe test using SPSS 18.0 program Results: The average of communication competence was 3.49(${\pm}0.28$). Of the sub-factors of communication competence, interpretational competence had the highest score of 3.65(${\pm}0.33$) followed by self-presentation 3.50(${\pm}0.49$), message conversion 3.50(${\pm}0.47$), role performance 3.44(${\pm}0.37$), and goal setting competence 3.28(${\pm}0.60$). There were significant effects in the organizational commitment including workplace(dental clinic=1, ${\beta}$=-0.254), weekly average working hours($${\leq_-}40$$ hours=1, ${\beta}$=0.182), role performance(${\beta}$=0.163), self-presentation(${\beta}$=0.144), goal setting competence(${\beta}$=0.130), and position(head=1, ${\beta}$=0.137). There were significants effects in the job satisfaction including position(head=1, ${\beta}$=0.217), weekly average working hours($${\leq_-}40$$ hours=1, ${\beta}$=0.204), education level(graduate school=1, ${\beta}$=0.184), job career(3~6 years=1, ${\beta}$=-0.181), goal setting competence(${\beta}$=0.194), and interpretational competence(${\beta}$=0.124). Conclusions: The communication competence of the dental hygienists showed a partial effect on the organizational effectiveness. In order to improve the organizational commitment and job satisfaction and the turnover intention, a variety of efforts must be taken and focused on goal setting competence, role performance, self-presentation, and interpretational competence.

• 대한치과보철학회지
• /
• 제48권4호
• /
• pp.259-265
• /
• 2010

연구 목적: $\beta$-Tricalcium phosphate/Hydroxyapatite ($\beta$-TCP/HA) 입자가 혼합된 합성 골 이식재의 particle size가 토끼의 두개골에서 타이타늄 메쉬를 이용해 시행된 골유도 재생술의 결과에 미치는 영향을 평가하고자 하였다. 연구 재료 및 방법: 여섯 마리의 수컷 뉴질랜드 산 백토끼 (5 kg)를 이용하여 실험 하였다. 토끼 두개골의 정 중앙을 절개하고 전층 판막을 형성하여 박리하였다. 두개골의 네 부위에 6 mm 직경의 트레핀 바 (XTP 5406; Dentium, Seoul, Korea)로 원형의 홈을 형성한 후 blood supply를 위해 원형의 홈안에 1 mm 직경의 라운드 바로 다섯 개의 작은 구멍을 형성하였다. 형성된 네 개의 홈 위에 표준화되어 맞춤 제작된 반구형 타이타늄 메쉬 (높이 3 mm, 직경 6 mm; Dentium, Seoul, Korea)를 위치시키고 세 개의 2 mm 길이의 티타늄 핀 (Dentium, Seoul, Korea)을 이용하여 고정하였다. 대조군은 이식재를 포함시키지 않았고 나머지 타이타늄 메쉬들은 실험군으로서 서로 다른 세 가지 크기의 이식재를 각각 담아서 고정하였다. 이식재 ($Osteon^{(R)}$, Dentium, Seoul, Korea)의 성분은 HA와 $\beta$-TCP ($\beta$-TCP/HA)가 혼합되어 있는 합성골 이식재이며 실험군으로 사용한 이식재의 크기는 각각 small (0.3 - 0.5 mm), medium (0.5 - 1.0 mm), large (1.0 - 2.0 mm) size 였다. 8주의 치유기간 후에 토끼를 희생시킨 후 조직 표본을 제작하고 CCD 카메라 (Polaroid DMC2 digital Microscope Camera (Polaroid Corporation, Cambridge, MA 02139, USA))가 부착되어 있는 광학 현미경 (Olympus BX, Tokyo, Japan)을 이용하여 두 가지 배율 (12.5배, 40배)로 조직학적 소견을 관찰하였다. 신생 골부위와 남은 골이식재 부위의 넓이를 측정하여 타이타늄 메쉬 내부 공간에서 차지하는 면적의 비율(%)을 구하였다. 그 수치들을 Mann-Whitney U-test와 Wilcoxon signed rank-test를 이용하여 통계 분석하였다 ($\alpha$ = .05). 결과: 대조군과 $\beta$-TCP/HA를 이식한 나머지 세 군의 신생골 형성을 비교하면 통계적으로 유의하게 $\beta$-TCP/HA를 이식한 군에서 신생골 형성이 더 많았다 (P = .003). 서로 다른 particle size 간 비교에서는 신생골 형성에 있어서 통계적으로 유의한 차이는 없었다. 하지만 형성된 수직골 총량 (신생골과 이식골의 면적의 합)을 각 그룹 간에 비교해 보면 대조군보다 $\beta$-TCP/HA를 이식한 군이 통계적으로 더 많은 비율을 나타내었고 (P = .001), 특히 $\beta$-TCP/HA 이식 군간 비교에서는 medium size 군이 large particle size 군보다 통계적으로 더 큰 면적을 나타내었다 (P = .039). 그러나 large particle size 군과 small particle size 군 사이 그리고 medium size 군과 small particle size 군 사이에는 통계적으로 유의한 차이를 보이지 않았다 (P> .05). 결론: 티타늄 메쉬를 이용한 수직골 증대술에서 $\beta$-TCP/HA 합성골을 사용하는 경우 수직골 형성에 기여하며 특히 medium size (0.5 - 1.0 mm)의 $\beta$-TCP/HA 이식재가 large size 이식재 보다 더 우수한 수직골 형성의 결과를 보였다.

• Journal of Yeungnam Medical Science
• /
• 제27권1호
• /
• pp.8-17
• /
• 2010

It is important to select appropriate antimicrobials for the treatment of infection according to the results of antimicrobial susceptibility tests (ASTs), yet the clinical isolates are sometimes susceptible to antibiotics that are clinically ineffective or this is due to technical error of the ASTs. So, interpretive reading of ASTs is needed and especially for the ${\beta}$-lactams for treating $Enterobacteriacae$. This review describes the interpretive reading of ASTs according to natural antimicrobial resistance and the mechanisms of mechanisms, with giving special attention to the antibiotics phenotypes for $Enterobacteriacae$. Further, as all the diffent tissues have a different antimicrobial concentration for identical antimicrobials, more information is needed on the antimicrobial tissue distribution for the appropriate treatment of infection. (ED note: I hope you send me the paper.)

• 한국산업융합학회 논문집
• /
• 제8권2호
• /
• pp.77-84
• /
• 2005

Foliated metamorphic, stratified sedimentary and regularity jointed rocks have properties(physical, mechanical) that vary with direction (${\beta}^{\circ}$) and are said to be anisotropic. The ground in Daegu area consists of shales, clastic sedimentary rocks. These shales have plane anisotropic or transversely isotropy characteristics. Engineering characteristics of shale in Daegu area are investigated by performing a series of rock test to the bedding(${\beta}$ =0, 30, 60, and 90 degrees). The results of tests show that the uniaxial compressive strength is a maximum at ${\beta}$ = 0, $90^{\circ}$ and is a minimum when ${\beta}$ is around 60 degree.

• 한국윤활학회:학술대회논문집
• /
• 한국윤활학회 2000년도 제32회 추계학술대회 정기총회
• /
• pp.115-121
• /
• 2000

The contaminant seperation performance of fitters has been widely investigated for many years. However, most of the proposed filter assessment techniques have proven disappointing for practical use. Although the Multipass (Beta) Filtration test method (ISO 4572) provides valuable information in assessing fi ters, it has a limitation on evaluating the increasing family of low-flow and high Beta filters. The limitation stems from two main sources: the over simplified theoretical model and the inherently complicated procedure in analysis of data. Hence a new advanced filtration theory, the Beta Prime developed on a draw-down test basis is applied to predict field operating characteristics of a filter for tractor hydraulic systems in this study.