• Journal of Pharmaceutical Investigation
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• v.14 no.1
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• pp.19-30
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• 1984

The pharmaceutical characteristics of solid indoprofen inclusion complex such as dissolution, permeation through a cellophane membrane, model analysis of interfacial tranesfer, absorption behaviors in rat intestine, and the plasma concentration of indoprofen after oral administrations to rabbits were examined in comparison with those indoprofen alone. The inclusion complex obtained by freeze-drying method showed the higher dissolution rate and membrane permeability among the test powders, and increased significantly the amont of indoprofen absorbed in rat intestine and the levels of plasma concentration of indoprofen after oral adminstrations to rabbits. The increase of bioavailability of $indoprofen-{\beta}-cyclodextrin$ complex was considered due to the increased solubility and dissolution rate of solid powder form.

• Korean Journal of Occupational Health Nursing
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• v.21 no.3
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• pp.290-298
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• 2012

Purpose: The purpose of this study was identify the influences of occupational stress and burnout on turnover intention of caregivers in geriatric hospitals. Methods: The data were collected from 176 caregivers working at three geriatric hospitals located in Gyeonggi province. A self-reported questionnaires was used to assess the level of occupational stress, burnout and turnover intention. The data were analyzed with descriptive statistics, t-test, ANOVA and Pearson correlation coefficients and multiple regression by SPSS/WIN 18.0 program. Results: The turnover intention was positively correlated with occupational stress(r=.438, p<.01) and burnout(r=.418, p<.01). The influencing factors of turnover intention were occupational stress(${\beta}$=.290, p<.001), burnout(${\beta}$=.253, p=.001) and education level(${\beta}$=.182, p=.006). Conclusion: The results of this study indicate that it is necessary to develop stress management program so that caregivers in geriatric hospitals can reduce occupational stress and burnout.

• Journal of Technologic Dentistry
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• v.30 no.1
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• pp.41-47
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• 2008

This study was to evaluate the biaxial flexural strength of zirconia ceramics after glass-infiltration on zirconia core. The zirconia specimens were made with diameter-15mm, thickness-0.6mm using zirconia block which divided into 1) sintered group, 2) heat - treated group, 3) Glass - infiltrated group and experimented fracture strength by each 10 specimens in experimental group. The biaxial flexural test was performed at crosshead speed of 0.1${\beta}\;{\AE}$ min. The experiment result average fracture strength was shown 541.0${\beta}\acute{A}$ in sintered group and glass-infiltrated group as 662.2${\beta}\acute{A}$ river of 22.4% rise appear. Weibull coefficient sintered group is 3.462 and glass-infiltrated group improved believability about fracture strength from melting permeation processing of glass by 4.716.

• Child Health Nursing Research
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• v.22 no.4
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• pp.363-369
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• 2016

Purpose: Fatigue in mothers of hospitalized children is an important component for her child's health. This study was done to identify factors influencing fatigue in mothers of hospitalized children. Methods: A descriptive correlation study design was used. Participants were 157 mothers of hospitalized children in a university hospital located in one city. Data were analyzed using t-test, ANOVA, Pearson correlation coefficients and stepwise multiple regression. Results: Mean score for fatigue in mothers of hospitalized children was $2.11{\pm}0.53$. There were significant differences in scores for fatigue in these mothers according to education, sleep satisfaction, and family support. Multiple regression analysis showed that the important factors related to fatigue in mothers of hospitalized children were parenting stress (${\beta}=.44$), hours of sleep (${\beta}=-.25$), and age (${\beta}=-.21$). These factors explained 38% of the total variance. Conclusion: Research results suggest that nursing interventions for mothers of hospitalized children are needed in order to improve the comfort and health of the mothers and facilitate the recovery of their child.

• Journal of the Korean Society of School Health
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• v.29 no.1
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• pp.33-41
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• 2016

Purpose: The purpose of this study was to examine relationships between optimism, coping and peer relations on mental wellbeing in adolescents, and to identify contributing factors on their mental wellbeing. Methods: A total of 132 students recruited from two middle schools. Data were analyzed using descriptive statistics, t-test, ANOVA, and Pearson's correlation coefficient, and multiple regression. Results: Adolescents' mental wellbeing was $4.23{\pm}0.84$. Their mental wellbeing was significantly influenced by optimism (${\beta}=.44$), peer relational skills (${\beta}=.21$), and active coping (${\beta}=.20$), explained 49.1% of the total variance. Conclusion: Considering the results of this study, optimism enhancement program for promoting adolescents' mental wellbeing should be builded. In addition, active coping skills and peer relational skills acquisition program need to be developed.

• Korean Journal of Medicinal Crop Science
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• v.13 no.2
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• pp.80-84
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• 2005

Five known anthraquinones, physcion (1), I-O-methylemodin (2), emodin (3), $physcion-8-O-{\beta},-D-glucopyranoside$ (5), $emodin-8-O-{\beta},-D-glucopyranoside$ (6) and two known stilbenes, trans-resveratrol (4), $trans-resveratrol-3-O-{\beta},-D-glucopyranoside$ (7) were isolated from MeOH extract of Reynoutria sachalinensis (Polygonaceae). All structures were unambiguously established by 1D and 2D NMR and MS data and the compounds were evaluated for their cytotoxicity against L1210, HL-60, BI6F10 tumor cell lines in MTT assay. Among the compounds, trans-resveratrol (4) exhibited significant cytotoxic activity with $IC_{50}$ values of 9.2, 6.7 and $9.8\;{\mu}g/ml$, against the test cell lines respectively, but compounds 1-3 exhibited the moderate cytotoxic activity.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09b
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• pp.857-858
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• 2006

In order to clarify the wear resistance as cutting tools, the effect of oxygen addition on oxidation behavior of the ${\beta}-Si_3N_4$ ceramics with 5 mass% $Y_2O_3$ and 2 or 4 mass% $Al_2O_3$ was investigated by performing oxidation tests in air at $1300^{\circ}$ to $1400^{\circ}C$ and cutting performance tests. From test results, we could conclude that the mechanical properties of ${\beta}-Si_3N_4$ ceramics depending on oxygen introduction are much effective on cutting performance improvements of ${\beta}-Si_3N_4$ ceramics.

• Bulletin of the Korean Chemical Society
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• v.30 no.3
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• pp.551-555
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• 2009

The ytterbium catalyst immobilized on the cross-linked poly(4-vinylpyridine/styrene) copolymer (P/S-Yb) was applied in the Mannich-type, three component one-pot synthesis of $\beta$-aminoketones. This catalytic system showed excellent catalytic activity and selectivity which resulted in the exclusive formation of $\beta$-aminoketone. The applicability of this immobilized catalyst system was shown by the reusability test and again highlighted by the synthesis of a $\beta$-aminoketone library using a broad range of substrates.

• Journal of Korean Biological Nursing Science
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• v.21 no.1
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• pp.70-76
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• 2019

Purpose: The aim of this study is to identify the influence of chronotype and self-efficacy on drinking problem in undergraduate students. Methods: A cross-sectional survey design was adopted for the 177 undergraduate students in D, G, and K city in 2017. The data was analyzed for descriptive statistics, t-test, ANOVA, Pearson's correlation coefficients and multiple regression analysis using the SPSS 18.0 program. Results: Chronotype (${\beta}=-.31$, p< .001), self-efficacy (${\beta}=27$, p< .001) and religion (${\beta}=-.19$, p= .005) were identified as the factors influencing drinking problem in the subjects. The model explained 19% of variance in drinking problem (F= 11.36, p< .001). Conclusion: It is necessary to develop and apply a program that would consider chronotype and self-efficacy factors to reduce the drinking problem in undergraduate students.

• Genomics & Informatics
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• v.20 no.4
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• pp.49.1-49.7
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• 2022

Many packages for a meta-analysis of genome-wide association studies (GWAS) have been developed to discover genetic variants. Although variations across studies must be considered, there are not many currently-accessible packages that estimate between-study heterogeneity. Thus, we propose a python based application called Beta-Meta which can easily process a meta-analysis by automatically selecting between a fixed effects and a random effects model based on heterogeneity. Beta-Meta implements flexible input data manipulation to allow multiple meta-analyses of different genotype-phenotype associations in a single process. It provides a step-by-step meta-analysis of GWAS for each association in the following order: heterogeneity test, two different calculations of an effect size and a p-value based on heterogeneity, and the Benjamini-Hochberg p-value adjustment. These methods enable users to validate the results of individual studies with greater statistical power and better estimation precision. We elaborate on these and illustrate them with examples from several studies of infertility-related disorders.