• Title/Summary/Keyword: beta test

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The Effect of $17{\beta}-Estradiol$ on the Gene Expression of IGF-I and Bone Matrix Protein in the Osteoblast-Like Cell (골아세포의 IGF-I 유전자 발현 및 골기질 단백질에 대한 $17{\beta}-estradiol$의 영향)

  • Yang, Won-Suk;Lee, Jae-Mok;Suh, Jo-Young
    • Journal of Periodontal and Implant Science
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    • v.30 no.2
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    • pp.375-390
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    • 2000
  • The purpose of this study is to evaluate the expression ofIGF-I, considered as the mediator of action of estrogen, and IGF-IA and IGF-IB, alternative slicing form of IGF-I, using $17{\beta}-estradiol$ in MC3T3-E1 cells. We observed the effect on type I collagen and osteopontin gene expression and DNA synthetic activity of MC3T3-E1 cells, added by estrogen, IGF-I and combination and the interactionon proliferation and differentiation of MC3T3-E1 cells. The results were as follows :RT-PCR experiment for observing timedependantIGF-I gene expression patternshowed IGF-IA and IB gene expression in both of control and test group. In these IGF-IA gene expression was appeared predominantly. In control, IGF-I geneexpression level was maintained until 24hr and then decreased gradually. In testgroup, IGF-I gene expression level increased as time goes by. Experiment measuring DNA synthetic activity, as it is added by $17{\beta}-estradiol$, IGF-I and combination, showed that first day , there was the tendency of more increase of synthetic activity in all test group than control but no statical significance(P>0.05), and third day, there was more increase of DNA synthetic activity in $17{\beta}-estradiol$ group and combination group and it was statically significant. (P<0.005) Experiment for observing type I collagen gene expression pattern showed more increase of expression in $17{\beta}-estradiol$ group than control and no significant difference in IGF-I group and combination group. Experiment for observing osteopontin gene expression pattern showed no significant difference in control and test group. In conclusion, $17{\beta}-estradiol$ in MC3T3- E1 cells increased IGF-I gene and DNA synthetic activity simultaneously, therefore it appeared that IGF-I is related to the action of estrogen. Combination treatment of IGF-I and $17{\beta}-estradiol$ has effect on cell proliferation but this effect is lower than IGF-I or $17{\beta}-estradiol$ alone. However, combination treatment has not great effect on type I collagen or osteopontin gene expression thus little effect of cell differentiation.

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Effects of macronutrients in mixed meals on postprandial glycemic response (식품 및 음식의 다량영양소 구성 성분에 따른 혈당 반응 연구)

  • Park, Mi-Hyeon;Chung, Sang-Jin;Shim, Jae Eun;Jang, Sung-Hee;Nam, Ki-Sun
    • Journal of Nutrition and Health
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    • v.51 no.1
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    • pp.31-39
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    • 2018
  • Purpose: The aim of study was to determine the effects of carbohydrate, fat, protein, and fiber contents on glycemic responses in a single food item or meal. Methods: Glycemic responses were measured in 30 healthy young adults (17 males and 13 females) with various test foods, including rice, egg whites, bean sprouts, olive oil, noodles, prune, broccoli, Korean dishes, Western dishes, and salad dishes, etc. Test foods were designed to contain various carbohydrate, fat, protein, and fiber contents in single or mixed foods or dishes. After 12 hours of fasting, participants consumed test foods, and the glycemic response was measured for a subsequent 120 min (0, 15, 30, 60, 90, and 120 min). Three hundred and fifty three glycemic responses from 62 foods were collected. The incremental area under the curve (AUC) was calculated for each test food for each subject to examine glycemic responses. Statistical analysis was conducted to identify which macronutrient (carbohydrate, fat, protein and fiber) affected the AUC using a mixed model. Results: Carbohydrates (${\beta}=37.18$, p < 0.0001) significantly increased while fat (${\beta}=-32.70$, p = 0.0054) and fiber (${\beta}=-32.01$, p = 0.0486) significantly reduced the glycemic response. Conclusion: It can be concluded that the glycemic response of a meal can be modified depending on the fat and fiber contents of ingredient foods, even though carbohydrate content is maintained.

Development of Durable Reliability Assessment Methods for Heavy Duty Coatings

  • Kim, Seung-Jin;Jung, Ho;Yang, In-Mo;Tanaka, Takeyuki
    • Corrosion Science and Technology
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    • v.4 no.4
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    • pp.155-163
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    • 2005
  • Heavy duty coating are required to have minimum durable period of 15 years under average usage environment because these paints are coated with purpose of anti-corrosion, antifouling, plastering etc. Onto steel structures constructed upon land and sea and other ferrous structures of electric power generation plants, electricity transmission towers, large structures of various plants, etc. Therefore we tried to estimate heavy duty coating longevity through reliability evaluation method and used combined cyclic anti-conrrosion test method composed of drying, moisturizing and salt spray as for accelerated life test to estimate longevity. Accelerated life test hours to heavy duty coating of first grade (with longevity not less than 15 years) specification may be obtained from troubleless test hours $t_n=\frac{B_p}{n^{1/\beta}}\left[\frac{1n(1-CL)}{1n(1-p)} \right]^{1/\beta}=19.671$ (yr) where shape parameter $\beta=1.1$, confidence level CL=80 %, warranty life $B_{10}=15$ yr and sampling size n=10 (2 sets). Because acceleration factor {AF} found by accelerated test is 41.7, accelerated life test hours required may be represented about 4,132 hr so that if this amount of hours is converted to number of cycles(6 hr/cycle) of complex cycle corrosion resistance test then the amount is tantamount about 690 cycles. That means if there does not occur trouble failure (with defect factor sum not more than 20) during when there is performed 690 cycles of combined cyclic anti-corrosion test to heavy duty coating specimen then it signifies that there can be warranted longevity $B_{10}$ of 15 yr under condition of confidence level CL=80 %.

Determination of Oxygen Transfer Characteristics (α, β and R) in an Aeration Basin at a Conventional Activated Sludge Wastewater Treatment Plant (활성슬러지 하수처리장 포기조내 산소 전달특성(α, β와 R)의 효율적 산정방안 개발)

  • Ko, Kwang Baik;Choi, Mee Young
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.14 no.4
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    • pp.989-997
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    • 1994
  • The major objective of this study is to develop an effective method to estimate ${\alpha}$ and ${\beta}$ in an aeration basin at a conventional activated sludge wastewater treatment plant. A series of unsteady state batch tests were simultaneously performed with clean water and mixed liquor in two batch reactors under identical operational conditions. Oxygen uptake rates (OURs) of the mixed liquor were measured during the tests. The results show that the OURs due to synthesis respiration and endogenous respiration were averaged about $17.96 mg/(l{\cdot}hr)$ and about $12.29mg/(l{\cdot}hr)$, respectively. The corresponding ${\alpha}$ and ${\beta}$ were ranged between 0.65 to 0.95, and between 0.88 to 0.93, respectively. Based on the overall experimental results, the proposed experimental test method and the proposed method for determination of ${\alpha}$ and ${\beta}$ are found to be relatively simple and easy to use in evaluating the characteristics of aeration systems.

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A Preliminary Study on the Preference Assessment on Individuals with Specific Display Location in Screen based on Electroencephalogram and Emotional Assessment (뇌파와 감성평가 기반의 스크린 상 특정 디스플레이 위치 선호도 평가에 관한 기초연구)

  • Wang, ChangWon;Min, Se Dong
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.63 no.7
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    • pp.968-975
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    • 2014
  • This paper proposed a evaluation method for individual's subjective preferred location using EEG and emotional assessment. Visual stimulus were sequentially presented a total six points(the top and the bottom of the left, the top and the bottom of the center and the top and the bottom of the right on the screen). EEG were measured from twenty subjects according to each six points. At the same time, we were executed evaluation of subjects preferred location from emotional assessment. Alpha and beta wave were measured in Fp1, Fp2, F7 and F8 location, followed by ten to twenty electrode system. Correlations and variations of alpha and beta wave from each channel were calculated and analyzed. Because of the number of subjects population under 30, we used Speareman test for a correlation analysis between alpha and beta wave. Also, emotional assessments which compose of visual sense harmony, visual sense stability, stability of position and the visibility were performed and were analyzed by average and frequency. After visual stimulus, emotional assessments were performed. From the variance analysis of EEG, beta wave from F7 was appeared statistically significant as significance probability of 0.006. Also, between alpha wave and beta wave appeared a negative correlation(r=-0.190). From the post-hoc test of F7 beta wave, location 1, 5 and 6 appeared to difference statistically significant. Emotional assessment result according to six positions showed 0.00 significance probability. Thus, location and emotional assessment appeared to influence on each other. From the average and frequency analysis of emotional assessment, location 2 showed obtained of best emotional assessment score and appeared lower beta wave than other locations. Finally, most subjects showed a preference for location 2. Through obtained results in this paper, will be helpful to about human emotional assessment and EEG research.

A Study on Anisotropic Characteristics of Sedimentary Rocks(Taegu area) (퇴적암의 비등방 특성에 관한 연구(대구지역))

  • Kim, Yeong-Su;Heo, No-Yeong;Seo, In-Sik
    • Geotechnical Engineering
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    • v.14 no.4
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    • pp.5-16
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    • 1998
  • The ground of Taegu area consists mainly of shales with elastic sedimentary rocks. These shales have a nonhomogeneous and anisotropic characteristics. So their physical and mechanical properties are very different due to the angles($\beta$ value) of bedding planes of sedimentary rock. In this study, the physical and mechanical characteristics of shales in Taegu area are studied by performing all kinds of rock test. According to results of test, apparent specific gravity of shale decreases as the $\beta$ value increases. On the contrary, porosity and absorption increase. Elastic wave velocity shorts the highest value at the $90^{\circ}$. And Young's modulus shows the maximum value at the $30^{\circ}$. The uniaxial strength, triaxial strength, cohesion and angle of friction show the minimum value at the $60^{\circ}$respectively.

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Factors Influencing Quality of Life of Alcoholics Anonymous Members in Korea (익명의 알코올중독자(AA) 모임 참여자의 삶의 질에 영향을 미치는 요인)

  • Yoo, Jae-Soon;Lee, Jongeun;Park, Woo-Young
    • Journal of Korean Academy of Nursing
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    • v.46 no.2
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    • pp.305-314
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    • 2016
  • Purpose: The purpose of this study was to determine quality of life (QOL) related factors in Alcoholics Anonymous (AA) members based on PRECEDE Model. Methods: A cross sectional survey was conducted with participants (N=203) from AA meeting in 11 alcohol counsel centers all over South Korea. Data were collected using a specially designed questionnaire based on the PRECEDE model and including QOL, epidemiological factors (including depression and perceived health status), behavioral factors (continuous abstinence and physical health status and practice), predisposing factors (abstinence self-efficacy and self-esteem), reinforcing factors (social capital and family functioning), and enabling factors. Data were analyzed using t-test, one way ANOVA, Tukey HSD test and hierarchical multiple regression analysis with SPSS (ver. 21.0). Results: Of the educational diagnostic variables, self-esteem (${\beta}=.23$), family functioning (${\beta}=.12$), abstinence self-efficacy (${\beta}=.12$) and social capital (${\beta}=.11$) were strong influential factors in AA members' QOL. In addition, epidemiological diagnostic variables such as depression (${\beta}=-.44$) and perceived health status (${\beta}=.35$) were the main factors in QOL. Also, physical health status and practice (${\beta}=.106$), one of behavioral diagnostic variables was a beneficial factor in QOL. Hierarchical multiple regression analysis showed the determinant variables accounted for 44.0% of the variation in QOL (F=25.76, p<.001). Conclusion: The finding of the study can be used as a framework for planning interventions in order to promote the quality of life of AA members. It is necessary to develop nursing intervention strategies for strengthening educational and epidemiological diagnostic variables in order to improve AA members' QOL.

Discordant Rate of Simultaneous Duplicate Throat Swab Culture for Discovering Beta-hemolytic Streptococcal Carrier from Normal School Children (초등학생의 베타용혈성 연쇄구균 보균자 검출에 있어서 인두부 중복배양(duplicate throat culture)의 유용성)

  • Cha, Sung-Ho;Han, Mi-Young;Choi, Yong-Mook;Kil, Young-Chul;Suh, Jin-Tae
    • Pediatric Infection and Vaccine
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    • v.3 no.2
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    • pp.123-127
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    • 1996
  • Purpose : The most patients with acute streptococcal pharyngitis lack of classic clinical manifestations, therefore diagnostic laboratory test such as the throat culture or a rapid antigen detection test are frequently employed in primary practices of developed countries. We'd like to know the accuracy of the throat swab culture as gold standard for diagnosis of streptococcal infection with studying the discordant and concordant rate of duplicate culture. Methods : The study included 89 normal school children (boys:50, girls:39) who were attending Uljin primary school in Uljin, Kyong Sang Buk Do on March 1996. We obtained simultaneous 2 times of throat swab from each subject, and plating and streaking on 5-7% of sheep blood agar separately. We counted the characteristic beta-hemolytic colonies after overnight incubation. Results : 1) The carrier rate of beta-hemolytic streptococci at first culture is 25.1% and second one is 29.2%. 2) Ten out of 89(11.2%) is discordant in duplicate culture. 3) Culture containing less than 50 colonies of beta-hemolytic streptococci (+2) in first culture is 70.4%, second one is 85.7%. 4) Number of colonies is less than 50 in all ten discordant children. Conclusions : The discordant rate of duplicate throat swab cullture for beta-hemolytic streptococci is 11.2%, even if the subjects are normal school children. About 5% of individuals harboring beta-hemolytic streptococci in the pharynx may be missed by a single throat culture. If we are trying to examine the patients with pharyngitis, the discordant rate will be much lower than this results.

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A Convergence Study on the Influence of Media Violence Acceptance and Violence Perception on Dating Violence in University Students (미디어 폭력성 수용 정도와 폭력 인식이 대학생의 데이트 폭력 행동에 미치는 영향에 대한 융합적 연구)

  • Park, Jummi;Shin, Nayeon;Park, Hyosun
    • Journal of the Korea Convergence Society
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    • v.10 no.4
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    • pp.237-246
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    • 2019
  • Purpose: The purpose of this study is to examine the factors influencing dating violence in University students. Methods: A descriptive regression design was used and the participants were 211 university students. Data analysis included t-test, ANOVA, pearson's correlations, multiple regression. Results: The significant factors affecting dating violence were justification of violence and irrational belief of date violence. The regression model explained approximately 24.7~33.0 % of dating violence. Conclusion: The findings recommend that nurses have to improve preventing dating violence of university students by considering violence perception.

Oswestry Low Back Pain Disability Index and Related Factors in Patients with Low Back Pain (일부 요통환자들의 오스웨스터리요통장애지수 및 관련요인)

  • Yi, Seung-Ju
    • The Journal of Korean Physical Therapy
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    • v.20 no.4
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    • pp.21-28
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    • 2008
  • Purpose: We measured the Oswestry Low Back Pain Disability Index (OLBPDI) and related factors in patients with low back pain. Methods: The sample consisted of 50 patients who received physical therapy at the physical therapy units of the Andong Seoul Sintong Clinic, St. Luke Clinic, and Yeongju Seoul Sintong Clinic in Andong and Yeongju city from October, 2007, to February, 2008. The OLBPDI questionnaire was administered by 5 physical therapists as a cross-sectional study. Student's t-test and analysis of variance (ANOVA/Tukey and Scheffe) were used to analyze OLBPDI score differences. We also used nonparametric statistic analysis (Wilcoxon rank sum test, Median test). Pearson correlation analysis (Spearman correlation analysis) was used to analyze the relationship between OLBPDI and the visual analogue scale (VAS). Multiple regression analysis was performed to determine the effects of independent variables on pain scores as defined by the OLBPDI. Results: The average patient age was 37.1 years (range: 18$\sim$78 years old), and time from onset was 21.7 months (1$\sim$180). OLBPD and VAS scores were 12.70 (3.0$\sim$28.0) and 5.14 (1$\sim$8), respectively. OLBPDI scores were 14.4 in patients taking medicine and 11.57 in those who did not. There was a statistically significant relationship between OLBPDI and VAS (r=0.54, p=0.0001; r=0.55, p=0.0001 by Spearman coefficient). Gender ($\beta$=6.14, p=0.0124), age ($\beta$=-2.01, p=0.0324), weight ($\beta$=0.31, p=0.0222), time from onset ($\beta$=1.54, p=0.0044), and VAS score ($\beta$=1.59, p=0.0004) were significantly associated with OLBPD by multiple regression analysis. Conclusion: Variables associated with OLBPD were gender, age, weight, time from onset, and VAS score. Collecting information on the pain index using OLBPDI was acceptable to patients with low back pain. Further research should explore the pain index by using larger sample sizes and longer follow-up periods.

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