• Biomolecules & Therapeutics
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• v.22 no.3
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• pp.232-238
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• 2014

Alzheimer's disease (AD) is the most common neurodegenerative disease without known ways to cure. A key neuropathologic manifestation of the disease is extracellular deposition of beta-amyloid peptide (Ab). Specific mechanisms underlying the development of the disease have not yet been fully understood. In this study, we investigated effects of 4-O-methylhonokiol on memory dysfunction in APP/PS1 double transgenic mice. 4-O-methylhonokiol (1 mg/kg for 3 month) significantly reduced deficit in learning and memory of the transgenic mice, as determined by the Morris water maze test and step-through passive avoidance test. Our biochemical analysis suggested that 4-O-methylhonokiol ameliorated $A{\beta}$ accumulation in the cortex and hippocampus via reduction in beta-site APP-cleaving enzyme 1 expression. In addition, 4-O-methylhonokiol attenuated lipid peroxidation and elevated glutathione peroxidase activity in the double transgenic mice brains. Thus, suppressive effects of 4-O-methylhonokiol on $A{\beta}$ generation and oxidative stress in the brains of transgenic mice may be responsible for the enhancement in cognitive function. These results suggest that the natural compound has potential to intervene memory deficit and progressive neurodegeneration in AD patients.

• The Journal of Korean Academic Society of Nursing Education
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• v.16 no.2
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• pp.283-291
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• 2010

Purpose: This study aims to assess university freshmen's concern of and satisfaction with their health and body and to analyze this in relation to their health habits, thereby aiding university students in forming sound health habits. Method: The subjects of this study were 338 freshmen at A University, located in B City. The questionnaire had 34 questions and the collected data was analyzed with t-test, $x^2$-test, and multiple regressions. Result: The average points of the subjects' health habits were 6.01 for male and 5.65 for female, showing a median range. Concern about health (male 13.63 points, female 13.10 points) and satisfaction with their own body (male 8.26 points, female 7.71 points) showed no significant difference between males and females. Females had more concern about their body (p=.001), and males' satisfaction with health was higher than females', which was statistically significant (p=.0.41). As for factors that have an effect on health habits, male students had health concerns ($\beta$=.395), health satisfaction ($\beta$=.212), and body concerns ($\beta$=-.209), and female students had health concerns ($\beta$=.317) and health satisfaction ($\beta$=.139). Conclusion: University freshmen are likely to have diverse undesirable health habits and therefore need positive improvement in their health habits.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.19 no.3
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• pp.374-382
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• 2012

Purpose: The study was done to influence of family function and degree of depression on impulsive behavior in adolescents. Method: Using convenience sampling 780 adolescents were recruited from October 29 and November 9, 2011. Data were collected using self-report questionnaires which included items on general characteristics, family function, depression, and impulsive behavior. Data were analyzed using t-test, ANOVA, Scheffe test, Pearson Correlation Coefficient, and hierarchical regression analysis. Results: The major findings of this study were as follow; 1) There was a significant negative relationship between family function and impulsive behavior (r=-.236, p<.001) and a positive relationship between depression and impulsive behavior (r=.342, p<.001). 2) Factors with a significant negative association with impulsive behavior were higher school records (${\beta}$=-.112, p<.001) and family function: positive resolution of family problems (${\beta}$=-.213, p=.008), while a significant positive association was found for unsatisfactory school life (${\beta}$=.103, p=.016), family function: emotional reactivity (${\beta}$=.159, p=.028), and depression (${\beta}$=.301, p<.001). These variables explained 20.1% of variance for impulsive behavior. Conclusion: The results of this study identify a relationship between family function, depression, and impulsive behavior in adolescents indicating variables to be addressed to reduce impulsive behavior. These variables can be used in developing intervention programs.

• Journal of Korean Academy of Nursing Administration
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• v.22 no.2
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• pp.148-157
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• 2016

Purpose: This study was designed to assess the level of super-leadership and self-leadership, identify correlations among variables and identify the factors influencing organizational commitment of clinical nurses. Methods: Participants were 217 nurses working in four hospitals located in Seoul and Gyeonggi Province. Data were analyzed using descriptive statistics, independent t-test, one way ANOVA, Scheffe. test, Pearson Correlation, and Multiple Regression. Results: The most influential factor for organizational commitment was super-leadership (${\beta}=.28$, p<.001), followed by education ${\beta}=.16$, p=.007), the number of unit nurses (${\beta}=.18$, p=.003), self-leadership (${\beta}=.17$, p=.008), and the number of patients being under 10 (${\beta}=.12$, p=.046). These factors accounted for 23% of the variance in organizational commitment (F=13.46, p<.001). Conclusion: The results of this study suggest a need for strategies to improve organizational commitment of nurses by enhancing nurse' self-leadership through nursing managers' super-leadership.

• The Journal of Korean Academic Society of Nursing Education
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• v.21 no.3
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• pp.382-392
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• 2015

Purpose: This study was performed to investigate the effects of moral sensitivity and ethical values on biomedical ethics awareness of nursing students. Methods: A descriptive survey design was used for this study. The participants were 324 nursing students from S University located in J city. The data were collected through a questionnaire survey done from September 30 to October 18, 2014. Data were analyzed using a t-test, ANOVA, Scheffe's test, Pearson correlation coefficients, and stepwise multiple regression. Results: The factors influencing nursing students' biomedical ethics awareness were identified as moral sensitivity(${\beta}=.34$), ethical values(${\beta}=.11$), awareness of Korean nurses' declaration of ethics(${\beta}=.15$), religion(${\beta}=.14$), and religious activity(${\beta}=.12$). Five factors explained 10.8% of nursing students' biomedical ethics awareness. Conclusion: The results of this study can be used to develop further educational programs on the moral sensitivity and ethical values for enhancement of nursing students' biomedical ethics awareness.

• The Journal of Korean Academic Society of Nursing Education
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• v.25 no.1
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• pp.115-124
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• 2019

Purpose: This study was performed to identify the influence of nursing professionalism and campus environment on the perception of ethical sensitivity among nursing students. Methods: A descriptive survey design was used for this study. The participants were 323 nursing students attending four universities in Busan and Kyungnam. Data collection was conducted from November 25 to December 25, 2017 using a self-report questionnaire. Data were analyzed using a t-test, ANOVA, Scheffe's test, Pearson's correlation coefficients, and stepwise multiple regression. Results: The factors influencing ethical sensitivity of nursing students were identified as professional self-concept (${\beta}=.36$), nursing role (${\beta}=.24$), scholarship (${\beta}=.17$), practicability (${\beta}=.17$), and propriety (${\beta}=-.13$). Five factors explained 40.5% of nursing students' ethical sensitivity. Conclusion: The results of this study can be used to develop further educational programs on nursing professionalism and campus environments for enhancement of nursing students' ethical sensitivity.

• Journal of Digital Convergence
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• v.13 no.8
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• pp.401-408
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• 2015

This study was done to examine the relation of cognitive function, depression and anxiety in elderly people above 65 years of age, and to identify factors influencing anxiety. The data were collected from June 1 to August 30 2014. Data were collected by questionnaire from 363 elderly people. The instruments for this study were MMSE-DS, depression, anxiety. The data were analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficients, and multiple linear regression with the SPSS/WIN 18.0 program. According to results, the significant factors influencing anxiety were sleeping time(${\beta}=-.249$, p<.001), depression(${\beta}=.218$, p<.001), cognitive function(${\beta}=-.209$, p<.001), occupation(${\beta}=-.133$, p=.006). The study reveals that it is necessary to develop a convergent program that maintain adequate sleep, prevents of cognitive impairment and decreases depression.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.11
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• pp.6710-6718
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• 2014

This study examined the factors affecting the sexual autonomy of female university students to provide the basic data for developing an intervention program for sex education. The data was collected from 322 female college students and analyzed with a t-test and multiple regression using the SPSS 21.0 program. The significant factors of sexual autonomy were intercourse experience (${\beta}=0.115$, p=.040), sex knowledge (${\beta}=0.118$, p=.028), permissiveness of sexual violence (${\beta}=-0.290$, p<.001), and the perception of unwed pregnancy (${\beta}=-0.104$, p=.048). These factors explained 21.7% of the variance in sexual autonomy. In conclusion, there is a need to develop a sex education program to increase sexual autonomy considering the factors affecting sexual autonomy.

• Journal of the Korea Convergence Society
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• v.7 no.5
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• pp.237-246
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• 2016

The purpose of this research is to analyze the depression, happiness on aging, self-esteem, life satisfaction and disability of daily living activity level of the elderly people, and to analyze the variables to impact on their depression. The study data were analyzed descriptive analysis, t-test, ANOVA, Pearson's Correlation Coefficient, and multiple regression analysis. The most influential variables on the elderly depression were self-esteem with 27.9% of explanatory power (${\beta}=-.318$, p<.001), followed by life satisfaction with 5.5%(${\beta}=-.248$, p<.001), happiness on aging 4.1%((${\beta}=-.200$, p<.001), disability of daily living activity 1.6%(${\beta}=.128$, p=.026), and 4 variables explaining 39.1% of the elderly depression. Therefore it is necessary to develop specific education programs to reduce depression and to improve self-esteem and happiness on aging of the elderly.

• Journal of the Korea Convergence Society
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• v.9 no.1
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• pp.31-39
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• 2018

This is a convergence study to investigate the factors affecting the physical health status of college students and to present a strategy for effective program development. The participants of this study were 200 college students in a region and collected data by self-reported questionnaire. Data were analyzed by descriptive statistics, t-test, ANOVA, correlation analysis and stepwise multiple regression analysis. The results were as follows: 1) The physical-health status of the college students was positively correlated with the subjective perception of health status(${\beta}=-.323$, p<.01), health awareness(${\beta}=-.278$, p<.01), gender(${\beta}=-.197$, p<.01), and breakfast habit(${\beta}=-.192$, p<.01). And the explanatory power($R_2$) by 4 variables was 33.1%. As a result, it was confirmed that strengthening subjective perception, positive reinforcement of health awareness, and habit of breakfast were important for improvement of physical health status. Therefore, it is necessary to develop a health promotion program based on the factors influencing on the physical health status and to analyze its application effect.