• 한국환경성돌연변이발암원학회지
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• 제24권2호
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• pp.79-84
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• 2004

Three synthetic chemicals, benzoyl chloride, 2-propyn-l-ol, and 2-phenoxy ethanol were selected for genotoxicity testing, based on production quantity and available genotoxic data. In our previous report, benzoyl chloride induced chromosomal aberrations in Chinese hamster lung (CHL) fibroblast in vitro with and without metabolic activation, while 2-propyn-l-ol and 2-phenoxy ethanol induced only with metabolic activation. To compare the genotoxicity of chromosome aberration assay, the single cell gel electrophoresis (comet) assay subjected using CHL cells. As a result, statistically significant differences of tail moment values of benzoyl chloride, 2-propyn-1-ol, and 2-phenoxy ethanol were observed compared with control values on almost all concentrations with S9 or without S9 metabolic activation system. This results suggest that genotoxic results of the comet assay and the chromosome aberration assay show correlationship of genotoxicity in the CHL fibroblast. In summary, the positive result of chromosome aberration of benzoyl chloride, 2-propyn-l-ol, and 2-phenoxy ethanol was also induced DNA damages in comet assay with same cell line. Consequently, comet assay will be useful and more accurate tool to detect and to confirm the genotoxicity especially DNA damages in CHL fibroblast.

• 공업화학
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• 제10권1호
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• pp.135-137
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• 1999

새로운 인돌 유도체인 항염증제를 합성하기 위하여 ${\alpha}$-benzoyl-1-ethyl-1,3,4,9-tetrahydro-8-ethyl-9-(N-benzoyl)pyrano[3,4-b]indole-1-acetic acid methyl ester(10)을 합성하였다. 출발물질은 7-ethylindole과 oxalyl chloride로 하여 4단계로 이루어졌다. 셋째 단계는 borontrifluoride diethyl etherate을 사용하여 66%로 고리화반응을 하였으며, 환원반응과 고리화반응도 효율적으로 단순화하였다. 최종생성물인 ${\alpha}$-benzoyl-1-ethyl-1,3,4,9-tetrahydro-8-ethyl-9-(N-benzoyl)pyrano[3,4-b]indole-1-acetic acid methyl ester는 4단계에서 얻은 methyl 1,8-dimethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetate(etodollic acid methyl ester)를 benzoyl chloride와 반응하여 66%의 수율로 얻었다.

• 대한화학회지
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• 제35권6호
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• pp.750-752
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• 1991

• Archives of Pharmacal Research
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• 제26권12호
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• pp.985-989
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• 2003

An efficient synthesis of 5-chloro-3-[4-(3-diethylaminopropoxy)benzoyl]-2-(4-methoxyphenyl)benzofuran (8), a potent $\beta$-amyloid aggregation inhibitor, is described. 5-Chloro-2-(4-methoxyphenyl)benzofuran (3) was obtained by the one-pot synthesis of 4-chlorophenol with $\omega$(methylsulfinyl)-p-methoxyacetophenone (1) under Pummerer reaction conditions, and it was followed by the desulfurization of the resultant 5-chloro-3-methylthio-2-(4-methoxyphenyl)benzofuran (2e). Acylation of benzofuran 3 with 4-(3-bromopropoxy)benzoyl chloride (6) gave the ketone 7, which was converted into compound 8 by the treatment of diethylamine.

• 분석과학
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• 제18권6호
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• pp.453-459
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• 2005

물중에 존재하는 11종의 페놀류를 benzoyl chloride를 사용하여 물에서 직접 유도체화한 후 추출하여 동시 분석하였다. 즉, 수용액 시료에 수산화나트륨 용액을 가하여 pH 13으로 조절한 다음 여기에 benzoyl chloride를 $500{\mu}L$을 가하여 15분간 흔들어 반응시키고 정치한 후 diethyl ether로 추출하여 GC/MS-SIM으로 정량하였다. 검량선은 $0.05-5.0{\mu}g/mL$ 농도범위에서 상관계수가 $r^2=0.9915$로 직선성이 좋았으며 상대표준편차는 8.5% 이하였고 이 방법의 회수율은 58.4-114.0% 이었다.

• 분석과학
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• 제10권6호
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• pp.445-452
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• 1997

뇨 중에 Putrescine, Spermidine 및 Spermine benzoyl chloride를 유도체화제로 처리한 다음 HPLC법으로 정량하였다. ${\mu}$-Bondapak $C_{18}$ 컬럼과 methanol/$H_2O$(50/50v/v)를 사용하여 정상인 및 자궁암 환자의 뇨 중에서 Putrescine, Spermidine 및 Spermine을 역상법으로 분석한 결과 암환자의 경우 정상인에 비해 이들 polyamine이 현저한 증가를 보였다.

• 약학회지
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• 제41권4호
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• pp.414-420
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• 1997

A rapid and sensitive high performance liquid chromatographic method with UV detection for the analysis of polyamines(putrescine, spermidine, spermine) has been developed. The benzoyl chloride derivatives of putrescine, spermidine and spermine are separated on a mc-Bondapak C18 reverse-phase column with 50% methanol as the mobile phase. This method was applied to the analysis of polyamines in the serum of normal human and uterine cancer patients. The results show that the mean level of polyamines in cancer patients serum is much higher than that in normal human serum.

• 대한화학회지
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• 제44권3호
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• pp.229-236
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• 2000

6-Chloro-2-hydrazinoquinoxaline4-oxide(10)를 아세틸아세톤 또는 디벤조일메탄과 반응시켜 분자내 고리화반응에 의한 6-chloro-2-(3,5-disubstituted pyrazol-1-yl) quinoxaline 4-oxide류(11)를 합성하였다. 화합물 11을 phosphoryl chloride로 염소와 반응시켜 3,6-dichloro-2-(3,5-disubstituted pyrazol-1-yl)quino-xaline류(12)를 합성한 다음 hydrazine hydrate 반응시켜 6-chloro-3-hydrazino-2-(3,5-disubstituted pyrazol-1-yl)quinoxaline류(13)를 합성하였다. 화합물 13을 치환 벤즈알데히드류, benzenesulfonyl chloride, 치환 benzoyl chloride류 및 acyl chlorid 류와 반응시켜 새로운 pyrazolylquinoxaline류(14-17)를 각각 합성하였다.

• 한국산업보건학회지
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• 제4권1호
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• pp.25-32
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• 1994

Arylmethyl halides(benzyl chloride, BZYC; benzal chloride, BZYA; benzotrichloride, BZTC) and related compounds(benzyl alcohol, BZYA; benzoyl chloride, BZOC) were determined by GC using capillary column. Detailed results are as follows. 1. Stability In methanol benzotrichloride slowly transferred to benzoyl chloride by hydrolysis(ca. 7.5% for 5 days), but the others were stable. Therefore, benzotrichloride solution should be prepared just before analysis. 2. GC analysis Tenax-GC was used to absorbent and desorption solvents were $CCl_4$ and MeOH. Arylmethyl halides were analyzed within 7.5min without interference with related compounds. The calibration curve(ca. 15-80 ppm in soln), repeatability(n=10) and the desorption efficiency were good. Limit of detection by NIOSH method was about 0.003 ppm for arylmethyl halide, respectively. To analyze arylmethyl halides and related compounds in working places GC using capillary column is anticipated to be used effectively.

• 약학회지
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• 제13권1호
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• pp.43-46
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• 1969

Five new acyl derivatives of isonicotinic acid hydrazide such as N-(2,4-dichlorophenoxyacetyl)-isoniotinic acid hydrazide (I), N-(p-nitrobenzoyl)-isonicotinic acid hydrazide (II), N-benzoylisonicotinic acid hydrazide (III), N-furoylisonicotinic acid hydrazide (IV) and N-(p-aminobenzoyl)-isonicotinic acid hydrazide (V) were synthesized. They were obtained by the action of 2,4-dichlorophenylacetyl chloride, p-nitrobenzoyl chloride, benzoyl chloride, furoyl chloride and p-aminobenzoyl chloride with isonicotinic acid hydrazide in pyridine solution. Evaluated for their in vitro antitubercular activity against Mycobaterium tuberculosis H$_{37}$ R$_{\upsilon}$ N-furoylisonicotinic acid hydrazide (IV) showed antitubercular activity at 1${\gamma}$/ml.