• 대한방사선기술학회지:방사선기술과학
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• 제30권3호
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• pp.237-243
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• 2007

방사성의약품을 이용한 핵의학적 영상기록에 있어 장기가 함유하고 있는 정보량을 최대한 묘출시켜 양질의 진단정보를 제공해야 한다는 것은 매우 중요하다. 그것을 위한 기술적인 문제를 비롯하여 장비성능의 유지관리에 많은 노력을 기울이고 있으며, 다양한 종류로 상업화되어 이용되고 있는 우수한 phantom들이 사용되고 있다. 본 연구에서 인체의 연부조직과 매우 흡사한 물리적 조건을 가지고 있으며 구입하기 쉬운 Paraffin을 이용하여 기존에 사용되고 있는 acryl thyroid phantom과 동일하게 paraffin phantom을 제작하였으며, 판매되고 있는 acryl thyroid phantom에서 측정할 수 있는 것 보다 더 높은 분해능을 측정할 수 있도록 작은 3mm와 6mm 직경의 cold area를 삽입한 paraffin thyroid phantom을 수작업으로 제작하였다. 방사성의약품 $^{99m}TcO_4$를 이용하고 pinhole collimator를 이용하여 상업화되어 사용되고 있는 acryl thyroid phantom과 본 연구를 위하여 제작한 paraffin thyroid phantom의 특성을 비교 분석한 결과 paraffin을 이용한 phantom도 상업화되어 사용 중인 acryl thyroid phantom과 동일한 물리적 특성을 유지하고, 오히려 분해능이 높은 부분을 측정할 수 있고 연부조직의 특성을 연구할 수 있는 등가물질로서 구입하기 쉽고 제작이 수월한 장점을 비롯하여 경제성이 있음을 증명하는 계기가 되었다.

• Journal of Chest Surgery
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• 제44권2호
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• pp.137-141
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• 2011

Background: There is controversy about the benefit of surgical correction of an atrial septal defect (ASD) in patients over 60 years old. The purpose of this study was to determine whether surgical treatment is beneficial in those 60 years of age or older. Materials and Methods: We reviewed the clinical course of 57 patients (mean age: $63.54{\pm}5.59$ years) diagnosed with an isolated secundum ASD after the age of 60. The 24 patients (group A) who underwent surgical repair were compared with the 33 patients (group B) who were treated non-surgically. The mean follow-up period was $6.8{\pm}4.5$ years. Results: One operative death, 5 late deaths (20.8%) in group A, and 9 deaths (27.3%) in group B occurred in the study period. Symptomatic improvement was noted in 18 patients (75%) of group A after surgery. However 13 patients (39.4%) of group B showed symptomatic improvement during the follow-up period (p=0.012). The incidence of new atrial arrhythmia of the two groups was significantly different (16.7% vs 36.7%, p=0.038). The actuarial 10 year survival rate was 79% in group A and 73% in group B. Conclusion: Although surgical correction of ASD did not increase survival in patients over 60 years old, the surgical outcomes of ASD showed low operative mortality and resulted in symptomatic improvement in the majority of these patients. This study has shown the benefits of surgical closure of ASD even in advanced age in comparison to medical treatment.

• 한국항공우주학회지
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• 제40권9호
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• pp.827-832
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• 2012

본 논문에서는 저궤도 위성의 반작용 휠 속도 측정을 위해 M-방식과 T-방식 모두 검출가능한 보드를 설계하여 두 방식의 장점을 이용할 수 있도록 하고, 실제 위성탑재컴퓨터에 장착하여 시험을 수행하고 이를 통하여 그 설계의 유용성을 검증한다. 위성에서 반작용 휠은 위성의 자세를 변화시킬 수 있는 대표적인 구동기의 하나로 반작용 휠 구동모터의 회전에 의해 발생하는 회전관성에 의해 자세 제어를 수행하게 된다. 반작용 휠의 회전속도를 검출하는 방법으로는 일정한 주기 T 동안 발생된 반작용 휠 내부 타코 펄스를 세어 휠의 속도를 검출하는 M-방식과 휠에서 발생되는 타코 펄스들 간의 시간을 측정해서 속도를 검출하는 T-방식으로 나눌 수 있다. M-방식은 구현이 간단하고 측정 시간이 일정하다는 장점이 있으나, 저속에서는 속도 측정 분해능이 떨어진다는 단점이 있다. 그에 반해, 타코 펄스간의 시간을 측정하는 T-방식은 저속에서 정밀한 속도를 측정할 수 있으며 측정에 따른 시간 지연이 작다는 장점이 있다. 그러나 이 방법 역시 실제 구현에 있어서 연산이 복잡하고 속도에 따라 연산 속도가 달라진다는 단점이 있다.

• 보건행정학회지
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• 제18권2호
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• pp.1-18
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• 2008

As medical insurance had been implemented for Magnetic Resonance Imaging (MRI) from January 1, 2005, this study investigated whether there had been any change in the amount of the medical care utilization of patients who undertook MRI before and after the insurance coverage, and was to examine factors affecting the amount of medical care utilization of MRI. Data were collected from patients who undertook MRI before and after the insurance coverage for a year at a general hospital in Kyeanggi-do. $X^2$ and t-test were used for the analysis of their general characteristics, the number of MRI, and its medical costs before and after the insurance coverage, and hierarchical multiple regression analysis for the factors affecting the amount of the medical care utilization of MRI. The results of this study were as follows. First, the number of MRI after the insurance coverage was significantly decreased. Second, there was no significant difference in the total medical costs of MRI after the insurance coverage, but a significant difference was found in patient's share of medical costs. Third, six variables were found to be affecting the amount of the medical care utilization of MRI, and the variables showed to lead the number of MRI decrease after the insurance coverage. These six factors explained 21.4% of the total number of MRI. As MRI had been covered by insurance, the use of MRI and patient's share of the costs were deceased, but the total medical costs were not affected. Reasons for that could be found in that MRI insurance, different from the case of CT insurance coverage, was allowed not to cover some items and the kinds of diseases subjected to the insurance coverage were extremely limited, lowering insurance prescription rate. In addition to that, the average medical cost of MRI was not changed after the insurance coverage. Therefore, as future measures for the MRI insurance, coverage, it should be considered to allow insurance coverage to no coverage items and to expand the scope of benefit coverage, or to lower patient's share of the costs. Furthermore, researches should be done to explore how recipients will act and how suppliers will react if the coverage is expanded, including expanding the scope of coverage and reducing patient's share of the costs, as well as to conduct research on its economic analysis according to case mix.

• 한국식품영양과학회지
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• 제46권7호
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• pp.857-867
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• 2017

본 연구는 저분자 해양성 콜라겐과 GABA 생성 L. brevis CFM20의 섭취 시 다양한 인체 장내 조건에 의한 유산균의 사멸과 콜라겐의 분해를 최소화하고자 진행되었다. 유산균과 저분자 해양성 콜라겐의 안정성을 향상하기 위하여 alginate와 chitosan을 이용하여 이중코팅캡슐을 제조하였다. L. brevis CFM20의 온도별 생육특성을 분석하여 캡슐화에 유리한 배양온도를 조사한 결과 $37^{\circ}C$에서 배양한 균의 대수기가 가장 빠르고 GABA양 또한 $400{\mu}g/mL$로 가장 높은 수치를 나타내어 생육속도에서 가장 유리한 것으로 나타났다. Calcium-alginate bead 법으로 캡슐을 제조한 결과 1~2 mm 사이의 일정한 구형의 캡슐을 제조하였으며, chitosan을 이용하여 이중코팅캡슐을 제조한 결과 캡슐의 크기가 감소하였고 외형적으로도 더욱 단단해짐을 확인하였다. 제조된 이중코팅캡슐을 CLSM과 SEM을 이용하여 관찰한 결과, chitosan 코팅을 한 이중코팅캡슐의 표면이 alginate와의 가교결합에 의해 더욱 치밀해짐을 확인하였다. 체내 위와 장내 조건에서 시간에 따른 이중코팅캡슐의 L. brevis CFM 20 생균수를 분석한 결과 캡슐화한 경우 균의 감소가 더디어 더 안정하다고 판단하였다. 이중코팅캡슐을 체내 위와 장내 조건에서 시간에 따른 GABA와 hydroxyproline의 용출량을 분석한 결과 두 경우 모두 위 조건에서는 낮은 수치를 나타내었고 장내 조건에서는 시간이 지남에 따라 급격하게 증가한 것을 확인하였다. 동물실험 결과 콜라겐 섭취군이 비섭취군에 비해 체중증가량, 혈청 지질 농도 등이 적은 것을 확인하였고, 혈액 내 hydroxyproline 함량, 진피의 피부조직 밀도가 더 높은 것으로 관찰되었다. 본 연구에서 개발된 이중코팅캡슐을 섭취하는 경우 위에서는 안정한 상태였다가 장에 도달한 후 붕해됨으로 인하여, 유산균, GABA, 콜라겐 및 키토산의 작용으로 인체에 유익한 효과를 기대할 수 있을 것으로 생각된다.

• Clinical and Experimental Reproductive Medicine
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• 제43권2호
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• pp.126-132
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• 2016

Objective: The purpose of this study was to identify useful clinical factors for the identification of patients with polycystic ovary syndrome (PCOS) who would benefit from in vitro maturation (IVM) treatment without exhibiting compromised pregnancy outcomes. Methods: A retrospective cohort study was performed of 186 consecutive patients with PCOS who underwent human chorionic gonadotropin-primed IVM treatment between March 2010 and March 2014. Only the first IVM cycle of each patient was included in this study. A retrospective case-control study was subsequently conducted to compare pregnancy outcomes between IVM and conventional in vitro fertilization (IVF) cycles. Results: Through logistic regression analyses, we arrived at the novel finding that serum $anti-M{\ddot{u}}llerian$ hormone (AMH) levels and the number of fertilized oocytes in IVM were independent predictive factors for live birth with unstandardized coefficients of 0.078 (95% confidence interval [CI], 1.005-1.164; p=0.037) and 0.113 (95% CI, 1.038-1.208; p=0.003), respectively. Furthermore, these two parameters were able to discriminate patients who experienced live births from non-pregnant IVM patients using cut-off levels of 8.5 ng/mL and five fertilized oocytes, respectively. A subsequent retrospective case-control study of patients with PCOS who had serum AMH levels ${\geq}8.5ng/mL$ showed that IVM had pregnancy outcomes comparable to conventional IVF, and that no cases of ovarian hyperstimulation syndrome were observed. Conclusion: Serum AMH levels are a useful factor for predicting pregnancy outcomes in PCOS patients before the beginning of an IVM cycle. IVM may be an alternative to conventional IVF for PCOS patients if the patients are properly selected according to predictive factors such as serum AMH levels.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2018년도 추계학술대회
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• pp.593-596
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• 2018

The speed of vehicles has remained a significant factor that influences the severity of accidents and traffic accident rate in many parts of the world including South Korea. This behavior where drivers drive at speeds which exceed a posted safe threshold is known as 'speeding'. Over the past twenty years, the Korean National Police Agency (NPA) has become aware of an increased frequency of drivers who are speeding. Therefore, fixed-type ASE systems [1] have been installed on hazardous road sections of many highways. These system monitor vehicle speeds using a camera. However, the use of ASE systems has changed the behavior of the drivers. Specifically, drivers reduce speed or avoid the route where the cameras are mounted. It is not practical to install cameras at every possible location. Therefore, it is challenging to thoroughly explore the location where speeding occurs. In view of these problems, the author of this paper designed and implemented a prototype visualization system in which point and color are used to show vehicle location and associated over-speed information. All of this information was used to create a comprehensive visualization application to show information about vehicle driving. In this paper, we present an approach detecting vehicles moving at speeds which exceed a threshold and visualizing the points those violations occur on a map. This was done using vehicle trajectory data collected in Daegu city. We propose steps for exploring the data collected from those sensors. The resulting mapping has two layers. The first layer contains the dynamic vehicle trajectory data. The second underlying layer contains the static road networks. This allows comparing the speed of vehicles on roads with the known maximum safe speed of those roads, and presents the results with a visualization tool. We also compared data about people who drive over threshold safe speeds on each road on days and weekends based on vehicle trajectories. Finally, our study suggests improved times and locations where law enforcement should use monitoring with speed cameras, and where they should be stricter with traffic law enforcement. We learned that people will drive over the speed limit at midnight more than 1.9 times as often when compared with rush hour traffic at 8 o'clock in the morning, and 4.5 times as often when compared with traffic at 7 o'clock in the evening. Our study can benefit the government by helping them select better locations for installation of speed cameras. This would ultimately reduce police labor in traffic speed enforcement, and also has the potential to improve traffic safety in Daegu city.

• Journal of Yeungnam Medical Science
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• 제2권1호
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• pp.191-202
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• 1985

우리 나라에서는 과거 20년간 경제사정이 호전되고 과학기술이 발달됨에 따라 국민 평균수명이 크게 연장 되였으며, 따라서 노인인구도 증가하게 되었다. 이와 같은 인구분포의 변화로 야기되는 여러 가지 문제중, 노령인구의 보건의학적인 현실성을 고찰하였다. 한국의 65세 이상 노인인구는 162만명으로 전체 인구의 4.0%를 차지하여 과거에 비하여 빨리 증가하였으나 8.9%, 10.3%, 15.8%의 일본, 미국 및 영국에 비해서는 아직 훨씬 낮은 편이다. 65세 이상 노인들의 25% 이상에서 진료를 요하는 높은 질환율을 나타내었으며, 질병별로는 순환기계질환 30.9%, 호흡기계질환 17.1%, 소화기계질환 8.6%, 정신장애 8.4%, 악성신생물 7.0% 등의 순이었다. 의료수혜 현황으로는 의료보호와 의료보험을 합하여 51%의 노인인구가 전액 혹은 일부 의료비 보조혜택을 받을 수 있으나 보험수혜노인의 수진율은 극히 낮아(1981년에 2.0%) 노인들의 진료 기피의 한국적 특색을 보여주고 있다. 노인들에 많은 성인병들은 만성진행형이어서 조기진단, 전문적관리 및 장기진료가 필요하나, 노인전문 진료기관, 장기수용시설 및 전문인력은 전무한 실정이다. 급속히 증가하는 노인인구의 보건을 위하여 양로시설과 장애노인수용소의 조속한 확충과 가정방문 간호원제도, 노인의료수혜 확장, 무료 신체검사, 성인병 예방운동 등 정부차원의 제도적 개선과 적극적 지원이 지금부터라도 시행되어야 되겠다.

• 사상체질의학회지
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• 제25권2호
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• pp.108-114
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• 2013

Objectives This study was aimed to review a standardized method of retention enema by extracting elements associated with methods of retention enema from papers involved. Methods 1) Data sources : Retrieval was made, using 'Enema' or 'Retention Enema' as search words in MEDLINE, The Cochrane Library, KISS, RISS, and NDSL DB. 2) Study selection : Two authors excluded irrelevant papers and chose qualified abstracts in the rest of the papers. The chosen studies were reviewed fully by the authors so that they could screen the significant papers based on the exclusion criteria. 3) Data extraction : Data on the total number of subjects, the target disease, the type, quality, length, diameter of catheter, the insertion length of catheter, the sample, the sample volume, the process of retention enema and the number of performing retention enema were extracted from the selected studies. Results & Conclusions The retention enema can be applied to gastrointestinal diseases, genitourinary diseases, metabolic diseases such as hypertension and diabetes, headaches and neurological disorders. The standardized treatment method is as following: 1) inserting a rental tube of 18-28 Fr that measures 20 to 30 cm into the patient's anus, 2) injecting herbal medicines which have purgative action or benefit on stomach and intestinal tract at the rate of 4 ml/min, and 3) holding them for 10 to 15 minutes.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제40권
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• pp.16.1-16.5
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• 2018

Background: Proliferative verrucous leukoplakia (PVL) is an oral potentially malignant disorder, characterized by multifocal expression, progressive clinical evolution, and a high rate of malignant transformation. Evidence-based information regarding optimal PVL management is lacking, due to the paucity of data. The present report describes a case of PVL associated with HPV-16 infection and epithelial dysplasia treated by diode laser surgery, and the outcome of disease clinical remission over a 2-year follow-up period. Case report: A 61-year-old Caucasian male with oral verrucous hyperkeratosis presented for diagnosis. The lesions were localized on the maxillary gingiva and palatal alveolar ridge. Multiple biopsy specimens have been taken by mapping the keratotic lesion area. Microscopic examination was compatible with a diagnosis of PVL with focal mild dysplasia, localized in the right maxillary gingiva. Polymerase chain reaction (PCR) was done for human papillomavirus (HPV) detection which revealed presence of HPV DNA, and the genotype revealed HPV 16 in the sample. The PVL in the right gingival area was treated on an outpatient basis by excision with a diode laser. This approach resulted in good clinical response and decreased morbidity over a 2-year follow-up period. Conclusions: This case illustrates the benefit of a conservative approach by diode laser treatment than wide surgical excision for management of the PVL lesions associated with mild dysplasia and HPV-16 infection.