• 한국농공학회논문집
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• 제51권6호
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• pp.45-52
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• 2009

This study was conducted in the process that the basic plan of the formation of the thermal energy complex in the Iwon reclaimed land of Taean was being made. Targeting for the large-sized greenhouse to be made in this area, it examined the cooling and heating load and the amount of ventilation, and also analyzed the economic efficiency of heating. The research results are as per the below: The minimum ambient temperature of this area was measured on January 7, 2001, which was $-18.7^{\circ}C$, and the maximum ambient temperature of this area was measured on July 24, 1994, which was $36.7^{\circ}C$. The maximum heating load was 39,011 MJ/h, but the date when the maximum heating load was not consistent with the date when the minimum temperature was measured. The maximum cooling load was 88,562MJ/h, It was approximately 2.3 times of the maximum heating load, which was measured at 14:00 hours on September 4, 2000. The maximum amount of ventilation heat was 138,639MJ/h. Assuming the rate of solar heat use as 10%, 20%, 50%, and 100%, the total sum of cost-benefit would be ￦-193,450,000, ￦-634,930,000, ￦-3,372,960,000, and ￦-9,850,420,000, respectively 20 years later. The break-even point of the geothermal heat pump would be about 4 years for 10% use, about 3 years for 20% or 50% use, and approximately 6 years for 100% use. It was found that 50% use would be most advantageous. In case two systems are combined, the break-even point will be 10 years, 8 years, and 11 years respectively.

• 한국콘텐츠학회논문지
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• 제16권5호
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• pp.783-801
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• 2016

본 연구는 여성장애인의 노동시장 진입에 영향을 미치는 요인을 파악하여, 여성장애인의 노동시장 진입을 지원할 수 있는 정책적인 대안을 제시하는 데 그 목적이 있다. 이를 위해서 장애인고용패널조사의 3차부터 7차까지의 종단자료를 활용하여 사건사분석을 실시하였다. 사건사분석을 통해 시간의 변화에 따른 여성장애인의 노동시장 진입이 어떠한 변화유형을 나타내는지, 영향을 미치는 요인은 무엇인지 분석하고자 하였다. 분석결과는 다음과 같다. 첫째, 미취업기간에 따른 노동시장 진입의 변화를 생명표 분석을 통해 분석한 결과, 최장 미취업기간(4년)까지 미취업상태로 남아있는 비율은 90%이고, 노동시장에 진입한 비율은 10%로 나타났다. 둘째, 노동시장 진입에 영향을 미치는 요인을 파악하고자 콕스회귀분석을 한 결 과 기초수급 여부, 장애정도, 구직 시 차별경험 요인이 노동시장 진입에 영향을 미치는 것으로 나타났다. 이러한 결과를 통해 여성장애인의 노동시장 진입 수준을 높이기 위한 실천적 방안을 제안하였다.

• 제어로봇시스템학회논문지
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• 제17권9호
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• pp.932-940
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• 2011

This paper presents an integrated analysis of supply chain and financing decisions of multi-national corporation. We construct a model in which multiple currency storage units are installed to manage the currency flows associated with multi-national supply chain activities such as raw material procurement, process operation, inventory control, transportation and finished product sales. Core contribution of this study is to quantitatively investigate the influence of macroscopic economic factors such as exchange rates and taxes on operational decisions. The supply chain is modeled by the Process-Storage Network with recycle streams. The objective function of the optimization is minimizing the opportunity costs of annualized capital investments and currency/material inventories minus the benefit to stockholders interpreted by home currency. The major constraints of the optimization are that the material and currency storage units must not be depleted. A production and inventory analysis formulation, the periodic square wave (PSW) model, provides useful expressions for the upper/lower bounds and average levels of the currency and material inventory holdups. The expressions for the Kuhn-Tucker conditions of the optimization problem are reduced to a subproblem and analytical lot sizing equations. The procurement, production, transportation and financial transaction lot sizes can be determined by analytical expressions after the average flow rates are already known. We show that, when corporate income tax is taken into consideration, the optimal production lot and storage sizes are smaller than is the case when such factors are not considered typically by 20 %.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4515-4520
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• 2015

GELOX (gemcitabine, oxaliplatin and L-asparaginase) regimen showed an impressive result in our previous study, but the effect of this new regimen is still dissatisfying for some patients, so it is necessary to identify which patients will benefit from this regimen. A total of fifty-one cases with nasal natural killer/T-cell lymphoma receiving initial GELOX chemotherapy were enrolled in this study. The ki-67 expression detected by immunohistochemistry (IHC) in the specimens ranged from 10% to 90%, with a median value of 70%, so cases higher than the median value (${\geq}70%$) were defined as high ki-67 expression, and the others were designated as low ki-67 expression. The response rate had no statistical difference between low ki-67 expression group and high ki-67 expression group (P=0.291) though the value in the former group was relatively high. After a median follow-up of 18.03 months, the 3-year progression-free survival (PFS) for patients with low ki-67 expression was significantly higher than those with high ki-67 expression (83.8% vs. 47.9%, P=0.038). In the stage I/II subgroup, 3-year PFS and overall survival (OS) were statistically higher in the patients with low ki-67 expression than those with high ki-67 expression. Multivariate analysis revealed high ki-67 expression was an independent prognostic factor for PFS. These results suggest that low ki-67 expression can predict a good response of GELOX in these patients, and the combination of ki-67 expression and early stage is helpful to identify an excellent prognosis subgroup from patients receiving GELOX in this disease.

• 한국환경과학회지
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• 제17권9호
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• pp.969-980
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• 2008

This research was performed to simulate shellfish production systems and sales in Gamak Bay, South Korea. To study the way the shellfish system generates maxima, a numerical model was developed to simulate the model under a control and a number of different scenarios. The program calculates the EMERGY flows by multiplying the flows of energy and materials by the appropriate solar transformity. In this study, an energy systems model was built to simulate the variation of sustainability for oyster aquaculture. The results of the simulation based on 2005 data that as oyster production yield slightly increases, money and assets increase to a steady state. When the program is run control simulation, the system reaches carrying capacity after 8 years. The simulation of models with price of purchased inputs increased with 3.5% inflation rate per year showed maximum benefit of shellfish production occurs after 6 years but amounts are less than control simulation, and then decreases slightly in money and yield results. The results with 3.5% inflation and increase of oyster price annually showed steady and slightly increase of money and yield.

• Biotechnology and Bioprocess Engineering:BBE
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• 제11권3호
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• pp.245-250
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• 2006

The effects of aliphatic hydrocarbons (n-hexadecane and n-dodecane) on the volumetric oxygen mass transfer coefficient $(k_L\;a)$ were studied in flat alveolar airlift reactor and continuous stirred tank reactors (CSTRs). In the flat alveolar airlift reactor, high aeration rates (>2vvm) were required in order to obtain efficient organic-aqueous phase dispersion and reliable $k_La$ measurements. Addition of 1% (v/v) n-hexadecane or n-dodecane increased the $k_La$ 1.55- and 1.33-fold, respectively, compared to the control (superficial velocity: $25.8{\times}10^{-3}m/s$, sparger orifice diameter: 0.5 mm). Analysis of the gas-liquid interfacial area a and the liquid film mass transfer coefficient $k_L$ suggests that the observed $k_La$ increase was a function of the media's liquid film mass transfer. Addition of 1% (v/v) n-hexadecane or n-dodecane to analogous setups using CSTRs led to a $k_La$ increase by a factor of 1.68 and 1.36, respectively (superficial velocity: $2.1{\times}10^{-3}m/s$, stirring rate: 250 rpm). These results propose that low-concentration addition of oxygen-vectors to aerobic microbial cultures has additional benefit relative to incubation in purely aqueous media.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7441-7447
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• 2015

Objective: This study evaluated the safety and objective response of combining $^{131}I$-labeled-metuximab (Licartin) with transarterial chemoembolization (TACE) in the treatment of unresectable hepatocellular carcinoma (HCC). Materials and Methods: In a multicenter open-label clinical trial, 341 enrolled patients with stage III/IV HCC according to TNM criteria were nonrandomly assigned to a trial group (n=167) and a control group (n=174), undergoing TACE following hepatic intra-arterial injection of licartin or TACE alone from July 2007 to July 2009. Radiopharmaceutical distribution was evaluated. The primary endpoint was overall survival; secondary endpoints included time-to-progression (TTP), toxicity and adverse events (AEs). Results: The radiobiological distribution demonstrated better localization of licartin in liver tumors than other tissues (P<0.01). The organ absorbed doses to liver and red marrow were $3.19{\pm}1.01Gy$ and $0.55{\pm}0.22Gy$, respectively. The 1-year survival rate was significantly higher [79.47% vs. 65.59%, hazard ratio (HR), 0.598, P=0.041] and TTP significantly improved ($6.82{\pm}1.28$ vs. $4.7{\pm}1.14months$, P=0.037) compared with the control group. Patients at stage III achieved more benefit of one year survival than stage IV in the trial group (86.9% vs. 53.8%, P<0.001). There were significant different toxicities in leukocytopenia, thrombocytopenia and increased total bilirubin level [P<0.001, P=0.013, P<0.01, relative risk (RR) 1.63, 1.33, 1.43], but no differences in severe AEs of upper GI hemorrhage and severe liver dysfunction between the groups (5.39% vs. 2.3%, P=0.136). Conclusions: Owing to excellent tumor-targeting, promised efficacy and favourable toxicity profile, the novel combination therapy of licartin and TACE could be applied in patients with unresectable HCC.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6397-6401
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• 2012

Background: No factor has thus far been identified to predict the efficacy of bevacizumab therapy for colorectal cancer. We here therefore studied PTEN, VEGF, HER2 and p53 by immunohistochemistry as possible prognostic and predictive factors. Materials and Methods: A total of 34 retrospectively collected tumor samples were evaluated, all from patients receiving bevacizumab-based regimens. VEGF-A, PTEN, HER2, p53 were assessed and data was compared with clinicopathologic characteristics of patients and the bevacizumab response rate. Results: In this study, the median age of the 34 metastatic colorectal cancer patients was 55.5 (24-75), twelve (35.3%) being women and 22 (64.7%) men. PTEN, VEGF, HER2, p53 expressions were compared with bevacizumab response and other chacteristics of disease. Statistical significant differences were not found between bevacizumab response rates and different expression levels of VEGF, PTEN, HER2 and p53 (respectively p=0.256, p=0.832, p=0.189, p=0.131). However, a survival difference was noted in the VEGF expression negative group (median OS:55 months; 95%CI, 22-88 months) (p=0.01). There was no statistically significant OS difference in other groups (PTEN p=0.6, HER2 p=0.189, p53 p=0.13). Conclusions: We did not find any predictive factor for BV therapy in our study. VEGF negative expression could be an important prognostic factor in metastatic colorectal carcinoma.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.5989-5994
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• 2012

Background: There is little information on longitudinal patterns of participation in faecal occult blood test (FOBT) based colorectal cancer (CRC) screening or on demographic or behavioural factors associated with participation in re-screening. The lack of an agreed system for describing participatory behaviour over multiple rounds also hampers our ability to report, understand and make use of observed associations. Our aims were to develop a system for describing patterns of participatory behaviour in FOBT-based CRC screening programs and to identify factors associated with particular behavioural patterns. Methods: A descriptive framework was developed and applied to a data extract of screening invitation outcomes over two rounds of the NBCSP. The proportion of invitees in each behaviour category was determined and associations between behaviour patterns and demographic and program factors were identified using multivariate analyses. Results: We considered Re-Participants, Dropouts, Late Entrants and Never Participants to be the most appropriate labels for the four possible observed participatory categories after two invitation rounds. The screening participation rate of the South Australian cohort of the NBCSP remained stable over two rounds at 51%, with second round Dropouts (10.3%) being balanced by Late Entrants (10.5%). Non-Participants comprised 38.7% of invitees. Relative to Re-Participants, Dropouts were older, more likely to be female, of lower SES, had changed their place of residence between offers had a positive test result in the first round. Late Entrants tended to be in the youngest age band. Conclusions: Specific demographic characteristics are associated with behavioural sub-groups defined by responses to 2 offers of CRC screening. Targeted group-specific strategies could reduce dropout behaviour or encourage those who declined the first invitation to participate in the second round. It will be important to keep first round participants engaged in order to maximise the benefit of a CRC screening program.

• 한국태양에너지학회:학술대회논문집
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• 한국태양에너지학회 2012년도 춘계학술발표대회 논문집
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• pp.370-375
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• 2012

국가개발연구원(KDI)에서는 새만금에 40MW 용량의 국산 풍력발전단지 조성을 위한 예비타당성 조사를 실시하였다. 본 사업에 대한 KDI의 비용편익 분석 결과 순 현재가치가 0보다 작고, B/C 비율은 0.73으로 경제적 타당성이 나타나지 않았다. 하지만 모든 비용과 편익을 화폐가치로 환산해 내는 비용편익분석은 여러 가지 외부효과로 인해 사업의 타당성 연구자들에 의해 주관적인 결과물이 나오기도 한다. 이에 따라 본 논문에서는 새만금 풍력발전 시범단지의 경제성 평가 재검토 연구를 실시하였다. 본 논문에서는 기존 경제성 평가 항목에 대하여 여러 가지 쟁점을 제시하고, 그 중에서 대기오염물질 저감 비용과 학습효과(learning effect)로 인한 비용 절감 편익을 추가적으로 산정하였다. 여기서 학습효과의 학습속도(learning rate) 를 세 가지 시나리오로 나누어 분석하였다. 두 가지의 추가 편익을 KDI의 기존 예비타당성 조사 분석에 추가한 순 현재가치는 상당한 양의 값이 나왔고, B/C 비율은 8.8 로 편익이 비용에 비해 크게 증가했다. 이러한 항목들의 포함 여부에 따라 타당성 결과가 현저하게 달라짐을 알 수 있다. 향 후 비용편익 분석이 정책 결정에 적절히 반영되기 위해서는 외부효과를 고려한 환경 비용, 그리고 학습효과와 같은 추가적인 사항들이 면밀히 검토되어야 한다. 시장에 기반하지 않은 이러한 외부효과로 인한 항목들은 대상과 시기에 따라 매우 다른 결과를 보여주기에 이에 대한 세부적인 연구가 필요한 시점이다.