• Natural Product Sciences
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• v.10 no.6
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• pp.284-288
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• 2004

We have recently reported that red ginseng acidic polysaccharide (RGAP), isolated from Korean red ginseng (Panax ginseng C. A. Meyer), showed immunomodulatory antitumor activities, mainly mediated by nitric oxide (NO) production by macrophage. In this study, we examined the effect of RGAP on anticancer activity using lung carcinoma 3LL, sarcoma 180 and adenocarcinoma JC tumor cells transplanted into mice as well as antimetastatic activity using B16-F10 melanoma. When RGAP (300 mg/kg) were treated to mice implanted with one of the three kinds of tumor cells, the tumor weight significantly decreased compared with control mice. Tumor inhibition ratios of RGAP (300 mg/kg) in mice transplanted with lung carcinoma 3LL, sarcoma 180 and adenocarcinoma JC cells were 26.8%, 29.3% and 31.6%, respectively. Hundred mg/kg of RGAP did not cause a significant decrease in tumor weight compared with control group. When RGAP was administered i.p. with the dose of 100 and 300 mg/kg in B16-F10 melanoma-bearing mice, lung metastasis were reduced significantly in mice. Corrected phagocytic index was also remarkably increased by RGAP. These results suggest that stimulation of phagocytic activity of macrophages may be a mechanism for in vivo anticancer and antimetastasis activities of RGAP.

• Earthquakes and Structures
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• v.12 no.1
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• pp.79-89
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• 2017

As a new type of energy dissipation component with excellent mechanical performance, the Buckling-Retrained Braces (BRBs) were gradually applied in retrofitting and improving seismic performance of reinforced concrete structures in China. In order to investigate the seismic performance of reinforced concrete structures retrofitted with BRBs, quasi-static test of two single-bay and 3-story reinforced concrete frames specimens was conducted and introduced in this paper. Two 1/2 scaled specimens were designed to reflect real prototype structure. For comparison, one control specimen was designed without BRBs, and the other specimen was retrofitted with BRBs. And particularly, for the specimen retrofitted with BRBs, the BRBs were eccentric layout instead of usually concentric or x-shaped layout, aiming to be more suitable for large-span frames. In the test, the failure mode, carrying capacity, deformability, ductility and energy dissipation ability of both two specimens were investigated. Based on the test results of the measured hysterical curves, skeleton curves, the seismic performances such as bearing capacity, plastic deformability, energy dissipation ability and ductility of two specimens were fully studied. And from the test results, it was indicated that the specimen retrofitted with BRBs showed much better seismic performance than the control specimen without BRBs, and the BRBs could effectively improve the seismic performance of the reinforced concrete frame. For the specimen retrofitted with BRBs, the BRBs firstly yielded before the beam-ends and the column-ends, and an expected yielding process or yielding mechanism as well as good seismic performance was obtained. For the specimens without BRBs, though the beam-ends yielded prior to the column-ends, the seismic performance was much poor than that of the specimen with BRBs.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.05
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• pp.245-248
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• 1997

Excessive stress on the bone-stem interface may cause local micromotion that could produce midthigh pain, interface bone resorption and prevent bony ingrowth. It is important for clinician and prosthetic designer to develop an understanding of the load transfer mechanism, its associated stress pattern and its relationships with the particular mechanical characteristics of the femoral stem designs. Finite element method (FEM) is preeminently suited to provide information in this respect. The authors developed 3-dimensional numerical finite element models implanted with the straight stem which is composed of total 1170 elements of 8 nodes and with the curved stem which is composed of total 885 elements of 8 node, and analysed the relative micromotions between the straight stem and the curved stem in immediate postoperative stage of an uncemented total hip replacement in load simulating the single leg stance. The results showed that the rotational displacement was occupied over 90% of total micromotion in both types of stem and was peak at the proximal medial portion of the stem, but markedly less distally. The curved stem was more stable especially in terms of rotational stability. It is recommended that surgeons do not allow the patient weight bearing until bony ingrowth was achieved. In the future more attention should be drawn to increase initial rotational stability of the two types of femoral stem to prevent loosening from excessive micromotion.

• Journal of Positioning, Navigation, and Timing
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• v.6 no.4
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• pp.195-203
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• 2017

A 2U cube satellite called SNUGLITE has been developed by GNSS Research Laboratory in Seoul National University. Its main mission is to perform actual operation by mounting dual-frequency global positioning system (GPS) receivers. Its scientific mission aims to observe space environments and collect data. It is essential for a cube satellite to control an Earth-oriented attitude for reliable and successful data transmission and reception. To this end, an attitude estimation and control algorithm, Attitude Determination and Control System (ADCS), has been implemented in the on-board computer (OBC) processor in real time. In this paper, the Extended Kalman Filter (EKF) was employed as the attitude estimation algorithm. For the attitude control technique, the Linear Quadratic Gaussian (LQG) was utilized. The algorithm was verified through the processor in the loop simulation (PILS) procedure. To validate the ADCS algorithm in the ground, the experimental verification via a single axis Hardware-in-the-loop simulation (HILS) was used due to the simplicity and cost effectiveness, rather than using the 3-axis HILS verification (Schwartz et al. 2003) with complex air-bearing mechanism design and high cost.

• Journal of Korean Medicine Rehabilitation
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• v.24 no.2
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• pp.51-64
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• 2014

Objectives This study was carried out to know the effects of Keonbodan (hereinafter referred to KBD) in osteoarthritis induced by Monosodium iodoacetate(hereinafter referred to MIA) on Wistar rat. Methods Osteoarthritis was induced by injection of MIA into left knee joint cavities of rat. Osteoarthritis rats were divided into 4 groups (normal (n=6), control (n=6), indomethacin (n=6), KBD (n=6) group). The control group was administered normal saline and indomethacin group was administered indomethacin (2 mg/kg). And the KBD group was administered KBD (142 mg/kg). Each groups were administered by orally for 4 weeks. This experiment were carried out in vivo. In vivo, at the end of the experiment (5 weeks after MIA injection), effects on hepatotoxicity and nephrotoxicity, cytokines in serum, arachidonic acid, osteocalcin, MMP-9, TIMP-1 and cartilage volume were evaluated. And histopathological examinations on the articular structures of knee joints were performed. Results 1. In weight-bearing measurement, level of weight was increased. 2. In order to hepatotoxicity and nephrotoxicity, ALT, AST, BUN and creatinine were tested. And there were no significant changes. 3. In serum, levels of TNF-$\alpha$, IL-$1{\beta}$ were significantly decreased. IL-6 was insignificantly decreased. 4. In serum, level of MMP-9 and TIMP-1 was decreased. 5. In serum, level of $LTB_4$, $PGE_2$ and osteocalcin was decreased. 6. In ${\mu}$CT-arthrography, the cartilage volume was greater than that of the control group. 7. The joint damage induced by osteoarthritis was lesser than the control group in histopathologic observation (H&E, Safranin-O staining). Conclusions These results demonstrated that KBD suppressed the osteoarthritis- inducing effects of MIA in rat. And further studies are required to find out more effective substance and anti-osteoarthritic mechanism in the future.

• Geomechanics and Engineering
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• v.19 no.6
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• pp.485-498
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• 2019

Pre-tensioned rock bolts can be classified into fully anchored, lengthening anchored and point anchored bolts based on the bond length of the resin or cement mortar inside the borehole. Bolts in varying anchoring methods may significantly affect the supporting effect of surrounding rock around a tunnel. However, thus far, the theoretical basis of selecting a proper anchoring method has not been thoroughly investigated. Based on this problem, 16 schemes were designed while incorporating the effects of anchoring length, pretension, bolt length, and spacing, and a systematic numerical experiment was performed in this paper. The distribution characteristics of the stress field in the surrounding rock, which corresponded to various anchoring scenarios, were obtained. Furthermore, an analytical approach for computing the active and passive strengthening index of the anchored surrounding rock is presented. A new fully anchoring method with pretension and matching technology are also provided. Then, an isolated loading model of the anchored surrounding rock was constructed. The physical simulation test for the bearing capacity of the model was performed with three schemes. Finally, the strengthening mechanism of varying anchoring methods was validated. The research findings in this paper may provide theoretical guidelines for the design and construction of bolting support in tunnels.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3907-3912
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• 2015

Purpose: To investigate the antitumor activity and mechanism of chloroquine (CQ) in combination with cisplatin (DDP) in nude mice xenografted with gastric cancer SGC7901 cells. Materials and Methods: 35 cases of gastric cancer patients with malignant ascites were enrolled and intraperitoneal cisplatin injection was performed. Ascites were collected before and 5 days after perfusion for assessment of autophagy levels in cancer cells. In addition, 24 tumor-bearing mice were randomly divided into control, DDP, CQ and CQ + DDP groups. Results: In 54.3% (19/35) of patients the treatment was therapeutically effective (OR), 5 days after peritoneal chemotherapy, 13 patients had the decreased ascites Beclin-1 mRNA levels. In 16 patients who had NR, only 2 cases had decreased Beclin-1 (P=0.001). Compared with the control group, the xenograft growth in nude mice in the DDP group was low, and the inhibition rate was 47.6%. In combination with chloroquine, the inhibition rate increased to 84.7% (P<0.01). The LC3-II/I ratio, and Beclin1 and MDR1/P-gp expression were decreased, while caspase 3 protein levels increased (P<0.05). Conclusions: Antitumor ability of cisplatin was associated with autophagy activity and chloroquine can enhance chemosensitivity to cisplatin in gastric cancer xenografts nude mice.

• Journal of Korean Society of Steel Construction
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• v.28 no.4
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• pp.231-242
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• 2016

Earthquake resistance of RC column-steel beam (RCS) joints with simplified details were studied. Simplified details are necessary for large columns to improve the productivity and constructability. To strengthen the beam-column joint, the effects of transverse beams, studs, and U-cross ties were used. Four 2/3 scale interior RCS connections were tested under cyclic lateral loading. The specimens generally exhibited good deformation capacity exceeding 4.0% story drift ratio after yielding of both beam and beam-column joint. Ultimately, the specimens failed by shear mechanism of the joint panel. The test strengths were compared with the predictions of existing design methods.

• Journal of the Korean Geotechnical Society
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• v.19 no.4
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• pp.223-233
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• 2003

Sand compaction pile (SCP) is one of the ground improvement techniques which are being used for not only accelerating consolidation but also increasing bearing capacity of loose sands or soft clay grounds. In this study, laboratory model tests and 3-D finite element analyses were performed to investigate the interaction between sand compaction piles and surrounding soft soils. Based on the results obtained, as the area replacement ratio increases, the stress concentration ratio increases at the pile point, the settlement decreases, and the relative displacement between column and soil also decreases. It is also found that numerical study is illustrated by good comparison with model test results, and the numerical analysis revealed slip effects which could not be specifically identified in the model tests.

• Korean Journal of Pharmacognosy
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• v.27 no.3
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• pp.231-237
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• 1996

The antitumor components of the protoplast fusants of Lentinula edodes and Ganoderma lucidum were examined for immunological activity to elucidate the mechanism of their antitumor activity. They did not show any direct cytotoxicity against tumor cells. But being examined for immunopotentiation activity, they increased the number of colonies in the bone marrow stem cells to 3.0 times. They also increased the activities of the acid phosphatase in activated macrophages to 2.1 times and the secretion of nitric oxide in RAW 264.7 to 2.2 times, respectively. They activated the components of the alternative complement pathway. In humoral immunity. they increased the activities of the alkaline phosphatase in differentiated B cells to 1.6 times and the number of plaque forming cells to 1.8 times, respectively. In cellular immunity, they restored the depressed response of delayed type hypersensitivity in tumor bearing mice to normal level.