• Journal of Korean Medicine Rehabilitation
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• v.31 no.1
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• pp.17-32
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• 2021

Objectives The present study was designed to find out the therapeutic effects and possible underlying mechanism of Buja-tang, a herbal complex formula on experimental monosodium iodoacetate (MIA)-induced osteoarthritis. Methods Osteoarthritis models were created via intra-joint injection of MIA (50 μL with 80 mg/mL) in rats. Rats were divided into five groups and each group consisted of seven. Normal group was not injected MIA and did a normal diet. Control group injected MIA and received distilled water. Indo injected MIA and oral administration of 5 mg/kg of indomethacin. BJTL injected MIA and oral administration of 100 mg/kg of Buja-tang. BJTH injected MIA and oral administration of 200 mg/kg of Buja-tang. We analyzed weight-bearing ability of hind paws, oxidative stress related factor, antioxidant protein, inflammatory protein, inflammatory messenger and cytokine in joint tissue. Pathological observation of knee cartilage tissue structures was also performed with hematoxylin & eosin and safranin-O chromosomes. Results Weight-bearing ability of hind paws showed a tendency to reduce pain. The incidence of nicotinamide adenine dinucleotide phosphate oxidase and p22phox in articular tissue was significantly reduced, and the incidence of nuclear factor-erythroid 2-related factor 2 and heme oxygenase-1 and superoxide dismutases was significantly increased. The incidence of phosphorylated inhibitor of κBα, nuclear factor-kappa B p65, inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor alpha, interleukin (IL)-6, and IL-1β decreased significantly. In pathological observation, cartilage tissue damaged by MIAs in biopsy has significantly recovered from Buja-tang administration. Conclusions Buja-tang has anti-inflammation, antioxidation and pain relief effects. So this is thought to inhibit the progress of osteoarthritis in rat caused by the MIA.

• Steel and Composite Structures
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• v.21 no.2
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• pp.267-287
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• 2016

The seismic performance of the ordinary steel reinforced concrete (SRC) columns has no significant improvement compared to the reinforced concrete (RC) columns mainly because I, H or core cross-shaped steel cannot provide sufficient confinement for core concrete. Two improved SRC columns by constructing with new-type shaped steel were put forward on this background, and they were named as enlarging cross-shaped steel and diagonal cross-shaped steel for short. The seismic behavior and carrying capacity of new-type SRC columns have been researched theoretically and experimentally, while the shear behavior remains unclear when the new-type columns are joined onto SRC beams. This paper presents an experimental study to investigate the shear capacity of new-type SRC joints. For this purpose, four new-type and one ordinary SRC joints under low reversed cyclic loading were tested, and the failure patterns, load-displacement hysteretic curves, joint shear deformation and steel strain were also observed. The ultimate shear force of joint specimens was calculated according to the beam-end counterforce, and effects of steel shape, load angel and structural measures on shear capacity of joints were analyzed. The test results indicate that: (1) the new-type SRC joints display shear failure pattern and has higher shear capacity than the ordinary one; (2) the oblique specimens have good bearing capacity if designed reasonably; and (3) the two proposed construction measures have little effect on the shear capacity of SRC joints embedded with diagonal cross-shaped steel. Based on the mechanism observed from the test, the formulas for calculating ultimate shear capacity considering the main factors (steel web, stirrup and axial compression ratio) were derived, and the calculated results agreed well with the experimental and simulated data.

• Structural Engineering and Mechanics
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• v.47 no.4
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• pp.575-598
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• 2013

The study presents the results of an experimental program concerning the shear force transfer between reinforced concrete (RC) jackets and existing columns with damages. In order to investigate the effectiveness of the repair method applied and the contribution of each shear transfer mechanism of the interface. It includes 22 concrete columns (core) (of 24,37MPa concrete strength) with square section (150mm side, 500 mm height and scale 1:2). Ten columns had initial construction damages and twelve were subjected to initial axial load. Sixteen columns have full jacketing at all four faces with 80mm thickness (of 31,7MPa concrete strength) and contain longitudinal bars (of 500MPa nominal strength) and closed stirrups spaced at 25mm, 50mm or 100mm (of 220MPa nominal strength). Fourteen of them contain dowels at the interface between old and new concrete. All columns were subjected to repeated (pseudo-seismic) axial compression with increasing deformation cycles up to failure with or without jacketing. Two load patterns were selected to examine the difference of the behavior of columns. The effects of the initial damages, of the reinforcement of the interface (dowels) and of the confinement generated by the stirrups are investigated through axial- deformation (slip) diagrams and the energy absorbed diagrams. The results indicate that the initial damages affect the total behavior of the column and the capacity of the interface to shear mechanisms and to slip: a) the maximum bearing load of old column is decreased affecting at the same time the loading capacity of the jacketed element, b) suitable repair of initially damaged specimens increases the capacity of the jacketed column to transfer load through the interface.

• Journal of the Korean Geotechnical Society
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• v.30 no.1
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• pp.103-116
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• 2014

This paper presents the results of a numerical investigation on the load carrying capacity and consolidation behavior of suction piles. Three dimensional numerical models which reflect realistic ground conditions and installation procedures including the ground-suction pile interface were adopted to conduct a parametric study on variables such as the length-diameter ratio and the loading configurations, i.e, vertical, horizontal, and combined loads. The results indicated that the load carrying capacity of a suction pile can only be realistically obtained when the interface behavior between the suction pile and the ground is correctly modeled. Also carried out was the stress-pore pressure coupled analysis to investigate the consolidation behavior of the suction pile after the application of a vertical loading. Based on the results, failure envelops and associated equations were developed, which can be used to estimate load carrying capacity of suction piles installed in similar conditions considered in this study. The results of consolidation analysis based on the stress-pore pressure coupled analysis indicate that no significant excess pore pressure and associated consolidation settlement occur for the loading configuration considered in part due to the load transfer mechanism of the suction pile.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.956-959
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• 2004

Recently the monitoring system of tool setting in high speed precision machining center is required for manufacturing products that have highly complex and small shape, high precision and high function. It is very important to reduce time to setup tool in order to improve the machining precision and the productivity and to protect the breakage of cutting tool as the shape of product is smaller and more complex. Generally, the combination of errors that geometrical clamping error of fixing tool at the spindle of machining tool and the asynchronized error of driving mechanism causes that the run-out of tool reaches to 3$^{\sim}$20 times of the thickness of cutting chip. And also the run-out is occurred by the misalignment between axis of tool shank and axis of spindle and spindle bearing in high speed rotation. Generally, high speed machining is considered when the rotating speed is more than 8,000 rpm. At that time, the life time of tool is reduced to about 50% and the roughness of machining surface is worse as the run-out is increased to 10 micron. The life time of tool could be increased by making monitoring of tool-setup easy, quick and precise in high speed machining tool. This means the consumption of tool is much more reduced. And also it reduces the manufacturing cost and increases the productivity by reducing the tool-setup time of operator. In this study, in order to establish the concept of tool-setup monitoring the measuring method of the geometrical error of tool system is studied when the spindle is stopped. And also the measuring method of run-out, dynamic error of tool system, is studied when the spindle is rotated in 8,000${\sim}$60,000 rpm. The dynamic phenomena of tool-setup are analyzed by implementing the monitoring system of rotating tool system and the non-contact measuring system of micro displacement in high speed.

• Journal of Korean Tunnelling and Underground Space Association
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• v.5 no.4
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• pp.349-360
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• 2003

A practical modeling approach has been proposed in this study to better understand the behavior of penetration grouting which is normally applied to the jointed rock masses to increase the bearing capacity and to reduce the ground water flow into the tunnel. Based on Bingham model together with a steady-state flow of the grout, penetration model is simulated in the commercial package called UDEC and, injection pressure as well as joint thickness are found to be the main parameters to determine the range of grout spread. Another numerical model on fracturing grouting is also suggested and, in this case, the tensile strength as well as cohesion of the rock masses are proven to be the major factors to decide the fracturing mechanism of the rock masses. The reinforcement effect of the grout-reinforced rock masses is calculated from the suggested algorithm on orthotropic material model and it is found that the directional stiffness of reinforced rock masses is increased up to 3 to 4 times compared with original jointed rock masses. Future work will be concentrated on the water control around the tunnel by the grout injection and a model test will also be performed to verify the suggested methods developed in this study.

• Steel and Composite Structures
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• v.21 no.5
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• pp.1157-1182
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• 2016

A newly puzzle shape of crestbond rib shear connector is a type of ductile perfobond rib shear connector. This shear connector has some advantages, including relatively easy rebar installation and cutting, as well as the higher shear resistance strength. Thus, this study proposed a newly puzzle shape of crestbond rib with a "${\mho}$" shape, and its shear resistance behaviors and shear strengths were examined using push-out tests. Five main parameters were considered in the push-out specimens to evaluate the effects of shear resistance parameters such as the dimensions of the crestbond rib, transverse rebars in the crestbond dowel, concrete strength, rebar strength, and dowel action on the shear strength. The shear loading test results were used to compare the changes in the shear behaviors, failure modes, and shear strengths. It was found that the concrete strength and number of transverse rebars in the crestbond rib were significantly related to its shear resistance. After the initial bearing resistance behavior of the concrete dowel, a relative slip occurred in all the specimens. However, its rigid behavior to shear loading decreased the ductility of the shear connection. The cross-sectional area of the crestbond rib was also shown to have a minor effect on the shear resistance of the crestbond rib shear connector. The failure mechanism of the crestbond rib shear connector was complex, and included compression, shear, and tension. As a failure mode, a crack was initiated in the middle of the concrete slab in a vertical direction, and propagated with increasing shear load. Then, horizontal cracks occurred and propagated to the front and rear faces of the specimens. Based on the results of this study, a design shear strength equation was proposed and compared with previously suggested equations.

• The Journal of Internal Korean Medicine
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• v.23 no.2
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• pp.202-211
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• 2002

1. Background The previous studies on anticancer medicine derived from korean traditional medicine have focused on the life elongation of cancer cell bearing animals. However, it is thought that more molecular biological studies are needed to reveal their mechanism. 2. Objective The aim of this study was to investigate the molecular biological function of Sagunjatang plus Cremastrae Appenediculatae Tuber on cytostaticity, apoptosis and apoptosis related genes revelation against human stomach cancer cells(AGS). 3. Methods After administrating Sagunjatang and Sagunjatang plus Cremastrae Appenediculatae Tuber to human stomach cancer cell. MTT assay was performed to compare and examine the efficacy of each medicine on the cytostaticity of stomach cancer cells in proportion to time and doses, and apoptosis assay was performed to examine their effect on apoptosis by using DAPI dye and counting the number of cells which developed in an apoptotic body. In addition, the quantitative RT-PCR was used to examine their effect on the revelation of Bcl-2, Bax and P53, which are genes related to apoptosis. 4. Result and Conclusion Sagunjatang plus Cremastrae Appenediculatae Tuber demonstrated increased cytostaticity. decreased apoptosis and unremarkable revelation of apoptosis related genes. But in the cytostaticity and apoptosis, Sagunjatang plus Cremastrae Appenediculatae Tuber showed a tendency to control stomach cancer cells. Therefore, we can expect the clinical application to the related diseases. Besides, it needs another experiment on various cancer cells, such as, lung cancer cell and hysterocarcinoma cell.

• Bulletin of the Korean Chemical Society
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• v.32 no.6
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• pp.1884-1890
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• 2011

A series of Ni(II) and Pd(II) complexes bearing N4-type tetradentate ligands, [Ni($X^1X^2$-6-$Me_2bpb$) 1] and [Pd($X^1X^2$-6-$Me_2bpb$) 2]; 6-$Me_2bpb$ = N,N'-(o-phenylene)bis(6-methylpyridine-2-carboxamidate), $X^1$ = Cl, H, or $CH_3$, $X^2$ = $NO_2$, Cl, F, H, $CH_3$, or $OCH_3$) were designed, synthesized, and characterized to investigate electronic and steric effects of ligand on the norbornene polymerization catalysts. Using modified methylaluminoxanes as an activator, the complexes exhibited high catalytic activities for the polymerization of norbornene and the nickel complexes exhibited better catalytic activity the palladium complexes. Ni complex 1a with $NO_2$ group on the benzene ring showed the highest catalytic activity of $4.9{\times}10^6$ g of PNBEs/$mol_{Ni}{\cdot}h$ and molecular weight of $15.28{\times}10^5$ g/mol with PDI < 2.30. Complexes with electron-withdrawing groups are more thermally stable (> 100 $^{\circ}C$), and tend to afford higher polymerization productivities than the ones having electron-donating groups. Amorphous polynorbornenes were obtained with good solubility in halogenated aromatic solvents. A vinyl addition mechanism has been proposed for the catalytic polymerization.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.1066-1069
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• 2004

Recently the monitoring system of tool setup in high speed precision machining tool is required for manufacturing products that have highly complex and small shape, high precision and high function. It is very important to reduce time to setup tool in order to improve the machining precision and productivity and to protect the breakage of cutting tool as the shape of product is smaller and more complex. Generally, the combination of errors that geometrical clamping error of fixing tool at the spindle of machining center and the asynchronized error of driving mechanism causes that the run-out of tool reaches to 3∼20 times of the thickness of cutting chip. And also the run-out is occurred by the misalignment between axis of tool shank and axis of spindle and spindle bearing in high speed rotation. Generally, high speed machining is considered when the rotating speed is more than 8,000 rpm. At that time, the life time of tool is reduced to about 50％ and the roughness of machining surface is worse as the run-out is increased to 10 micron. The life time of tool could be increased by making monitoring of tool-setting easy, quick and precise in high speed machining center. This means the consumption of tool is much more reduced. And also it reduces the manufacturing cost and increases the productivity by reducing the tool-setup time of operator. In this study, in order to establish the concept of tool-setting monitoring the measuring method of the geometrical error of tool system is studied when the spindle is stopped. And also the measuring method of run-out, dynamic error of tool system, is studied when the spindle is rotated in 8,000 ∼ 60,000 rpm. The dynamic phenomena of tool-setup is analyzed by implementing the monitoring system of rotating tool system and the noncontact measuring system of micro displacement in high speed.