• Archives of Pharmacal Research
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• v.29 no.12
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• pp.1140-1146
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• 2006

Ceramide analogs are potential chemotherapeutic agents. We report that a ceramide analog induces apoptosis in human prostate cancer cells. The ceramide analog induced cell death through an apoptotic mechanism, which was demonstrated by DNA fragmentation, the cleavage of poly ADP ribose polymerase (PARP), and a loss of membrane asymmetry. Treating the cells with ceramide analog resulted in the release of various proapoptotic mitochondrial proteins including cytochrome c and Smac/DIBLO into the cytosol, and a decrease in the mitochondrial membrane potential. In addition, the ceramide analog decreased the phospho-Akt and phospho-Bad levels. The expression of the antiapoptotic Bcl-2 decreased slightly with increasing Bax to Bcl-2 ratio. These results suggest that the ceramide analog induces apoptosis by regulating multiple signaling pathways that involve the mitochondrial pathway.

• JSTS:Journal of Semiconductor Technology and Science
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• v.6 no.4
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• pp.281-285
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• 2006

In order to widen the tuning range, capacitive degeneration is applied to fully CMOS LC VCOs. Small signal analysis shows that the fixed MOSFET capacitance seen by the LC tank is smaller than that of the traditional LC VCO, resulting in significant extension in the tuning range. This improvement in the tuning range has been verified through measurement of a 10-GHz LC VCO fabricated by $0.18{\mu}m$ CMOS process. The measured tuning range is from 9.8-GHz to 12-GHz, which is better than those of the reported CMOS LC VCOs in 10-GHz band. The measured phase noise is - 103dBc/Hz at 1MHz offset.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2001.11a
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• pp.209-212
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• 2001

본 논문에서는 Ka-band 위성 중계기용 국부 발진기에 사용하게 될 전압제어 발진기의 EM (Engineering Model)을 비선형 방법으로 설계하였다. 전압제어 발진기의 위상잡음을 개선하기 위하여 공진기로 사용되는 유전체 공진기와 결합하는 마이크로스트립 라인을 high impedance inverter로 구현함으로써 공진회로의 quality factor를 우수하게 유지하여 능동소자에 전달되도록 하였다. 개발된 전압제어 발진기는 0～12V의 제어전압으로 9.7965～9.8032GHz의 발진범위를 갖으며 공급전력은 8V, 17mA을 필요로 한다. 제작된 전압제어 발진기의 위상잡음은 -96.51dB/Hz @10KHz와 -116.5dBc/Hz @100KHz의 특성을 나타내며 출력전력은 7.33dBm을 얻었다.

• Journal of electromagnetic engineering and science
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• v.7 no.4
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• pp.175-182
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• 2007

In this paper, a study on the reflector type frequency doubler, to suppress the undesired harmonics, is presented. A 12 to 24 GHz reflective frequency doubler is simulated and experimented. Design procedure of the frequency doubler with reflector is provided and the frequency doubler with good spectral purity is fabricated successfully. It has harmonic suppression of the $40{\sim}50\;dBc$ in the $1^{st}$ harmonic and the $50{\sim}60\;dB$ in the $3^{rd}$ harmonic with no additional filter. And, it has conversion gain with the input power of 0 dBm over bandwidth of 500 MHz. A NEC's ne71300(N) GaAs FET is used and the nonlinear model(EEFET3) using IC-CAP program is extracted for harmonic load pull simulation. Good agreement between simulated and measured results has been achieved.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.9 no.2
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• pp.219-225
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• 1998

A voltage controlled oscillator for the local oscillator in 380 MHz TRS handset is designed and fabricated. To improve the phase noise characteristics, the NEC's 2SC4226 transistor with NF=1.2 at 1 GHz and Toshiba's 1SV229 varactor diode with Q=70 are used. And an inductor of VCO is realized by microstrip line. At the bias condition of 5 V and 10 mA, the output power and phase noise in the operating frequency range of 357∼387 MHz are above 3.7 dBm and 111 dBc/Hz at 12.5KHz offset from the carrier, respectively. And FM sensitivity deviation are within ±0.4 KHz. This VCO is well suited for TRS handset.

• The International Journal of Costume Culture
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• v.12 no.1
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• pp.97-100
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• 2009

Patchwork is a handicraft to put some certain shapes of small cloths together. Historical records of patchwork was discovered in Ancient Egypt as far back as BC 1000. Patchwork has been popular in the England and in around 13-$14^{th}$ century, European spliced little pieces of cloths for cold necessities, which made the handle of patchwork techniques gradually tend to decorative other than utility. Patchwork designs and techniques were taken across the Atlantic to North America with the early settlers in the mid-eighteenth century. In the early years of $20^{th}$ century, owing to the continuous technological advances, woman got more job opportunities that made patchwork technologies withered. Patchwork art continually evolved on the basis of historical and cultural factors to new styles, the famous Hawaiian, Stained Glass, Mola, Celtic, Victoria, Seminole and many other patchwork styles like that perfect embodied different art and cultures of different nations in different times.

• Journal of electromagnetic engineering and science
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• v.12 no.4
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• pp.234-239
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• 2012

This paper presents a compact K-band Doppler radar sensor for human vital signal detection that uses a radar configuration with only single coupler. The proposed radar front-end configuration can reduce the chip size and the additional RF power loss. The radar front-end IC is composed of a Lange coupler, VCO, and single balanced mixer. The oscillation frequency of the VCO is from 27.3 to 27.8 GHz. The phase noise of the VCO is -91.2 dBc/Hz at a 1 MHz offset frequency, and the output power is -4.8 dBm. The conversion gain of the mixer is about 11 dB. The chip size is $0.89{\times}1.47mm^2$. The compact Ka-band Doppler radar system was developed in order to demonstrate remote human vital signal detection. The radar system consists of a Ka-band Doppler radar module with a $2{\times}2$ patch array antenna, baseband signal conditioning block, DAQ system, and signal processing program. The front-end module size is $2.5{\times}2.5cm^2$. The proposed radar sensor can properly capture a human heartbeat and respiration rate at the distance of 50 cm.

• JSTS:Journal of Semiconductor Technology and Science
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• v.12 no.1
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• pp.1-9
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• 2012

A 10-b 500 MS/s A/D converter (ADC) with a hybrid calibration and error correction logic is described. The ADC employs a single-channel cascaded folding-interpolating architecture whose folding rate (FR) is 25 and interpolation rate (IR) is 8. To overcome the disadvantage of an offset error, we propose a hybrid self-calibration circuit at the open-loop amplifier. Further, a novel prevision digital error correction logic (DCL) for the folding ADC is also proposed. The ADC prototype using a 130 nm 1P6M CMOS has a DNL of ${\pm}0.8$ LSB and an INL of ${\pm}1.0$ LSB. The measured SNDR is 52.34-dB and SFDR is 62.04-dBc when the input frequency is 78.15 MHz at 500 MS/s conversion rate. The SNDR of the ADC is 7-dB higher than the same circuit without the proposed calibration. The effective chip area is $1.55mm^2$, and the power dissipates 300 mW including peripheral circuits, at a 1.2/1.5 V power supply.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.10 no.5
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• pp.851-856
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• 2006

This paper studies about design of a transceiver using a single PLL. The transceiver has bandwidth of $424.7\sim424.95MHz$ and the communication method used 21 channels 12.5 KHz channel bandwidth and FSK modulation/demodulation method. Also, we designed low power wireless transceiver for data transmission using a single PLL. Finally, the transceiver set achieves the following characteristics : 8.15dBm output power, 45.97dBc spurious property.

• The Korean Journal of Food And Nutrition
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• v.12 no.4
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• pp.421-426
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• 1999

The major flavor compounds of Takju mash which was brewed with a modified Nuruk made by inocu-lation and cultivation of Rhizopus japonicus T2, Aspergillus oryzae L2 and Hansenula sp. BC26 isolated from Nuruk, were analyzed, as compared with those with current fermenting agents such as commerical Nur-uk and rice koji of Aspergillus kawachii. The contents of isoamyl alcohol isobutyl alcohol and ethyl acet-ate which were known as aroma compounds in Takju were much higher in mash of modified Nuruk than in that of commercial Nuruk or ricd koji. The major organic acids were lactic fumalic and succinic acid in mash of modified and lactic and acetic acid in mash of commercial Nuruk and citric lactic and suc-cinic acid in mash of rice koji. The contents of total organic acids were 5,146mg/L, 1,706mg/L and 1, 388 mg/L in mash of commercial Nuruk rice koji and modified Nuruk respectively. The major free amino acids were glutamic acid alanine proline and histidine in mash of modified Nuruk and glutamic acid proline leucine and histidine in mash of commercial Nuruk and arginine proline and glutamic acid in mash of rice koji. The contents of total free amino acids were 14,090mg/L 12,202mg/L and 7,152 mg/L in mash of modified Nuruk commercial Nurcuk and rice koji respectively. Therefore it seemed that the Takju mash of modified Nuruk was better than that of commercial Nuruk or rice koji.