• Journal of Astronomy and Space Sciences
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• v.29 no.2
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• pp.97-101
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• 2012

Monitoring sunspots consistently is the most basic step required to study various aspects of solar activity. To achieve this goal, the observers must regularly calculate their own correction factor $k$ and keep it stable. Relatively recently, two observing teams in South Korea have presented interesting papers which claim that revisions that take the yearly-basis $k$ into account lead to a better agreement with the international relative sunspot number $R_i$, and that yearly $k$ apparently varies with the solar cycle. In this paper, using artificial data sets we have modeled the sunspot numbers as a superposition of random noise and a slowly varying background function, and attempted to investigate whether the variation in the correction factor is coupled with the solar cycle. Regardless of the statistical distributions of the random noise, we have found the correction factor increases as sunspot numbers increase, as claimed in the reports mentioned above. The degree of dependence of correction factor $k$ on the sunspot number is subject to the signal-to-noise ratio. Therefore, we conclude that apparent dependence of the value of the correction factor $k$ on the phase of the solar cycle is not due to a physical property, but a statistical property of the data.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2019.05a
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• pp.80-81
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• 2019

Change requests occur persistently in the construction phase of a construction project. The law requires that the contract amount be adjusted in accordance with the relevant regulations when there is a change in the construction amount due to the design change in the construction contract. SAVE international, on the other hand, defines the value methodology as a systematic and structured approach to improving projects, products and processes. Design Changes in the construction projects require organizational efforts to improve value and quality. However, the law does not include change requests in which the VE object is fixed and related data is collected and function analysis can be derived in a short time. Therefore, it is necessary to apply VE to the design change procedure, which can further improve the value of construction work. The application derived from this study need to be presented as simply as possible without compromising the basic concept of VE. If the application is extended to the field and proved to be effective, it is expected to contribute to the overall value of construction work.

• BMB Reports
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• v.37 no.2
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• pp.139-143
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• 2004

The antioxidant responsive element (ARE) is a cis-acting regulatory element of genes encoding phase II detoxification enzymes and antioxidant proteins, such as NAD(P)H: quinone oxidoreductase 1, glutathione S-transferases, and glutamate-cysteine ligase. Interestingly, it has been reported that Nrf2 (NF-E2-related factor 2) regulates a wide array of ARE-driven genes in various cell types. Nrf2 is a basic leucine zipper transcription factor, which was originally identified as a binding protein of locus control region of ss-globin gene. The DNA binding sequence of Nrf2 and ARE sequence are very similar, and many studies demonstrated that Nrf2 binds to the ARE sites leading to up-regulation of downstream genes. The function of Nrf2 and its downstream target genes suggests that the Nrf2-ARE pathway is important in the cellular antioxidant defense system. In support of this, many studies showed a critical role of Nrf2 in cellular protection and anti-carcinogenicity, implying that the Nrf2-ARE pathway may serve as a therapeutic target for neurodegenerative diseases and cancers, in which oxidative stress is closely implicated.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.27 no.6
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• pp.575-580
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• 2005

Transitional implants were developed to support provisional restorations and to allow for load-free osseointegration of conventional implants while a patient was provided with immediate esthetics and function and are usually placed simultaneously at the time of definitive implant placement. Transitional implants are placed in a non-submerged fashion in a single-stage surgery and are designed to be immediately loaded. They generally are made of commercially pure titanium or titanium alloy and are designed as 1-piece implants composed of root and crown replacement segments. Transitional implants can be used in a wide range of indications, such as basic use as temporary implant, to support and protect the primary implants during the healing phase, single crown in the edentulous anterior region of mandibular, anchorage for orthodontic treatment, support a surgical and radiographic template, and primary implant to extremely atrophied alveolar crests of the mandible and maxilla. This article describes the clinical use of transitional implants to support the provisional complete denture and single crown in the restricted edenturous central incisor region of mandible.

• BMB Reports
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• v.42 no.6
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• pp.315-323
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• 2009

In order to elucidate ultimate biological function of the genome, the model animal system carrying mutations is indispensable. Recently, large-scale mutagenesis projects have been launched in various species. Especially, the mouse is considered to be an ideal model to human because it is a mammalian species accompanied with well-established genetic as well as embryonic technologies. In 1990', large-scale mouse mutagenesis projects firstly initiated with a potent chemical mutagen, N-ethyl-N-nitrosourea (ENU) by the phenotype-driven approach or forward genetics. The knockout mouse mutagenesis projects with trapping/conditional mutagenesis have then followed as Phase II since 2006 by the gene-driven approach or reverse genetics. Recently, the next-generation gene targeting system has also become available to the research community, which allows us to establish and analyze mutant mice carrying an allelic series of base substitutions in target genes as another reverse genetics. Overall trends in the large-scale mouse mutagenesis will be reviewed in this article particularly focusing on the new advancement of the next-generation gene targeting system. The drastic expansion of the mutant mouse resources altogether will enhance the systematic understanding of the life. The construction of the mutant mouse resources developed by the forward and reverse genetic mutagenesis is just the beginning of the annotation of mammalian genome. They provide basic infrastructure to understand the molecular mechanism of the gene and genome and will contribute to not only basic researches but also applied sciences such as human disease modelling, genomic medicine and personalized medicine.

• Journal of KIISE:Software and Applications
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• v.26 no.12
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• pp.1468-1481
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• 1999

didates.본 논문은 절차 중심 소프트웨어를 객체 지향 소프트웨어로 재/역공학하기 위한 다단계 절차중 첫 절차인 객체 추출 절차에 대하여 기술한다. 사용한 객체 추출 방법은 전처리, 기본 분할 및 결합, 정제 결합, 결정 및 통합의 다섯 단계로 이루어진다 : 1) 전처리 과정에서는 객체 추출을 위한 FTV(Function, Type, Variable) 그래프를 생성/분할 및 클러스터링하고, 2) 기본 분할 및 결합 단계에서는 다중 객체 추출을 위한 그래프를 생성하고 생성된 그래프의 정적 객체를 추출하며, 3) 정제 결합 단계에서는 동적 객체를 추출하며, 4) 결정 단계에서는 영역 모델링과 다중 객체 후보군과의 유사도를 측정하여 영역 전문가가 하나의 최적합 후보를 선택할 수 있는 측정 결과를 제시하며, 5) 통합 단계에서는 전처리 과정에서 분리된 그래프가 여러 개 존재할 경우 각각의 처리된 그래프를 통합한다. 본 논문에서는 클러스터링 순서가 고정된 결정론적 방법을 사용하였으며, 가능한 경우의 수에 따른 다중 객체 후보, 객관적이고 의미가 있는 객체 추출 방법으로의 정제와 결정, 영역 모델링을 통한 의미적 관점에 기초한 방법 등을 사용한다. 이러한 방법을 사용함으로써 전문가는 객체 추출 단계에서 좀더 다양하고 객관적인 선택을 할 수 있다.Abstract This paper presents an object extraction process, which is the first phase of a methodology to transform procedural software to object-oriented software. The process consists of five steps: the preliminary, basic clustering & inclusion, refinement, decision and integration. In the preliminary step, FTV(Function, Type, Variable) graph for object extraction is created, divided and clustered. In the clustering & inclusion step, multiple graphs for static object candidate groups are generated. In the refinement step, each graph is refined to determine dynamic object candidate groups. In the decision step, the best candidate group is determined based on the highest similarity to class group modeled from domain engineering. In the final step, the best group is integrated with the domain model. The paper presents a new clustering method based on static clustering steps, possible object candidate grouping cases based on abstraction concept, a new refinement algorithm, a similarity algorithm for multiple n object and m classes, etc. This process provides reengineering experts an comprehensive and integrated environment to select the best or optimal object candidates.

• Journal of the Korea Concrete Institute
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• v.15 no.5
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• pp.662-669
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• 2003

Recently, the serviceability and durability of concrete structures under thermal load have received great attention. The thermal stress and clacking behavior of concrete at early ages are one of the important factors that affect such serviceability and durability of concrete structures. Nevertheless, most studies on the behavior of early-age concrete have been confined to the temperature and strain development itself in the laboratory. The desirable efforts to explore the material properties of concrete at early-ages have not been made extensively so far. The purpose of the present study is, therefore, to identify some important material properties that affect the stress behavior of concrete at early-ages. To this end, full-scale concrete base-restrained wall members have been fabricated, and many sensors including thermocouples, strain meters and stress meters were installed inside of the wall members. These sensors were to measure the development of temperatures, strains and stresses at several location in concrete walls during the hardening and curing phase of early-age concrete. By using these measured values of strain and stress, the compliance function at early-age was identified. The basic form of compliance function derived in this study follows the double-power law. However, the results of present study indicate that the values of existing compliance functions are much lower than actual values, especially at very early-ages. It can be seen that the prediction of stresses of early-age concrete based on the proposed compliance function agrees very well with test data. The present study allows more realistic evaluation of varying stresses in early-age concrete under thermal load.

• Journal of Sasang Constitutional Medicine
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• v.10 no.2
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• pp.15-28
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• 1998

One's constitution is formed congenitally and is also acquired, and is relatively stable in its individually manifested function, structure and temperament. It has characteristics of universality, complexity, generality and continuity. It is also manifested in physiological responses and expresses pathologic tendencies including susceptibility. Attempts at understanding constitution has had a long history throughout the world. In Oriental Medicine, the constitution had been acknowledged from the "Huangdi Neijing", which has been a bible in Oriental Medicine for about two thousand years. In many aspects, the "Huangdi Neijing" provides the basis for both basic and practical fields. In order to derive the ideal structure from the "Huangdi Neijing" to Lee Je-ma's(Lee Jayma's) Sasang Constitutional ideas, which can strengthen the understanding of ideal core of Oriental Medicine's constitutional characteristics, the author launched his analysis of the constitutional understandings in the "Huangdi Neijing" as a first step and came to the following: 1. The constitutional understanding in the "Huangdi Neijing" was done both via the physiological responses to heat, pain and acupuncture treatment and the pathologic tendencies via body structure, strength, body heat, courage and obesity. 2. It was recognized that the constitution was formed congenitally and also acquired factors like living conditions including food customs, residents and geographical conditions were explained in detailed. 3. The constitutional typology was suggested both by the general and systematic criterion according to the Yin-yang and the Five phase theories and by single criterion such as obesity, courage and the response to acupuncture treatment. 4. As diagnosis is related to the constitution, courage was adopted for the disease caused by emotions, obesity was for its manifestations of qi and blood, the quantities of qi-blood and Yin-yang in the typology by the Yin-yang and Five phase theories were suggested. 5. In the case of obesity, Yin-yang and Five phase theory, treatment according to the constitutional ideas was mentioned, and their goals were concluded as "being the balancing between Yin and Yang" which means the Yin-yang theory is more practical than the Five phase theory in Oriental Constitutional Medical field. According to the above understandings, the author would like to suggest that the constitutional ideas in the "Huangdi Neijing" based on the Yin-yang theory blossomed via the practical spirit of Zhang Zhong-jing's "Shanghanlun" and at last from Lee Je-ma's(Lee Jayma's) Sasang Constitutional Medicine which realized "the balancing between Yin and yang" through the practical applications of herbal treatments.

• Tuberculosis and Respiratory Diseases
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• v.48 no.3
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• pp.347-356
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• 2000

Background : Patients with obstructive sleep apnea syndrome are known to have high long-term mortality compared to healthy subjects because of their cardiovascular dysfunction. The observation of hemodynamic changes by obstructive apneas is helpful when attempting to understand the pathophysiological mechanism of the development of cardiovascular dysfunction in those patients. Therefore, we studied the changes in cardiovascular function with an animal model and tried to obtain the basic data for an ideal experimental model (this phrase is unclear), a requirement for a more advanced study. Methods : Sixteen anesthetized dogs with ${\alpha}$-chloralose delete were divided into two groups : 8 dogs of room air breathing group and 8 dogs of oxygen breathing group. We measured $PaO_2$, $PaCO_2$, heart rate, cardiac output, mean femoral artery pressure, and mean pulmonary artery pressure at specified times during the apnea-breathing cycle before endotracheal tube occlusion (baseline), 25 seconds after endotracheal tube occlusion (apneic period), 10 seconds (early phase of postapneic period, EPA) and 25 seconds (late phase of postapneic period, LPA) after spontaneous breathing. Results : In room air breathing group, the heart rate significantly decreased during the apneic period compared to that at baseline (P<0.01) and increased at EPA and LPA compared to that during the apneic period (P<0.01). But, the heart rate showed no significant changes during apneic and postapneic periods in the oxygen breathing group. Cardiac output tended to decrease during apneic period compared to that at baseline, but was statistically significant. Cardiac output significantly decreased at LP A compared to at baseline (P<0.01). Mean femoral artery pressure was significantly decreased at during apneic period compared to that at baseline (P<0.05). Conclusion : Through this experiment, we were partially able to understand the changes of cardiovascular function indirectly, but delete new experimental animal model displaying physiological mechanism close to natural sleep should be established, and the advanced study in the changes of cardiovascular function and their causes should be continued.

• Journal of Dental Rehabilitation and Applied Science
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• v.16 no.2
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• pp.149-159
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• 2000

Occlusal disease is comparable to periodontitis in that it is generally not reversible. Occlusal disease, however, like periodontitis, often maintainable. It does itself to treatment and when restorative dentistry is utilized it becomes, in that sense, reversible. Moreover, a systematized and integrated approach will lead to a prognosis that is favorable and predictable. This approach facilitates development of optimum oral function, comfort, and esthetics, resulting in a satisfied patient. Such a systematized approach consists of four logical phase : (1) patient evaluation, (2) comprehensive analysis and treatment planning, (3) integrated and systematic reconstruction, and (4) postoperative maintenance. An integrated treatment plan is first developed on one set of diagnostic casts, properly mounted on a semiadjustable articulator using jaw relationship records. This is accomplished by using wax to make reconstructive modifications to the casts. These modified casts become the blueprint for planned occlusal changes and the fabrication of provisional restorations. The treatment goals are : (1) comfortably functioning temporomandibular joints and stomatognathic musculature, (2) adherence to the basic principle of occlusion advocated by Schuyler, (3) anterior guidance that is in harmony with the envelope of function, (4) restorations that will not violate the patient's neutral zone. This report shows the treatment procedures for a patient whose mandibular position has been altered due to posterior bite collapse. Migration of the maxillary anterior teeth had occurred, and the posterior occlusal contacts showed pathologic interference. Precise diagnosis using mounted casts was executed and prosthodontic reconstruction by the aid of an unconventional orthodontic correction on maxillary flaring was planned. An unconventional orthodontic correction can be accomplished by using preexisting natural teeth, which can be modified for use in active tooth movement or splinted together for orthodontic anchorage. This technique has an advantage over conventional fixed appliance orthodontic therapy because it can accomplish tooth movement concurrently with restorative and periodontal therapy. On occasion, minor tooth movement can be necessary to achieve the optimum occlusal scheme, crown form, and tooth position for the forces of occlusion to be displaced down the long axis of the periodontally compromised teeth. Once the occlusion, periodontal health, and crown contours for the provisional splinted restoration are acceptable, the final splinted restoration can be similarly fabricated, and it becomes an excellent orthodontic retainer.