• Title/Summary/Keyword: baseline sensitivity

Search Result 142, Processing Time 0.027 seconds

Comparison of the Diagnostic Accuracies of 1.5T and 3T Stress Myocardial Perfusion Cardiovascular Magnetic Resonance for Detecting Significant Coronary Artery Disease

  • Min, Jee Young;Ko, Sung Min;Song, In Young;Yi, Jung Geun;Hwang, Hweung Kon;Shin, Je Kyoun
    • Korean Journal of Radiology
    • /
    • v.19 no.6
    • /
    • pp.1007-1020
    • /
    • 2018
  • Objective: To compare the diagnostic performance of cardiovascular magnetic resonance (CMR) myocardial perfusion at 1.5- and 3-tesla (T) for detecting significant coronary artery disease (CAD), with invasive coronary angiography (ICA) as the reference method. Materials and Methods: We prospectively enrolled 281 patients (age $62.4{\pm}8.3$ years, 193 men) with suspected or known CAD who had undergone 1.5T or 3T CMR and ICA. Two independent radiologists interpreted perfusion defects. With ICA as the reference standard, the diagnostic performance of 1.5T and 3T CMR for identifying significant CAD (${\geq}50%$ diameter reduction of the left main and ${\geq}70%$ diameter reduction of other epicardial arteries) was determined. Results: No differences were observed in baseline characteristics or prevalence of CAD and old myocardial infarction (MI) using 1.5T (n = 135) or 3T (n = 146) systems. Sensitivity, specificity, positive and negative predictive values, and area under the receiver operating characteristic curve (AUC) for detecting significant CAD were similar between the 1.5T (84%, 64%, 74%, 76%, and 0.75 per patient and 68%, 83%, 66%, 84%, and 0.76 per vessel) and 3T (80%, 71%, 71%, 80%, and 0.76 per patient and 75%, 86%, 64%, 91%, and 0.81 per vessel) systems. In patients with multi-vessel CAD without old MI, the sensitivity, specificity, and AUC with 3T were greater than those with 1.5T on a per-vessel basis (71% vs. 36%, 92% vs. 69%, and 0.82 vs. 0.53, respectively). Conclusion: 3T CMR has similar diagnostic performance to 1.5T CMR in detecting significant CAD, except for higher diagnostic performance in patients with multi-vessel CAD without old MI.

Association Between Dental Implants and Cognitive Function in Community-dwelling Older Adults in Korea

  • Ki, Seungkook;Yun, Jihye;Kim, Jinhee;Lee, Yunhwan
    • Journal of Preventive Medicine and Public Health
    • /
    • v.52 no.5
    • /
    • pp.333-343
    • /
    • 2019
  • Objectives: This study aimed to evaluate the association between dental implants and cognitive function in community-dwelling older adults. Methods: Data were collected from the baseline survey (2016-2017) of the Korean Frailty and Aging Cohort Study. The study sample comprised 1115 community-dwelling people aged 70 years to 84 years who had 0-19 natural teeth. Dental implants and natural teeth were identified by panoramic radiography, while the cognitive function was assessed by the Korean version of the Mini-Mental State Examination (MMSE-KC). The association between dental implants and cognitive function was analyzed by multiple linear regression. Sensitivity analysis was performed to test for potential bias. Results: The mean number of natural teeth in the study population was 9.50 (standard deviation [SD], 6.42), and the mean MMSE-KC score was 24.93 (SD, 3.55). In the simple univariate analysis, tooth replacement, age, sex, smoking status, alcohol consumption, body mass index, osteoporosis, number of natural teeth, periodontitis, chewing discomfort, tooth-brushing frequency, education level, monthly household income, participation in economic activity, living alone, and marital status had a significant impact on the association. After adjusting for confounders, the association between dental implants and cognitive function remained significant (B, 0.85; standard error, 0.40; p<0.05). Age, body mass index, periodontitis, tooth-brushing frequency, and education level were also significantly associated with cognitive function. The results of the sensitivity analyses were consistent with those of the primary analysis. Conclusions: Dental implants were associated with cognitive function in older adults living in the community. Dental implants as tooth replacements may play a role in preserving cognitive function.

Analysis of Levelized Cost of Hydrogen and Financial Performance Risk by CCU System (CCU 시스템을 통한 균등화 수소원가 및 재무적 위험도 분석)

  • MINHEE SON;HEUNGKOO LEE;KYUNG NAM KIM
    • Transactions of the Korean hydrogen and new energy society
    • /
    • v.33 no.6
    • /
    • pp.660-673
    • /
    • 2022
  • In achieving carbon neutrality and the hydrogen economy, the estimation of H2 cost is critical in terms of CCU technologies. This study analyzes LCOH of hydrogen produced by the carbon utilization unit with methane reforming and CO2 from thermal power plant. LCOH for H2 made with CO is estimated in three ways of Joint Cost Allocations with financial performance risk assessment. Regarding cost analysis, the zero value of LCOH is $6,003/ton. We found that the CCU technology has economic feasibility in terms of profitability. The sensitivity analysis result shows that the input ratio is more influential to the LCOH than other variables. Risk analysis presents the baseline price of zero value of LCOH - $8,408/ton, which is higher than the cost analysis - $6,003/ton. Mainly, the price variability of natural gas primarily affects the LCOH. The study has significant value in analyzing the financial performance risks as well as the cost of H2 produced by a Plasma-based CCU system.

Techno-economic Analysis of Power To Gas (P2G) Process for the Development of Optimum Business Model: Part 2 Methane to Electricity Production Pathway

  • Partho Sarothi Roy;Young Don Yoo;Suhyun Kim;Chan Seung Park
    • Clean Technology
    • /
    • v.29 no.1
    • /
    • pp.53-58
    • /
    • 2023
  • This study shows the summary of the economic performance of excess electricity conversion to hydrogen as well as methane and returned conversion to electricity using a fuel cell. The methane production process has been examined in a previous study. Here, this study focuses on the conversion of methane to electricity. As a part of this study, capital expenditure (CAPEX) is estimated under various sized plants (0.3, 3, 9, and 30 MW). The study shows a method for economic optimization of electricity generation using a fuel cell. The CAPEX and operating expenditure (OPEX) as well as the feed cost are used to calculate the discounted cash flow. Then the levelized cost of returned electricity (LCORE) is estimated from the discounted cash flow. This study found the LCORE value was ¢10.2/kWh electricity when a 9 MW electricity generating fuel cell was used. A methane production plant size of 1,500 Nm3/hr, a methane production cost of $11.47/mcf, a storage cost of $1/mcf, and a fuel cell efficiency of 54% were used as a baseline. A sensitivity analysis was performed by varying the storage cost, fuel cell efficiency, and excess electricity cost by ±20%, and fuel cell efficiency was found as the most dominating parameter in terms of the LCORE sensitivity. Therefore, for the best cost-performance, fuel cell manufacturing and efficiency need to be carefully evaluated. This study provides a general guideline for cost performance comparison with LCORE.

Novel Algorithms for Early Cancer Diagnosis Using Transfer Learning with MobileNetV2 in Thermal Images

  • Swapna Davies;Jaison Jacob
    • KSII Transactions on Internet and Information Systems (TIIS)
    • /
    • v.18 no.3
    • /
    • pp.570-590
    • /
    • 2024
  • Breast cancer ranks among the most prevalent forms of malignancy and foremost cause of death by cancer worldwide. It is not preventable. Early and precise detection is the only remedy for lowering the rate of mortality and improving the probability of survival for victims. In contrast to present procedures, thermography aids in the early diagnosis of cancer and thereby saves lives. But the accuracy experiences detrimental impact by low sensitivity for small and deep tumours and the subjectivity by physicians in interpreting the images. Employing deep learning approaches for cancer detection can enhance the efficacy. This study explored the utilization of thermography in early identification of breast cancer with the use of a publicly released dataset known as the DMR-IR dataset. For this purpose, we employed a novel approach that entails the utilization of a pre-trained MobileNetV2 model and fine tuning it through transfer learning techniques. We created three models using MobileNetV2: one was a baseline transfer learning model with weights trained from ImageNet dataset, the second was a fine-tuned model with an adaptive learning rate, and the third utilized early stopping with callbacks during fine-tuning. The results showed that the proposed methods achieved average accuracy rates of 85.15%, 95.19%, and 98.69%, respectively, with various performance indicators such as precision, sensitivity and specificity also being investigated.

EVALUATION OF ROAD-INDUCED NOISE OF A VEHICLE USING EXPERIMENTAL APPROACH

  • Ko, K.-H.;Heo, J.-J.;Kook, H.
    • International Journal of Automotive Technology
    • /
    • v.4 no.1
    • /
    • pp.21-30
    • /
    • 2003
  • In this paper a systematic test procedure for evaluation of road-induced noise of a vehicle and guidelines for each test are presented. Also, a practical application of the test procedure to a small SUV is presented. According to the test procedure, all the tests were performed to evaluate road-induced booming noise that is in low frequency range. First of all the information on characteristics of road-induced noise was obtained through baseline test. Coupling effects between body structure and acoustic cavity of a compartment were obtained by means of modal tests for a structure and an acoustic cavity. Local stiffness of joint areas between chassis system and car-body was determined by test for measurement of input point inertance. Noise sensitivities of body joints to operational forces were obtained through test for measurement of noise transfer functions. Operational deflection shapes made us analyze behaviors of chassis system under running condition and then find sources of noise due to resonance of the chassis system. Finally, Principal Component Analysis and Transfer Path Analysis were utilized to investigate main paths of road-induced noise. In order to evaluate road-induced booming noise exactly, all of tests mentioned above should be performed systematically.

Rocking response of unanchored rectangular rigid bodies to simulated earthquakes

  • Aydin, Kamil
    • Structural Engineering and Mechanics
    • /
    • v.18 no.3
    • /
    • pp.343-362
    • /
    • 2004
  • Rocking response of rigid bodies with rectangular footprint, freely standing on horizontal rigid plane is studied analytically. Bodies are subjected to simulated single component of horizontal earthquakes. The effect of baseline correction, applied to simulated excitations, on the rocking response is first examined. The sensitiveness of rocking motion to the details of earthquakes and geometric properties of rigid bodies is investigated. Due to the demonstrated sensitivity of rocking response to these factors, prediction of rocking stability must be made in the framework of probability theory. Therefore, using a large number of simulated earthquakes, the effects of duration and shape of intensity function of simulated earthquakes on overturning probability of rigid bodies are studied. In the case when a rigid body is placed on any floor of a building, the corresponding probability is compared to that of a body placed on the ground. For this purpose, several shear frames are employed. Finally, the viability of the energy balance equation, which was introduced by Housner in 1963 and widely used by nuclear power industry to estimate the rocking stability of bodies, is evaluated. It is found that the equation is robust. Examples are also given to show how this equation can be used.

Development, Validation, and Application of a Portable SPR Biosensor for the Direct Detection of Insecticide Residues

  • Yang, Gil-Mo;Cho, Nam-Hong
    • Food Science and Biotechnology
    • /
    • v.17 no.5
    • /
    • pp.1038-1046
    • /
    • 2008
  • This study was carried out to develop a small-sized biosensor based on surface plasmon resonance (SPR) for the rapid identification of insecticide residues for food safety. The SPR biosensor module consists of a single 770 nm-light emitting diodes (LED) light source, several optical lenses for transferring light, a hemisphere sensor chip, photo detector, A/D converter, power source, and software for signal processing using a computer. Except for the computer, the size and weight of the sensor module are 150 (L)$\times$70 (W)$\times$120 (H) mm and 828 g, respectively. Validation and application procedures were designed to assess refractive index analysis, affinity properties, sensitivity, linearity, limits of detection, and robustness which includes an analysis of baseline stability and reproducibility of ligand immobilization using carbamate (carbofuran and carbaryl) and organophosphate (cadusafos, ethoprofos, and chlorpyrifos) insecticide residues. With direct binding analysis, insecticide residues were detected at less than the minimum 0.01 ppm and analyzed in less than 100 sec with a good linear relationship. Based on these results, we find that the binding interaction with active target groups in enzymes using the miniaturized SPR biosensor could detect low concentrations which satisfy the maximum residue limits for pesticide tolerance in Korea, Japan, and the USA.

Optical Multi-Channel Intensity Interferometry - or: How To Resolve O-Stars in the Magellanic Clouds

  • Trippe, Sascha;Kim, Jae-Young;Lee, Bangwon;Choi, Changsu;Oh, Junghwan;Lee, Taeseok;Yoon, Sung-Chul;Im, Myungshin;Park, Yong-Sun
    • The Bulletin of The Korean Astronomical Society
    • /
    • v.39 no.2
    • /
    • pp.111-111
    • /
    • 2014
  • Intensity interferometry, based on the Hanbury Brown--Twiss effect, is a simple and inexpensive method for optical interferometry at microarcsecond angular resolutions. Motivated by recent technical developments, we argue that the sensitivity of large modern intensity interferometers can be improved by factors up to approximately 25,000, corresponding to 11 photometric magnitudes, compared to the pioneering Narrabri Stellar Interferometer of the 1970s when resolving. Our approach, based on spectrally resolved light, permits the construction of large optical interferometers at the cost of (very) long-baseline radio interferometers. Realistic intensity interferometers are able to spatially resolve main-sequence O-type stars in the Magellanic Clouds. Multi-channel intensity interferometers can address a wide variety of science cases: (i) linear radii, effective temperatures, and luminosities of stars; (ii) mass-radius relationships of compact stellar remnants; (iii) stellar rotation; (iv) stellar convection and the interaction of stellar photospheres and magnetic fields; (v) the structure and evolution of multiple stars; (vi) direct measurements of interstellar distances; (vii) the physics of gas accretion onto supermassive black holes; and (viii) calibration of amplitude interferometers by providing a sample of calibrator stars.

  • PDF

THE AUTOMATIC CALIBRATION OF KOREAN VLBI NETWORK DATA

  • HODGSON, JEFFREY A.;LEE, SANG-SUNG;ZHAO, GUANG-YAO;ALGABA, JUAN-CARLOS;YUN, YOUNGJOO;JUNG, TAEHYUN;BYUN, DO-YOUNG
    • Journal of The Korean Astronomical Society
    • /
    • v.49 no.4
    • /
    • pp.137-144
    • /
    • 2016
  • The calibration of Very Long Baseline Interferometry (VLBI) data has long been a time consuming process. The Korean VLBI Network (KVN) is a simple array consisting of three identical antennas. Because four frequencies are observed simultaneously, phase solutions can be transferred from lower frequencies to higher frequencies in order to improve phase coherence and hence sensitivity at higher frequencies. Due to the homogeneous nature of the array, the KVN is also well suited for automatic calibration. In this paper we describe the automatic calibration of single-polarisation KVN data using the KVN Pipeline and comparing the results against VLBI data that has been manually reduced. We find that the pipelined data using phase transfer produces better results than a manually reduced dataset not using the phase transfer. Additionally we compared the pipeline results with a manually reduced phase-transferred dataset and found the results to be identical.