• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.2059-2065
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• 2013

This goal of this research was to evaluate the cost-effectiveness of the National Cancer Screening Program (NCSP) for breast cancer in the Republic of Korea from a government expenditure perspective. In 2002-2003 (baseline), a total of 8,724,860 women aged 40 years or over were invited to attend breast cancer screening by the NCSP. Those who attended were identified using the NCSP database, and women were divided into two groups, women who attended screening at baseline (screened group) and those who did not (non-screened group). Breast cancer diagnosis in both groups at baseline, and during 5-year follow-up was identified using the Korean Central Cancer Registry. The effectiveness of the NCSP for breast cancer was estimated by comparing 5-year survival and life years saved (LYS) between the screened and the unscreened groups, measured using mortality data from the Korean National Health Insurance Corporation and the National Health Statistical Office. Direct screening costs, indirect screening costs, and productivity costs were considered in different combinations in the model. When all three of these costs were considered together, the incremental cost to save one life year of a breast cancer patient was 42,305,000 Korean Won (KW) (1 USD=1,088 KW) for the screened group compared to the non-screened group. In sensitivity analyses, reducing the false-positive rate of the screening program by half was the most cost-effective (incremental cost-effectiveness ratio, ICER=30,110,852 KW/LYS) strategy. When the upper age limit for screening was set at 70 years, it became more cost-effective (ICER=39,641,823 KW/LYS) than when no upper age limit was set. The NCSP for breast cancer in Korea seems to be accepted as cost-effective as ICER estimates were around the Gross Domestic Product. However, cost-effectiveness could be further improved by increasing the sensitivity of breast cancer screening and by setting appropriate age limits.

• Anxiety and mood
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• v.9 no.1
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• pp.25-30
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• 2013

Objective : Panic disorder is a chroni, debilitating illness, and has been known to be affected by high anxiety sensitivity and a poor quality of life. We examined if 12 weeks of pharmacotherapy with escitalopram could affect anxiety sensitivity, quality of life, and general disability in patients with panic disorder. Method : We enrolled 27 patients who met the DSM-IV-TR criteria for panic disorder, with or without agoraphobia, and completed 12 weeks of escitalopram treatment. We enrolled 29 normal control subjects who were matched for age and sex compared with the panic patients. All subjects were assessed using the Hamilton Rating Scale for depression (HAM-D), Hamilton Rating Scale for Anxiety (HAM-A), Panic Disorder Severity Scale (PDSS), Anxiety Sensitivity Index-Revised (ASI-R), WHO quality of life assessment (WHO-QOL) and Sheehan Disability Scale (SDS) before and after 12 weeks of treatment. Result : Panic disorder patients had a higher Anxiety sensitivity, a poorer Quality of life, and significant disability than normal control subjects at baseline. After the treatment, Panic disorder patients showed significant improvement in the severity of panic symptoms in terms of the HAM-A p<0.001), HAM-D (p<0.001) in addition, the reached a remission state in terms of the PDSS score. They also showed significant improvement in the ASI-R (p<0.001), WHO-QOL (p<0.001) and SDS (p<0.001), but mean scores of the ASI-R, WHO-QOL and SDS in panic disorder patients were did not reach normal levels. Conclusion : This study suggests that 12 weeks of pharmacotherapy with escitalopram could improve anxiety sensitivity, quality of life, and disability in panic disorder patients, although their anxiety sensitivity, quality of life and disability were not yet normalized after short-term pharmacotherapy. Thus, long-term pharmacotherapy may be necessary for panic disorder patients in order to get an optimal clinical response in terms of anxiety sensitivity, quality of life, and general disability.

• Transactions of the Korean Society of Automotive Engineers
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• v.16 no.4
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• pp.179-185
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• 2008

The purpose of this paper is to propose a systematic method on the weld pitch design of a vehicle sub-frame considering the fatigue life of spot welding points. The input data, which perform the fatigue analysis on the spot welding nuggets, are obtained by both the dynamic analysis of the multi-body vehicle model passing through the virtual proving ground of a typical Belgian road and the quasi-static analysis with the finite element model of the vehicle sub-frame. By utilizing the life cycle data obtained from the fatigue analysis, the welding points to perform the pitch change are determined. The sensitivity analysis on the fatigue life of the welding points is carried out by using the three-level orthogonal array design, and through the results of the sensitivity analysis, the best combination on the welding pitch is determined. This study shows that as compared with the baseline design, the sub-frame redesigned by the proposed technique improves the fatigue life about 7 percent while reducing the number of welding points about 19 percent.

• International Journal of Aeronautical and Space Sciences
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• v.17 no.2
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• pp.268-283
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• 2016

Aircraft manufacturing companies have to consider multiple derivatives to satisfy various market requirements. They modify or extend an existing aircraft to meet new market demands while keeping the development time and cost to a minimum. Many researchers have studied the derivative design process, but these research efforts consider baseline and derivative designs together, while using the whole set of design variables. Therefore, an efficient process that can reduce cost and time for aircraft derivative design is needed. In this research, a more efficient design process is proposed which obtains global changes from local changes in aircraft design in order to develop aircraft derivatives efficiently. Sensitivity analysis was introduced to remove unnecessary design variables that have a low impact on the objective function. This prevented wasting computational effort and time on low priority variables for design requirements and objectives. Additionally, uncertainty from the fidelity of analysis tools was considered in design optimization to increase the probability of optimization results. The Reliability Based Design Optimization (RBDO) and Possibility Based Design Optimization (PBDO) methods were proposed to handle the uncertainty in aircraft conceptual design optimization. In this paper, Collaborative Optimization (CO) based framework with RBDO and PBDO was implemented to consider uncertainty. The proposed method was applied for civil jet aircraft derivative design that increases cruise range and the number of passengers. The proposed process provided deterministic design optimization, RBDO, and PBDO results for given requirements.

• 한국방재학회:학술대회논문집
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• 2008.02a
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• pp.695-698
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• 2008

The SWAT model was used to assess the impacts of potential future climate change on the hydrology of the Upper Geum River Basin(UGRB). Calibration and validation of SWAT were performed on a monthly basis for 1982-1995 and 1996-2005, respectively. The impact of ten 15-year(1988-2002) scenarios were then analyzed relative to a scenario baseline. Among them, scenario 1-6 were set to show the sensitivity response. A doubling of atmospheric CO2 concentration was predicted to result in an maximum monthly flow increase of 11 percent. Non-linear impacts were predicted among precipitation change scenarios of -42, -17, 17, and 42 percent, which resulted in average annual flow changes in UGRB of -55, -24, 26, and 65 percent.

• Journal of the Korean Society of Clothing and Textiles
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• v.42 no.2
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• pp.327-341
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• 2018

This study analyzed the influence of social distance and visual information on consumers' fashion style preferences in terms of information characteristics and providers. Data were collected from 521 females in their twenties and thirties who had experience using SNS. The empirical study results were as follows. First, with other factors of exposure under control, the social distance of information characteristics and providers showed a significant impact on fashion style preferences only when social distances were close. Second, the impact of social distance varied depending on the consumer's characteristics. This proved that innovation had significant negative influences, while conformity and informational sensitivity to others showed positive influences on the effects of social distance in terms of information characteristics. Innovation and fashion leadership also showed a negative influence on the social distance effect in terms of information providers. Third, conformity, informational sensitivity to others, and fashion leadership, proved to have a significant impact on the acceptance of eWOM in fashion styles, but innovativeness and normative sensitivity to others did not have a significant influence. This study can be used as baseline data in SNS marketing strategies for vitalizing information spread through eWOM.

• Progress in Superconductivity
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• v.13 no.1
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• pp.1-6
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• 2011

Measurement of magnetic signals generated from electric activity of myocardium provides useful information for the functional diagnosis of heart diseases. Key technical component of the magnetocardiography (MCG) technology is SQUID. To measure MCG signals with high signal-to-noise ratio, sensitive SQUID magnetic field sensors are needed. Present magnetic field sensors based on Nb SQUIDs have field sensitivity good enough to measure most of MCG signals. However, for accurate measurement of fine signal pattern or detection of local atrial fibrillation signals, we may need higher field sensitivity. In addition to field sensitivity, economic aspect of the SQUID system is also important. To simplify the SQUID readout electronics, the output voltage or flux-to-voltage transfer of SQUID should be large enough so that direct measurement of SQUID output can be done using room-temperature preamplifiers. Double relaxation oscillation SQUID (DROS), having about 10 times larger flux-to-voltage transfers than those of DC-SQUIDs, was shown to be a good choice to make the electronics compact. For effective cancellation of external noise inside a thin economic shielded room, first-order axial gradiometer with high balance, simple structure and long-baseline is needed. We developed a technology to make the axial gradiometer compact using direct bonding of superconductive wires between pickup coil and input coil. Conventional insert has mechanical support to hold the gradiometer array, and the dewar neck has equal diameter with the dewar bottom. Boiling of the liquid He can generate mechanical vibrations in the gradiometer array due to mechanical connection structure. Elimination of the mechanical support, and direct mounting of the gradiometer array into the dewar bottom can reduce the dewar neck diameter, resulting in the reduction of liquid He consumption.

• Clinical and Experimental Reproductive Medicine
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• v.40 no.2
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• pp.95-99
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• 2013

Objective: To evaluate the correlation between serum levels of anti-M$\ddot{u}$llerian hormone (AMH) and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome (PCOS). Methods: Seventy-four cycles of mild stimulation (clomiphene citrate+gonadotropin followed by timed intercourse or intrauterine insemination) performed in normoovulatory women (57 cycles) and anovulatory women with PCOS (17 cycles). Ovarian sensitivity was defined by the number of mature follicles (${\geq}14mm$) on triggering day per 100 IU of gonadotropin. A correlation between ovarian sensitivity and the baseline serum AMH level (absolute or multiples of the median [MoM] value for each corresponding age) was calculated. Correlation between ovarian response and serum AMH level was evaluated. Results: Ovarian sensitivity to mild stimulation was positively correlated with absolute serum AMH (r=0.535, p<0.001) or AMH-MoM value (r=0.390, p=0.003) in normoovulatory women, but this correlation was not observed in anovulatory women with PCOS (r=0.105, p>0.05, r=-0.265, p>0.05, respectively). Conclusion: Ovarian response to mild stimulation is possibly predicted by the serum AMH level in normoovulatory women, but not in anovulatory women with PCOS.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.13 no.5
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• pp.327-333
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• 2003

Several tests are performed to evaluate road booming noise. Baseline test delivers the information of road noise characteristics. Coupling effect between structure and acoustics is obtained from the mode shapes and the natural frequencies by the modal test. Equivalent stiffness at joint areas between chassis and car-body system can be determined by the input point inertance test. Noise sensitivity of body mounting point of a chassis part can be obtained from the noise transfer function test with input point inertance test. Operational deflection shape makes us analyze the actual vibration modes of the chassis system under actual leading and find noise sources very easily. Finally, the transfer path analysis is used to Identify noise Paths through the chassis system. The objectives and the procedures of the tests are described in this Paper Also, the guideline for efficient road noise evaluation test can be found.

• Proceedings of the Korean Society of Plant Pathology Conference
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• 2004.10a
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• pp.36-38
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• 2004

Ethaboxam is a new fungicidal active ingredient that inhibits growth of plant pathogens specifically belonging to Oomycetes with protective, curative, systemic and translaminar activity in plants. Modes of action studies revealed that ethaboxam simultaneously inhibits cytoskeleton formation and mitochondrial respiration of Phytophthora infestans at low concentrations. There have been no indications of resistance development when tested for baseline resistance monitoring to 261 isolates of P. infestans in Korea and Europe and 150 populations of Plasmopara viticola populations in Europe for 3 years since 2000. In a selective study with vine trees artificially inoculated with P. viticola repeatedly for 10 generations in greenhouse, there have been no changes in sensitivity to ethaboxam among four natural populations of P. viticola. Furthermore, ethamoxam has not shown any cross resistance with azoxystrobin, mefenoxam, dimethomorph and cymoxanil. Based on the study results from modes of action and resistance development, ethaboxam appears to be unlikely to develop resistance in field applications.