• Archives of Pharmacal Research
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• v.28 no.8
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• pp.930-935
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• 2005

We have investigated the effects of relatively high concentration of carbachol (CCh), an agonist of muscarinic acetylcholine receptor (mAChR), on cardiac automaticity in mouse heart. Action potentials from automatically beating right atria of mice were measured with conventional microelectrodes. When atria were treated with $100{\mu}M$ CCh, atrial beating was immediately arrested and diastolic membrane potential (DMP) was depolarized. After exposure of the atria to CCh for $\~4 min$, action potentials were regenerated. The regenerated action potentials had lower frequency and shorter duration when compared with the control. When atria were pre-exposed to pirenzepine $(1{\mu}M)$, an $M_1$ mAChR antagonist, there was complete inhibition of CCh-induced depolarization of DMP and regeneration of action potentials. Pre-exposure to AFDX-116 (11 ({2-[(diethylamino)-methyl]-1-piperidyl}acetyl)-5, 11-dihydro-6H-pyridol[2,3-b][1,4] benzodiazepine-6-one base, $1{\mu}M$), an $M_2$ mAChR antagonist, failed to block CCh-induced arrest of the beating. However, prolonged exposure to CCh elicited gradual depolarization of DMP and slight acceleration in beating rate. Our data indicate that high concentration of CCh depolarizes membrane potential and recovers right atrial automaticity via $M_1$ mAChR, providing functional evidence for the role of $M_1$ mAChR in the atrial myocytes.

• Journal of the Ergonomics Society of Korea
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• v.30 no.1
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• pp.237-250
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• 2011

The train transportation has a lot of advantages-energy efficiency is high, it is eco-friendly, safety is better than normal roads and it is possible for people to arrive on time. In these days, the valuation of ride comfort, which is only limited to road transportation, is newly recognized in order to having competitiveness from other transportation. Especially, in the development of the Korean high-speed railroad business, the ride comfort enhancement of train is very important problem to be solved. Currently, there are international standards of ride comfort such as UIC13, ISO2631. In Korea case, although it has own standard like KS R9216, it mainly depends on the physical parameter such as vibration and noise. So recently, in the valuation of ride comfort, the movements of living parameter technique introduction are increasing on the base of Japan and many developed countries of Europe techniques. Presently, the method of train ride comfort is mainly based of vibration, that is, mechanical parameter adding selection of variable acceleration and noise. This paper would like to show biological parameter; heart rate and blood pressure variation. This method is more direct, based on human body response, than mechanical parameter method. In this experiment, the variability of heart rate and blood pressure of passengers according to tilting angle change of Train, the Korean tilting train, we are supposed to know that the extent of tilting on the simulation has influence on variability of heart rate and blood pressure, which are living parameter of heart's blood.

• Geotechnical Engineering
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• v.5 no.1
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• pp.27-34
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• 1989

This study presents a probabilistic analysis of the stability of homogeneous soil slopes during earthquakes. The stability of the slope is measured through its probability of failure rather than the customary factor of safety. The maximum horizontal ground acceleration is deterimined with Donovan and McGuire equation. The earthquake magnitude (m) is a random variable the Probability density function f(m) has been obtained with a use of Richter law. The potential failure surfaces are taken to be of an exponential shape (log-spiral) , Uncertainties of the shear strength parameters along potential failure surface are expressed by one-dimensional random field model. From a first order analysis the mean and variance of safety margin is osculated. The dependence on significant seismic parameters of the probability of failure of the slope is examined and the results are presented in a number of graphs and tables. On the base of the results obtained in this study, it is concluled that (1) the present model is useful in assessing the reliability of soil slopes under both static and seismic conditions: and (2) the probability of failure of a soil slope is greatly affected by the values of the seismic parameters that are associated with it.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2013.06a
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• pp.252-254
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• 2013

When Coming alongside the shallow water or narrow pier, they apply sea area with small mooring facilities and Floating matter because of the diversity of ships and limitation and effective in cutting expenses. However, when ships, applying Small mooring facilities and Floating matter, come alongside, there can be some impulse by waves between the Floating things and ships which possibly leads to mass disaster. Therefore, there should be forecasts and analysis of the movement caused by waves. On this Study, it introduces the composition and principles of the developed system provides the base of the movement traits through measuring 3-D exercise data and acceleration of the Mooring and Floating matters.

• Journal of the Korean Society of Safety
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• v.26 no.3
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• pp.52-58
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• 2011

The earthquake characteristic assessment of social overhead facilities would be an important examination issue for seismic capacity enhancement. This study is intended to reasonably evaluate the structural behavior of longperiod frame structures considering near-fault and far-fault earthquake characteristics. Elastic/inelastic time history analyses were performd by selecting the objective structure which can precisely reflect the effect of input ground motion. Based on the result of numerical analysis, we have investigated response aspects of shear force, moment, acceleration and displacement according to earthquake characteristics. Moreover, in order to understand the inelastic behavior of the objective structure, we have analyzed and compared collapse modes by considering the occurrence process of plastic hinges. The outcome of this research is expected to provide the basic information for the seismic safety assessment of long-period frame structures.

• Land and Housing Review
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• v.8 no.3
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• pp.181-187
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• 2017

To proactively respond to internal and external changes such as the recent demographic change and rising demand for diversified housing types, this study investigated the framed-structure free plan public house model proposed by the LH to look at the seismic performance of framed-structure apartment according to damper system use through non-linear analysis. The effectiveness thereof was also examined in terms of performance and economy. As a result, the proposed damper system application method to framed-structure free plan public house model was found to meet the performance requirements of the present earthquake-resistant design (KBC2016) and effective to apply to designs. The max response displacement and max response acceleration were compared based on the nonlinear analysis. As a result, the building with damper system showed better earthquake resistance performance than earthquake-resistant structure thanks to the damper system, although the base shear of earthquake-resistant system was reduced by 20% in design. The damper system is expected to help reduce building damage while ensuring excellent earthquake resistance performance. In addition, the framework quantities of earthquake-resistant structure and structure with damping system were compared. As a result, columns were found to reduce concrete amount by about 3.9% and rebar, by about 7.3%. Walls showed about 12.6% reduction in concrete and about 10.7% in rebar. In terms of cost, framework construction cost including formwork and foundation expenses was expected to drop by about 5~6%.

• Earthquakes and Structures
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• v.15 no.6
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• pp.639-654
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• 2018

Rocking motion have been used for achieving the 'resilient buildings' against earthquakes in recent studies. Low-rise buildings, unlike the tall ones, because of their small aspect ratio tend to slide rather than move in rocking mode. However, since rocking is more effective in seismic response reduction than sliding, it is desired to create rocking motion in low-rise buildings too. One way for this purpose is making the building's structure rock on its internal bay(s) by reducing the number of bays at the lower part of the building's skeleton, giving it a mushroom form. In this study 'mushroom skeleton' has been used for creating multi-story rocking regular steel buildings with square plan to rock on its one-by-one bay central lowest story. To show if this idea is effective, a set of mushroom buildings have been considered, and their seismic responses have been compared with those of their conventional counterparts, designed based on a conventional code. Also, a set of similar buildings with skeleton stronger than code requirement, to have immediate occupancy (IO) performance level, have been considered for comparison. Seismic responses, obtained by nonlinear time history analyses, using scaled three-dimensional accelerograms of selected earthquakes, show that by using appropriate 'mushroom skeleton' the seismic performance of buildings is upgraded to mostly IO level, while all of the conventional buildings experience collapse prevention (CP) level or beyond. The strong-skeleton buildings mostly present IO performance level as well, however, their base shear and absolute acceleration responses are much higher than the mushroom buildings.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.55 no.3
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• pp.267-277
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• 2022

This study investigated changes in the physicochemical and microbiological properties of fermented fish sauces based on the pacific sand lance Ammodytes personatus during fermentation according to rice koji treatments and salt contents. In total, six fish sauces were prepared, with rice koji treatment for 24 or 72 h before salt addition, and salt contents of 10 or 20%, including two controls to compare the response to different salt contents without koji treatment. The initial pH values of the sauces with koji treatments were notably lower than those of the controls. Over the 10 months of fermentation, the amino nitrogen contents of the sauces with 10% salt were higher than those with 20% salt, while the volatile base nitrogen value was also increased. In the microbial community, the initial numbers of lactic acid bacteria and mold were higher in the sauces with koji treatment than in the controls. After 8 months of fermentation, the free amino acid and organic acid contents were higher in the sauces with koji treatment than in the controls. Although the fermentation rate was affected to a greater extent by salt contents, the rice koji treatment also exerted a positive effect on the acceleration of fermentation.

• Earthquakes and Structures
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• v.23 no.1
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• pp.23-34
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• 2022

This paper presents experimental studies on reinforced concrete moment resisting frames that have engineered cementitious composite (ECC) in plastic hinge length (PHL) of beam/column members and beam-column joints. A two-story frame structure reduced by a 1:3 scale was further tested through a shake-table (seismic simulator) using multiple levels of simulated earthquake motions. One model conformed to all the ACI-318 requirements for IMRF, whereas the second model used lower-strength concrete in the beam/column members outside PHL. The acceleration time history of the 1994 Northridge earthquake was selected and scaled to multiple levels for shake-table testing. This study reports the observed damage mechanism, lateral strength-displacement capacity curve, and the computed response parameters for each model. The tests verified that nonlinearity remained confined to beam/column ends, i.e., member joint interface. Calculated response modification factors were 11.6 and 9.6 for the code-conforming and concrete strength deficient models. Results show that the RC-ECC frame's performance in design-based and maximum considered earthquakes; without exceeding maximum permissible drift under design-base earthquake motions and not triggering any unstable mode of damage/failure under maximum considered earthquakes. This research also indicates that the introduction of ECC in PHL of the beam/column members' detailing may be relaxed for the IMRF structures.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.23 no.8
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• pp.759-769
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• 2013

Electronic equipment has been applied to virtually every area associated with commercial, industrial, and military applications. Specifically, electronics have been incorporated into avionics components installed in aircraft. This equipment is exposed to dynamic loads such as vibration, shock, and acceleration. Especially, avionics components installed in a helicopter are subjected to simultaneous sine and random base excitations. These are denoted as sine on random vibrations according to MIL-STD-810F, Method 514.5. In the past, isolators have been applied to avionics components to reduce vibration and shock. However, an isolator applied to an avionics component installed in a helicopter can amplify the vibration magnitude, and damage the chassis, circuit card assembly, and the isolator itself via resonance at low-frequency sinusoidal vibrations. The objective of this study is to investigate the dynamic characteristics of an avionics component installed in a helicopter and the structural dynamic modification of its tray plate without an isolator using both a finite element analysis and experiments. The structure is optimized by dynamic loads that are selected by comparing the vibration, shock, and acceleration loads using vibration and shock response spectra. A finite element model(FEM) was constructed using a simplified geometry and valid element types that reflect the dynamic characteristics. The FEM was verified by an experimental modal analysis. Design parameters were extracted and selected to modify the structural dynamics using topology optimization, and design of experiments(DOE). A prototype of a modified model was constructed and its feasibility was evaluated using an FEM and a performance test.