• Journal of Korean Medicine Rehabilitation
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• v.20 no.4
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• pp.33-49
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• 2010

Objectives : This study was designed to elucidate the anti-pathogenetic and curative effects of Gyehyeoldeungbokhap-bang(Jixietengfuge-fang, GCP) on Type II collagen-induced arthritis(CIA) in mice. Methods : In experiment, twenty four mices were divided into non-treated normal group(n=6), bovine type II collagen-induced control group(n=6), collagen immunized and treated two group medicated with extract of GCP(concentration of extraction: 200 mg/kg n=6, 400 mg/kg n=6) for 4 weeks after collagen immunization, Various experimental such as arthritis, incidence, index, total cell number of spleen, total cell number of peripheral lymph node(PLN), paw joint total cell number, analysis on the percentage of immunofluorescent cells of spleen in CIA induced mice, effects of inflammatory gene expression in spleen, PLN and paw joint of CIA mice, production of cytokine(IFN-${\gamma}$, IL-4, TNF-${\alpha}$, IL-6), analysis of rheumatoid factor(anti-collagen lgG, lgM level in serum) and histopathological study on the paw joint. The arthritis index, incidence were measured a week over 4 weeks after second boosting. Total cell number of spleen, peripheral lymph node, paw joint were measure after performed experiment over 7 weeks. Concentration of cytokine and rheumatoid factor in serum were measured after experiment finished. Histopathological study on the paw joint was measured after 40 days medicated with extract of GCP. Results : 1. Incidence of arthritis and index of arthritis were significantly decreased in treated group with 400 mg/kg. 2. Total cell number of spleen, PLN and paw joint were significantly decreased in treated group. 3. Analysis on the percentage of immunofluorescent cells of spleen in CIA induced mice were significantly controled compare with control group. 4. Effects of inflammatory gene expression in spleen, PLN and paw joint of CIA induced mice were significantly controled compare with control group. 5. IFN-${\gamma}$, IL-6, TNF-${\alpha}$, concentration($pg/m{\ell}$) in serum of treated group was significantly decreased compare with control group. But IL-4 was significantly increased. 6. lgM and lgG concentration($pg/m{\ell}$) in serum of treated group was significantly decreased compare with control group. 7. Histopathologically, suppurative and destructive lesion of synovial membrane, articular cartilage and subchondral bony tissue in treated group were alleviated compare with those of control group. Conclusions : Based on the results described above, it might be consider that Gyehyeoldeungbokhap-bang(Jixietengfuge-fang, GCP) has antiarthritic and analgesic effects and also inhibitory effects on the progression of collagen-induced arthritis mice.

• Journal of the Korean Society for Precision Engineering
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• v.12 no.6
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• pp.128-136
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• 1995

The problem addressed in this paper is that of the on-line computational burden of time-optimal control laws for quick, strongly nonlinear systems like revolute robots. It will be demonstrated that a large amount of off-line computation can be substituted for most of the on-line burden in cases of time optimization with constrained inputs if differential point-to- point specifications can be relaxed to cell-to-cell transitions. These cells result from a coarse discretization of likely swaths of state space into a set of nonuniform, contiguous volumes of relatively simple shapes. The cell boundaries approximate stream surfaces of the phase fluid and surfaces of equal transit times. Once the cells have been designed, the bang- bang schedules for the inputs are determined for all likely starting cells and terminating cells. The scheduling process is completed by treating all cells into which the trajectories might unex- pectedly stray as additional starting cells. Then an efficient-to-compute control law can be based on the resulting table of optimal strategies.

• Proceedings of the KIEE Conference
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• 1996.07a
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• pp.603-605
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• 1996

The SLIM used in the conveyance system has been generally developed the controller based on the slip frequency control and the VVVF method to obtain the quick response for the position control signal. This paper deals with the trust control of the SLIM by vector control with Bang-Bang condition. Also, the control system is composed of the PI controller for soft start of the SLIM and the q-axis current controller for correction in phase with Space Vector for reducing the harmonic pulsation in low speed. The processing for vector control and robust dynamic breaking control is carried out by MC80196KC micro processor and IGBT module. The proposed scheme is verified through the computer simulation and experiments for the 10KW SLIM.

• 대한예방의학회:학술대회논문집
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• 2001.04a
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• pp.82-82
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• 2001

• Journal of Korean Association for Spatial Structures
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• v.10 no.4
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• pp.5-10
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• 2010

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.31 no.3
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• pp.111-118
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• 2003

• Journal of Advanced Marine Engineering and Technology
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• v.15 no.1
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• pp.85-95
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• 1991

All physical systems are nonlinear to some degree. The examples are relay, backlash, deadzone, saturation element and so on. In the linear control system design, it is useful method to restrict the nonlinearity to the linearity of system over the operation range. It is worth noting that nonlinearities may be intentionally introduced in to a system. A simple of an intentional non-linearity is the Bang-Bang controller which uses the On-Off relay. In this paper, an angular position servosystem made of a DC servomotor controlled by a microcomputer is discribed. Authors use two methods in the design of controller. The one is linear controller designed by the optimal feedback control theory only and the other is nonlinear controller designed by On-Off relay with optimal feedback control theory. To do the real time control, the controller is designed by using 16bit personal computer and A/D.D/A converter(12bit) is used in order to convert the signal. According to this way, the results from real time control are as follows. 2) Under the On-Off controller with hysterisis the influence of disturbance is considerably smaller than the linerar controller. 3) An increase in the sampling period has a destabilizing effect. 4)In the controller performance, the response time of the On-Off controller is longer than that of the linear controller. To close, we note that the On-Off controller with hysterisis is more attractive than the linear controller in the presence of the input limit.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.3
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• pp.490-503
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• 2010

This study was carried out to know the effects of Gwanjul9-bang (hereinafter reffered to GJ9) on the inhibition of arthritis induced by collagen on DBA/1J mouse. For this purpose, GJ9 was orally administered to mouse with arthritis induced by collagen II. Cytotoxicity, hepatotoxicity, arthritis index, value of immunocyte in draining lymph node and paw joint, rheumatoid factor (IgG, IgM) in serum were measured in vivo. The cytotoxicity against hFCs was not measured in any concentration. The hepatotoxicity was low in GJ9 treated group compared with MTX group. The arthritis index was decreased significantly. In total cell counts of DLN and paw joint, the cells in DLN increased significantly while there was significantly decrease in paw joint. In lymph nodes, $CD19^+$, $CD3^+$, $CD4^+$, $CD3^+CD69^+$, $CD8^+$, $CD4^+CD25^+$, $CD3^+CD49b^+$, $CD4^+CD44^+$, $CD3^+CD8^+$ cells increased significantly, $B220^+CD23^+$cells decreased significantly. In joints, $CD3^+$, $CD4^+$, $CD4^+CD25^+$, $CD11b^+Gr-1^+$ cells decreased significantly. The levels of IgG and IgM was significantly decreased compared with control. Anti-collagen II in serum was significantly decreased compared with control. The degree of arthritis induced damage of joint of GJ9 group is slight compared with control group in histopathologic observation (Hematoxylin & Eosin, Masson's Trichrome). Comparison of the results for this study showed that GJ9 had immunomodulatory effects. So we expect that GJ9 should be used as a effective drugs for not only rheumatoid arthritis but also another auto-immune disease. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.

• Journal of Korean Medicine Rehabilitation
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• v.20 no.2
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• pp.17-34
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• 2010

Objectives : This study was carried out to know the effects of Gwanjul8-bang(here in after reffered to GJ8) on the inhibition of arthritis induced by collagen on DBA/1J mice. Methods : For this purpose, GJ8 was orally administered to mouse with arthritis induced by collagen II. Cytotoxicity, hepatotoxicity, arthritis index, value of immunocyte in draining lymph node(DLN) and paw joint, cytokine in serum were measured in vivo. Results : 1. The arthritis index was decreased significantly. 2. In total cell counts of DLN and paw joint, the cells in DLN increased significantly while there was a significant decrease in paw joint. 3. In lymph nodes, $CD19^+$, $CD3^+$, $CD4^+/CD25^+$ cells increased significantly, and $B220^+/CD23^+$ cells decreased significantly. 4. In joints, $CD3^+$, $CD4^+$, $CD11b^+/Gr-1^+$ cells decreased significantly. 5. The levels of $TNF-{\alpha}$, IL-6, IL-17, MCP-1 and vascular endothelial growth factor(VEGF) in serum was significantly decreased compared with control. 6. Anti-collagen II in serum was significantly decreased compared with control. 7. The degree of arthritis induced damage of joint of GJ8 group is slight compared with control group in histopathologic observation(hematoxylin & eosin(H&E), Masson-Trichrome(MT) staining). Conclusions : Comparison of the results for this study showed that GJ8 had immunomodulatory effects. So we expect that GJ8 should be used as a effective drugs for not only rheumatoid arthritis but also another auto-immune disease. Therefore there seems to be many clinical research needed in the future.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.22-24
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• 1996

Small size DC motor control method for portable drug delivery system has been developed to be used for the actuator of insulins pump. The control method gives the controllabilities both in high speed(40-50 revolution per second(rps)) DC motor drive and also in low speed(0.5-1rps). In low speed mode DC motor is controlled to act like stepping motor and in high speed to optimize power consumption. To control both mode modified bang bang control is suggested. Using this method small size DC motor(spec.) speed is controlled from 0.2 rps to 50 rps. Experimental setup is developed using micro-processor(PIC16C73, Micro Chips co., USA), motor turns checking circuitry, small size DC motor for pager(SM1012, Samhong co., Korea) and gear box. Results from experiment meet need for vailable load condition which is require for portable drug delivery system.