• Journal of Korean Society of Archives and Records Management
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• v.21 no.3
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• pp.139-162
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• 2021

As the demand for finding clearer information amid vast information acquisition increases, the enhancement of academic research services is highly important. In 2019, the Presidential Archives opened the only academic research services among the permanent archives management institutions. This study aims to identify the status of the insufficient use of academic research services implemented in the Presidential Archives, analyze problems and requirements through interviews with users who have used the Presidential Archives for academic purposes and conducted research, suggest a plan to upgrade the research services of the Presidential Archives, and offer a plan to improve the services of archives institutions accordingly. Researchers mostly sought information through an online search, but the information gap was large depending on the background knowledge, and the research scope was reduced because of insufficient information. Moreover, problems occurred regarding search tools, records management, and records disclosure, and most users were unaware of the academic research services. Therefore, the advancement plans entailed reducing the information gap among researchers, improving the search tool functions, creating more detailed descriptions of records, resolving geographic constraints, promoting academic research services and developing content, nurturing subject-specialized archivists, and providing online chatting services.

• Tuberculosis and Respiratory Diseases
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• v.84 no.2
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• pp.148-158
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• 2021

Background: Radiotherapy is a common treatment option for lung or esophageal cancer, particularly when surgery is not feasible for patients with poor lung function. However, radiotherapy can affect pulmonary function and thereby induce pneumonitis or pneumonia, which can be fatal in patients with respiratory impairment. The purpose of this study is to evaluate if reductions in pulmonary function after radiotherapy can be minimized through simultaneous pulmonary rehabilitation (PR). Methods: In this matched case control study, we retrospectively analyzed patients who had undergone radiotherapy for thoracic malignant disease between January 2018 and June 2019. We analyzed results from pulmonary function tests and 6-minute walking tests (6MWT) conducted within the six months before and after radiotherapy treatment. Results: In total, results from 144 patients were analyzed, with 11 of the patients receiving PR and radiotherapy simultaneously. Of the 133 patients in the control group, 33 were matched with 11 patients in the PR group. Changes in forced expiratory volume in one second (FEV₁) and FEV₁/forced vital capacity were significantly different between the PR group and the matched control group (240 mL vs. -10 mL, p=0.017 and 5.5% vs. 1.0%, p=0.038, respectively). The median distance of 6MWT in the PR group also increased significantly, from 407.5 m to 493.0 m after radiotherapy (p=0.017). Conclusion: Simultaneous PR improved pulmonary function, particularly in measures of FEV₁, and exercise capacity for patients with lung or esophageal cancer even after radiotherapy treatment. These findings may provide an important base of knowledge for further large population studies with long-term follow-up analysis in the identification of the PR's effects during thoracic radiotherapy.

• Nutrition Research and Practice
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• v.15 no.3
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• pp.367-381
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• 2021

BACKGROUND/OBJECTIVES: This study aimed to establish a mother and child cohort in the Chinese population, and investigate human breastmilk (HBM) composition and its relationship with maternal body mass index (BMI) and infant growth during the first 3 mon of life. SUBJECTS/METHODS: A total of 101 Chinese mother and infant pairs were included in this prospective cohort. Alterations in the milk macronutrients of Chinese mothers at 1 mon (T1), 2 mon (T2), and 3 mon (T3) lactation were analyzed. HBM fatty acid (FA) profiles were measured by gas chromatography (GC), and HBM proteomic profiling was achieved by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). RESULTS: During the first 3 mon of lactation (P < 0.05), significant decreases were determined in the levels of total energy, fat, protein, and osteopontin (OPN), as well as ratios of long-chain saturated FA (including C16:0, C22:0 and C24:0), monounsaturated FA (including C16:1), and n-6 poly unsaturated FA (PUFA) (including C20:3n-6 and C20:4n-6, and n-6/n-3). Conversely, butyrate, C6:0 and n-3 PUFA C18:3n-3 (α-linolenic acid, ALA) were significantly increased during the first 3 mon (P < 0.05). HBM proteomic analyses distinguished compositional protein differences over time (P = 0.001). Personalized motherinfant analyses demonstrated that HBM from high BMI mothers presented increased total energy, fat, protein and OPN, and increased content of n-6 PUFA (including C18:3n-6, C20:3n-6 and n-6/n-3 ratio) as compared with low BMI mothers (P < 0.05). Furthermore, BMI of the mothers positively correlated with the head circumference (HC) of infants as well as the specific n-6 PUFA C20:3n-6 over the 3 time points examined. Infant HC was negatively associated with C18:0. CONCLUSION: This study provides additional evidence to the Chinese HBM database, and further knowledge of FA function. It also helps to establish future maternal strategies that support the healthy growth and development of Chinese infants.

• The Journal of the Korea Contents Association
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• v.21 no.6
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• pp.435-444
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• 2021

This paper discusses the geometrical interpretation of the Taegeuk Shapes of Kameun Temple through the geometric analysis of mathematics. Based on the literature, This paper attempted to clarify that the origin of Gameunsa's founding of the spirit of patriotism may coincide with historical records through historical literature and geometric meaning. First, the background of the founding of Kameun temple, geographical location located near the East Sea, especially the history of the ancient Chinese mathematics at the time, And that mathematical knowledge influenced all fields such as agriculture, architecture, and art. Secondly, it is related to the historical record as the space of about 60 centimeters, which is uniquely underground, was identified as the structure of the excavated space. It is thought that there is a strong correlation with the origin that the King Munmu changed into a dragon, and set up the temple to be able to stay. Based on these, the clues of the interpretation of the taegeuk and the triangular pattern were searched in the samcheon yanggi(參天兩地) of the Oriental and circumference of the Western. The taegeuk and triangular patterns represent the symbols of yin-yang harmony, which correspond to the origin of its creation. the Korean people regarded the mysterious dragon as a symbol of yinyang harmony. In conclusion the Shapes of Kameun temple's stone is consistent with the contents mentioned in the historical record.

• Journal of The Korean Association For Science Education
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• v.41 no.2
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• pp.71-82
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• 2021

Learning efficiency can be maximized by careful matching of text features to expected reader features (i.e., linguistic and cognitive abilities, and background knowledge). The present study aims to explore whether this systematic principle is reflected in the development of science textbooks. The current study examined science textbook texts on 20 measures provided by Auto-Kohesion, a Korean language analysis tool. In addition to surface-level features (basic counts, word-related measures, syntactic complexity measures) which have been commonly used in previous text analysis studies, the present study included cohesion-related features as well (noun overlap ratios, connectives, pronouns). The main findings demonstrate that the surface measures (e.g., word and sentence length, word frequency) overall increased in complexity with grade levels, whereas the majority of the other measures, particularly cohesion-related measures, did not systematically vary across grade levels. The current results suggest that students of lower grades are expected to experience learning difficulties and lowered motivation due to the challenging texts. Textbooks are also not likely to be suitable for students of higher grades to develop the ability to process difficulty level texts required for higher education. The current study suggests that various text-related features including cohesion-related measures need to be carefully considered in the process of textbook development.

• Journal of Music and Human Behavior
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• v.18 no.1
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• pp.103-122
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• 2021

The purpose of this study was to investigate music therapists' awareness of the music therapy national certification (MTNC). Online questionnaires were distributed to music therapists who voluntarily agreed to participate in this research and 143 completed surveys were collected for analysis. The questionnaire consisted of 37 questions (background information, awareness of the necessity for MTNC, expected effects of national certification, and qualification management). According to the collected data, music therapists reported that they were highly aware of the necessity for MTNC. The participants believed that excessive issueing of private licenses might deteriorate the quality of music therapy services and job opportunities. As alternatives to address private license-related issues, participants agreed with the establishment of national certification system. Given that participants did not have enough knowledge of MTNC and the MTNC may have both pros and cons, the results should be generalized with caution. Still, this study could provide basic information for further discussion on the establishment of MTNC.

• Journal of Ginseng Research
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• v.45 no.1
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• pp.183-190
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• 2021

Background: The circadian rhythm is the internal clock that controls sleep-wake cycles, metabolism, cognition, and several processes in the body, and its disruption has been associated with aging. The differentiated embryo chondrocyte (Dec) gene is related to circadian rhythm. To our knowledge, there are no reports of the relationship between dec gene expression and KRG effect. Therefore, we treated Dec gene knockout (KO) aging mice with KRG to study anti-aging related effects and possible mechanisms. Methods: We evaluated KRG and expression of Dec genes in an ototoxicity model. Dec genes expression in livers of aging mice was further analyzed. Then, we assessed the effects of DEC KO on hearing function in mice by ABR. Finally, we performed DNA microarray to identify KRG-related gene expression changes in mouse liver and assessed the results using KEGG analysis. Results: KRG decreased the expression of Dec genes in ototoxicity model, which may contribute to its anti-aging efficacy. Moreover, KRG suppressed Dec genes expression in liver of wild type indicating inhibition of senescence. ABR test indicated that KRG improved auditory function in aging mouse, demonstrating KRG efficacy on aging related diseases. Conclusion: Finally, in KEGG analysis of 238 genes that were activated and 158 that were inhibited by KRG in DEC KO mice, activated genes were involved in proliferation signaling, mineral absorption, and PPAR signaling whereas the inhibited genes were involved in arachidonic acid metabolism and peroxisomes. Our data indicate that inhibition of senescence-related Dec genes may explain the anti-aging efficacy of KRG.

• The Journal of the Korea Contents Association
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• v.21 no.4
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• pp.38-49
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• 2021

This study analyzed the trend of the term 'false and exaggerated advertisement' in 5,141 newspaper articles from 1990 to 2019 using text mining methodology. First of all, we identified the most frequent keywords of false and exaggerated advertisements through frequency analysis for all newspaper articles, and understood the context between the extracted keywords. Next, to examine how false and exaggerated advertisements have changed, the frequency analysis was performed by separating articles by 10 years, and the tendency of the keyword that became an issue was identified by comparing the number of academic papers on the subject of the highest keywords of each year. Finally, we identified trends in false and exaggerated advertisements based on the detailed keywords in the topic using the topic modeling. In our results, it was confirmed that the topic that became an issue at a specific time was extracted as the frequent keywords, and the keyword trends by period changed in connection with social and environmental factors. This study is meaningful in helping consumers spend wisely by cultivating background knowledge about unfair advertising. Furthermore, it is expected that the core keyword extraction will provide the true purpose of advertising and deliver its implications to companies and related employees who commit misconduct.

• Journal of Ginseng Research
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• v.46 no.6
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• pp.738-749
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• 2022

Background: Ginseng possesses antitumor effects, and ginsenosides are considered to be one of its main active chemical components. Ginsenosides can further be hydrolyzed to generate secondary saponins, and 20(R)-panaxotriol is an important sapogenin of ginsenosides. We aimed to synthesize a new ginsengenin derivative from 20(R)-panaxotriol and investigate its antitumor activity in vivo and in vitro. Methods: Here, 20(R)-panaxotriol was selected as a precursor and was modified into its derivatives. The new products were characterized by ¹H-NMR, ¹³C-NMR and HR-MS and evaluated by molecular docking, MTT, luciferase reporter assay, western blotting, immunofluorescent staining, colony formation assay, EdU labeling and immunofluorescence, apoptosis assay, cells migration assay, transwell assay and in vivo antitumor activity assay. Results: The derivative with the best antitumor activity was identified as 6,12-dihydroxy-4,4,8,10,14-pentamethyl-17-(2,6,6-trimethyltetrahydro-2H-pyran-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl(tert-butoxycarbonyl)glycinate (A11). The focus of this research was on the antitumor activity of the derivatives. The efficacy of the derivative A11 (IC₅₀ < 0.3 µM) was more than 100 times higher than that of 20(R)- panaxotriol (IC₅₀ > 30 µM). In addition, A11 inhibited the protein expression and nuclear accumulation of the hypoxia-inducible factor HIF-1α in HeLa cells under hypoxic conditions in a dose-dependent manner. Moreover, A11 dose-dependently inhibited the proliferation, migration, and invasion of HeLa cells, while promoting their apoptosis. Notably, the inhibition by A11 was more significant than that by 20(R)-panaxotriol (p < 0.01) in vivo. Conclusion: To our knowledge, this is the first study to report the production of derivative A11 from 20(R)-panaxotriol and its superior antitumor activity compared to its precursor. Moreover, derivative A11 can be used to further study and develop novel antitumor drugs.

• Journal of the Korean Chemical Society
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• v.66 no.5
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• pp.376-389
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• 2022

The purpose of this study was to investigate the effects of implementing semantic mapping reading strategy in the science class on high school students' science text reading ability. 3^rd grade students of science core high school in a small and medium-sized city participated in this study for a semester. Texts with socio-scientific issues and chemistry subjects were used to implement semantic mapping reading strategy in the science class. To investigate the changes in students' science text reading ability, experimental group students participated in the pre-reading and post-science reading ability tests and the results were analyzed. The results of this study showed that the mean of the science reading ability test score of experimental group was significantly higher than that of the comparison group. We found that drawing a semantic mapping before solving a reading task made it easier for students to find information and infer meaning from text. It can be seen that students also recognize that the semantic mapping is helpful in understanding the text because it is easy to understand the relationship between concepts by visualizing the content of the text, and can connect their background knowledge with the text content.