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A Cipadesin Limonoid and a Tirucallane Triterpene from the Fruit of Sandoricum koetjape and their Inhibitory Properties against Receptor Tyrosine Kinases

  • Rachmadhaningtiyas, Dyah Ayu;Heliawati, Leny;Hermawati, Elvira;Syah, Yana Maolana
    • Natural Product Sciences
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    • v.27 no.2
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    • pp.134-139
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    • 2021
  • A new cipadesin limonoid, i.e. 3-epi-cipadonoid C (1), and a new tirucallane triterpene, i.e. hispidol B 3-palmitate (3), have been isolated from the seeds and fruit peels extract of Sandoricum koetjape, respectively. Along with these compounds the known limonoid, cipaferen G (2), and two pentacyclic triterpenes, bryonolic (4) and bryononic (5) acids, were also isolated. The strucrures of the new compounds were elucidated by the analysis of NMR and mass spectral data. Compounds 1 - 5 were evaluated as the inhibitor of receptor tyrosine kinases (EGFR, Epidermal Growth Factor Receptor; HER2, HER4, Human Epidermal growth factor Receptor 2, -4; IGFR, Insulin-like Growth Factor Receptor; InsR, Insulin Receptor; KDR, Kinase insert Domain Receptor; PDGFRα, and PDGFRβ, Platelet-Derived Growth Factor Receptor-α and -β). The results showed only 1 and 3 that have weak activity against InsR.

Optimization of a Savonius hydrokinetic turbine for performance improvement: A comprehensive analysis of immersion depth and rotation direction

  • Mafira Ayu Ramdhani;Il Hyoung Cho
    • Ocean Systems Engineering
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    • v.14 no.2
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    • pp.141-156
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    • 2024
  • The turbine system converts the kinetic energy of water flow to electricity by rotating the rotor in a restricted waterway between the seabed and free surface. A turbine system's immersion depth and rotation direction are significantly critical in the turbine's performance along with the shape of the rotor. This study has investigated the hydrodynamic performance of the Savonius hydrokinetic turbine (SHT) according to the immersion depth and rotation direction using computational fluid dynamics (CFD) simulations. The instantaneous torque, torque coefficient, and power coefficients are calculated for the immersion ratios Z/D ranging [0.25, 3.0] and both clockwise (CW) and counterclockwise (CCW) rotations. A flow visualization around the rotor is shown to clarify the correlation between the turbine's performance and the flow field. The CFD simulations show that the CCW rotation produces a higher power at shallow immersion, while the CW rotation performs better at deeper immersion. The immersion ratio should be greater than the minimum of Z/D=1.0 to obtain the maximum power production regardless of the rotation direction.

Distribution and Ecology of a Land-Locked Ayu, Plecoglossusaltivelis (Pisces: Osmeridae) in Lake Okjeong, Korea (옥정호 육봉형 은어 Plecoglossus altivelis (Pisces: Osmeridae)의 서식분포와 생태)

  • Ko, Myeong-Hun;Kim, Ik-Soo;Park, Jong-Yeong;Lee, Yong-Joo
    • Korean Journal of Ichthyology
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    • v.19 no.1
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    • pp.24-34
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    • 2007
  • After releasing more than 1,000,000 fertilized eggs of Plecoglossus altivelis into Lake Okjeong, Jeollabuk-do, on October, 2001 by KOWACO, they seem to be land-locked. Study on the distribution and ecology of a land-locked ayu, P. altivelis, was performed from Lake Okjeong to upper streams as Jowon, Churyeong, Oknyedong where consisted of rocky bottom with fast current freshwater system during April to October. The hatched larva and juveniles descended from streams to Lake Okjeong and inhabit Lake Okjeong from November to next March. The sex ratio of female to male was 1 : 2.70, and the size in standard length of females and males was similar, in $90{\sim}220(142{\pm}29.3)mm$. During the middle September to the middle October, they laid eggs on the pebbly bottom of the rapids which are $20{\sim}22^{\circ}C$ in water temperature and 30~70 cm in depth. The number of full-grown eggs was greatly various from 14,283~91,500.

Monthly Species Composition of Upstream-Migrating Fish in the Cheonjeyeon Estuary of Jeju, Korea (제주 천제연 하구 소상어류의 월별 종조성)

  • Hwang, Hak Bin;Lee, Tae Won;Hwang, Sun Wan;Kim, Byung-Jik
    • Korean Journal of Ichthyology
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    • v.20 no.3
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    • pp.210-219
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    • 2008
  • Monthly variation in species composition of upstream-migrating fish in the Cheonjeyeon Estuary was determined by analyzing fish data collected January~September 2004 and January~August 2007. Fish migrating from the sea to freshwater through the channels were collected by a rectangular net with a mesh size of 2 mm during the day and at night in the new moon. Of 14 species collected, ayu (Plecoglossus altivelis altivelis) and mullet (Mugil cephalus) predominated in abundance. Glass eels (Anguilla japonica) occurred mainly during the night from February to May. Other fishes collected included brackish-water gobiids (Gymnogobius urotaenia, Rhinogobius giurinus, Tridentiger obscurus, and Sicyopterus japonicus), freshwater fishes (Misgurnus anguillicaudatus and Rhynchocypris oxycephalus), and coastal marine fishes (Engraulis japonicus, Pempheris japonica, Plotosus lineatus, Takifugu niphobles, and Terapon jarbua). Ayu occurred during almost all sampling periods. They ranged principally from 55 to 100 mm total length (TL), with some fish larger than 100 mm TL collected after April. Mullet also occurred during almost all sampling periods. They ranged principally 25~58 mm TL, with some larger fish of 103~240 mm TL collected in February and April. That only a few freshwater and brackish-water fishes occurred in the study area is probably related to the freshwater systems having long been isolated from the continental systems and to the poorly developed estuaries in Jeju Island reflecting limited river discharge.

Comparison of Growth and Spawning Characteristics of Ayu, Plecoglossus altivelis in Seomjin River and Streams Flowing to the East Sea, Korea (동해로 유입하는 하천과 섬진강에 서식하는 은어 Plecoglossus altivelis의 성장 및 산란 특징의 비교)

  • Lee, Wan-Ok;Yoon, Seung-Woon;Kim, Jong-Hwa;Kim, Dae-Hee
    • Korean Journal of Ichthyology
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    • v.20 no.3
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    • pp.179-189
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    • 2008
  • Standard length (SL) and gonadosomatic index (GSI) of Plecoglossus altivelis were investigated from March to October 2007 in Seomjin River and streams flowing to the East Sea, Korea. Water temperatures were $17{\sim}23^{\circ}C$ during the spawning season, which ran from late September to early November in Seomjin River and early August to mid-October in streams flowing to the East Sea. The GSI and HSI variations of ayu population in Seomjin River increased earlier than in populations in streams flowing to the East Sea with similar variation in water temperature. Histological study of ovaries showed that the start of spawning of P. altivelis in Seomjin River was later than in streams flowing to the East Sea. Overall, fecundity increased with increase in SL and not by site specificity. The SL of P. altivelis increased as the river scale increased. Mean length of specimens from Seomjin River (river length: 223.86 km, river area: $4,911.89km^2$) was $194{\pm}15.3mm$, from Osip Stream (55.76 km, $393.78km^2$) $185{\pm}15.5mm$, from Yangyang Namdae Stream (54 km, $474.08km^2$) $142{\pm}11.8mm$, and from Joosoo Stream (21.1 km, $141.47km^2$) $136{\pm}16.7 mm$.

Multi Parameter Design in AIML Framework for Balinese Calendar Knowledge Access

  • Sukarsa, I Made;Buana, Putu Wira;Yogantara, Urip
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.14 no.1
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    • pp.114-130
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    • 2020
  • Balinese calendar is defined as a unique calendar system for combining solar-based and lunar-based system and assuming local system. It is considered as guidance of Balinese societies' activities management, starting from meeting arrangement, wedding ceremony, to religious ceremonies. Practically, it has developed in the form of printed Balinese calendar and electronic Balinese calendar, either web or mobile application. The core of the function is to find out the day with its various characteristics in the Balinese Calendar. In general, society usually asks the religious leader to find out the day in detail. The technology of NLP combined with models of pattern discoveries supports the arrangement of the interaction model in searching the good day in Balinese Calendar to equip the conventional searching system in the previous applications. This study will design a dialog model with AIML method in multi-parameter basis; therefore, the users will be dynamically able to use the searching content in various ways by chatting in similar with consulting to a religious leader. This model will be applied in a chatbot basis service in telegram machine. The addition of the context recognition section into 4 paterns has been successfully improve the ability of AIML to recognize input patterns with many criteria. Based on the testing with 50 random input patterns obtained a success rate of 92.5%.

Prevention Technologies of environmental contamination and IMO action in Arctic Ice-covered Waters (극지해역에서의 환경오염 방지 기술 및 IMO 동향)

  • Kang, Jae-Sung;Kim, Ki-Pyoung;Kang, Ho-Keun;Kim, Dae-Heon
    • Proceedings of the Korean Society of Marine Engineers Conference
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    • 2011.06a
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    • pp.237-239
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    • 2011
  • 최근 국제해사기구(International Maritime Organization, IMO)는 "극지를 운항하는 선박에 대한 안전기준(Polar Code)"를 제정하여 결정하기로 하였으며, 2012년까지 완료하여 법제화하기로 하였다. 이는 최근의 극해 지역의 연속적인 사고의 심각성에 대한 대비책의 일환이다. 2004년도에 알라스카 앞바다에 침몰한 Selendang Ayu 는 6600만 톤의 콩, 170만 리터의 연료유와 55,564 리터의 MDO 및 다른 오염물질을 바다에 유출하였다. 이는 주변의 동물들에게 심각한 영향을 끼쳤고, 아직까지도 유출되어진 오염물질들을 완전히 처리하지 못한 상태이다(Arctic marine shipping assessment, Arctic council 2009.). 즉, 기름이 유출을 하면 방재시설이 다른 육상에서 오기 전까지는 상당히 오랜 시간 동안, 사고 지역 주변을 오염시키게 되며, 유빙이나 극한의 온도는 방재 작업을 더욱 힘들게 한다. 본 연구에서는 극해와 같은 해역에서 기름이 유출 하였을 때에 대응하는 방법, 즉 현존하는 기계적인 복구 방식, 점화식 처리 방식 과 유처리제 방식을 소개하고, 그에 대한 국제규정 및 기술 발전 동향에 대해서도 설명한다.

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Efficiency of transformation mediated by Agrobacterium tumefaciens using vacuum infiltration in rice (Oryza sativa L.)

  • Safitri, Fika Ayu;Ubaidillah, Mohammad;Kim, Kyung-Min
    • Journal of Plant Biotechnology
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    • v.43 no.1
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    • pp.66-75
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    • 2016
  • Agrobacterium-mediated gene transfer has recently been developed to improve rice transformation. In this study, 3 different transformation methods were tested including soaking, co-cultivation, and vacuum infiltration. Agrobacterium tumefaciens GV3101 harboring the binary vector pGreen:: LeGSNOR was used in this experiment. This study aimed to identify the most appropriate method for transferring LeGSNOR into rice. Vacuum infiltration of the embryonic calli for 5 min in Ilpum resulted in high transformation efficiency based on confirmation by PCR, RT-PCR, and qRT-PCR analyses. In conclusion, we described the development of an efficient transformation protocol for the stable integration of foreign genes into rice; furthermore, the study results confirmed that PCR is suitable for efficient detection of the integrated gene. The vacuum infiltration system is a potentially useful tool for future studies focusing on transferring important genes into rice seed calli, and may help reduce time and effort.

Preparation and application of reduced graphene oxide as the conductive material for capacitive deionization

  • Nugrahenny, Ayu Tyas Utami;Kim, Jiyoung;Kim, Sang-Kyung;Peck, Dong-Hyun;Yoon, Seong-Ho;Jung, Doo-Hwan
    • Carbon letters
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    • v.15 no.1
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    • pp.38-44
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    • 2014
  • This paper reports the effect of adding reduced graphene oxide (RGO) as a conductive material to the composition of an electrode for capacitive deionization (CDI), a process to remove salt from water using ionic adsorption and desorption driven by external applied voltage. RGO can be synthesized in an inexpensive way by the reduction and exfoliation of GO, and removing the oxygen-containing groups and recovering a conjugated structure. GO powder can be obtained from the modification of Hummers method and reduced into RGO using a thermal method. The physical and electrochemical characteristics of RGO material were evaluated and its desalination performance was tested with a CDI unit cell with a potentiostat and conductivity meter, by varying the applied voltage and feed rate of the salt solution. The performance of RGO was compared to graphite as a conductive material in a CDI electrode. The result showed RGO can increase the capacitance, reduce the equivalent series resistance, and improve the electrosorption capacity of CDI electrode.

Bioremediation of Crude Oil by White Rot Fungi Polyporus sp. S133

  • Kristanti, Risky Ayu;Hadibarata, Tony;Toyama, Tadashi;Tanaka, Yasuhiro;Mori, Kazuhiro
    • Journal of Microbiology and Biotechnology
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    • v.21 no.9
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    • pp.995-1000
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    • 2011
  • The bioremediation potential of crude oil by Polyporus sp. S133 pre-grown in wood meal was investigated in two separate experiment trials; liquid medium and soil. The effect of three nutrients (glucose, polypeptone, and wood meal), oxygen flow, and some absorbent on the efficiency of the process was also evaluated. Degradation of crude oil in soil was significantly increased with an addition of oxygen flow and some absorbent (kapok and pulp). The highest degradation rate of crude oil was 93% in the soil with an addition of 10% kapok. The present study clearly demonstrates that, if suitably developed, Polyporus sp. S133 could be used to remediate soil contaminated with crude oil.